Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase

Baulig A, Helmle I, Bader M, Wolf F, Kulik A, Al-Dilaimi A, Wibberg D, Kalinowski J, Gross H, Kaysser L (2019)
CHEMICAL SCIENCE 10(16): 4486-4490.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Phosphoramidon is a potent metalloprotease inhibitor and a widespread tool in cell biology research. It contains a dipeptide backbone that is uniquely linked to a 6-deoxysugar via a phosphoramidate bridge. Herein, we report the identification of a gene cluster for the formation of phosphoramidon and its detailed characterization. In vitro reconstitution of the biosynthesis established TalE as a phosphoramidate-forming kinase and TalC as the glycosyltransferase which installs the L-rhamnose moiety by phosphoester linkage.
Erscheinungsjahr
2019
Zeitschriftentitel
CHEMICAL SCIENCE
Band
10
Ausgabe
16
Seite(n)
4486-4490
ISSN
2041-6520
eISSN
2041-6539
Page URI
https://pub.uni-bielefeld.de/record/2935580

Zitieren

Baulig A, Helmle I, Bader M, et al. Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase. CHEMICAL SCIENCE. 2019;10(16):4486-4490.
Baulig, A., Helmle, I., Bader, M., Wolf, F., Kulik, A., Al-Dilaimi, A., Wibberg, D., et al. (2019). Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase. CHEMICAL SCIENCE, 10(16), 4486-4490. doi:10.1039/c9sc00641a
Baulig, A., Helmle, I., Bader, M., Wolf, F., Kulik, A., Al-Dilaimi, A., Wibberg, D., Kalinowski, J., Gross, H., and Kaysser, L. (2019). Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase. CHEMICAL SCIENCE 10, 4486-4490.
Baulig, A., et al., 2019. Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase. CHEMICAL SCIENCE, 10(16), p 4486-4490.
A. Baulig, et al., “Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase”, CHEMICAL SCIENCE, vol. 10, 2019, pp. 4486-4490.
Baulig, A., Helmle, I., Bader, M., Wolf, F., Kulik, A., Al-Dilaimi, A., Wibberg, D., Kalinowski, J., Gross, H., Kaysser, L.: Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase. CHEMICAL SCIENCE. 10, 4486-4490 (2019).
Baulig, Alexandra, Helmle, Irina, Bader, Marius, Wolf, Felix, Kulik, Andreas, Al-Dilaimi, Arwa, Wibberg, Daniel, Kalinowski, Jörn, Gross, Harald, and Kaysser, Leonard. “Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase”. CHEMICAL SCIENCE 10.16 (2019): 4486-4490.

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