Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters
Wendler S, Otto A, Ortseifen V, Bonn F, Neshat A, Schneiker-Bekel S, Wolf T, Zemke T, Wehmeier UF, Hecker M, Kalinowski J, et al. (2016)
Journal of Proteomics 131: 140-148.
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Autor*in
Wendler, SergejUniBi;
Otto, Andreas;
Ortseifen, VeraUniBi
;
Bonn, Florian;
Neshat, ArminUniBi;
Schneiker-Bekel, SusanneUniBi;
Wolf, TimoUniBi;
Zemke, Till;
Wehmeier, Udo F.;
Hecker, Michael;
Kalinowski, JörnUniBi;
Becher, Doerte
Alle
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Alle
Einrichtung
Abstract / Bemerkung
Actinoplanes sp. SE50/110 is known for the production of the la.-glucosidase inhibitor and anti-diabetic drug acarbose. Acarbose (acarviosyl-maltose) is produced as the major product when the bacterium is grown in medium with maltose, while acarviosyl-glucose is the major product when glucose is the sole carbon source in the medium. In this study, a state-of-the-art proteomics approach was applied combining subcellular fractionation, in vivo metabolic labeling and shotgun mass spectrometry to analyze differences in the proteome of Actinoplanes sp. SE50/110 cultures grown in minimal medium containing either maltose or glucose as the sole carbon source. To study proteins in distinct subcellular locations, a cytosolic, an enriched membrane, a membrane shaving and an extracellular fraction were included in the analysis. Altogether, quantitative proteome data was obtained for 2497 proteins representing about 30% of the ca. 8270 predicted proteins of Actinoplanes sp. SE50/110. When comparing protein quantities of maltose- to glucose-grown cultures, differences were observed for saccharide transport and metabolism proteins, whereas differences for acarbose biosynthesis gene cluster proteins were almost absent The maltose-inducible alpha-glucosidase/maltase Mall. as well as the ABC-type saccharide transporters AglEFG, MalEFG and MstEAF had significantly higher quantities in the maltose growth condition. The only highly abundant saccharide transporter in the glucose condition was the monosaccharide transporter MstEAF, which may indicate that MstEAF is the major glucose importer. Taken all findings together, the previously observed formation of acarviosyl-maltose and acarviosyl-glucose is more closely connected to the transport of saccharides than to a differential expression of the acarbose gene cluster. Biological significance: Diabetes is a global pandemic accounting for about 11% of the worldwide healthcare expenditures (>600 billion US dollars) and is projected to affect 592 million people by 2035 (www.idf.org). Whether Actinoplanes sp. SE50/110 produces type 2 diabetes drug acarbose (acarviosyl-maltose) or another acarviose metabolite such as acarviosyl-glucose as the major product depends on the offered carbon source. The differences observed in this proteome in this study suggest that the differences in the formation of acarviosyl-maltose and acarviosyl-glucose are more closely connected to the transport of saccharides than to a differential expression of the acarbose gene cluster. In addition, the present study provides a comprehensive overview of the proteome of Actinoplanes sp. SE50/110. (C) 2015 Elsevier B.V. All rights reserved.
Stichworte
Actinoplanes
Erscheinungsjahr
2016
Zeitschriftentitel
Journal of Proteomics
Band
131
Seite(n)
140-148
ISSN
1874-3919
eISSN
1876-7737
Page URI
https://pub.uni-bielefeld.de/record/2901243
Zitieren
Wendler S, Otto A, Ortseifen V, et al. Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics. 2016;131:140-148.
Wendler, S., Otto, A., Ortseifen, V., Bonn, F., Neshat, A., Schneiker-Bekel, S., Wolf, T., et al. (2016). Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics, 131, 140-148. doi:10.1016/j.jprot.2015.10.023
Wendler, Sergej, Otto, Andreas, Ortseifen, Vera, Bonn, Florian, Neshat, Armin, Schneiker-Bekel, Susanne, Wolf, Timo, et al. 2016. “Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters”. Journal of Proteomics 131: 140-148.
Wendler, S., Otto, A., Ortseifen, V., Bonn, F., Neshat, A., Schneiker-Bekel, S., Wolf, T., Zemke, T., Wehmeier, U. F., Hecker, M., et al. (2016). Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics 131, 140-148.
Wendler, S., et al., 2016. Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics, 131, p 140-148.
S. Wendler, et al., “Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters”, Journal of Proteomics, vol. 131, 2016, pp. 140-148.
Wendler, S., Otto, A., Ortseifen, V., Bonn, F., Neshat, A., Schneiker-Bekel, S., Wolf, T., Zemke, T., Wehmeier, U.F., Hecker, M., Kalinowski, J., Becher, D., Pühler, A.: Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters. Journal of Proteomics. 131, 140-148 (2016).
Wendler, Sergej, Otto, Andreas, Ortseifen, Vera, Bonn, Florian, Neshat, Armin, Schneiker-Bekel, Susanne, Wolf, Timo, Zemke, Till, Wehmeier, Udo F., Hecker, Michael, Kalinowski, Jörn, Becher, Doerte, and Pühler, Alfred. “Comparative proteome analysis of Actinoplanes sp SE50/110 grown with maltose or glucose shows Minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters”. Journal of Proteomics 131 (2016): 140-148.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
3 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Evaluation of vector systems and promoters for overexpression of the acarbose biosynthesis gene acbC in Actinoplanes sp. SE50/110.
Schaffert L, März C, Burkhardt L, Droste J, Brandt D, Busche T, Rosen W, Schneiker-Bekel S, Persicke M, Pühler A, Kalinowski J., Microb Cell Fact 18(1), 2019
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Schaffert L, März C, Burkhardt L, Droste J, Brandt D, Busche T, Rosen W, Schneiker-Bekel S, Persicke M, Pühler A, Kalinowski J., Microb Cell Fact 18(1), 2019
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Genome improvement of the acarbose producer Actinoplanes sp. SE50/110 and annotation refinement based on RNA-seq analysis.
Wolf T, Schneiker-Bekel S, Neshat A, Ortseifen V, Wibberg D, Zemke T, Pühler A, Kalinowski J., J Biotechnol 251(), 2017
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Wolf T, Schneiker-Bekel S, Neshat A, Ortseifen V, Wibberg D, Zemke T, Pühler A, Kalinowski J., J Biotechnol 251(), 2017
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The MalR type regulator AcrC is a transcriptional repressor of acarbose biosynthetic genes in Actinoplanes sp. SE50/110.
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PMID: 21168419
Licht A, Bulut H, Scheffel F, Daumke O, Wehmeier UF, Saenger W, Schneider E, Vahedi-Faridi A., J. Mol. Biol. 406(1), 2010
PMID: 21168419
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