Hybrid-hybrid correction of errors in long reads with HERO
Kang X, Xu J, Luo X, Schönhuth A (2023)
Genome Biology 24(1): 275.
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Although generally superior, hybrid approaches for correcting errors in third-generation sequencing (TGS) reads, using next-generation sequencing (NGS) reads, mistake haplotype-specific variants for errors in polyploid and mixed samples. We suggest HERO, as the first "hybrid-hybrid" approach, to make use of both de Bruijn graphs and overlap graphs for optimal catering to the particular strengths of NGS and TGS reads. Extensive benchmarking experiments demonstrate that HERO improves indel and mismatch error rates by on average 65% (27[Formula: see text]95%) and 20% (4[Formula: see text]61%). Using HERO prior to genome assembly significantly improves the assemblies in the majority of the relevant categories. © 2023. The Author(s).
Erscheinungsjahr
2023
Zeitschriftentitel
Genome Biology
Band
24
Ausgabe
1
Art.-Nr.
275
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1474-760X
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Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
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https://pub.uni-bielefeld.de/record/2985113
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Kang X, Xu J, Luo X, Schönhuth A. Hybrid-hybrid correction of errors in long reads with HERO. Genome Biology . 2023;24(1): 275.
Kang, X., Xu, J., Luo, X., & Schönhuth, A. (2023). Hybrid-hybrid correction of errors in long reads with HERO. Genome Biology , 24(1), 275. https://doi.org/10.1186/s13059-023-03112-7
Kang, Xiongbin, Xu, Jialu, Luo, Xiao, and Schönhuth, Alexander. 2023. “Hybrid-hybrid correction of errors in long reads with HERO”. Genome Biology 24 (1): 275.
Kang, X., Xu, J., Luo, X., and Schönhuth, A. (2023). Hybrid-hybrid correction of errors in long reads with HERO. Genome Biology 24:275.
Kang, X., et al., 2023. Hybrid-hybrid correction of errors in long reads with HERO. Genome Biology , 24(1): 275.
X. Kang, et al., “Hybrid-hybrid correction of errors in long reads with HERO”, Genome Biology , vol. 24, 2023, : 275.
Kang, X., Xu, J., Luo, X., Schönhuth, A.: Hybrid-hybrid correction of errors in long reads with HERO. Genome Biology . 24, : 275 (2023).
Kang, Xiongbin, Xu, Jialu, Luo, Xiao, and Schönhuth, Alexander. “Hybrid-hybrid correction of errors in long reads with HERO”. Genome Biology 24.1 (2023): 275.
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