IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates

Schlüter A, Nordmann P, Bonnin RA, Millemann Y, Eikmeyer FG, Wibberg D, Pühler A, Poirel L (2014)
Antimicrobial Agents and Chemotherapy 58(7): 3768-3773.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
DOI
Autor*in
Schlüter, AndreasUniBi ; Nordmann, Patrice; Bonnin, Rémy A.; Millemann, Yves; Eikmeyer, Felix GregorUniBi ; Wibberg, DanielUniBi; Pühler, AlfredUniBi ; Poirel, Laurent
Einrichtung
Centrum für Biotechnologie > Graduate Center > Graduate Cluster Industrial Biotechnology
Centrum für Biotechnologie > Arbeitsgruppe A. Pühler
Abstract / Bemerkung
The whole sequence of plasmid pENVA carrying the extended-spectrum beta-lactamase gene blaCTX-M-15 was determined. It was identified from a series of clonally related Klebsiella pneumoniae sequence type 274 strains recovered from companion animals. This plasmid was 253,984 bp in size and harbored, in addition to blaCTX-M-15, a large array of genes encoding resistance to many antibiotic molecules, including beta-lactams (blaTEM-1, blaDHA-1), aminoglycosides (aacA2, aadA1), tetracycline (tetA), quinolones (qnrB4), trimethoprim (dfrA15), and sulfonamides (two copies of sul1). In addition, genes encoding resistance to mercury, tellurium, nickel, and quaternary compounds were identified. It also carried genes encoding DNA damage protection and mutagenesis repair and a locus for a CRISPR system, which corresponds to an immune system involved in protection against bacteriophages and plasmids. Comparative analysis of the plasmid scaffold showed that it possessed a structure similar to that of only a single plasmid, which was pNDM-MAR encoding the carbapenemase NDM-1 and identified from human K. pneumoniae isolates. Both plasmids possessed two replicons, namely, those of IncFIB-like and IncHIB-like plasmids, which were significantly different from those previously characterized. The blaCTX-M-15 gene, together with the other antibiotic resistance genes, was part of a large module likely acquired through a transposition process. We characterized here a new plasmid type carrying the blaCTX-M-15 gene identified in a K. pneumoniae isolate of animal origin. The extent to which this plasmid type may spread efficiently and possibly further enhance the dissemination of blaCTX-M-15 among animal and human isolates remains to be determined.
Erscheinungsjahr
2014
Zeitschriftentitel
Antimicrobial Agents and Chemotherapy
Band
58
Ausgabe
7
Seite(n)
3768-3773
ISSN
0066-4804
eISSN
1098-6596
Page URI
https://pub.uni-bielefeld.de/record/2676049

Zitieren

Schlüter A, Nordmann P, Bonnin RA, et al. IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates. Antimicrobial Agents and Chemotherapy. 2014;58(7):3768-3773.
Schlüter, A., Nordmann, P., Bonnin, R. A., Millemann, Y., Eikmeyer, F. G., Wibberg, D., Pühler, A., et al. (2014). IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates. Antimicrobial Agents and Chemotherapy, 58(7), 3768-3773. doi:10.1128/AAC.02695-14
Schlüter, Andreas, Nordmann, Patrice, Bonnin, Rémy A., Millemann, Yves, Eikmeyer, Felix Gregor, Wibberg, Daniel, Pühler, Alfred, and Poirel, Laurent. 2014. “IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates”. Antimicrobial Agents and Chemotherapy 58 (7): 3768-3773.
Schlüter, A., Nordmann, P., Bonnin, R. A., Millemann, Y., Eikmeyer, F. G., Wibberg, D., Pühler, A., and Poirel, L. (2014). IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates. Antimicrobial Agents and Chemotherapy 58, 3768-3773.
Schlüter, A., et al., 2014. IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates. Antimicrobial Agents and Chemotherapy, 58(7), p 3768-3773.
A. Schlüter, et al., “IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates”, Antimicrobial Agents and Chemotherapy, vol. 58, 2014, pp. 3768-3773.
Schlüter, A., Nordmann, P., Bonnin, R.A., Millemann, Y., Eikmeyer, F.G., Wibberg, D., Pühler, A., Poirel, L.: IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates. Antimicrobial Agents and Chemotherapy. 58, 3768-3773 (2014).
Schlüter, Andreas, Nordmann, Patrice, Bonnin, Rémy A., Millemann, Yves, Eikmeyer, Felix Gregor, Wibberg, Daniel, Pühler, Alfred, and Poirel, Laurent. “IncH-type plasmid harboring the blaCTX-M-15, blaDHA-1, and qnrB4 genes recovered from animal isolates”. Antimicrobial Agents and Chemotherapy 58.7 (2014): 3768-3773.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Diverse Plasmids Harboring blaCTX-M-15 in Klebsiella pneumoniae ST11 Isolates from Several Asian Countries.
Kim SY, Ko KS., Microb Drug Resist 25(2), 2019
PMID: 30212274
Characterization of the population structure, drug resistance mechanisms and plasmids of the community-associated Enterobacter cloacae complex in China.
Zhou K, Yu W, Cao X, Shen P, Lu H, Luo Q, Rossen JWA, Xiao Y., J Antimicrob Chemother 73(1), 2018
PMID: 29088362
The CRISPR-Cas system in Enterobacteriaceae.
Medina-Aparicio L, Dávila S, Rebollar-Flores JE, Calva E, Hernández-Lucas I., Pathog Dis 76(1), 2018
PMID: 29325038
Plasmids carrying DHA-1 β-lactamases.
Hennequin C, Ravet V, Robin F., Eur J Clin Microbiol Infect Dis 37(7), 2018
PMID: 29663096
Diversity of DHA-1-encoding plasmids in Klebsiella pneumoniae isolates from 16 French hospitals.
Hennequin C, Chlilek A, Beyrouthy R, Bonnet R, Robin F., J Antimicrob Chemother 73(11), 2018
PMID: 30060165
Draft Genome Sequence of Klebsiella pneumoniae KGM-IMP216 Harboring blaCTX-M-15, blaDHA-1, blaTEM-1B, blaNDM-1, blaSHV-28, and blaOXA-1, Isolated from a Patient in Lebanon.
Tokajian S, Eisen JA, Jospin G, Matar G, Araj GF, Coil DA., Genome Announc 4(1), 2016
PMID: 26823584
Finished Genome Sequence of the Highly Multidrug-Resistant Human Urine Isolate Citrobacter freundii Strain SL151.
Leski TA, Taitt CR, Bangura U, Ansumana R, Stenger DA, Wang Z, Vora GJ., Genome Announc 4(6), 2016
PMID: 27811104

52 References

Daten bereitgestellt von Europe PubMed Central.

Public health risks of enterobacterial isolates producing extended-spectrum β-lactamases or AmpC β-lactamases in food and food-producing animals: an EU perspective of epidemiology, analytical methods, risk factors, and control options.
Liebana E, Carattoli A, Coque TM, Hasman H, Magiorakos AP, Mevius D, Peixe L, Poirel L, Schuepbach-Regula G, Torneke K, Torren-Edo J, Torres C, Threlfall J., Clin. Infect. Dis. 56(7), 2012
PMID: 23243183
Reservoirs of antimicrobial resistance in pet animals.
Lloyd DH., Clin. Infect. Dis. 45 Suppl 2(), 2007
PMID: 17683019
Extended-spectrum beta-lactamases: a clinical update.
Paterson DL, Bonomo RA., Clin. Microbiol. Rev. 18(4), 2005
PMID: 16223952
Genetic support and diversity of acquired extended-spectrum β-lactamases in Gram-negative rods.
Poirel L, Bonnin RA, Nordmann P., Infect. Genet. Evol. 12(5), 2012
PMID: 22414916
Animal reservoirs for extended spectrum beta-lactamase producers.
Carattoli A., Clin. Microbiol. Infect. 14 Suppl 1(), 2008
PMID: 18154535
Extended-spectrum beta-lactamase CTX-M-1 in Escherichia coli isolates from healthy poultry in France.
Girlich D, Poirel L, Carattoli A, Kempf I, Lartigue MF, Bertini A, Nordmann P., Appl. Environ. Microbiol. 73(14), 2007
PMID: 17513592
Escherichia coli producing CTX-M-2 beta-lactamase in cattle, Japan.
Shiraki Y, Shibata N, Doi Y, Arakawa Y., Emerging Infect. Dis. 10(1), 2004
PMID: 15078599
CTX-M-type extended-spectrum β-lactamases present in Escherichia coli from the feces of cattle in Ohio, United States.
Wittum TE, Mollenkopf DF, Daniels JB, Parkinson AE, Mathews JL, Fry PR, Abley MJ, Gebreyes WA., Foodborne Pathog. Dis. 7(12), 2010
PMID: 20707724
Mechanisms of antibiotic resistance in Escherichia coli isolates recovered from wild animals.
Costa D, Poeta P, Saenz Y, Vinue L, Coelho AC, Matos M, Rojo-Bezares B, Rodrigues J, Torres C., Microb. Drug Resist. 14(1), 2008
PMID: 18321208
Seagulls and beaches as reservoirs for multidrug-resistant Escherichia coli.
Simoes RR, Poirel L, Da Costa PM, Nordmann P., Emerging Infect. Dis. 16(1), 2010
PMID: 20031053
Genetic characterisation of extended-spectrum β-lactamases in Escherichia coli isolated from retail chicken products including CTX-M-9 containing isolates: a food safety risk factor.
Silva N, Costa L, Goncalves A, Sousa M, Radhouani H, Brito F, Igrejas G, Poeta P., Br. Poult. Sci. 53(6), 2012
PMID: 23398418
Prevalence of extended-spectrum cephalosporinase (ESC)-producing Escherichia coli in Danish slaughter pigs and retail meat identified by selective enrichment and association with cephalosporin usage.
Agerso Y, Aarestrup FM, Pedersen K, Seyfarth AM, Struve T, Hasman H., J. Antimicrob. Chemother. 67(3), 2011
PMID: 22207594
AmpC beta-lactamases.
Jacoby GA., Clin. Microbiol. Rev. 22(1), 2009
PMID: 19136439
Resistance plasmid families in Enterobacteriaceae.
Carattoli A., Antimicrob. Agents Chemother. 53(6), 2009
PMID: 19307361
Evolution of IncA/C blaCMY-₂-carrying plasmids by acquisition of the blaNDM-₁ carbapenemase gene.
Carattoli A, Villa L, Poirel L, Bonnin RA, Nordmann P., Antimicrob. Agents Chemother. 56(2), 2011
PMID: 22123704
Comparative genomics of IncL/M-type plasmids: evolution by acquisition of resistance genes and insertion sequences.
Bonnin RA, Nordmann P, Carattoli A, Poirel L., Antimicrob. Agents Chemother. 57(1), 2012
PMID: 23114767
Evolution of IncHI2 plasmids via acquisition of transposons carrying antibiotic resistance determinants.
Cain AK, Hall RM., J. Antimicrob. Chemother. 67(5), 2012
PMID: 22334605
Evolution of IncHI1 plasmids: two distinct lineages.
Cain AK, Hall RM., Plasmid 70(2), 2013
PMID: 23567475
Comparative analysis of IncHI2 plasmids carrying blaCTX-M-2 or blaCTX-M-9 from Escherichia coli and Salmonella enterica strains isolated from poultry and humans.
Garcia Fernandez A, Cloeckaert A, Bertini A, Praud K, Doublet B, Weill FX, Carattoli A., Antimicrob. Agents Chemother. 51(11), 2007
PMID: 17698627
Characterization of blaCTX-M IncFII plasmids and clones of Escherichia coli from pets in France.
Dahmen S, Haenni M, Chatre P, Madec JY., J. Antimicrob. Chemother. 68(12), 2013
PMID: 23852541
IncI1/ST3 plasmids contribute to the dissemination of the blaCTX-M-1 gene in Escherichia coli from several animal species in France.
Dahmen S, Haenni M, Madec JY., J. Antimicrob. Chemother. 67(12), 2012
PMID: 22872449
Non-ST131 Escherichia coli from cattle harbouring human-like bla(CTX-M-15)-carrying plasmids.
Madec JY, Poirel L, Saras E, Gourguechon A, Girlich D, Nordmann P, Haenni M., J. Antimicrob. Chemother. 67(3), 2011
PMID: 22210752
Extended-spectrum β-lactamase CTX-M-15-producing Klebsiella pneumoniae of sequence type ST274 in companion animals.
Poirel L, Nordmann P, Ducroz S, Boulouis HJ, Arne P, Millemann Y., Antimicrob. Agents Chemother. 57(5), 2013
PMID: 23422912

AUTHOR UNKNOWN, 2013
Insights into the completely annotated genome of Lactobacillus buchneri CD034, a strain isolated from stable grass silage.
Heinl S, Wibberg D, Eikmeyer F, Szczepanowski R, Blom J, Linke B, Goesmann A, Grabherr R, Schwab H, Puhler A, Schluter A., J. Biotechnol. 161(2), 2012
PMID: 22465289
Complete genome sequencing of Agrobacterium sp. H13-3, the former Rhizobium lupini H13-3, reveals a tripartite genome consisting of a circular and a linear chromosome and an accessory plasmid but lacking a tumor-inducing Ti-plasmid.
Wibberg D, Blom J, Jaenicke S, Kollin F, Rupp O, Scharf B, Schneiker-Bekel S, Sczcepanowski R, Goesmann A, Setubal JC, Schmitt R, Puhler A, Schluter A., J. Biotechnol. 155(1), 2011
PMID: 21329740
Complete sequencing of an IncH plasmid carrying the blaNDM-1, blaCTX-M-15 and qnrB1 genes.
Villa L, Poirel L, Nordmann P, Carta C, Carattoli A., J. Antimicrob. Chemother. 67(7), 2012
PMID: 22511638
r2cat: synteny plots and comparative assembly.
Husemann P, Stoye J., Bioinformatics 26(4), 2009
PMID: 20015948
Consed: a graphical tool for sequence finishing.
Gordon D, Abajian C, Green P., Genome Res. 8(3), 1998
PMID: 9521923
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
The complete genome sequences of four new IncN plasmids from wastewater treatment plant effluent provide new insights into IncN plasmid diversity and evolution.
Eikmeyer F, Hadiati A, Szczepanowski R, Wibberg D, Schneiker-Bekel S, Rogers LM, Brown CJ, Top EM, Puhler A, Schluter A., Plasmid 68(1), 2012
PMID: 22326849
Sequencing and comparative analysis of IncP-1α antibiotic resistance plasmids reveal a highly conserved backbone and differences within accessory regions.
Szczepanowski R, Eikmeyer F, Harfmann J, Blom J, Rogers LM, Top EM, Schluter A., J. Biotechnol. 155(1), 2010
PMID: 21115076
Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria.
Ilyina TV, Koonin EV., Nucleic Acids Res. 20(13), 1992
PMID: 1630899
Clustal W and Clustal X version 2.0.
Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG., Bioinformatics 23(21), 2007
PMID: 17846036
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.
Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S., Mol. Biol. Evol. 28(10), 2011
PMID: 21546353
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou N, Nei M., Mol. Biol. Evol. 4(4), 1987
PMID: 3447015
Identification of plasmids by PCR-based replicon typing.
Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ., J. Microbiol. Methods 63(3), 2005
PMID: 15935499
IncP-1β plasmids of Comamonas sp. and Delftia sp. strains isolated from a wastewater treatment plant mediate resistance to and decolorization of the triphenylmethane dye crystal violet.
Stolze Y, Eikmeyer F, Wibberg D, Brandis G, Karsten C, Krahn I, Schneiker-Bekel S, Viehover P, Barsch A, Keck M, Top EM, Niehaus K, Schluter A., Microbiology (Reading, Engl.) 158(Pt 8), 2012
PMID: 22653947
M-GCAT: interactively and efficiently constructing large-scale multiple genome comparison frameworks in closely related species.
Treangen TJ, Messeguer X., BMC Bioinformatics 7(), 2006
PMID: 17022809
CRISPR-based adaptive immune systems.
Terns MP, Terns RM., Curr. Opin. Microbiol. 14(3), 2011
PMID: 21531607
The IS1111 family members IS4321 and IS5075 have subterminal inverted repeats and target the terminal inverted repeats of Tn21 family transposons.
Partridge SR, Hall RM., J. Bacteriol. 185(21), 2003
PMID: 14563872
Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti.
Potron A, Munoz-Price LS, Nordmann P, Cleary T, Poirel L., Antimicrob. Agents Chemother. 55(12), 2011
PMID: 21930877
ISEcp1B-mediated transposition of blaCTX-M in Escherichia coli.
Poirel L, Lartigue MF, Decousser JW, Nordmann P., Antimicrob. Agents Chemother. 49(1), 2005
PMID: 15616333
Complete nucleotide sequence of Klebsiella pneumoniae multidrug resistance plasmid pKP048, carrying blaKPC-2, blaDHA-1, qnrB4, and armA.
Jiang Y, Yu D, Wei Z, Shen P, Zhou Z, Yu Y., Antimicrob. Agents Chemother. 54(9), 2010
PMID: 20547789
The SOS response promotes qnrB quinolone-resistance determinant expression.
Da Re S, Garnier F, Guerin E, Campoy S, Denis F, Ploy MC., EMBO Rep. 10(8), 2009
PMID: 19556999
The nucleotide sequence of the mercuric resistance operons of plasmid R100 and transposon Tn501: further evidence for mer genes which enhance the activity of the mercuric ion detoxification system.
Brown NL, Misra TK, Winnie JN, Schmidt A, Seiff M, Silver S., Mol. Gen. Genet. 202(1), 1986
PMID: 3007931
Bacteriophage lambda lysis gene product modified and inserted into Escherichia coli outer membrane: Rz1 lipoprotein.
Taylor A, Kedzierska S, Wawrzynow A., Microb. Drug Resist. 2(1), 1996
PMID: 9158738
Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.
Huang TW, Chen TL, Chen YT, Lauderdale TL, Liao TL, Lee YT, Chen CP, Liu YM, Lin AC, Chang YH, Wu KM, Kirby R, Lai JF, Tan MC, Siu LK, Chang CM, Fung CP, Tsai SF., PLoS ONE 8(4), 2013
PMID: 23658651
Characterization of pKP1433, a novel KPC-2-encoding plasmid from Klebsiella pneumoniae sequence type 340.
Papagiannitsis CC, Miriagou V, Giakkoupi P, Tzouvelekis LS, Vatopoulos AC., Antimicrob. Agents Chemother. 57(7), 2013
PMID: 23629721
-1 frameshifting at a CGA AAG hexanucleotide site is required for transposition of insertion sequence IS1222.
Mejlhede N, Licznar P, Prere MF, Wills NM, Gesteland RF, Atkins JF, Fayet O., J. Bacteriol. 186(10), 2004
PMID: 15126494
A note on the neighbor-joining algorithm of Saitou and Nei.
Studier JA, Keppler KJ., Mol. Biol. Evol. 5(6), 1988
PMID: 3221794
Emergence of NDM-1-producing Klebsiella pneumoniae in Morocco.
Poirel L, Benouda A, Hays C, Nordmann P., J. Antimicrob. Chemother. 66(12), 2011
PMID: 21930570
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 24752252
PubMed | Europe PMC

Suchen in

Google Scholar