Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.

Koster J, Dijkstra LJ, Marschall T, Schönhuth A (2020)
Genome biology 21(1).

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Koster, Johannes; Dijkstra, Louis J; Marschall, Tobias; Schönhuth, AlexanderUniBi
Abstract / Bemerkung
Abstract Accurate discovery of somatic variants is of central importance in cancer research. However, count statistics on discovered somatic insertions and deletions (indels) indicate that large amounts of discoveries are missed because of the quantification of uncertainties related to gap and alignment ambiguities, twilight zone indels, cancer heterogeneity, sample purity, sampling, and strand bias. We provide a unifying statistical model whose dependency structures enable accurate quantification of all inherent uncertainties in short time. Consequently, false discovery rate (FDR) in somatic indel discovery can now be controlled at utmost accuracy, increasing the amount of true discoveries while safely suppressing the FDR
Erscheinungsjahr
2020
Zeitschriftentitel
Genome biology
Band
21
Ausgabe
1
eISSN
1474-760X
Page URI
https://pub.uni-bielefeld.de/record/2943113

Zitieren

Koster J, Dijkstra LJ, Marschall T, Schönhuth A. Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology. 2020;21(1).
Koster, J., Dijkstra, L. J., Marschall, T., & Schönhuth, A. (2020). Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology, 21(1). doi:10.1186/s13059-020-01993-6
Koster, J., Dijkstra, L. J., Marschall, T., and Schönhuth, A. (2020). Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology 21.
Koster, J., et al., 2020. Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology, 21(1).
J. Koster, et al., “Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.”, Genome biology, vol. 21, 2020.
Koster, J., Dijkstra, L.J., Marschall, T., Schönhuth, A.: Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology. 21, (2020).
Koster, Johannes, Dijkstra, Louis J, Marschall, Tobias, and Schönhuth, Alexander. “Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.”. Genome biology 21.1 (2020).

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