An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome.

Lesker TR, Durairaj AC, Galvez EJC, Lagkouvardos I, Baines JF, Clavel T, Sczyrba A, McHardy AC, Strowig T (2020)
Cell reports 30(9): 2909-2922.e6.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Lesker, Till R; Durairaj, Abilash C; Galvez, Eric J C; Lagkouvardos, Ilias; Baines, John F; Clavel, Thomas; Sczyrba, AlexanderUniBi ; McHardy, Alice C; Strowig, Till
Abstract / Bemerkung
The complexity of host-associated microbial ecosystems requires host-specific reference catalogs to survey the functions and diversity of these communities. We generate a comprehensive resource, the integrated mouse gut metagenome catalog (iMGMC), comprising 4.6 million unique genes and 660 metagenome-assembled genomes (MAGs), many (485 MAGs, 73%) of which are linked to reconstructed full-length 16S rRNA gene sequences. iMGMC enables unprecedented coverage and taxonomic resolution of the mouse gut microbiota; i.e., more than 92% of MAGs lack species-level representatives in public repositories (<95% ANI match). The integration of MAGs and 16S rRNA gene data allows more accurate prediction of functional profiles of communities than predictions based on 16S rRNA amplicons alone. Accompanying iMGMC, we provide a set of MAGs representing 1,296 gut bacteria obtained through complementary assembly strategies. We envision that integrated resources such as iMGMC, together with MAG collections, will enhance the resolution of numerous existing and future sequencing-based studies. Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Erscheinungsjahr
2020
Zeitschriftentitel
Cell reports
Band
30
Ausgabe
9
Seite(n)
2909-2922.e6
ISSN
2211-1247
eISSN
2211-1247
Page URI
https://pub.uni-bielefeld.de/record/2941704

Zitieren

Lesker TR, Durairaj AC, Galvez EJC, et al. An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell reports. 2020;30(9):2909-2922.e6.
Lesker, T. R., Durairaj, A. C., Galvez, E. J. C., Lagkouvardos, I., Baines, J. F., Clavel, T., Sczyrba, A., et al. (2020). An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell reports, 30(9), 2909-2922.e6. doi:10.1016/j.celrep.2020.02.036
Lesker, T. R., Durairaj, A. C., Galvez, E. J. C., Lagkouvardos, I., Baines, J. F., Clavel, T., Sczyrba, A., McHardy, A. C., and Strowig, T. (2020). An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell reports 30, 2909-2922.e6.
Lesker, T.R., et al., 2020. An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell reports, 30(9), p 2909-2922.e6.
T.R. Lesker, et al., “An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome.”, Cell reports, vol. 30, 2020, pp. 2909-2922.e6.
Lesker, T.R., Durairaj, A.C., Galvez, E.J.C., Lagkouvardos, I., Baines, J.F., Clavel, T., Sczyrba, A., McHardy, A.C., Strowig, T.: An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell reports. 30, 2909-2922.e6 (2020).
Lesker, Till R, Durairaj, Abilash C, Galvez, Eric J C, Lagkouvardos, Ilias, Baines, John F, Clavel, Thomas, Sczyrba, Alexander, McHardy, Alice C, and Strowig, Till. “An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome.”. Cell reports 30.9 (2020): 2909-2922.e6.

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