PUB - Publikationen an der Universität Bielefeld

Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes.
Umezawa H, Aoyagi T, Tanaka T, Suda H, Okuyama A, Naganawa H, Hamada M, Takeuchi T., J. Antibiot. 38(11), 1985
PMID: 2867082

Actinonin: an antibiotic substance produced by an actinomycete.
GORDON JJ, KELLY BK, MILLER GA., Nature 195(), 1962
PMID: 13900478

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.
Chen DZ, Patel DV, Hackbarth CJ, Wang W, Dreyer G, Young DC, Margolis PS, Wu C, Ni ZJ, Trias J, White RJ, Yuan Z., Biochemistry 39(6), 2000
PMID: 10684604

Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.
Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA., J. Clin. Invest. 114(8), 2004
PMID: 15489958

Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.
Sawafuji K, Miyakawa Y, Weisberg E, Griffin JD, Ikeda Y, Kizaki M., Leuk. Lymphoma 44(11), 2003
PMID: 14738154

The crystal structures of four peptide deformylases bound to the antibiotic actinonin reveal two distinct types: a platform for the structure-based design of antibacterial agents.
Guilloteau JP, Mathieu M, Giglione C, Blanc V, Dupuy A, Chevrier M, Gil P, Famechon A, Meinnel T, Mikol V., J. Mol. Biol. 320(5), 2002
PMID: 12126617

Matlystatins, new inhibitors of type IV collagenases from Actinomadura atramentaria. III. Structure elucidation of matlystatins A to F.
Haruyama H, Ohkuma Y, Nagaki H, Ogita T, Tamaki K, Kinoshita T., J. Antibiot. 47(12), 1994
PMID: 7844042

Propioxatins A and B, new enkephalinase B inhibitors. I. Taxonomy, fermentation, isolation and biological properties.
Inaoka Y, Tamaoki H, Takahashi S, Enokita R, Okazaki T., J. Antibiot. 39(10), 1986
PMID: 3536826

Inhibition of metalloproteinase activity of rheumatoid arthritis synovial cells by a new inhibitor [BE16627B; L-N-(N-hydroxy-2-isobutylsuccinamoyl)-seryl-L-valine].
Naito K, Nakajima S, Kanbayashi N, Okuyama A, Goto M., Agents Actions 39(3-4), 1993
PMID: 8304246

YM-24074, a new peptide antibiotic. II. Structural elucidation.
Sato T, Takebayashi Y, Tokunaga T, Ozasa T., J. Antibiot. 49(8), 1996
PMID: 8823515

Safety, tolerability, and efficacy of GSK1322322 in the treatment of acute bacterial skin and skin structure infections.
Corey R, Naderer OJ, O'Riordan WD, Dumont E, Jones LS, Kurtinecz M, Zhu JZ., Antimicrob. Agents Chemother. 58(11), 2014
PMID: 25136015

Biosynthesis of the β-Lactone Proteasome Inhibitors Belactosin and Cystargolide.
Wolf F, Bauer JS, Bendel TM, Kulik A, Kalinowski J, Gross H, Kaysser L., Angew. Chem. Int. Ed. Engl. 56(23), 2017
PMID: 28452105

AUTHOR UNKNOWN, Angew. Chem. 129(), 2017

Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an Acyl-CoA Dehydrogenase-Like Enzyme.
Zettler J, Zubeil F, Kulik A, Grond S, Kaysser L., Chembiochem 17(9), 2016
PMID: 26789439

Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors.
Leipoldt F, Santos-Aberturas J, Stegmann DP, Wolf F, Kulik A, Lacret R, Popadic D, Keinhorster D, Kirchner N, Bekiesch P, Gross H, Truman AW, Kaysser L., Nat Commun 8(1), 2017
PMID: 29213087

Seemann, Bioinformatics (), 2014

GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369

AUTHOR UNKNOWN, 0

Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
Erb TJ, Retey J, Fuchs G, Alber BE., J. Biol. Chem. 283(47), 2008
PMID: 18819910

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway.
Erb TJ, Berg IA, Brecht V, Muller M, Fuchs G, Alber BE., Proc. Natl. Acad. Sci. U.S.A. 104(25), 2007
PMID: 17548827

The lyngbyatoxin biosynthetic assembly line: chain release by four-electron reduction of a dipeptidyl thioester to the corresponding alcohol.
Read JA, Walsh CT., J. Am. Chem. Soc. 129(51), 2007
PMID: 18044902

Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester.
Li Y, Weissman KJ, Muller R., J. Am. Chem. Soc. 130(24), 2008
PMID: 18498160

AUTHOR UNKNOWN, 0

Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity.
Wilson MC, Moore BS., Nat Prod Rep 29(1), 2011
PMID: 22124767

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.
Eustaquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS., Proc. Natl. Acad. Sci. U.S.A. 106(30), 2009
PMID: 19590008

Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.
Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ., J. Am. Chem. Soc. 133(4), 2010
PMID: 21175203

Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase.
Kurteva-Yaneva N, Zahn M, Weichler MT, Starke R, Harms H, Muller RH, Strater N, Rohwerder T., J. Biol. Chem. 290(15), 2015
PMID: 25720495

Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase.
Zhang W, Ames BD, Tsai SC, Tang Y., Appl. Environ. Microbiol. 72(4), 2006
PMID: 16597959

Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.
Qu X, Jiang N, Xu F, Shao L, Tang G, Wilkinson B, Liu W., Mol Biosyst 7(3), 2011
PMID: 21416665

AUTHOR UNKNOWN, 0

A new class of arylamine oxygenases: evidence that p-aminobenzoate N-oxygenase (AurF) is a di-iron enzyme and further mechanistic studies.
Simurdiak M, Lee J, Zhao H., Chembiochem 7(8), 2006
PMID: 16927313

Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin: involvement of an unprecedented N-oxygenase.
He J, Hertweck C., J. Am. Chem. Soc. 126(12), 2004
PMID: 15038705

Characterization of the N-oxygenase AurF from Streptomyces thioletus.
Chanco E, Choi YS, Sun N, Vu M, Zhao H., Bioorg. Med. Chem. 22(20), 2014
PMID: 24973817

Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer.
Kudo K, Ozaki T, Shin-Ya K, Nishiyama M, Kuzuyama T., J. Am. Chem. Soc. 139(20), 2017
PMID: 28497964

Kieser, 2000

Sambrook, 2001

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.
Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R., Nucleic Acids Res. 39(Web Server issue), 2011
PMID: 21672958

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ., Nucleic Acids Res. 25(17), 1997
PMID: 9254694

NRPSpredictor2--a web server for predicting NRPS adenylation domain specificity.
Rottig M, Medema MH, Blin K, Weber T, Rausch C, Kohlbacher O., Nucleic Acids Res. 39(Web Server issue), 2011
PMID: 21558170

Minimum Information about a Biosynthetic Gene cluster.
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Dusterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kotter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nutzmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gomez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Hofte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Mendez C, Metsa-Ketela M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Muller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Sussmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glockner FO., Nat. Chem. Biol. 11(9), 2015
PMID: 26284661

Merochlorins A-D, cyclic meroterpenoid antibiotics biosynthesized in divergent pathways with vanadium-dependent chloroperoxidases.
Kaysser L, Bernhardt P, Nam SJ, Loesgen S, Ruby JG, Skewes-Cox P, Jensen PR, Fenical W, Moore BS., J. Am. Chem. Soc. 134(29), 2012
PMID: 22784372

Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors.
Schorn M, Zettler J, Noel JP, Dorrestein PC, Moore BS, Kaysser L., ACS Chem. Biol. 9(1), 2013
PMID: 24168704

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.
Datsenko KA, Wanner BL., Proc. Natl. Acad. Sci. U.S.A. 97(12), 2000
PMID: 10829079

Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector.
MacNeil DJ, Gewain KM, Ruby CL, Dezeny G, Gibbons PH, MacNeil T., Gene 111(1), 1992
PMID: 1547955

High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes.
Flett F, Mersinias V, Smith CP., FEMS Microbiol. Lett. 155(2), 1997
PMID: 9351205

PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.
Gust B, Challis GL, Fowler K, Kieser T, Chater KF., Proc. Natl. Acad. Sci. U.S.A. 100(4), 2003
PMID: 12563033