N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII

Hamed A, Abdel-Razek AS, Frese M, Wibberg D, El-Haddad AF, Ibrahim TMA, Kalinowski J, Sewald N, Shaaban M (2018)
ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES 73(1-2): 49-57.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
In the course of our screening program for new bioactive compounds, a naturally new 18-membered macrolide antibiotic, N-acetylborrelidin B (1) along with borrelidin (2) were obtained from the marine Streptomyces mutabilis sp. MII. The strain was isolated from a sediment sample collected in the Red Sea at the Hurghada Coast and characterized taxonomically. Additional nine diverse bioactive compounds were reported: 6-prenyl-indole-3-acetonitrile (3), sitosteryl-3 ss-d-glucoside, campesterol, ferulic acid, linoleic acid methyl ester, linoleic acid, N-acetylanthranilic acid, indole 3-acetic acid methyl ester, indole 3-carboxylic acid, and adenosine. Structure 1 was confirmed by in-depth NMR studies and by mass spectra, and comparison with related literature data. The antimicrobial activity of the strain extract and compounds 1 and 2 were studied using a panel of pathogenic microorganisms. The in vitro cytotoxicity of compounds 1 and 2 as well as the crude extract were tested against the human cervix carcinoma cell line (KB-3-1).
Stichworte
biological activity; N-acetylborrelidin B; Streptomyces mutabilis sp; MII; taxonomy
Erscheinungsjahr
2018
Zeitschriftentitel
ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Band
73
Ausgabe
1-2
Seite(n)
49-57
ISSN
0939-5075
eISSN
1865-7125
Page URI
https://pub.uni-bielefeld.de/record/2918668

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Hamed A, Abdel-Razek AS, Frese M, et al. N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII. ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES. 2018;73(1-2):49-57.
Hamed, A., Abdel-Razek, A. S., Frese, M., Wibberg, D., El-Haddad, A. F., Ibrahim, T. M. A., Kalinowski, J., et al. (2018). N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII. ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 73(1-2), 49-57. doi:10.1515/znc-2017-0140
Hamed, A., Abdel-Razek, A. S., Frese, M., Wibberg, D., El-Haddad, A. F., Ibrahim, T. M. A., Kalinowski, J., Sewald, N., and Shaaban, M. (2018). N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII. ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES 73, 49-57.
Hamed, A., et al., 2018. N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII. ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 73(1-2), p 49-57.
A. Hamed, et al., “N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII”, ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, vol. 73, 2018, pp. 49-57.
Hamed, A., Abdel-Razek, A.S., Frese, M., Wibberg, D., El-Haddad, A.F., Ibrahim, T.M.A., Kalinowski, J., Sewald, N., Shaaban, M.: N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII. ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES. 73, 49-57 (2018).
Hamed, Abdelaaty, Abdel-Razek, Ahmed S., Frese, Marcel, Wibberg, Daniel, El-Haddad, Atef F., Ibrahim, Tarek M. A., Kalinowski, Jörn, Sewald, Norbert, and Shaaban, Mohamed. “N-Acetylborrelidin B: a new bioactive metabolite from Streptomyces mutabilis sp MII”. ZEITSCHRIFT FÜR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES 73.1-2 (2018): 49-57.

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