Comparing tandem repeats with duplications and excisions of variable degree

Sammeth M, Stoye J (2006)
IEEE/ACM Transactions on Computational Biology and Bioinformatics 3(4): 395-407.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
Traditional sequence comparison by alignment employs a mutation model comprised of two events, substitutions and indels (insertions or deletions) of single positions. However, modern genetic analysis knows a variety of more complex mutation events (e. g., duplications, excisions, and rearrangements), especially regarding DNA. With ever more DNA sequence data becoming available, the need to accurately compare sequences which have clearly undergone more complicated types of mutational processes is becoming critical. Herein we introduce a new method for pairwise alignment and comparison of sequences with respect to the special evolution of tandem repeats: substitutions and indels of single positions and, additionally, duplications and excisions of variable degree (i.e., of one or more repeat copies simultaneously) are taken into account. To evaluate our method, we apply it to the spa VNTR (variable number of tandem repeats) cluster of Staphylococcus aureus, a bacterium of high medical importance.
Stichworte
dynamic programming; sequence comparison; pairwise alignment; tandem repeats; repeat duplication history; variable number of tandem repeats
Erscheinungsjahr
2006
Zeitschriftentitel
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Band
3
Ausgabe
4
Seite(n)
395-407
ISSN
1545-5963
Page URI
https://pub.uni-bielefeld.de/record/1597213

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Sammeth M, Stoye J. Comparing tandem repeats with duplications and excisions of variable degree. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2006;3(4):395-407.
Sammeth, M., & Stoye, J. (2006). Comparing tandem repeats with duplications and excisions of variable degree. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 3(4), 395-407. doi:10.1109/TCBB.2006.46
Sammeth, M., and Stoye, J. (2006). Comparing tandem repeats with duplications and excisions of variable degree. IEEE/ACM Transactions on Computational Biology and Bioinformatics 3, 395-407.
Sammeth, M., & Stoye, J., 2006. Comparing tandem repeats with duplications and excisions of variable degree. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 3(4), p 395-407.
M. Sammeth and J. Stoye, “Comparing tandem repeats with duplications and excisions of variable degree”, IEEE/ACM Transactions on Computational Biology and Bioinformatics, vol. 3, 2006, pp. 395-407.
Sammeth, M., Stoye, J.: Comparing tandem repeats with duplications and excisions of variable degree. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 3, 395-407 (2006).
Sammeth, Michael, and Stoye, Jens. “Comparing tandem repeats with duplications and excisions of variable degree”. IEEE/ACM Transactions on Computational Biology and Bioinformatics 3.4 (2006): 395-407.

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