Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification

Lopez-Rincon A, Mendoza-Maldonado L, Martinez-Archundia M, Schönhuth A, Kraneveld AD, Garssen J, Tonda A (2020)
Cancers 12(7): 1785.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Lopez-Rincon, Alejandro; Mendoza-Maldonado, Lucero; Martinez-Archundia, Marlet; Schönhuth, AlexanderUniBi ; Kraneveld, Aletta D.; Garssen, Johan; Tonda, Alberto
Abstract / Bemerkung
Circulating microRNAs (miRNA) are small noncoding RNA molecules that can be detected in bodily fluids without the need for major invasive procedures on patients. miRNAs have shown great promise as biomarkers for tumors to both assess their presence and to predict their type and subtype. Recently, thanks to the availability of miRNAs datasets, machine learning techniques have been successfully applied to tumor classification. The results, however, are difficult to assess and interpret by medical experts because the algorithms exploit information from thousands of miRNAs. In this work, we propose a novel technique that aims at reducing the necessary information to the smallest possible set of circulating miRNAs. The dimensionality reduction achieved reflects a very important first step in a potential, clinically actionable, circulating miRNA-based precision medicine pipeline. While it is currently under discussion whether this first step can be taken, we demonstrate here that it is possible to perform classification tasks by exploiting a recursive feature elimination procedure that integrates a heterogeneous ensemble of high-quality, state-of-the-art classifiers on circulating miRNAs. Heterogeneous ensembles can compensate inherent biases of classifiers by using different classification algorithms. Selecting features then further eliminates biases emerging from using data from different studies or batches, yielding more robust and reliable outcomes. The proposed approach is first tested on a tumor classification problem in order to separate 10 different types of cancer, with samples collected over 10 different clinical trials, and later is assessed on a cancer subtype classification task, with the aim to distinguish triple negative breast cancer from other subtypes of breast cancer. Overall, the presented methodology proves to be effective and compares favorably to other state-of-the-art feature selection methods.
Stichworte
miRNAs; TNBC; machine learning; feature selection; circulating
Erscheinungsjahr
2020
Zeitschriftentitel
Cancers
Band
12
Ausgabe
7
Art.-Nr.
1785
eISSN
2072-6694
Page URI
https://pub.uni-bielefeld.de/record/2945617

Zitieren

Lopez-Rincon A, Mendoza-Maldonado L, Martinez-Archundia M, et al. Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification. Cancers. 2020;12(7): 1785.
Lopez-Rincon, A., Mendoza-Maldonado, L., Martinez-Archundia, M., Schönhuth, A., Kraneveld, A. D., Garssen, J., & Tonda, A. (2020). Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification. Cancers, 12(7), 1785. doi:10.3390/cancers12071785
Lopez-Rincon, A., Mendoza-Maldonado, L., Martinez-Archundia, M., Schönhuth, A., Kraneveld, A. D., Garssen, J., and Tonda, A. (2020). Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification. Cancers 12:1785.
Lopez-Rincon, A., et al., 2020. Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification. Cancers, 12(7): 1785.
A. Lopez-Rincon, et al., “Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification”, Cancers, vol. 12, 2020, : 1785.
Lopez-Rincon, A., Mendoza-Maldonado, L., Martinez-Archundia, M., Schönhuth, A., Kraneveld, A.D., Garssen, J., Tonda, A.: Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification. Cancers. 12, : 1785 (2020).
Lopez-Rincon, Alejandro, Mendoza-Maldonado, Lucero, Martinez-Archundia, Marlet, Schönhuth, Alexander, Kraneveld, Aletta D., Garssen, Johan, and Tonda, Alberto. “Machine Learning-Based Ensemble Recursive Feature Selection of Circulating miRNAs for Cancer Tumor Classification”. Cancers 12.7 (2020): 1785.

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