Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells

Wippermann, Anna; Rupp, Oliver; Brinkrolf, Karina; Hoffrogge, Raimund; Noll, Thomas

Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells

Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T (2016)
Journal of Biotechnology 257: 150-161.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1016/j.jbiotec.2016.11.020

Autor*in

Wippermann, Anna^UniBi; Rupp, Oliver; Brinkrolf, Karina; Hoffrogge, Raimund^UniBi ; Noll, Thomas^UniBi

Einrichtung

Centrum für Biotechnologie > Arbeitsgruppe T. Noll
Technische Fakultät > AG Zellkulturtechnik
Centrum für Biotechnologie > Graduate Center > Graduate Cluster Industrial Biotechnology

Erscheinungsjahr

2016

Zeitschriftentitel

Journal of Biotechnology

Band

257

Seite(n)

150-161

ISSN

0168-1656

Page URI

https://pub.uni-bielefeld.de/record/2907079

Zitieren

Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T. Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology. 2016;257:150-161.

Wippermann, A., Rupp, O., Brinkrolf, K., Hoffrogge, R., & Noll, T. (2016). Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology, 257, 150-161. doi:10.1016/j.jbiotec.2016.11.020

Wippermann, Anna, Rupp, Oliver, Brinkrolf, Karina, Hoffrogge, Raimund, and Noll, Thomas. 2016. “Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells”. Journal of Biotechnology 257: 150-161.

Wippermann, A., Rupp, O., Brinkrolf, K., Hoffrogge, R., and Noll, T. (2016). Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology 257, 150-161.

Wippermann, A., et al., 2016. Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology, 257, p 150-161.

A. Wippermann, et al., “Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells”, Journal of Biotechnology, vol. 257, 2016, pp. 150-161.

Wippermann, A., Rupp, O., Brinkrolf, K., Hoffrogge, R., Noll, T.: Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells. Journal of Biotechnology. 257, 150-161 (2016).

Wippermann, Anna, Rupp, Oliver, Brinkrolf, Karina, Hoffrogge, Raimund, and Noll, Thomas. “Integrative analysis of DNA methylation and gene expression in butyrate-treated CHO cells”. Journal of Biotechnology 257 (2016): 150-161.

4 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development.
Allen J, Sears CL., Genome Med 11(1), 2019
PMID: 30803449

CRISPR-Based Targeted Epigenetic Editing Enables Gene Expression Modulation of the Silenced Beta-Galactoside Alpha-2,6-Sialyltransferase 1 in CHO Cells.
Marx N, Grünwald-Gruber C, Bydlinski N, Dhiman H, Ngoc Nguyen L, Klanert G, Borth N., Biotechnol J 13(10), 2018
PMID: 29802757

Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MS.
Müller B, Heinrich C, Jabs W, Kaspar-Schönefeld S, Schmidt A, Rodrigues de Carvalho N, Albaum SP, Baessmann C, Noll T, Hoffrogge R., J Biotechnol 257(), 2017
PMID: 28363874

Activation of unfolded protein response pathway is important for valproic acid mediated increase in immunoglobulin G productivity in recombinant Chinese hamster ovary cells.
Segar KP, Chandrawanshi V, Mehra S., J Biosci Bioeng 124(4), 2017
PMID: 28601608

96 References

Daten bereitgestellt von Europe PubMed Central.

The molecular hallmarks of epigenetic control.
Allis CD, Jenuwein T., Nat. Rev. Genet. 17(8), 2016
PMID: 27346641

The analysis of matched proportions
Altham, Biometrika 58(), 1971

Andrews, 2010

DREME: motif discovery in transcription factor ChIP-seq data.
Bailey TL., Bioinformatics 27(12), 2011
PMID: 21543442

The impact of intragenic CpG content on gene expression.
Bauer AP, Leikam D, Krinner S, Notka F, Ludwig C, Langst G, Wagner R., Nucleic Acids Res. 38(12), 2010
PMID: 20203083

Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.
Becker J, Hackl M, Rupp O, Jakobi T, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, Noll T, Puhler A, Tauch A, Brinkrolf K., J. Biotechnol. 156(3), 2011
PMID: 21945585

Transcriptome analyses of CHO cells with the next-generation microarray CHO41K: development and validation by analysing the influence of the growth stimulating substance IGF-1 substitute LongR(3.).
Becker J, Timmermann C, Rupp O, Albaum SP, Brinkrolf K, Goesmann A, Puhler A, Tauch A, Noll T., J. Biotechnol. 178(), 2014
PMID: 24613301

Effects of high passage cultivation on CHO cells: a global analysis.
Beckmann TF, Kramer O, Klausing S, Heinrich C, Thute T, Buntemeyer H, Hoffrogge R, Noll T., Appl. Microbiol. Biotechnol. 94(3), 2012
PMID: 22331235

Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture.
Bedoya-Lopez A, Estrada K, Sanchez-Flores A, Ramirez OT, Altamirano C, Segovia L, Miranda-Rios J, Trujillo-Roldan MA, Valdez-Cruz NA., PLoS ONE 11(3), 2016
PMID: 26991106

Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.
Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S., Int. J. Cancer 128(11), 2010
PMID: 20715114

Suppression of histone deacetylation in vivo and in vitro by sodium butyrate.
Boffa LC, Vidali G, Mann RS, Allfrey VG., J. Biol. Chem. 253(10), 1978
PMID: 649576

Trimmomatic: a flexible trimmer for Illumina sequence data.
Bolger AM, Lohse M, Usadel B., Bioinformatics 30(15), 2014
PMID: 24695404

Butyrate and Wnt signaling: a possible solution to the puzzle of dietary fiber and colon cancer risk?
Bordonaro M, Lazarova DL, Sartorelli AC., Cell Cycle 7(9), 2008
PMID: 18418037

Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2.
Braganca J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S., J. Biol. Chem. 277(10), 2001
PMID: 11744733

DNA methylation of the first exon is tightly linked to transcriptional silencing.
Brenet F, Moh M, Funk P, Feierstein E, Viale AJ, Socci ND, Scandura JM., PLoS ONE 6(1), 2011
PMID: 21267076

Proteomic profiling of a high-producing Chinese hamster ovary cell culture.
Carlage T, Hincapie M, Zang L, Lyubarskaya Y, Madden H, Mhatre R, Hancock WS., Anal. Chem. 81(17), 2009
PMID: 19663468

Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine.
Choi KH, Basma H, Singh J, Cheng PW., Glycoconj. J. 22(1-2), 2005
PMID: 15864436

Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation.
Corfe BM., Mol Biosyst 8(6), 2012
PMID: 22446977

Kruppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death.
Cruz-Topete D, He B, Xu X, Cidlowski JA., J. Biol. Chem. 291(37), 2016
PMID: 27451392

Comparative transcriptional analysis of mouse hybridoma and recombinant Chinese hamster ovary cells undergoing butyrate treatment.
De Leon Gatti M, Wlaschin KF, Nissom PM, Yap M, Hu WS., J. Biosci. Bioeng. 103(1), 2007
PMID: 17298905

CpG islands and the regulation of transcription.
Deaton AM, Bird A., Genes Dev. 25(10), 2011
PMID: 21576262

Parental olfactory experience influences behavior and neural structure in subsequent generations.
Dias BG, Ressler KJ., Nat. Neurosci. 17(1), 2013
PMID: 24292232

Enhancement of production of protein biopharmaceuticals by mammalian cell cultures: the metabolomics perspective.
Dickson AJ., Curr. Opin. Biotechnol. 30(), 2014
PMID: 24995573

The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation.
Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ., Mol. Cell 48(4), 2012
PMID: 23063526

Convergent evolution of genomic imprinting in plants and mammals.
Feil R, Berger F., Trends Genet. 23(4), 2007
PMID: 17316885

Nutrient utilization by cells isolated from rat jejunum, cecum and colon.
Fleming SE, Fitch MD, DeVries S, Liu ML, Kight C., J. Nutr. 121(6), 1991
PMID: 1903440

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J., J. Cell. Sci. 126(Pt 3), 2012
PMID: 23264731

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H., Nature 504(7480), 2013
PMID: 24226770

A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency.
Geng Y, Zhao Y, Schuster LC, Feng B, Lynn DA, Austin KM, Stoklosa JD, Morrison JD., Stem Cell Reports 5(6), 2015
PMID: 26549849

The role of FoxO in the regulation of metabolism.
Gross DN, van den Heuvel AP, Birnbaum MJ., Oncogene 27(16), 2008
PMID: 18391974

Complex heatmaps reveal patterns and correlations in multidimensional genomic data.
Gu Z, Eils R, Schlesner M., Bioinformatics 32(18), 2016
PMID: 27207943

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.
Guo X, Wang L, Li J, Ding Z, Xiao J, Yin X, He S, Shi P, Dong L, Li G, Tian C, Wang J, Cong Y, Xu Y., Nature 517(7536), 2014
PMID: 25383530

Quantifying similarity between motifs.
Gupta S, Stamatoyannopoulos JA, Bailey TL, Noble WS., Genome Biol. 8(2), 2007
PMID: 17324271

SATB2 interacts with chromatin-remodeling molecules in differentiating cortical neurons.
Gyorgy AB, Szemes M, de Juan Romero C, Tarabykin V, Agoston DV., Eur. J. Neurosci. 27(4), 2008
PMID: 18333962

Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering.
Hackl M, Jakobi T, Blom J, Doppmeier D, Brinkrolf K, Szczepanowski R, Bernhart SH, Honer Zu Siederdissen C, Bort JA, Wieser M, Kunert R, Jeffs S, Hofacker IL, Goesmann A, Puhler A, Borth N, Grillari J., J. Biotechnol. 153(1-2), 2011
PMID: 21392545

Review article: the role of butyrate on colonic function.
Hamer HM, Jonkers D, Venema K, Vanhoutvin S, Troost FJ, Brummer RJ., Aliment. Pharmacol. Ther. 27(2), 2007
PMID: 17973645

Xist has properties of the X-chromosome inactivation centre.
Herzing LB, Romer JT, Horn JM, Ashworth A., Nature 386(6622), 1997
PMID: 9069284

Identifying biological themes within lists of genes with EASE.
Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA., Genome Biol. 4(10), 2003
PMID: 14519205

Extracting biological meaning from large gene lists with DAVID
Huang, Curr. Protoc. Bioinformatics 13(), 2009

Sodium butyrate stimulates monoclonal antibody over-expression in CHO cells by improving gene accessibility.
Jiang Z, Sharfstein ST., Biotechnol. Bioeng. 100(1), 2008
PMID: 18023047

KLF13 promotes porcine adipocyte differentiation through PPARγ activation.
Jiang S, Wei H, Song T, Yang Y, Zhang F, Zhou Y, Peng J, Jiang S., Cell Biosci 5(), 2015
PMID: 26085920

Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans.
Jiang X, Yan J, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Caudill MA., FASEB J. 26(8), 2012
PMID: 22549509

The role of DNA methylation in mammalian epigenetics.
Jones PA, Takai D., Science 293(5532), 2001
PMID: 11498573

KEGG: kyoto encyclopedia of genes and genomes.
Kanehisa M, Goto S., Nucleic Acids Res. 28(1), 2000
PMID: 10592173

Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment.
Kantardjieff A, Jacob NM, Yee JC, Epstein E, Kok YJ, Philp R, Betenbaugh M, Hu WS., J. Biotechnol. 145(2), 2009
PMID: 19770009

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies.
Kim M, O'Callaghan PM, Droms KA, James DC., Biotechnol. Bioeng. 108(10), 2011
PMID: 21538334

Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment - comparative transcriptome analysis with CHO cDNA microarrays.
Klausing S, Kramer O, Noll T., BMC Proc 5 Suppl 8(), 2011
PMID: 22373269

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.
Kubo N, Toh H, Shirane K, Shirakawa T, Kobayashi H, Sato T, Sone H, Sato Y, Tomizawa S, Tsurusaki Y, Shibata H, Saitsu H, Suzuki Y, Matsumoto N, Suyama M, Kono T, Ohbo K, Sasaki H., BMC Genomics 16(), 2015
PMID: 26290333

Fast gapped-read alignment with Bowtie 2.
Langmead B, Salzberg SL., Nat. Methods 9(4), 2012
PMID: 22388286

ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity.
Lee K, Gollahon LS., Biochem. Biophys. Res. Commun. 466(4), 2015
PMID: 26403970

Impact of Maternal Diet on the Epigenome during In Utero Life and the Developmental Programming of Diseases in Childhood and Adulthood.
Lee HS., Nutrients 7(11), 2015
PMID: 26593940

Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study.
Lee HS, Barraza-Villarreal A, Hernandez-Vargas H, Sly PD, Biessy C, Ramakrishnan U, Romieu I, Herceg Z., Am. J. Clin. Nutr. 98(2), 2013
PMID: 23761484

Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production.
Lee YY, Wong KT, Tan J, Toh PC, Mao Y, Brusic V, Yap MG., J. Biotechnol. 143(1), 2009
PMID: 19527755

Butyrate induces profound changes in gene expression related to multiple signal pathways in bovine kidney epithelial cells.
Li RW, Li C., BMC Genomics 7(), 2006
PMID: 16972989

The Sequence Alignment/Map format and SAMtools.
Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, Marth G, Abecasis G, Durbin R; 1000 Genome Project Data Processing Subgroup., Bioinformatics 25(16), 2009
PMID: 19505943

Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.
Li G, Yao W, Jiang H., J. Nutr. 144(12), 2014
PMID: 25320182

Pathview: an R/Bioconductor package for pathway-based data integration and visualization.
Luo W, Brouwer C., Bioinformatics 29(14), 2013
PMID: 23740750

GAGE: generally applicable gene set enrichment for pathway analysis.
Luo W, Friedman MS, Shedden K, Hankenson KD, Woolf PJ., BMC Bioinformatics 10(), 2009
PMID: 19473525

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.
Lynch MD, Smith AJ, De Gobbi M, Flenley M, Hughes JR, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L, Meek S, Burdon T, Gibbons RJ, Garrick D, Higgs DR., EMBO J. 31(2), 2011
PMID: 22056776

Label-free protein quantification of sodium butyrate treated CHO cells by ESI-UHR-TOF-MS.
Muller B, Heinrich C, Jabs W, Kaspar-Schonefeld S, Schmidt A, Rodrigues de Carvalho N, Albaum SP, Baessmann C, Noll T, Hoffrogge R., J. Biotechnol. 257(), 2017
PMID: 28363874

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.
Martins R, Lithgow GJ, Link W., Aging Cell 15(2), 2015
PMID: 26643314

Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.
Meleady P, Doolan P, Henry M, Barron N, Keenan J, O'Sullivan F, Clarke C, Gammell P, Melville MW, Leonard M, Clynes M., BMC Biotechnol. 11(), 2011
PMID: 21781345

High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells.
Moritz B, Woltering L, Becker PB, Gopfert U., Biotechnol. Prog. 32(3), 2016
PMID: 27073121

The histone deacetylase inhibitor sodium butyrate promotes cell death and differentiation and reduces neurosphere formation in human medulloblastoma cells.
Nor C, Sassi FA, de Farias CB, Schwartsmann G, Abujamra AL, Lenz G, Brunetto AL, Roesler R., Mol. Neurobiol. 48(3), 2013
PMID: 23516101

Exposing the DNA methylome iceberg.
Ndlovu MN, Denis H, Fuks F., Trends Biochem. Sci. 36(7), 2011
PMID: 21497094

Effect of butyrate on the expression of the human preprourokinase gene introduced into Chinese hamster ovary cells.
Okabayashi K, Kaneda T, Arimura H., Cell Struct. Funct. 14(5), 1989
PMID: 2620348

Promoter methylation and transgene copy numbers predict unstable protein production in recombinant Chinese hamster ovary cell lines.
Osterlehner A, Simmeth S, Gopfert U., Biotechnol. Bioeng. 108(11), 2011
PMID: 21618470

Production of analytical quantities of recombinant proteins in Chinese hamster ovary cells using sodium butyrate to elevate gene expression.
Palermo DP, DeGraaf ME, Marotti KR, Rehberg E, Post LE., J. Biotechnol. 19(1), 1991
PMID: 1369310

The Rel/NF-kappa B family: friend and foe.
Perkins ND., Trends Biochem. Sci. 25(9), 2000
PMID: 10973057

Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence.
Ruiz-Hernandez A, Kuo CC, Rentero-Garrido P, Tang WY, Redon J, Ordovas JM, Navas-Acien A, Tellez-Plaza M., Clin Epigenetics 7(), 2015
PMID: 25984247

Construction of a public CHO cell line transcript database using versatile bioinformatics analysis pipelines.
Rupp O, Becker J, Brinkrolf K, Timmermann C, Borth N, Puhler A, Noll T, Goesmann A., PLoS ONE 9(1), 2014
PMID: 24427317

Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis.
Sadler T, Bhasin JM, Xu Y, Barnholz-Sloan J, Chen Y, Ting AH, Stylianou E., Clin Epigenetics 8(), 2016
PMID: 26973718

Histone deacetylase inhibitors reverse CpG methylation by regulating DNMT1 through ERK signaling.
Sarkar S, Abujamra AL, Loew JE, Forman LW, Perrine SP, Faller DV., Anticancer Res. 31(9), 2011
PMID: 21868513

Chromatin function modifying elements in an industrial antibody production platform--comparison of UCOE, MAR, STAR and cHS4 elements.
Saunders F, Sweeney B, Antoniou MN, Stephens P, Cain K., PLoS ONE 10(4), 2015
PMID: 25849659

Function and information content of DNA methylation.
Schubeler D., Nature 517(7534), 2015
PMID: 25592537

Upregulation of GADD153 by butyrate: involvement of MAPK.
Scott DW, Longpre JM, Loo G., DNA Cell Biol. 27(11), 2008
PMID: 18767967

Molecular portrait of high productivity in recombinant NS0 cells.
Seth G, Philp RJ, Lau A, Jiun KY, Yap M, Hu WS., Biotechnol. Bioeng. 97(4), 2007
PMID: 17149768

Ofd1, a human disease gene, regulates the length and distal structure of centrioles.
Singla V, Romaguera-Ros M, Garcia-Verdugo JM, Reiter JF., Dev. Cell 18(3), 2010
PMID: 20230748

Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.
Smales CM, Dinnis DM, Stansfield SH, Alete D, Sage EA, Birch JR, Racher AJ, Marshall CT, James DC., Biotechnol. Bioeng. 88(4), 2004
PMID: 15459912

Smyth, 2005

A reference methylome database and analysis pipeline to facilitate integrative and comparative epigenomics.
Song Q, Decato B, Hong EE, Zhou M, Fang F, Qu J, Garvin T, Kessler M, Zhou J, Smith AD., PLoS ONE 8(12), 2013
PMID: 24324667

Butyrate histone deacetylase inhibitors.
Steliou K, Boosalis MS, Perrine SP, Sangerman J, Faller DV., Biores Open Access 1(4), 2012
PMID: 23514803

HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.
Stricher F, Macri C, Ruff M, Muller S., Autophagy 9(12), 2013
PMID: 24121476

Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells.
Sun S, Li W, Zhang H, Zha L, Xue Y, Wu X, Zou F., Biosci. Rep. 32(1), 2012
PMID: 21699495

Effect of sodium butyrate on the production, heterogeneity and biological activity of human thrombopoietin by recombinant Chinese hamster ovary cells.
Sung YH, Song YJ, Lim SW, Chung JY, Lee GM., J. Biotechnol. 112(3), 2004
PMID: 15313009

STRING v10: protein-protein interaction networks, integrated over the tree of life.
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, Kuhn M, Bork P, Jensen LJ, von Mering C., Nucleic Acids Res. 43(Database issue), 2014
PMID: 25352553

Overexpression of YY1 increases the protein production in mammalian cells.
Tastanova A, Schulz A, Folcher M, Tolstrup A, Puklowski A, Kaufmann H, Fussenegger M., J. Biotechnol. 219(), 2015
PMID: 26686315

Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines.
Veith N, Ziehr H, MacLeod RA, Reamon-Buettner SM., BMC Biotechnol. 16(), 2016
PMID: 26800878

Sp1 transcription factor: A long-standing target in cancer chemotherapy.
Vizcaino C, Mansilla S, Portugal J., Pharmacol. Ther. 152(), 2015
PMID: 25960131

Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene.
Wei Y, Melas PA, Wegener G, Mathe AA, Lavebratt C., Int. J. Neuropsychopharmacol. 18(2), 2014
PMID: 25618518

Establishment of a CpG island microarray for analyses of genome-wide DNA methylation in Chinese hamster ovary cells.
Wippermann A, Klausing S, Rupp O, Albaum SP, Buntemeyer H, Noll T, Hoffrogge R., Appl. Microbiol. Biotechnol. 98(2), 2013
PMID: 24146078

The DNA methylation landscape of Chinese hamster ovary (CHO) DP-12 cells.
Wippermann A, Rupp O, Brinkrolf K, Hoffrogge R, Noll T., J. Biotechnol. 199(), 2015
PMID: 25701679

Transcriptome characterization by RNA-seq unravels the mechanisms of butyrate-induced epigenomic regulation in bovine cells.
Wu S, Li RW, Li W, Li CJ., PLoS ONE 7(5), 2012
PMID: 22615851

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.
Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S, Andersen MR, Neff N, Passarelli B, Koh W, Fan HC, Wang J, Gui Y, Lee KH, Betenbaugh MJ, Quake SR, Famili I, Palsson BO, Wang J., Nat. Biotechnol. 29(8), 2011
PMID: 21804562

Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment.
Yee JC, de Leon Gatti M, Philp RJ, Yap M, Hu WS., Biotechnol. Bioeng. 99(5), 2008
PMID: 17929327

Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells.
Zhang Y, Zhou L, Bao YL, Wu Y, Yu CL, Huang YX, Sun Y, Zheng LH, Li YX., Chem. Biol. Interact. 185(3), 2010
PMID: 20346929

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