DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin

Sreij R, Dargel C, Geisler P, Hertle Y, Radulescu A, Pasini S, Perez J, Hernandez Moleiro L, Hellweg T (2018)
PHYSICAL CHEMISTRY CHEMICAL PHYSICS 20(14): 9070-9083.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Sreij, RamsiaUniBi; Dargel, CarinaUniBi; Geisler, PhilippeUniBi; Hertle, YvonneUniBi; Radulescu, Aurel; Pasini, Stefano; Perez, Javier; Hernandez Moleiro, LaraUniBi; Hellweg, ThomasUniBi
Einrichtung
Center of Excellence - Cognitive Interaction Technology CITEC
Fakultät für Chemie > Physikalische und Biophysikalische Chemie
Technische Fakultät > AG Kognitronik und Sensorik
Abstract / Bemerkung
Vesicle shape and bilayer parameters are studied by small-angle X-ray (SAXS) and small-angle neutron (SANS) scattering in the presence of the saponin aescin. We confirm successful incorporation of aescin molecules by analysis of the radii of gyration RG and study furthermore the impact of aescin incorporation on bilayer thickness parameters from the neutron and X-ray perspective. Additionally, the bending elasticity (k) of these 1,2-dimyristoyl-sn-glycero-3-phosphocholine vesicle bilayers is studied in the presence of aescin. Neutron spin-echo spectroscopy (NSE) allows to detect subtle changes in the dynamics and k of lipid membranes. Changes of k are detectable at temperatures below and above the main phase transition temperature Tm of the lipid. The impact of aescin is much more significant below Tm. It has been found that below Tm the addition of aescin to the vesicles decreases the value of k and softens the bilayer. Above Tm the value of k increases with increasing aescin content and the bilayer becomes more rigid. Altogether, we demonstrate by analysis of the structure and dynamics of the vesicles that the impact of aescin strongly depends on the lipid state. Below Tm the membrane becomes fluidized and softer, above Tm solidified and stiffer compared to a DMPC membrane without additive at similar conditions.
Erscheinungsjahr
2018
Zeitschriftentitel
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Band
20
Ausgabe
14
Seite(n)
9070-9083
ISSN
1463-9076
eISSN
1463-9084
Page URI
https://pub.uni-bielefeld.de/record/2919290

Zitieren

Sreij R, Dargel C, Geisler P, et al. DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 2018;20(14):9070-9083.
Sreij, R., Dargel, C., Geisler, P., Hertle, Y., Radulescu, A., Pasini, S., Perez, J., et al. (2018). DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 20(14), 9070-9083. doi:10.1039/c7cp08027a
Sreij, Ramsia, Dargel, Carina, Geisler, Philippe, Hertle, Yvonne, Radulescu, Aurel, Pasini, Stefano, Perez, Javier, Hernandez Moleiro, Lara, and Hellweg, Thomas. 2018. “DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin”. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 20 (14): 9070-9083.
Sreij, R., Dargel, C., Geisler, P., Hertle, Y., Radulescu, A., Pasini, S., Perez, J., Hernandez Moleiro, L., and Hellweg, T. (2018). DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 20, 9070-9083.
Sreij, R., et al., 2018. DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 20(14), p 9070-9083.
R. Sreij, et al., “DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin”, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 20, 2018, pp. 9070-9083.
Sreij, R., Dargel, C., Geisler, P., Hertle, Y., Radulescu, A., Pasini, S., Perez, J., Hernandez Moleiro, L., Hellweg, T.: DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin. PHYSICAL CHEMISTRY CHEMICAL PHYSICS. 20, 9070-9083 (2018).
Sreij, Ramsia, Dargel, Carina, Geisler, Philippe, Hertle, Yvonne, Radulescu, Aurel, Pasini, Stefano, Perez, Javier, Hernandez Moleiro, Lara, and Hellweg, Thomas. “DMPC vesicle structure and dynamics in the presence of low amounts of the saponin aescin”. PHYSICAL CHEMISTRY CHEMICAL PHYSICS 20.14 (2018): 9070-9083.

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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Sreij R, Dargel C, Schweins R, Prévost S, Dattani R, Hellweg T., Sci Rep 9(1), 2019
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Material in PUB:
Teil dieser Dissertation
Self-Assembly in Phospolipid-Saponin Mixtures. From Small Unilamellar Vesicles to Bicelles
Dargel C (2019)
Bielefeld: Universität Bielefeld.
Teil dieser Dissertation
Structure & dynamics of DMPC model membranes in the presence of the saponin β-aescin. With and without additives
Sreij R (2018)
Bielefeld: Universität Bielefeld.
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