Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia
Schuster FR, Hubner B, Führer M, Eckermann O, Gombert M, Dornmair K, Binder V, Reuther S, Krell P, Keller T, Borkhardt A (2011)
Blood Cancer Journal 1(3): e8.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Schuster, F R;
Hubner, B;
Führer, M;
Eckermann, O;
Gombert, M;
Dornmair, K;
Binder, V;
Reuther, S;
Krell, PinaUniBi;
Keller, T;
Borkhardt, A
Einrichtung
Abstract / Bemerkung
One of the major obstacles of immunosuppressive therapy (IST) in children with severe aplastic anemia (SAA) comes from the often months-long unpredictability of bone-marrow (BM) recovery. In this prospective study in children with newly diagnosed very severe AA (n=10), who were enrolled in the therapy study SAA-BFM 94, we found a dramatically reduced diversity of both CD4+ and CD8+ BM cells, as scored by comprehensive V-beta chain T-cell receptor (TCR) analysis. Strongly skewed TCR V-beta pattern was highly predictive for good or at least partial treatment response (n=6, CD8+ complexity scoring median 35.5, range 24–73). In contrast, IST in patients with rather moderate reduction of TCR V-beta diversity (n=4, CD8+ complexity scoring median 109.5, range 82–124) always failed (P=0.0095). If confirmed in a larger series of patients, TCR V-beta repertoire in BM may help to assign children with SAA up-front either to IST or to allogeneic stem-cell transplantation.
Erscheinungsjahr
2011
Zeitschriftentitel
Blood Cancer Journal
Band
1
Ausgabe
3
Seite(n)
e8
ISSN
2044-5385
eISSN
2044-5385
Page URI
https://pub.uni-bielefeld.de/record/2492807
Zitieren
Schuster FR, Hubner B, Führer M, et al. Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal. 2011;1(3):e8.
Schuster, F. R., Hubner, B., Führer, M., Eckermann, O., Gombert, M., Dornmair, K., Binder, V., et al. (2011). Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal, 1(3), e8. doi:10.1038/bcj.2011.6
Schuster, F R, Hubner, B, Führer, M, Eckermann, O, Gombert, M, Dornmair, K, Binder, V, et al. 2011. “Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia”. Blood Cancer Journal 1 (3): e8.
Schuster, F. R., Hubner, B., Führer, M., Eckermann, O., Gombert, M., Dornmair, K., Binder, V., Reuther, S., Krell, P., Keller, T., et al. (2011). Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal 1, e8.
Schuster, F.R., et al., 2011. Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal, 1(3), p e8.
F.R. Schuster, et al., “Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia”, Blood Cancer Journal, vol. 1, 2011, pp. e8.
Schuster, F.R., Hubner, B., Führer, M., Eckermann, O., Gombert, M., Dornmair, K., Binder, V., Reuther, S., Krell, P., Keller, T., Borkhardt, A.: Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia. Blood Cancer Journal. 1, e8 (2011).
Schuster, F R, Hubner, B, Führer, M, Eckermann, O, Gombert, M, Dornmair, K, Binder, V, Reuther, S, Krell, Pina, Keller, T, and Borkhardt, A. “Highly skewed T-cell receptor V-beta chain repertoire in the bone marrow is associated with response to immunosuppressive drug therapy in children with very severe aplastic anemia”. Blood Cancer Journal 1.3 (2011): e8.
7 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Deep sequencing and flow cytometric characterization of expanded effector memory CD8+CD57+ T cells frequently reveals T-cell receptor Vβ oligoclonality and CDR3 homology in acquired aplastic anemia.
Giudice V, Feng X, Lin Z, Hu W, Zhang F, Qiao W, Ibanez MDPF, Rios O, Young NS., Haematologica 103(5), 2018
PMID: 29419434
Giudice V, Feng X, Lin Z, Hu W, Zhang F, Qiao W, Ibanez MDPF, Rios O, Young NS., Haematologica 103(5), 2018
PMID: 29419434
The Pathophysiology of Acquired Aplastic Anemia: Current Concepts Revisited.
Schoettler ML, Nathan DG., Hematol Oncol Clin North Am 32(4), 2018
PMID: 30047412
Schoettler ML, Nathan DG., Hematol Oncol Clin North Am 32(4), 2018
PMID: 30047412
Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.
Boddu PC, Kadia TM., Expert Rev Hematol 10(5), 2017
PMID: 28452257
Boddu PC, Kadia TM., Expert Rev Hematol 10(5), 2017
PMID: 28452257
CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing.
Schneider-Hohendorf T, Mohan H, Bien CG, Breuer J, Becker A, Görlich D, Kuhlmann T, Widman G, Herich S, Elpers C, Melzer N, Dornmair K, Kurlemann G, Wiendl H, Schwab N., Nat Commun 7(), 2016
PMID: 27040081
Schneider-Hohendorf T, Mohan H, Bien CG, Breuer J, Becker A, Görlich D, Kuhlmann T, Widman G, Herich S, Elpers C, Melzer N, Dornmair K, Kurlemann G, Wiendl H, Schwab N., Nat Commun 7(), 2016
PMID: 27040081
The complex pathophysiology of acquired aplastic anaemia.
Zeng Y, Katsanis E., Clin Exp Immunol 180(3), 2015
PMID: 25683099
Zeng Y, Katsanis E., Clin Exp Immunol 180(3), 2015
PMID: 25683099
Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS).
Fang H, Yamaguchi R, Liu X, Daigo Y, Yew PY, Tanikawa C, Matsuda K, Imoto S, Miyano S, Nakamura Y., Oncoimmunology 3(12), 2014
PMID: 25964866
Fang H, Yamaguchi R, Liu X, Daigo Y, Yew PY, Tanikawa C, Matsuda K, Imoto S, Miyano S, Nakamura Y., Oncoimmunology 3(12), 2014
PMID: 25964866
Next-generation-sequencing-spectratyping reveals public T-cell receptor repertoires in pediatric very severe aplastic anemia and identifies a β chain CDR3 sequence associated with hepatitis-induced pathogenesis.
Krell PF, Reuther S, Fischer U, Keller T, Weber S, Gombert M, Schuster FR, Asang C, Stepensky P, Strahm B, Meisel R, Stoye J, Borkhardt A., Haematologica 98(9), 2013
PMID: 23716544
Krell PF, Reuther S, Fischer U, Keller T, Weber S, Gombert M, Schuster FR, Asang C, Stepensky P, Strahm B, Meisel R, Stoye J, Borkhardt A., Haematologica 98(9), 2013
PMID: 23716544
14 References
Daten bereitgestellt von Europe PubMed Central.
Bone marrow graft in man after conditioning by antilymphocytic serum.
Mathe G, Amiel JL, Schwarzenberg L, Choay J, Trolard P, Schneider M, Hayat M, Schlumberger JR, Jasmin C., Br Med J 2(5702), 1970
PMID: 4909449
Mathe G, Amiel JL, Schwarzenberg L, Choay J, Trolard P, Schneider M, Hayat M, Schlumberger JR, Jasmin C., Br Med J 2(5702), 1970
PMID: 4909449
The pathophysiology of acquired aplastic anemia.
Young NS, Maciejewski J., N. Engl. J. Med. 336(19), 1997
PMID: 9134878
Young NS, Maciejewski J., N. Engl. J. Med. 336(19), 1997
PMID: 9134878
T cells selectively infiltrate bone marrow areas with residual haemopoiesis of patients with acquired aplastic anaemia.
Melenhorst JJ, van Krieken JH, Dreef E, Landegent JE, Willemze R, Fibbe WE., Br. J. Haematol. 99(3), 1997
PMID: 9401058
Melenhorst JJ, van Krieken JH, Dreef E, Landegent JE, Willemze R, Fibbe WE., Br. J. Haematol. 99(3), 1997
PMID: 9401058
Fludarabine, cyclophosphamide, antithymocyte globulin, with or without low dose total body irradiation, for alternative donor transplants, in acquired severe aplastic anemia: a retrospective study from the EBMT-SAA Working Party.
Bacigalupo A, Socie' G, Lanino E, Prete A, Locatelli F, Locasciulli A, Cesaro S, Shimoni A, Marsh J, Brune M, Van Lint MT, Oneto R, Passweg J; Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation., Haematologica 95(6), 2010
PMID: 20494932
Bacigalupo A, Socie' G, Lanino E, Prete A, Locatelli F, Locasciulli A, Cesaro S, Shimoni A, Marsh J, Brune M, Van Lint MT, Oneto R, Passweg J; Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation., Haematologica 95(6), 2010
PMID: 20494932
Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival.
Fuhrer M, Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, Friedrich W, Ebell W, Borkhardt A, Bender-Goetze C., Blood 106(6), 2005
PMID: 15933058
Fuhrer M, Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, Friedrich W, Ebell W, Borkhardt A, Bender-Goetze C., Blood 106(6), 2005
PMID: 15933058
The International Prognostic Scoring System (IPSS) for childhood myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukemia (JMML).
Hasle H, Baumann I, Bergstrasser E, Fenu S, Fischer A, Kardos G, Kerndrup G, Locatelli F, Rogge T, Schultz KR, Stary J, Trebo M, van den Heuvel-Eibrink MM, Harbott J, Nollke P, Niemeyer CM; European Working Group on childhood MDS., Leukemia 18(12), 2004
PMID: 15496981
Hasle H, Baumann I, Bergstrasser E, Fenu S, Fischer A, Kardos G, Kerndrup G, Locatelli F, Rogge T, Schultz KR, Stary J, Trebo M, van den Heuvel-Eibrink MM, Harbott J, Nollke P, Niemeyer CM; European Working Group on childhood MDS., Leukemia 18(12), 2004
PMID: 15496981
Reconstitution of paired T cell receptor alpha- and beta-chains from microdissected single cells of human inflammatory tissues.
Seitz S, Schneider CK, Malotka J, Nong X, Engel AG, Wekerle H, Hohlfeld R, Dornmair K., Proc. Natl. Acad. Sci. U.S.A. 103(32), 2006
PMID: 16882720
Seitz S, Schneider CK, Malotka J, Nong X, Engel AG, Wekerle H, Hohlfeld R, Dornmair K., Proc. Natl. Acad. Sci. U.S.A. 103(32), 2006
PMID: 16882720
Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism.
Wu CJ, Chillemi A, Alyea EP, Orsini E, Neuberg D, Soiffer RJ, Ritz J., Blood 95(1), 2000
PMID: 10607724
Wu CJ, Chillemi A, Alyea EP, Orsini E, Neuberg D, Soiffer RJ, Ritz J., Blood 95(1), 2000
PMID: 10607724
Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.
Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS., JAMA 304(12), 2010
PMID: 20858879
Scheinberg P, Cooper JN, Sloand EM, Wu CO, Calado RT, Young NS., JAMA 304(12), 2010
PMID: 20858879
Th17 immune responses contribute to the pathophysiology of aplastic anemia.
de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, Chen J, Young NS., Blood 116(20), 2010
PMID: 20733158
de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, Chen J, Young NS., Blood 116(20), 2010
PMID: 20733158
Limited heterogeneity of T cell receptor BV usage in aplastic anemia.
Zeng W, Maciejewski JP, Chen G, Young NS., J. Clin. Invest. 108(5), 2001
PMID: 11544283
Zeng W, Maciejewski JP, Chen G, Young NS., J. Clin. Invest. 108(5), 2001
PMID: 11544283
In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing.
Risitano AM, Maciejewski JP, Green S, Plasilova M, Zeng W, Young NS., Lancet 364(9431), 2004
PMID: 15276395
Risitano AM, Maciejewski JP, Green S, Plasilova M, Zeng W, Young NS., Lancet 364(9431), 2004
PMID: 15276395
Changes in T-cell receptor VB repertoire in aplastic anemia: effects of different immunosuppressive regimens.
Kook H, Risitano AM, Zeng W, Wlodarski M, Lottemann C, Nakamura R, Barrett J, Young NS, Maciejewski JP., Blood 99(10), 2002
PMID: 11986222
Kook H, Risitano AM, Zeng W, Wlodarski M, Lottemann C, Nakamura R, Barrett J, Young NS, Maciejewski JP., Blood 99(10), 2002
PMID: 11986222
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 22829127
PubMed | Europe PMC
Suchen in
Google Scholar