Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters
Wendler S, Otto A, Ortseifen V, Bonn F, Neshat A, Schneiker-Bekel S, Wolf T, Zemke T, Wehmeier UF, Hecker M, Kalinowski J, et al. (2016)
Journal of Proteomics 131: 140-148.
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Autor*in
Wendler, SergejUniBi;
Otto, Andreas;
Ortseifen, VeraUniBi ;
Bonn, Florian;
Neshat, ArminUniBi;
Schneiker-Bekel, SusanneUniBi;
Wolf, TimoUniBi;
Zemke, Till;
Wehmeier, Udo F.;
Hecker, Michael;
Kalinowski, JörnUniBi;
Becher, Doerte
Alle
Alle
Einrichtung
Abstract / Bemerkung
Actinoplanes sp. SE50/110 is known for the production of the la.-glucosidase inhibitor and anti-diabetic drug acarbose. Acarbose (acarviosyl-maltose) is produced as the major product when the bacterium is grown in medium with maltose, while acarviosyl-glucose is the major product when glucose is the sole carbon source in the medium. In this study, a state-of-the-art proteomics approach was applied combining subcellular fractionation, in vivo metabolic labeling and shotgun mass spectrometry to analyze differences in the proteome of Actinoplanes sp. SE50/110 cultures grown in minimal medium containing either maltose or glucose as the sole carbon source. To study proteins in distinct subcellular locations, a cytosolic, an enriched membrane, a membrane shaving and an extracellular fraction were included in the analysis. Altogether, quantitative proteome data was obtained for 2497 proteins representing about 30% of the ca. 8270 predicted proteins of Actinoplanes sp. SE50/110. When comparing protein quantities of maltose- to glucose-grown cultures, differences were observed for saccharide transport and metabolism proteins, whereas differences for acarbose biosynthesis gene cluster proteins were almost absent The maltose-inducible alpha-glucosidase/maltase Mall. as well as the ABC-type saccharide transporters AglEFG, MalEFG and MstEAF had significantly higher quantities in the maltose growth condition. The only highly abundant saccharide transporter in the glucose condition was the monosaccharide transporter MstEAF, which may indicate that MstEAF is the major glucose importer. Taken all findings together, the previously observed formation of acarviosyl-maltose and acarviosyl-glucose is more closely connected to the transport of saccharides than to a differential expression of the acarbose gene cluster. Biological significance: Diabetes is a global pandemic accounting for about 11% of the worldwide healthcare expenditures (>600 billion US dollars) and is projected to affect 592 million people by 2035 (www.idf.org). Whether Actinoplanes sp. SE50/110 produces type 2 diabetes drug acarbose (acarviosyl-maltose) or another acarviose metabolite such as acarviosyl-glucose as the major product depends on the offered carbon source. The differences observed in this proteome in this study suggest that the differences in the formation of acarviosyl-maltose and acarviosyl-glucose are more closely connected to the transport of saccharides than to a differential expression of the acarbose gene cluster. In addition, the present study provides a comprehensive overview of the proteome of Actinoplanes sp. SE50/110. (C) 2015 Elsevier B.V. All rights reserved.
Stichworte
Actinoplanes
Erscheinungsjahr
2016
Zeitschriftentitel
Journal of Proteomics
Band
131
Seite(n)
140-148
ISSN
1874-3919
eISSN
1876-7737
Page URI
https://pub.uni-bielefeld.de/record/2901243
Zitieren
Wendler S, Otto A, Ortseifen V, et al. Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics. 2016;131:140-148.
Wendler, S., Otto, A., Ortseifen, V., Bonn, F., Neshat, A., Schneiker-Bekel, S., Wolf, T., et al. (2016). Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics, 131, 140-148. doi:10.1016/j.jprot.2015.10.023
Wendler, Sergej, Otto, Andreas, Ortseifen, Vera, Bonn, Florian, Neshat, Armin, Schneiker-Bekel, Susanne, Wolf, Timo, et al. 2016. “Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters”. Journal of Proteomics 131: 140-148.
Wendler, S., Otto, A., Ortseifen, V., Bonn, F., Neshat, A., Schneiker-Bekel, S., Wolf, T., Zemke, T., Wehmeier, U. F., Hecker, M., et al. (2016). Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics 131, 140-148.
Wendler, S., et al., 2016. Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics, 131, p 140-148.
S. Wendler, et al., “Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters”, Journal of Proteomics, vol. 131, 2016, pp. 140-148.
Wendler, S., Otto, A., Ortseifen, V., Bonn, F., Neshat, A., Schneiker-Bekel, S., Wolf, T., Zemke, T., Wehmeier, U.F., Hecker, M., Kalinowski, J., Becher, D., Pühler, A.: Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics. 131, 140-148 (2016).
Wendler, Sergej, Otto, Andreas, Ortseifen, Vera, Bonn, Florian, Neshat, Armin, Schneiker-Bekel, Susanne, Wolf, Timo, Zemke, Till, Wehmeier, Udo F., Hecker, Michael, Kalinowski, Jörn, Becher, Doerte, and Pühler, Alfred. “Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters”. Journal of Proteomics 131 (2016): 140-148.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
3 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Evaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110.
Schaffert L, März C, Burkhardt L, Droste J, Brandt D, Busche T, Rosen W, Schneiker-Bekel S, Persicke M, Pühler A, Kalinowski J., Microb Cell Fact 18(1), 2019
PMID: 31253141
Schaffert L, März C, Burkhardt L, Droste J, Brandt D, Busche T, Rosen W, Schneiker-Bekel S, Persicke M, Pühler A, Kalinowski J., Microb Cell Fact 18(1), 2019
PMID: 31253141
Genome improvement of the acarbose producer Actinoplanes sp. SE50/110 and annotation refinement based on RNA-seq analysis.
Wolf T, Schneiker-Bekel S, Neshat A, Ortseifen V, Wibberg D, Zemke T, Pühler A, Kalinowski J., J Biotechnol 251(), 2017
PMID: 28427920
Wolf T, Schneiker-Bekel S, Neshat A, Ortseifen V, Wibberg D, Zemke T, Pühler A, Kalinowski J., J Biotechnol 251(), 2017
PMID: 28427920
The MalR type regulator AcrC is a transcriptional repressor of acarbose biosynthetic genes in Actinoplanes sp. SE50/110.
Wolf T, Droste J, Gren T, Ortseifen V, Schneiker-Bekel S, Zemke T, Pühler A, Kalinowski J., BMC Genomics 18(1), 2017
PMID: 28743243
Wolf T, Droste J, Gren T, Ortseifen V, Schneiker-Bekel S, Zemke T, Pühler A, Kalinowski J., BMC Genomics 18(1), 2017
PMID: 28743243
51 References
Daten bereitgestellt von Europe PubMed Central.
Chemistry and biochemistry of microbial α-glucosidase inhibitors
Truscheit, Angew. Chem. Int. Ed. Engl. 20(), 1981
Truscheit, Angew. Chem. Int. Ed. Engl. 20(), 1981
Biotechnology and molecular biology of the alpha-glucosidase inhibitor acarbose.
Wehmeier UF, Piepersberg W., Appl. Microbiol. Biotechnol. 63(6), 2003
PMID: 14669056
Wehmeier UF, Piepersberg W., Appl. Microbiol. Biotechnol. 63(6), 2003
PMID: 14669056
Acarbose - ein neues Wirkprinzip in der Diabetestherapie
Bischoff, Nachr. Chem. Tech. Lab. 42(), 1994
Bischoff, Nachr. Chem. Tech. Lab. 42(), 1994
Studies designed to localize the essential structural unit of glycoside-hydrolase inhibitors of the acarbose type
Heiker, 1981
Heiker, 1981
Carbon source dependent biosynthesis of acarviose metabolites in Actinoplanes sp. SE50/110.
Wendler S, Ortseifen V, Persicke M, Klein A, Neshat A, Niehaus K, Schneiker-Bekel S, Walter F, Wehmeier UF, Kalinowski J, Puhler A., J. Biotechnol. 191(), 2014
PMID: 25169663
Wendler S, Ortseifen V, Persicke M, Klein A, Neshat A, Niehaus K, Schneiker-Bekel S, Walter F, Wehmeier UF, Kalinowski J, Puhler A., J. Biotechnol. 191(), 2014
PMID: 25169663
alpha-Glucosidase inhibitors. New complex oligosaccharides of microbial origin.
Schmidt DD, Frommer W, Junge B, Muller L, Wingender W, Truscheit E, Schafer D., Naturwissenschaften 64(10), 1977
PMID: 337162
Schmidt DD, Frommer W, Junge B, Muller L, Wingender W, Truscheit E, Schafer D., Naturwissenschaften 64(10), 1977
PMID: 337162
[New enzyme inhibitors from microorganisms (author's transl)]
Frommer W, Junge B, Muller L, Schmidt D, Truscheit E., Planta Med. 35(3), 1979
PMID: 432298
Frommer W, Junge B, Muller L, Schmidt D, Truscheit E., Planta Med. 35(3), 1979
PMID: 432298
Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli.
Brunkhorst C, Andersen C, Schneider E., J. Bacteriol. 181(8), 1999
PMID: 10198028
Brunkhorst C, Andersen C, Schneider E., J. Bacteriol. 181(8), 1999
PMID: 10198028
The biosynthesis and metabolism of acarbose in actinoplanes sp. SE 50/110: a progress report
Wehmeier, Biocatal. Biotransform. 21(), 2003
Wehmeier, Biocatal. Biotransform. 21(), 2003
The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.
Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A., BMC Genomics 13(), 2012
PMID: 22443545
Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A., BMC Genomics 13(), 2012
PMID: 22443545
Improving the genome annotation of the acarbose producer Actinoplanes sp. SE50/110 by sequencing enriched 5'-ends of primary transcripts.
Schwientek P, Neshat A, Kalinowski J, Klein A, Ruckert C, Schneiker-Bekel S, Wendler S, Stoye J, Puhler A., J. Biotechnol. 190(), 2014
PMID: 24642337
Schwientek P, Neshat A, Kalinowski J, Klein A, Ruckert C, Schneiker-Bekel S, Wendler S, Stoye J, Puhler A., J. Biotechnol. 190(), 2014
PMID: 24642337
Comparative RNA-sequencing of the acarbose producer Actinoplanes sp. SE50/110 cultivated in different growth media.
Schwientek P, Wendler S, Neshat A, Eirich C, Ruckert C, Klein A, Wehmeier UF, Kalinowski J, Stoye J, Puhler A., J. Biotechnol. 167(2), 2012
PMID: 23142701
Schwientek P, Wendler S, Neshat A, Eirich C, Ruckert C, Klein A, Wehmeier UF, Kalinowski J, Stoye J, Puhler A., J. Biotechnol. 167(2), 2012
PMID: 23142701
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A., J. Biotechnol. 167(2), 2012
PMID: 22944206
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A., J. Biotechnol. 167(2), 2012
PMID: 22944206
Comprehensive proteome analysis of Actinoplanes sp. SE50/110 highlighting the location of proteins encoded by the acarbose and the pyochelin biosynthesis gene cluster.
Wendler S, Otto A, Ortseifen V, Bonn F, Neshat A, Schneiker-Bekel S, Walter F, Wolf T, Zemke T, Wehmeier UF, Hecker M, Kalinowski J, Becher D, Puhler A., J Proteomics 125(), 2015
PMID: 25896738
Wendler S, Otto A, Ortseifen V, Bonn F, Neshat A, Schneiker-Bekel S, Walter F, Wolf T, Zemke T, Wehmeier UF, Hecker M, Kalinowski J, Becher D, Puhler A., J Proteomics 125(), 2015
PMID: 25896738
Systems-wide temporal proteomic profiling in glucose-starved Bacillus subtilis.
Otto A, Bernhardt J, Meyer H, Schaffer M, Herbst FA, Siebourg J, Mader U, Lalk M, Hecker M, Becher D., Nat Commun 1(), 2010
PMID: 21266987
Otto A, Bernhardt J, Meyer H, Schaffer M, Herbst FA, Siebourg J, Mader U, Lalk M, Hecker M, Becher D., Nat Commun 1(), 2010
PMID: 21266987
Global proteome analysis of vancomycin stress in Staphylococcus aureus.
Hessling B, Bonn F, Otto A, Herbst FA, Rappen GM, Bernhardt J, Hecker M, Becher D., Int. J. Med. Microbiol. 303(8), 2013
PMID: 24161710
Hessling B, Bonn F, Otto A, Herbst FA, Rappen GM, Bernhardt J, Hecker M, Becher D., Int. J. Med. Microbiol. 303(8), 2013
PMID: 24161710
A correlation algorithm for the automated quantitative analysis of shotgun proteomics data.
MacCoss MJ, Wu CC, Liu H, Sadygov R, Yates JR 3rd., Anal. Chem. 75(24), 2003
PMID: 14670053
MacCoss MJ, Wu CC, Liu H, Sadygov R, Yates JR 3rd., Anal. Chem. 75(24), 2003
PMID: 14670053
Picking vanished proteins from the void: how to collect and ship/share extremely dilute proteins in a reproducible and highly efficient manner.
Bonn F, Bartel J, Buttner K, Hecker M, Otto A, Becher D., Anal. Chem. 86(15), 2014
PMID: 24987932
Bonn F, Bartel J, Buttner K, Hecker M, Otto A, Becher D., Anal. Chem. 86(15), 2014
PMID: 24987932
The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013.
Vizcaino JA, Cote RG, Csordas A, Dianes JA, Fabregat A, Foster JM, Griss J, Alpi E, Birim M, Contell J, O'Kelly G, Schoenegger A, Ovelleiro D, Perez-Riverol Y, Reisinger F, Rios D, Wang R, Hermjakob H., Nucleic Acids Res. 41(Database issue), 2012
PMID: 23203882
Vizcaino JA, Cote RG, Csordas A, Dianes JA, Fabregat A, Foster JM, Griss J, Alpi E, Birim M, Contell J, O'Kelly G, Schoenegger A, Ovelleiro D, Perez-Riverol Y, Reisinger F, Rios D, Wang R, Hermjakob H., Nucleic Acids Res. 41(Database issue), 2012
PMID: 23203882
A quantitative analysis software tool for mass spectrometry-based proteomics.
Park SK, Venable JD, Xu T, Yates JR 3rd., Nat. Methods 5(4), 2008
PMID: 18345006
Park SK, Venable JD, Xu T, Yates JR 3rd., Nat. Methods 5(4), 2008
PMID: 18345006
Statistical analysis of membrane proteome expression changes in Saccharomyces cerevisiae.
Zybailov B, Mosley AL, Sardiu ME, Coleman MK, Florens L, Washburn MP., J. Proteome Res. 5(9), 2006
PMID: 16944946
Zybailov B, Mosley AL, Sardiu ME, Coleman MK, Florens L, Washburn MP., J. Proteome Res. 5(9), 2006
PMID: 16944946
Universal seeds for cDNA-to-genome comparison.
Zhou L, Stanton J, Florea L., BMC Bioinformatics 9(), 2008
PMID: 18215286
Zhou L, Stanton J, Florea L., BMC Bioinformatics 9(), 2008
PMID: 18215286
Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis.
Phadnis SH, Parlow MH, Levy M, Ilver D, Caulkins CM, Connors JB, Dunn BE., Infect. Immun. 64(3), 1996
PMID: 8641799
Phadnis SH, Parlow MH, Levy M, Ilver D, Caulkins CM, Connors JB, Dunn BE., Infect. Immun. 64(3), 1996
PMID: 8641799
GroEL heat shock protein of Haemophilus ducreyi: association with cell surface and capacity to bind to eukaryotic cells.
Frisk A, Ison CA, Lagergard T., Infect. Immun. 66(3), 1998
PMID: 9488422
Frisk A, Ison CA, Lagergard T., Infect. Immun. 66(3), 1998
PMID: 9488422
Immunogold localization of the DnaK heat shock protein in Escherichia coli cells.
Bukau B, Reilly P, McCarty J, Walker GC., J. Gen. Microbiol. 139(1), 1993
PMID: 8450312
Bukau B, Reilly P, McCarty J, Walker GC., J. Gen. Microbiol. 139(1), 1993
PMID: 8450312
GroEL (Hsp60) of Clostridium difficile is involved in cell adherence.
Hennequin C, Porcheray F, Waligora-Dupriet A, Collignon A, Barc M, Bourlioux P, Karjalainen T., Microbiology (Reading, Engl.) 147(Pt 1), 2001
PMID: 11160803
Hennequin C, Porcheray F, Waligora-Dupriet A, Collignon A, Barc M, Bourlioux P, Karjalainen T., Microbiology (Reading, Engl.) 147(Pt 1), 2001
PMID: 11160803
Exploring the membrane proteome--challenges and analytical strategies.
Helbig AO, Heck AJ, Slijper M., J Proteomics 73(5), 2010
PMID: 20096812
Helbig AO, Heck AJ, Slijper M., J Proteomics 73(5), 2010
PMID: 20096812
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.
Goeke K, Drepper A, Pape H., J. Antibiot. 49(7), 1996
PMID: 8784426
Goeke K, Drepper A, Pape H., J. Antibiot. 49(7), 1996
PMID: 8784426
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.
Drepper A, Pape H., J. Antibiot. 49(7), 1996
PMID: 8784428
Drepper A, Pape H., J. Antibiot. 49(7), 1996
PMID: 8784428
Identification and enzymatic characterization of the maltose-inducible alpha-glucosidase MalL (sucrase-isomaltase-maltase) of Bacillus subtilis.
Schonert S, Buder T, Dahl MK., J. Bacteriol. 180(9), 1998
PMID: 9573215
Schonert S, Buder T, Dahl MK., J. Bacteriol. 180(9), 1998
PMID: 9573215
Properties of maltose-inducible alpha-glucosidase MalL (sucrase-isomaltase-maltase) in Bacillus subtilis: evidence for its contribution to maltodextrin utilization.
Schonert S, Buder T, Dahl MK., Res. Microbiol. 150(3), 1999
PMID: 10229946
Schonert S, Buder T, Dahl MK., Res. Microbiol. 150(3), 1999
PMID: 10229946
A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides.
Willis LB, Walker GC., J. Bacteriol. 181(14), 1999
PMID: 10400573
Willis LB, Walker GC., J. Bacteriol. 181(14), 1999
PMID: 10400573
Redundancy in periplasmic binding protein-dependent transport systems for trehalose, sucrose, and maltose in Sinorhizobium meliloti.
Jensen JB, Peters NK, Bhuvaneswari TV., J. Bacteriol. 184(11), 2002
PMID: 12003938
Jensen JB, Peters NK, Bhuvaneswari TV., J. Bacteriol. 184(11), 2002
PMID: 12003938
Characterization of maltose and maltotriose transport in the acarbose-producing bacterium Actinoplanes sp.
Brunkhorst C, Schneider E., Res. Microbiol. 156(8), 2005
PMID: 15939574
Brunkhorst C, Schneider E., Res. Microbiol. 156(8), 2005
PMID: 15939574
Analysis of the yeast transcriptome with structural and functional categories: characterizing highly expressed proteins.
Jansen R, Gerstein M., Nucleic Acids Res. 28(6), 2000
PMID: 10684945
Jansen R, Gerstein M., Nucleic Acids Res. 28(6), 2000
PMID: 10684945
Analysis of mRNA expression and protein abundance data: an approach for the comparison of the enrichment of features in the cellular population of proteins and transcripts.
Greenbaum D, Jansen R, Gerstein M., Bioinformatics 18(4), 2002
PMID: 12016056
Greenbaum D, Jansen R, Gerstein M., Bioinformatics 18(4), 2002
PMID: 12016056
Protein abundance profiling of the Escherichia coli cytosol.
Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D., BMC Genomics 9(), 2008
PMID: 18304323
Ishihama Y, Schmidt T, Rappsilber J, Mann M, Hartl FU, Kerner MJ, Frishman D., BMC Genomics 9(), 2008
PMID: 18304323
Characterizations of highly expressed genes of four fast-growing bacteria.
Karlin S, Mrazek J, Campbell A, Kaiser D., J. Bacteriol. 183(17), 2001
PMID: 11489855
Karlin S, Mrazek J, Campbell A, Kaiser D., J. Bacteriol. 183(17), 2001
PMID: 11489855
A proteomic view of an important human pathogen--towards the quantification of the entire Staphylococcus aureus proteome.
Becher D, Hempel K, Sievers S, Zuhlke D, Pane-Farre J, Otto A, Fuchs S, Albrecht D, Bernhardt J, Engelmann S, Volker U, van Dijl JM, Hecker M., PLoS ONE 4(12), 2009
PMID: 19997597
Becher D, Hempel K, Sievers S, Zuhlke D, Pane-Farre J, Otto A, Fuchs S, Albrecht D, Bernhardt J, Engelmann S, Volker U, van Dijl JM, Hecker M., PLoS ONE 4(12), 2009
PMID: 19997597
Towards the entire proteome of the model bacterium Bacillus subtilis by gel-based and gel-free approaches.
Wolff S, Antelmann H, Albrecht D, Becher D, Bernhardt J, Bron S, Buttner K, van Dijl JM, Eymann C, Otto A, Tam le T, Hecker M., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 849(1-2), 2006
PMID: 17055787
Wolff S, Antelmann H, Albrecht D, Becher D, Bernhardt J, Bron S, Buttner K, van Dijl JM, Eymann C, Otto A, Tam le T, Hecker M., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 849(1-2), 2006
PMID: 17055787
Global proteome survey of protocatechuate- and glucose-grown Corynebacterium glutamicum reveals multiple physiological differences.
Haussmann U, Poetsch A., J Proteomics 75(9), 2012
PMID: 22450470
Haussmann U, Poetsch A., J Proteomics 75(9), 2012
PMID: 22450470
The maltose ATP-binding cassette transporter in the 21st century--towards a structural dynamic perspective on its mode of action.
Bordignon E, Grote M, Schneider E., Mol. Microbiol. 77(6), 2010
PMID: 20659291
Bordignon E, Grote M, Schneider E., Mol. Microbiol. 77(6), 2010
PMID: 20659291
The malEFG gene cluster of Streptomyces coelicolor A3(2): characterization, disruption and transcriptional analysis.
van Wezel GP, White J, Bibb MJ, Postma PW., Mol. Gen. Genet. 254(5), 1997
PMID: 9197422
van Wezel GP, White J, Bibb MJ, Postma PW., Mol. Gen. Genet. 254(5), 1997
PMID: 9197422
Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacl-galR family of regulatory genes.
van Wezel GP, White J, Young P, Postma PW, Bibb MJ., Mol. Microbiol. 23(3), 1997
PMID: 9044287
van Wezel GP, White J, Young P, Postma PW, Bibb MJ., Mol. Microbiol. 23(3), 1997
PMID: 9044287
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
Molecular genetics of a receptor protein for D-xylose, encoded by the gene xylF, in Escherichia coli.
Sumiya M, Davis EO, Packman LC, McDonald TP, Henderson PJ., Recept. Channels 3(2), 1995
PMID: 8581399
Sumiya M, Davis EO, Packman LC, McDonald TP, Henderson PJ., Recept. Channels 3(2), 1995
PMID: 8581399
Sugar-mediated induction of Agrobacterium tumefaciens virulence genes: structural specificity and activities of monosaccharides.
Ankenbauer RG, Nester EW., J. Bacteriol. 172(11), 1990
PMID: 2121715
Ankenbauer RG, Nester EW., J. Bacteriol. 172(11), 1990
PMID: 2121715
Molecular basis of ChvE function in sugar binding, sugar utilization, and virulence in Agrobacterium tumefaciens.
He F, Nair GR, Soto CS, Chang Y, Hsu L, Ronzone E, DeGrado WF, Binns AN., J. Bacteriol. 191(18), 2009
PMID: 19633083
He F, Nair GR, Soto CS, Chang Y, Hsu L, Ronzone E, DeGrado WF, Binns AN., J. Bacteriol. 191(18), 2009
PMID: 19633083
The chromosomal virulence gene, chvE, of Agrobacterium tumefaciens is regulated by a LysR family member.
Doty SL, Chang M, Nester EW., J. Bacteriol. 175(24), 1993
PMID: 8253677
Doty SL, Chang M, Nester EW., J. Bacteriol. 175(24), 1993
PMID: 8253677
Sugars induce the Agrobacterium virulence genes through a periplasmic binding protein and a transmembrane signal protein.
Cangelosi GA, Ankenbauer RG, Nester EW., Proc. Natl. Acad. Sci. U.S.A. 87(17), 1990
PMID: 2118656
Cangelosi GA, Ankenbauer RG, Nester EW., Proc. Natl. Acad. Sci. U.S.A. 87(17), 1990
PMID: 2118656
Crystal structures of the bacterial solute receptor AcbH displaying an exclusive substrate preference for β-D-galactopyranose.
Licht A, Bulut H, Scheffel F, Daumke O, Wehmeier UF, Saenger W, Schneider E, Vahedi-Faridi A., J. Mol. Biol. 406(1), 2010
PMID: 21168419
Licht A, Bulut H, Scheffel F, Daumke O, Wehmeier UF, Saenger W, Schneider E, Vahedi-Faridi A., J. Mol. Biol. 406(1), 2010
PMID: 21168419
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