Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.
Koster J, Dijkstra LJ, Marschall T, Schönhuth A (2020)
Genome biology 21(1).
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Koster, Johannes;
Dijkstra, Louis J;
Marschall, Tobias;
Schönhuth, AlexanderUniBi ![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Einrichtung
Abstract / Bemerkung
Abstract
Accurate discovery of somatic variants is of central importance in cancer research. However, count statistics on discovered somatic insertions and deletions (indels) indicate that large amounts of discoveries are missed because of the quantification of uncertainties related to gap and alignment ambiguities, twilight zone indels, cancer heterogeneity, sample purity, sampling, and strand bias. We provide a unifying statistical model whose dependency structures enable accurate quantification of all inherent uncertainties in short time. Consequently, false discovery rate (FDR) in somatic indel discovery can now be controlled at utmost accuracy, increasing the amount of true discoveries while safely suppressing the FDR
Erscheinungsjahr
2020
Zeitschriftentitel
Genome biology
Band
21
Ausgabe
1
eISSN
1474-760X
Page URI
https://pub.uni-bielefeld.de/record/2943113
Zitieren
Koster J, Dijkstra LJ, Marschall T, Schönhuth A. Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology. 2020;21(1).
Koster, J., Dijkstra, L. J., Marschall, T., & Schönhuth, A. (2020). Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology, 21(1). https://doi.org/10.1186/s13059-020-01993-6
Koster, Johannes, Dijkstra, Louis J, Marschall, Tobias, and Schönhuth, Alexander. 2020. “Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.”. Genome biology 21 (1).
Koster, J., Dijkstra, L. J., Marschall, T., and Schönhuth, A. (2020). Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology 21.
Koster, J., et al., 2020. Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology, 21(1).
J. Koster, et al., “Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.”, Genome biology, vol. 21, 2020.
Koster, J., Dijkstra, L.J., Marschall, T., Schönhuth, A.: Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery. Genome biology. 21, (2020).
Koster, Johannes, Dijkstra, Louis J, Marschall, Tobias, and Schönhuth, Alexander. “Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery.”. Genome biology 21.1 (2020).
Daten bereitgestellt von European Bioinformatics Institute (EBI)
Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
References
Daten bereitgestellt von Europe PubMed Central.
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 32345333
PubMed | Europe PMC
Suchen in