Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia

Trost E, Blom J, de Castro Soares S, Huang I-H, Al-Dilaimi A, Schröder J, Jaenicke S, Dorella FA, Rocha FS, Miyoshi A, Azevedo V, et al. (2012)
Journal of bacteriology 194(12): 3199-3215.

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DOI
Autor*in
Trost, EvaUniBi ; Blom, JochenUniBi; de Castro Soares, Siomar; Huang, I-Hsiu; Al-Dilaimi, ArwaUniBi; Schröder, JasminUniBi; Jaenicke, SebastianUniBi; Dorella, Fernanda A; Rocha, Flavia S; Miyoshi, Anderson; Azevedo, Vasco; Schneider, Maria P
Alle
Einrichtung
Centrum für Biotechnologie > Graduate Center > Graduate Cluster Industrial Biotechnology
Centrum für Biotechnologie > Arbeitsgruppe A. Tauch
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Technische Fakultät > Computational Genomics
Centrum für Biotechnologie > Technologieplattformen > Bioinformatics Resource Facility
Technische Fakultät > AG Genominformatik
Abstract / Bemerkung
Corynebacterium diphtheriae is one of the most prominent human pathogens and the causative agent of the communicable disease diphtheria. The genomes of 12 strains isolated from patients with classical diphtheria, endocarditis, and pneumonia were completely sequenced and annotated. Including the genome of C. diphtheriae NCTC 13129, we herewith present a comprehensive comparative analysis of 13 strains and the first characterization of the pangenome of the species C. diphtheriae. Comparative genomics showed extensive synteny and revealed a core genome consisting of 1,632 conserved genes. The pangenome currently comprises 4,786 protein-coding regions and increases at an average of 65 unique genes per newly sequenced strain. Analysis of prophages carrying the diphtheria toxin gene tox revealed that the toxoid vaccine producer C. diphtheriae Park-Williams no. 8 has been lysogenized by two copies of the omega(tox)(+) phage, whereas C. diphtheriae 31A harbors a hitherto-unknown tox(+) corynephage. DNA binding sites of the tox-controlling regulator DtxR were detected by genome-wide motif searches. Comparative content analysis showed that the DtxR regulons exhibit marked differences due to gene gain, gene loss, partial gene deletion, and DtxR binding site depletion. Most predicted pathogenicity islands of C. diphtheriae revealed characteristics of horizontal gene transfer. The majority of these islands encode subunits of adhesive pili, which can play important roles in adhesion of C. diphtheriae to different host tissues. All sequenced isolates contain at least two pilus gene clusters. It appears that variation in the distributed genome is a common strategy of C. diphtheriae to establish differences in host-pathogen interactions.
Erscheinungsjahr
2012
Zeitschriftentitel
Journal of bacteriology
Band
194
Ausgabe
12
Seite(n)
3199-3215
ISSN
0021-9193
Page URI
https://pub.uni-bielefeld.de/record/2513347

Zitieren

Trost E, Blom J, de Castro Soares S, et al. Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia. Journal of bacteriology. 2012;194(12):3199-3215.
Trost, E., Blom, J., de Castro Soares, S., Huang, I. - H., Al-Dilaimi, A., Schröder, J., Jaenicke, S., et al. (2012). Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia. Journal of bacteriology, 194(12), 3199-3215. doi:10.1128/JB.00183-12
Trost, Eva, Blom, Jochen, de Castro Soares, Siomar, Huang, I-Hsiu, Al-Dilaimi, Arwa, Schröder, Jasmin, Jaenicke, Sebastian, et al. 2012. “Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia”. Journal of bacteriology 194 (12): 3199-3215.
Trost, E., Blom, J., de Castro Soares, S., Huang, I. - H., Al-Dilaimi, A., Schröder, J., Jaenicke, S., Dorella, F. A., Rocha, F. S., Miyoshi, A., et al. (2012). Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia. Journal of bacteriology 194, 3199-3215.
Trost, E., et al., 2012. Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia. Journal of bacteriology, 194(12), p 3199-3215.
E. Trost, et al., “Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia”, Journal of bacteriology, vol. 194, 2012, pp. 3199-3215.
Trost, E., Blom, J., de Castro Soares, S., Huang, I.-H., Al-Dilaimi, A., Schröder, J., Jaenicke, S., Dorella, F.A., Rocha, F.S., Miyoshi, A., Azevedo, V., Schneider, M.P., Silva, A., Camello, T.C., Sabbadini, P.S., Santos, C.S., Santos, L.S., Hirata, R.J., Mattos-Guaraldi, A.L., Efstratiou, A., Schmitt, M.P., Ton-That, H., Tauch, A.: Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia. Journal of bacteriology. 194, 3199-3215 (2012).
Trost, Eva, Blom, Jochen, de Castro Soares, Siomar, Huang, I-Hsiu, Al-Dilaimi, Arwa, Schröder, Jasmin, Jaenicke, Sebastian, Dorella, Fernanda A, Rocha, Flavia S, Miyoshi, Anderson, Azevedo, Vasco, Schneider, Maria P, Silva, Artur, Camello, Thereza C, Sabbadini, Priscila S, Santos, Cintia S, Santos, Louisy S, Hirata, Raphael Jr, Mattos-Guaraldi, Ana L, Efstratiou, Androulla, Schmitt, Michael P, Ton-That, Hung, and Tauch, Andreas. “Pangenomic Study of Corynebacterium diphtheriae That Provides Insights into the Genomic Diversity of Pathogenic Isolates from Cases of Classical Diphtheria, Endocarditis, and Pneumonia”. Journal of bacteriology 194.12 (2012): 3199-3215.

58 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

NGS-based phylogeny of diphtheria-related pathogenicity factors in different Corynebacterium spp. implies species-specific virulence transmission.
Dangel A, Berger A, Konrad R, Sing A., BMC Microbiol 19(1), 2019
PMID: 30709334
Integrating Culture-based Antibiotic Resistance Profiles with Whole-genome Sequencing Data for 11,087 Clinical Isolates.
Galata V, Laczny CC, Backes C, Hemmrich-Stanisak G, Schmolke S, Franke A, Meese E, Herrmann M, von Müller L, Plum A, Müller R, Stähler C, Posch AE, Keller A., Genomics Proteomics Bioinformatics 17(2), 2019
PMID: 31100356
Genomic analysis of a novel nontoxigenic Corynebacterium diphtheriae strain isolated from a cancer patient.
Ramdhan ND, Blom J, Sutcliffe IC, Pereira-Ribeiro PMA, Santos CS, Mattos-Guaraldi AL, Burkovski A, Sangal V., New Microbes New Infect 30(), 2019
PMID: 31061711
Comparative evolutionary genomics of Corynebacterium with special reference to codon and amino acid usage diversities.
Pal S, Sarkar I, Roy A, Mohapatra PKD, Mondal KC, Sen A., Genetica 146(1), 2018
PMID: 28921302
Transcriptome sequencing of the human pathogen Corynebacterium diphtheriae NCTC 13129 provides detailed insights into its transcriptional landscape and into DtxR-mediated transcriptional regulation.
Wittchen M, Busche T, Gaspar AH, Lee JH, Ton-That H, Kalinowski J, Tauch A., BMC Genomics 19(1), 2018
PMID: 29370758
Adhesion properties of toxigenic corynebacteria.
Ott L., AIMS Microbiol 4(1), 2018
PMID: 31294205
The Druggable Pocketome of Corynebacterium diphtheriae: A New Approach for in silico Putative Druggable Targets.
Hassan SS, Jamal SB, Radusky LG, Tiwari S, Ullah A, Ali J, Behramand, de Carvalho PVSD, Shams R, Khan S, Figueiredo HCP, Barh D, Ghosh P, Silva A, Baumbach J, Röttger R, Turjanski AG, Azevedo VAC., Front Genet 9(), 2018
PMID: 29487617
Microbe Profile: Corynebacterium diphtheriae - an old foe always ready to seize opportunity.
Hoskisson PA., Microbiology 164(6), 2018
PMID: 29465341
Corynebacterium diphtheriae Iron-Regulated Surface Protein HbpA Is Involved in the Utilization of the Hemoglobin-Haptoglobin Complex as an Iron Source.
Lyman LR, Peng ED, Schmitt MP., J Bacteriol 200(7), 2018
PMID: 29311283
Searching whole genome sequences for biochemical identification features of emerging and reemerging pathogenic Corynebacterium species.
Santos AS, Ramos RT, Silva A, Hirata R, Mattos-Guaraldi AL, Meyer R, Azevedo V, Felicori L, Pacheco LGC., Funct Integr Genomics 18(5), 2018
PMID: 29752561
Phage Therapy: What Have We Learned?
Górski A, Międzybrodzki R, Łobocka M, Głowacka-Rutkowska A, Bednarek A, Borysowski J, Jończyk-Matysiak E, Łusiak-Szelachowska M, Weber-Dąbrowska B, Bagińska N, Letkiewicz S, Dąbrowska K, Scheres J., Viruses 10(6), 2018
PMID: 29843391
Characterization of two related Erwinia myoviruses that are distant relatives of the PhiKZ-like Jumbo phages.
Arens DK, Brady TS, Carter JL, Pape JA, Robinson DM, Russell KA, Staley LA, Stettler JM, Tateoka OB, Townsend MH, Whitley KV, Wienclaw TM, Williamson TL, Johnson SM, Grose JH., PLoS One 13(7), 2018
PMID: 29979759
Genome sequence of a multidrug-resistant Corynebacterium striatum isolated from bloodstream infection from a nosocomial outbreak in Rio de Janeiro, Brazil.
Ramos JN, Rodrigues IDS, Baio PVP, Veras JFC, Ramos RTJ, Pacheco LG, Azevedo VA, Hirata Júnior R, Marín MA, Mattos-Guaraldi AL, Vieira VV., Mem Inst Oswaldo Cruz 113(9), 2018
PMID: 29995109
Distinct Genomic Features Characterize Two Clades of Corynebacterium diphtheriae: Proposal of Corynebacterium diphtheriae Subsp. diphtheriae Subsp. nov. and Corynebacterium diphtheriae Subsp. lausannense Subsp. nov.
Tagini F, Pillonel T, Croxatto A, Bertelli C, Koutsokera A, Lovis A, Greub G., Front Microbiol 9(), 2018
PMID: 30174653
The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems.
Weerasekera D, Stengel F, Sticht H, de Mattos Guaraldi AL, Burkovski A, Azevedo Antunes C., BMC Microbiol 18(1), 2018
PMID: 30180805
A SNP-based phylogenetic analysis of Corynebacterium diphtheriae in Malaysia.
Hii SYF, Ahmad N, Hashim R, Liow YL, Abd Wahab MA, Mohd Khalid MKN., BMC Res Notes 11(1), 2018
PMID: 30359301
Genome-wide comparison of Corynebacterium diphtheriae isolates from Australia identifies differences in the Pan-genomes between respiratory and cutaneous strains.
Timms VJ, Nguyen T, Crighton T, Yuen M, Sintchenko V., BMC Genomics 19(1), 2018
PMID: 30509172
The underlying mechanisms of genetic innovation and speciation in the family Corynebacteriaceae: A phylogenomics approach.
Zhi XY, Jiang Z, Yang LL, Huang Y., Mol Phylogenet Evol 107(), 2017
PMID: 27864136
Characterization of the second conserved domain in the heme uptake protein HtaA from Corynebacterium diphtheriae.
Uluisik RC, Akbas N, Lukat-Rodgers GS, Adrian SA, Allen CE, Schmitt MP, Rodgers KR, Dixon DW., J Inorg Biochem 167(), 2017
PMID: 27974280
Comparative analysis of Corynebacterium glutamicum genomes: a new perspective for the industrial production of amino acids.
Yang J, Yang S., BMC Genomics 18(suppl 1), 2017
PMID: 28198668
Molecular Characterization of Corynebacterium diphtheriae Outbreak Isolates, South Africa, March-June 2015.
du Plessis M, Wolter N, Allam M, de Gouveia L, Moosa F, Ntshoe G, Blumberg L, Cohen C, Smith M, Mutevedzi P, Thomas J, Horne V, Moodley P, Archary M, Mahabeer Y, Mahomed S, Kuhn W, Mlisana K, McCarthy K, von Gottberg A., Emerg Infect Dis 23(8), 2017
PMID: 28726616
Multilocus Sequencing of Corynebacterium pseudotuberculosis Biotype Ovis Strains.
Sellyei B, Bányai K, Bartha D, Hajtós I, Fodor L, Makrai L., Biomed Res Int 2017(), 2017
PMID: 29159175
Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species.
Oliveira A, Oliveira LC, Aburjaile F, Benevides L, Tiwari S, Jamal SB, Silva A, Figueiredo HCP, Ghosh P, Portela RW, De Carvalho Azevedo VA, Wattam AR., Front Microbiol 8(), 2017
PMID: 29075239
Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s.
Grosse-Kock S, Kolodkina V, Schwalbe EC, Blom J, Burkovski A, Hoskisson PA, Brisse S, Smith D, Sutcliffe IC, Titov L, Sangal V., BMC Genomics 18(1), 2017
PMID: 29132312
GIPSy: Genomic island prediction software.
Soares SC, Geyik H, Ramos RT, de Sá PH, Barbosa EG, Baumbach J, Figueiredo HC, Miyoshi A, Tauch A, Silva A, Azevedo V., J Biotechnol 232(), 2016
PMID: 26376473
Caenorhabditis elegans star formation and negative chemotaxis induced by infection with corynebacteria.
Antunes CA, Clark L, Wanuske MT, Hacker E, Ott L, Simpson-Louredo L, de Luna Md, Hirata R, Mattos-Guaraldi AL, Hodgkin J, Burkovski A., Microbiology 162(1), 2016
PMID: 26490043
GI-SVM: A sensitive method for predicting genomic islands based on unannotated sequence of a single genome.
Lu B, Leong HW., J Bioinform Comput Biol 14(1), 2016
PMID: 26907990
Evolution, epidemiology and diversity of Corynebacterium diphtheriae: New perspectives on an old foe.
Sangal V, Hoskisson PA., Infect Genet Evol 43(), 2016
PMID: 27291708
Transcription of Sialic Acid Catabolism Genes in Corynebacterium glutamicum Is Subject to Catabolite Repression and Control by the Transcriptional Repressor NanR.
Uhde A, Brühl N, Goldbeck O, Matano C, Gurow O, Rückert C, Marin K, Wendisch VF, Krämer R, Seibold GM., J Bacteriol 198(16), 2016
PMID: 27274030
Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets.
Hassan A, Naz A, Obaid A, Paracha RZ, Naz K, Awan FM, Muhmmad SA, Janjua HA, Ahmad J, Ali A., BMC Genomics 17(1), 2016
PMID: 27634541
Utilization of host iron sources by Corynebacterium diphtheriae: multiple hemoglobin-binding proteins are essential for the use of iron from the hemoglobin-haptoglobin complex.
Allen CE, Schmitt MP., J Bacteriol 197(3), 2015
PMID: 25404705
Pan-genome analysis of human gastric pathogen H. pylori: comparative genomics and pathogenomics approaches to identify regions associated with pathogenicity and prediction of potential core therapeutic targets.
Ali A, Naz A, Soares SC, Bakhtiar M, Tiwari S, Hassan SS, Hanan F, Ramos R, Pereira U, Barh D, Figueiredo HC, Ussery DW, Miyoshi A, Silva A, Azevedo V., Biomed Res Int 2015(), 2015
PMID: 25705648
Diphtheria outbreak in Maranhão, Brazil: microbiological, clinical and epidemiological aspects.
Santos LS, Sant'anna LO, Ramos JN, Ladeira EM, Stavracakis-Peixoto R, Borges LL, Santos CS, Napoleão F, Camello TC, Pereira GA, Hirata R, Vieira VV, Cosme LM, Sabbadini PS, Mattos-Guaraldi AL., Epidemiol Infect 143(4), 2015
PMID: 25703400
Recent developments in understanding the iron acquisition strategies of gram positive pathogens.
Sheldon JR, Heinrichs DE., FEMS Microbiol Rev 39(4), 2015
PMID: 25862688
Genome informatics and vaccine targets in Corynebacterium urealyticum using two whole genomes, comparative genomics, and reverse vaccinology.
Guimarães L, Soares S, Trost E, Blom J, Ramos R, Silva A, Barh D, Azevedo V., BMC Genomics 16 Suppl 5(), 2015
PMID: 26041051
The bacterial pangenome as a new tool for analysing pathogenic bacteria.
Rouli L, Merhej V, Fournier PE, Raoult D., New Microbes New Infect 7(), 2015
PMID: 26442149
Inside the Pan-genome - Methods and Software Overview.
Guimarães LC, Florczak-Wyspianska J, de Jesus LB, Viana MV, Silva A, Ramos RT, Soares Sde C, Soares Sde C., Curr Genomics 16(4), 2015
PMID: 27006628
Draft Genome Sequence of Corynebacterium striatum 1961 BR-RJ/09, a Multidrug-Susceptible Strain Isolated from the Urine of a Hospitalized 37-Year-Old Female Patient.
Mattos-Guaraldi AL, Guimarães LC, Santos CS, Veras AA, Carneiro AR, Soares SC, Ramos JN, Souza C, Vieira VV, Hirata R, Azevedo V, Pacheco LG, Silva A, Ramos RT., Genome Announc 3(4), 2015
PMID: 26251495
Adherence and invasive properties of Corynebacterium diphtheriae strains correlates with the predicted membrane-associated and secreted proteome.
Sangal V, Blom J, Sutcliffe IC, von Hunolstein C, Burkovski A, Hoskisson PA., BMC Genomics 16(), 2015
PMID: 26452736
Heme Binding by Corynebacterium diphtheriae HmuT: Function and Heme Environment.
Draganova EB, Akbas N, Adrian SA, Lukat-Rodgers GS, Collins DP, Dawson JH, Allen CE, Schmitt MP, Rodgers KR, Dixon DW., Biochemistry 54(43), 2015
PMID: 26478504
A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing.
Sangal V, Burkovski A, Hunt AC, Edwards B, Blom J, Hoskisson PA., Infect Genet Evol 21(), 2014
PMID: 24200588
New diphtheria toxin repressor types depicted in a Romanian collection of Corynebacterium diphtheriae isolates.
Dinu S, Damian M, Badell E, Dragomirescu CC, Guiso N., J Basic Microbiol 54(10), 2014
PMID: 24293345
Draft Genome Sequence of Sphingobium sp. Strain C100, a Polycyclic Aromatic Hydrocarbon-Degrading Bacterium from the Deep-Sea Sediment of the Arctic Ocean.
Dong C, Bai X, Lai Q, Xie Y, Chen X, Shao Z., Genome Announc 2(1), 2014
PMID: 24482512
Complete Genome Sequence of Corynebacterium imitans DSM 44264, Isolated from a Five-Month-Old Boy with Suspected Pharyngeal Diphtheria.
Möllmann S, Albersmeier A, Rückert C, Tauch A., Genome Announc 2(6), 2014
PMID: 25414508
Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island.
Meinel DM, Margos G, Konrad R, Krebs S, Blum H, Sing A., Genome Med 6(11), 2014
PMID: 25587356
Contribution of phage-derived genomic islands to the virulence of facultative bacterial pathogens.
Busby B, Kristensen DM, Koonin EV., Environ Microbiol 15(2), 2013
PMID: 23035931
The pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strains.
Soares SC, Silva A, Trost E, Blom J, Ramos R, Carneiro A, Ali A, Santos AR, Pinto AC, Diniz C, Barbosa EG, Dorella FA, Aburjaile F, Rocha FS, Nascimento KK, Guimarães LC, Almeida S, Hassan SS, Bakhtiar SM, Pereira UP, Abreu VA, Schneider MP, Miyoshi A, Tauch A, Azevedo V., PLoS One 8(1), 2013
PMID: 23342011
Cell envelope of corynebacteria: structure and influence on pathogenicity.
Burkovski A., ISRN Microbiol 2013(), 2013
PMID: 23724339
Conserved host-pathogen PPIs. Globally conserved inter-species bacterial PPIs based conserved host-pathogen interactome derived novel target in C. pseudotuberculosis, C. diphtheriae, M. tuberculosis, C. ulcerans, Y. pestis, and E. coli targeted by Piper betel compounds.
Barh D, Gupta K, Jain N, Khatri G, León-Sicairos N, Canizalez-Roman A, Tiwari S, Verma A, Rahangdale S, Shah Hassan S, dos Santos AR, Ali A, Guimarães LC, Thiago Jucá Ramos R, Devarapalli P, Barve N, Bakhtiar M, Kumavath R, Ghosh P, Miyoshi A, Silva A, Kumar A, Misra AN, Blum K, Baumbach J, Azevedo V., Integr Biol (Camb) 5(3), 2013
PMID: 23288366
Analysis of novel iron-regulated, surface-anchored hemin-binding proteins in Corynebacterium diphtheriae.
Allen CE, Burgos JM, Schmitt MP., J Bacteriol 195(12), 2013
PMID: 23585541
Complete genome sequence analysis of Nocardia brasiliensis HUJEG-1 reveals a saprobic lifestyle and the genes needed for human pathogenesis.
Vera-Cabrera L, Ortiz-Lopez R, Elizondo-Gonzalez R, Ocampo-Candiani J., PLoS One 8(6), 2013
PMID: 23755230
Pilus gene pool variation and the virulence of Corynebacterium diphtheriae clinical isolates during infection of a nematode.
Broadway MM, Rogers EA, Chang C, Huang IH, Dwivedi P, Yildirim S, Schmitt MP, Das A, Ton-That H., J Bacteriol 195(16), 2013
PMID: 23772071
High efficiency application of a mate-paired library from next-generation sequencing to postlight sequencing: Corynebacterium pseudotuberculosis as a case study for microbial de novo genome assembly.
Ramos RT, Carneiro AR, de Castro Soares S, Barbosa S, Varuzza L, Orabona G, Tauch A, Azevedo V, Schneider MP, Silva A., J Microbiol Methods 95(3), 2013
PMID: 23792707
Tool for rapid annotation of microbial SNPs (TRAMS): a simple program for rapid annotation of genomic variation in prokaryotes.
Reumerman RA, Tucker NP, Herron PR, Hoskisson PA, Sangal V., Antonie Van Leeuwenhoek 104(3), 2013
PMID: 23828175
Novel configurations of type I and II CRISPR-Cas systems in Corynebacterium diphtheriae.
Sangal V, Fineran PC, Hoskisson PA., Microbiology 159(pt 10), 2013
PMID: 23904149
Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication.
Sevigny LM, Booth BJ, Rowley KJ, Leav BA, Cheslock PS, Garrity KA, Sloan SE, Thomas W, Babcock GJ, Wang Y., Infect Immun 81(11), 2013
PMID: 23940209
Novel configurations of type I and II CRISPR-Cas systems in Corynebacterium diphtheriae.
Sangal V, Fineran PC, Hoskisson PA., Microbiology 159(10), 2013
PMID: 28206911
Draft genome sequence of Corynebacterium diphtheriae biovar intermedius NCTC 5011.
Sangal V, Tucker NP, Burkovski A, Hoskisson PA., J Bacteriol 194(17), 2012
PMID: 22887653

86 References

Daten bereitgestellt von Europe PubMed Central.

Bacterial iron homeostasis.
Andrews SC, Robinson AK, Rodriguez-Quinones F., FEMS Microbiol. Rev. 27(2-3), 2003
PMID: 12829269
CRITICA: coding region identification tool invoking comparative analysis.
Badger JH, Olsen GJ, Woese CR., Mol. Biol. Evol. 16(4), 1999
PMID: 10331277
Phage-host relationships in nontoxigenic and toxigenic diphtheria bacilli.
BARDSDALE WL, PAPPENHEIMER AM Jr., J. Bacteriol. 67(2), 1954
PMID: 13129217
EDGAR: a software framework for the comparative analysis of prokaryotic genomes.
Blom J, Albaum SP, Doppmeier D, Puhler A, Vorholter FJ, Zakrzewski M, Goesmann A., BMC Bioinformatics 10(), 2009
PMID: 19457249
Comparative genomics of the genus Bifidobacterium.
Bottacini F, Medini D, Pavesi A, Turroni F, Foroni E, Riley D, Giubellini V, Tettelin H, van Sinderen D, Ventura M., Microbiology (Reading, Engl.) 156(Pt 11), 2010
PMID: 20634238
The DtxR protein acting as dual transcriptional regulator directs a global regulatory network involved in iron metabolism of Corynebacterium glutamicum.
Brune I, Werner H, Huser AT, Kalinowski J, Puhler A, Tauch A., BMC Genomics 7(), 2006
PMID: 16469103
The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.
Cerdeno-Tarraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG, Parkhill J., Nucleic Acids Res. 31(22), 2003
PMID: 14602910
Genetics and assembly line enzymology of siderophore biosynthesis in bacteria.
Crosa JH, Walsh CT., Microbiol. Mol. Biol. Rev. 66(2), 2002
PMID: 12040125
Reannotation of the NCTC13129 genome as a new approach to studying gene targets connected to virulence and pathogenicity in diphtheria
D'Afonseca V., 2012
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Darling AE, Mau B, Perna NT., PLoS ONE 5(6), 2010
PMID: 20593022
Improved microbial gene identification with GLIMMER.
Delcher AL, Harmon D, Kasif S, White O, Salzberg SL., Nucleic Acids Res. 27(23), 1999
PMID: 10556321
Successful control of epidemic diphtheria in the states of the Former Union of Soviet Socialist Republics: lessons learned.
Dittmann S, Wharton M, Vitek C, Ciotti M, Galazka A, Guichard S, Hardy I, Kartoglu U, Koyama S, Kreysler J, Martin B, Mercer D, Ronne T, Roure C, Steinglass R, Strebel P, Sutter R, Trostle M., J. Infect. Dis. 181 Suppl 1(), 2000
PMID: 10657185
PHYLIP—Phylogeny Inference Package (version 3.2)
Felsenstein J., 1989
The Pfam protein families database.
Finn RD, Mistry J, Tate J, Coggill P, Heger A, Pollington JE, Gavin OL, Gunasekaran P, Ceric G, Forslund K, Holm L, Sonnhammer EL, Eddy SR, Bateman A., Nucleic Acids Res. 38(Database issue), 2009
PMID: 19920124
Evidence for direct regulation of diphtheria toxin gene transcription by an Fe2+-dependent DNA-binding repressor, DtoxR, in Corynebacterium diphtheriae.
Fourel G, Phalipon A, Kaczorek M., Infect. Immun. 57(10), 1989
PMID: 2506133
Insights on biology and evolution from microbial genome sequencing.
Fraser-Liggett CM., Genome Res. 15(12), 2005
PMID: 16339357
Studies on the virulence of bacteriophage-infected strains of Corynebacterium diphtheriae.
FREEMAN VJ., J. Bacteriol. 61(6), 1951
PMID: 14850426
Assembly of distinct pilus structures on the surface of Corynebacterium diphtheriae.
Gaspar AH, Ton-That H., J. Bacteriol. 188(4), 2006
PMID: 16452436
Corynebacterium diphtheriae as an emerging pathogen in nephrostomy catheter-related infection: evaluation of traits associated with bacterial virulence.
Gomes DL, Martins CA, Faria LM, Santos LS, Santos CS, Sabbadini PS, Souza MC, Alves GB, Rosa AC, Nagao PE, Pereira GA, Hirata R Jr, Mattos-Guaraldi AL., J. Med. Microbiol. 58(Pt 11), 2009
PMID: 19628642
Consed: a graphical tool for sequence finishing.
Gordon D, Abajian C, Green P., Genome Res. 8(3), 1998
PMID: 9521923
Iron and bacterial virulence--a brief overview.
Griffiths E., Biol Met 4(1), 1991
PMID: 1830211
On-line resources for bacterial micro-evolution studies using MLVA or CRISPR typing.
Grissa I, Bouchon P, Pourcel C, Vergnaud G., Biochimie 90(4), 2007
PMID: 17822824
CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats.
Grissa I, Vergnaud G, Pourcel C., Nucleic Acids Res. 35(Web Server issue), 2007
PMID: 17537822
The pathology of diphtheria.
Hadfield TL, McEvoy P, Polotsky Y, Tzinserling VA, Yakovlev AA., J. Infect. Dis. 181 Suppl 1(), 2000
PMID: 10657202
Calculating orthologs in bacteria and Archaea: a divide and conquer approach.
Halachev MR, Loman NJ, Pallen MJ., PLoS ONE 6(12), 2011
PMID: 22174796
Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome.
Hiller NL, Janto B, Hogg JS, Boissy R, Yu S, Powell E, Keefe R, Ehrlich NE, Shen K, Hayes J, Barbadora K, Klimke W, Dernovoy D, Tatusova T, Parkhill J, Bentley SD, Post JC, Ehrlich GD, Hu FZ., J. Bacteriol. 189(22), 2007
PMID: 17675389
Patterns of adherence to HEp-2 cells and actin polymerisation by toxigenic Corynebacterium diphtheriae strains.
Hirata R Jr, Souza SM, Rocha-de-Souza CM, Andrade AF, Monteiro-Leal LH, Formiga LC, Mattos-Guaraldi AL., Microb. Pathog. 36(3), 2004
PMID: 14726229
Biology and molecular epidemiology of diphtheria toxin and the tox gene.
Holmes RK., J. Infect. Dis. 181 Suppl 1(), 2000
PMID: 10657208
A case of afebrile pneumonia caused by non-toxigenic
Honma Y., 2009
r2cat: synteny plots and comparative assembly.
Husemann P, Stoye J., Bioinformatics 26(4), 2009
PMID: 20015948
Genome organization and pathogenicity of Corynebacterium diphtheriae C7(-) and PW8 strains.
Iwaki M, Komiya T, Yamamoto A, Ishiwa A, Nagata N, Arakawa Y, Takahashi M., Infect. Immun. 78(9), 2010
PMID: 20547743
mlstdbNet - distributed multi-locus sequence typing (MLST) databases.
Jolley KA, Chan MS, Maiden MC., BMC Bioinformatics 5(), 2004
PMID: 15230973
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.
Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Kramer R, Linke B, McHardy AC, Meyer F, Mockel B, Pfefferle W, Puhler A, Rey DA, Ruckert C, Rupp O, Sahm H, Wendisch VF, Wiegrabe I, Tauch A., J. Biotechnol. 104(1-3), 2003
PMID: 12948626
Review of diphtheria, tetanus and pertussis vaccines in clinical development.
Kitchin NR., Expert Rev Vaccines 10(5), 2011
PMID: 21604982
Ueber Diphtherie
Klebs E., 1883
Identification of Corynebacterium diphtheriae gene involved in adherence to epithelial cells.
Kolodkina V, Denisevich T, Titov L., Infect. Genet. Evol. 11(2), 2010
PMID: 21111065
Analysis of a DtxR-regulated iron transport and siderophore biosynthesis gene cluster in Corynebacterium diphtheriae.
Kunkle CA, Schmitt MP., J. Bacteriol. 187(2), 2005
PMID: 15629913
Analysis of the Corynebacterium diphtheriae DtxR regulon: identification of a putative siderophore synthesis and transport system that is similar to the Yersinia high-pathogenicity island-encoded yersiniabactin synthesis and uptake system.
Kunkle CA, Schmitt MP., J. Bacteriol. 185(23), 2003
PMID: 14617647
Clustal W and Clustal X version 2.0.
Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG., Bioinformatics 23(21), 2007
PMID: 17846036
Characterization of the diphtheria tox transcript in Corynebacterium diphtheriae and Escherichia coli.
Leong D, Murphy JR., J. Bacteriol. 163(3), 1985
PMID: 2411714
From gene trees to organismal phylogeny in prokaryotes: the case of the gamma-Proteobacteria.
Lerat E, Daubin V, Moran NA., PLoS Biol. 1(1), 2003
PMID: 12975657
REGANOR: a gene prediction server for prokaryotic genomes and a database of high quality gene predictions for prokaryotes.
Linke B, McHardy AC, Neuweger H, Krause L, Meyer F., Appl. Bioinformatics 5(3), 2006
PMID: 16922601
Untersuchung über die Bedeutung der Mikroorganismen für die Entstehung der Diphtherie
Loeffler F., 1884
Comparison of 61 sequenced Escherichia coli genomes.
Lukjancenko O, Wassenaar TM, Ussery DW., Microb. Ecol. 60(4), 2010
PMID: 20623278
The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria.
Mandlik A, Das A, Ton-That H., Proc. Natl. Acad. Sci. U.S.A. 105(37), 2008
PMID: 18779588
Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells.
Mandlik A, Swierczynski A, Das A, Ton-That H., Mol. Microbiol. 64(1), 2007
PMID: 17376076
Characterization of surface saccharides in two Corynebacterium diphtheriae strains.
Mattos-Guaraldi AL, Cappelli EA, Previato JO, Formiga LC, Andrade AF., FEMS Microbiol. Lett. 170(1), 1999
PMID: 9919665
The microbial pan-genome.
Medini D, Donati C, Tettelin H, Masignani V, Rappuoli R., Curr. Opin. Genet. Dev. 15(6), 2005
PMID: 16185861
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
Corynebacterium diphtheriae endocarditis--surgery for some but not all!
Mishra B, Dignan RJ, Hughes CF, Hendel N., Asian Cardiovasc Thorac Ann 13(2), 2005
PMID: 15905338
Corynebacterium diphtheriae spoligotyping based on combined use of two CRISPR loci.
Mokrousov I, Limeschenko E, Vyazovaya A, Narvskaya O., Biotechnol J 2(7), 2007
PMID: 17431853
The amino acid requirements of Corynebacterium diphtheriae PW 8 substrain CN 2000.
Nagarkar PP, Ravetkar SD, Watve MG., J. Appl. Microbiol. 92(2), 2002
PMID: 11849348
Growth versus maintenance: a trade-off dictated by RNA polymerase availability and sigma factor competition?
Nystrom T., Mol. Microbiol. 54(4), 2004
PMID: 15522072
Analysis of genes that encode DtxR-like transcriptional regulators in pathogenic and saprophytic corynebacterial species.
Oram DM, Avdalovic A, Holmes RK., Infect. Immun. 72(4), 2004
PMID: 15039307
Corynebacterium diphtheriae invasion-associated protein (DIP1281) is involved in cell surface organization, adhesion and internalization in epithelial cells.
Ott L, Holler M, Gerlach RG, Hensel M, Rheinlaender J, Schaffer TE, Burkovski A., BMC Microbiol. 10(), 2010
PMID: 20051108
THE PRODUCTION OF DIPHTHERIA TOXIN.
Park WH, Williams AW., J. Exp. Med. 1(1), 1896
PMID: 19866791
SignalP 4.0: discriminating signal peptides from transmembrane regions.
Petersen TN, Brunak S, von Heijne G, Nielsen H., Nat. Methods 8(10), 2011
PMID: 21959131
A multiplex PCR assay for simultaneous detection of Corynebacterium diphtheriae and differentiation between non-toxigenic and toxigenic isolates.
Pimenta FP, Hirata R Jr, Rosa AC, Milagres LG, Mattos-Guaraldi AL., J. Med. Microbiol. 57(Pt 11), 2008
PMID: 18927428
Integration of corynebacteriophages beta tox+, omega tox+, and gamma tox- into two attachment sites on the Corynebacterium diphtheriae chromosome.
Rappuoli R, Michel JL, Murphy JR., J. Bacteriol. 153(3), 1983
PMID: 6402488
Restriction endonuclease map of corynebacteriophage omega ctox+ isolated from the Park-Williams no. 8 strain of Corynebacterium diphtheriae.
Rappuoli R, Michel JL, Murphy JR., J. Virol. 45(2), 1983
PMID: 6300416
A tRNA(2Arg) gene of Corynebacterium diphtheriae is the chromosomal integration site for toxinogenic bacteriophages.
Ratti G, Covacci A, Rappuoli R., Mol. Microbiol. 25(6), 1997
PMID: 9350874
Adhesion by pathogenic corynebacteria.
Rogers EA, Das A, Ton-That H., Adv. Exp. Med. Biol. 715(), 2011
PMID: 21557059
Why are antibiotic resistance genes so resistant to elimination?
Salyers AA, Amabile-Cuevas CF., Antimicrob. Agents Chemother. 41(11), 1997
PMID: 9371327
CARMEN - Comparative Analysis and in silico Reconstruction of organism-specific MEtabolic Networks.
Schneider J, Vorholter FJ, Trost E, Blom J, Musa YR, Neuweger H, Niehaus K, Schatschneider S, Tauch A, Goesmann A., Genet. Mol. Res. 9(3), 2010
PMID: 20799163
Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient.
Schroder J, Maus I, Meyer K, Wordemann S, Blom J, Jaenicke S, Schneider J, Trost E, Tauch A., BMC Genomics 13(), 2012
PMID: 22524407
Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements.
Shapiro JA., Proc. Natl. Acad. Sci. U.S.A. 76(4), 1979
PMID: 287033
Analysis of DNA replication in vivo by flow cytometry.
Skarstad K, Bernander R, Boye E., Meth. Enzymol. 262(), 1995
PMID: 8594381
PIPS: pathogenicity island prediction software.
Soares SC, Abreu VA, Ramos RT, Cerdeira L, Silva A, Baumbach J, Trost E, Tauch A, Hirata R Jr, Mattos-Guaraldi AL, Miyoshi A, Azevedo V., PLoS ONE 7(2), 2012
PMID: 22355329
A probabilistic method for identifying start codons in bacterial genomes.
Suzek BE, Ermolaeva MD, Schreiber M, Salzberg SL., Bioinformatics 17(12), 2001
PMID: 11751220
Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae.
Swaminathan A, Mandlik A, Swierczynski A, Gaspar A, Das A, Ton-That H., Mol. Microbiol. 66(4), 2007
PMID: 17919283
Type III pilus of corynebacteria: Pilus length is determined by the level of its major pilin subunit.
Swierczynski A, Ton-That H., J. Bacteriol. 188(17), 2006
PMID: 16923899
MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0.
Tamura K, Dudley J, Nei M, Kumar S., Mol. Biol. Evol. 24(8), 2007
PMID: 17488738
Iron, DtxR, and the regulation of diphtheria toxin expression.
Tao X, Schiering N, Zeng HY, Ringe D, Murphy JR., Mol. Microbiol. 14(2), 1994
PMID: 7830565
CRISPR-based adaptive immune systems.
Terns MP, Terns RM., Curr. Opin. Microbiol. 14(3), 2011
PMID: 21531607
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome".
Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O'Connor KJ, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM., Proc. Natl. Acad. Sci. U.S.A. 102(39), 2005
PMID: 16172379
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.
Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM., Science 293(5529), 2001
PMID: 11463916
Comparative genomics: the bacterial pan-genome.
Tettelin H, Riley D, Cattuto C, Medini D., Curr. Opin. Microbiol. 11(5), 2008
PMID: 19086349
Assembly of pili on the surface of Corynebacterium diphtheriae.
Ton-That H, Schneewind O., Mol. Microbiol. 50(4), 2003
PMID: 14622427
Comparative analysis of two complete Corynebacterium ulcerans genomes and detection of candidate virulence factors.
Trost E, Al-Dilaimi A, Papavasiliou P, Schneider J, Viehoever P, Burkovski A, Soares SC, Almeida SS, Dorella FA, Miyoshi A, Azevedo V, Schneider MP, Silva A, Santos CS, Santos LS, Sabbadini P, Dias AA, Hirata R Jr, Mattos-Guaraldi AL, Tauch A., BMC Genomics 12(), 2011
PMID: 21801446
The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence.
Trost E, Ott L, Schneider J, Schroder J, Jaenicke S, Goesmann A, Husemann P, Stoye J, Dorella FA, Rocha FS, Soares Sde C, D'Afonseca V, Miyoshi A, Ruiz J, Silva A, Azevedo V, Burkovski A, Guiso N, Join-Lambert OF, Kayal S, Tauch A., BMC Genomics 11(), 2010
PMID: 21192786
Genomics of Actinobacteria: tracing the evolutionary history of an ancient phylum.
Ventura M, Canchaya C, Tauch A, Chandra G, Fitzgerald GF, Chater KF, van Sinderen D., Microbiol. Mol. Biol. Rev. 71(3), 2007
PMID: 17804669
Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil.
Viguetti SZ, Pacheco LG, Santos LS, Soares SC, Bolt F, Baldwin A, Dowson CG, Rosso ML, Guiso N, Miyoshi A, Hirata R Jr, Mattos-Guaraldi AL, Azevedo V., Epidemiol. Infect. 140(4), 2011
PMID: 21669023
Diphtheria.
Vitek CR., Curr. Top. Microbiol. Immunol. 304(), 2006
PMID: 16989265
Zur Behandlung der Diphtherie mit Diphtherieheilserum
von EA., 1893
The genus —medical, p 819–842
von A, Bernard K., 2006
Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R.
Yukawa H, Omumasaba CA, Nonaka H, Kos P, Okai N, Suzuki N, Suda M, Tsuge Y, Watanabe J, Ikeda Y, Vertes AA, Inui M., Microbiology (Reading, Engl.) 153(Pt 4), 2007
PMID: 17379713
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