Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia
Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T, Borkhardt A (2011)
Blood Cancer Journal 1(3): e8.
Zeitschriftenaufsatz
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Autor*in
Schuster, F R;
Hubner, B;
Führer, M;
Eckermann, O;
Gombert, M;
Dornmair, K;
Binder, V;
Reuther, S;
Krell, PinaUniBi;
Keller, T;
Borkhardt, A
Einrichtung
Abstract / Bemerkung
One of the major obstacles of immunosuppressive therapy (IST) in children with severe aplastic anemia (SAA) comes from the often months-long unpredictability of bone-marrow (BM) recovery. In this prospective study in children with newly diagnosed very severe AA (n=10), who were enrolled in the therapy study SAA-BFM 94, we found a dramatically reduced diversity of both CD4+ and CD8+ BM cells, as scored by comprehensive V-beta chain T-cell receptor (TCR) analysis. Strongly skewed TCR V-beta pattern was highly predictive for good or at least partial treatment response (n=6, CD8+ complexity scoring median 35.5, range 24–73). In contrast, IST in patients with rather moderate reduction of TCR V-beta diversity (n=4, CD8+ complexity scoring median 109.5, range 82–124) always failed (P=0.0095). If confirmed in a larger series of patients, TCR V-beta repertoire in BM may help to assign children with SAA up-front either to IST or to allogeneic stem-cell transplantation.
Erscheinungsjahr
2011
Zeitschriftentitel
Blood Cancer Journal
Band
1
Ausgabe
3
Seite(n)
e8
ISSN
2044-5385
eISSN
2044-5385
Page URI
https://pub.uni-bielefeld.de/record/2492807
Zitieren
Schuster FR, Hubner B, Führer M, et al. Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal. 2011;1(3):e8.
Schuster, F. R., Hubner, B., Führer, M., Eckermann, O., Gombert, M., Dornmair, K., Binder, V., et al. (2011). Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal, 1(3), e8. doi:10.1038/bcj.2011.6
Schuster, F R, Hubner, B, Führer, M, Eckermann, O, Gombert, M, Dornmair, K, Binder, V, et al. 2011. “Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia”. Blood Cancer Journal 1 (3): e8.
Schuster, F. R., Hubner, B., Führer, M., Eckermann, O., Gombert, M., Dornmair, K., Binder, V., Reuther, S., Krell, P., Keller, T., et al. (2011). Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal 1, e8.
Schuster, F.R., et al., 2011. Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal, 1(3), p e8.
F.R. Schuster, et al., “Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia”, Blood Cancer Journal, vol. 1, 2011, pp. e8.
Schuster, F.R., Hubner, B., Führer, M., Eckermann, O., Gombert, M., Dornmair, K., Binder, V., Reuther, S., Krell, P., Keller, T., Borkhardt, A.: Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal. 1, e8 (2011).
Schuster, F R, Hubner, B, Führer, M, Eckermann, O, Gombert, M, Dornmair, K, Binder, V, Reuther, S, Krell, Pina, Keller, T, and Borkhardt, A. “Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia”. Blood Cancer Journal 1.3 (2011): e8.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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