Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7

Strauch E, Hammerl JA, Konietzny A, Schneiker-Bekel S, Arnold W, Goesmann A, Pühler A, Beutin L (2008)
Infection and Immunity 76(12): 5466-5477.

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Autor*in
Strauch, Eckhard; Hammerl, Jens Andre; Konietzny, Antje; Schneiker-Bekel, SusanneUniBi; Arnold, WalterUniBi; Goesmann, AlexanderUniBi ; Pühler, AlfredUniBi ; Beutin, Lothar
Abstract / Bemerkung
The production of Shiga toxin (Stx) (verocytotoxin) is a major virulence factor of Escherichia coli O157:H7 strains (Shiga toxin-producing E. coli [STEC] O157). Two types of Shiga toxins, designated Stx1 and Stx2, are produced in STEC O157. Variants of the Stx2 type (Stx2, Stx2c) are associated with high virulences of these strains for humans. A bacteriophage designated 2851 from a human STEC O157 encoding the Stx2c variant was described previously. Nucleotide sequence analysis of the phage 2851 genome revealed 75 predicted coding sequences and indicated a mosaic structure typical for lambdoid phages. Analyses of free phages and K-12 phage 2851 lysogens revealed that upon excision from the bacterial chromosome, the loss of a phage-encoded IS629 element leads to fusion of phage antA and antB genes, with the generation of a recombined antAB gene encoding a strong antirepressor. In wild-type E. coli O157 as well as in K-12 strains, phage 2851 was found to be integrated in the sbcB locus. Additionally, phage 2851 carries an open reading frame which encodes an OspB-like type III effector similar to that found in Shigella spp. Investigation of 39 stx(2c) E. coli O157 strains revealed that all except 1 were positive for most phage 2851-specific genes and possessed a prophage with the same border sequences integrated into the sbcB locus. Phage 2851-specific sequences were absent from most stx(2c)-negative E. coli O157 strains, and we suggest that phage 2851-like phages contributed significantly to the dissemination of the Stx2c variant toxin within this group of E. coli.
Erscheinungsjahr
2008
Zeitschriftentitel
Infection and Immunity
Band
76
Ausgabe
12
Seite(n)
5466-5477
ISSN
0019-9567
Page URI
https://pub.uni-bielefeld.de/record/1990198

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Strauch E, Hammerl JA, Konietzny A, et al. Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7. Infection and Immunity. 2008;76(12):5466-5477.
Strauch, E., Hammerl, J. A., Konietzny, A., Schneiker-Bekel, S., Arnold, W., Goesmann, A., Pühler, A., et al. (2008). Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7. Infection and Immunity, 76(12), 5466-5477. https://doi.org/10.1128/IAI.00875-08
Strauch, Eckhard, Hammerl, Jens Andre, Konietzny, Antje, Schneiker-Bekel, Susanne, Arnold, Walter, Goesmann, Alexander, Pühler, Alfred, and Beutin, Lothar. 2008. “Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7”. Infection and Immunity 76 (12): 5466-5477.
Strauch, E., Hammerl, J. A., Konietzny, A., Schneiker-Bekel, S., Arnold, W., Goesmann, A., Pühler, A., and Beutin, L. (2008). Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7. Infection and Immunity 76, 5466-5477.
Strauch, E., et al., 2008. Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7. Infection and Immunity, 76(12), p 5466-5477.
E. Strauch, et al., “Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7”, Infection and Immunity, vol. 76, 2008, pp. 5466-5477.
Strauch, E., Hammerl, J.A., Konietzny, A., Schneiker-Bekel, S., Arnold, W., Goesmann, A., Pühler, A., Beutin, L.: Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7. Infection and Immunity. 76, 5466-5477 (2008).
Strauch, Eckhard, Hammerl, Jens Andre, Konietzny, Antje, Schneiker-Bekel, Susanne, Arnold, Walter, Goesmann, Alexander, Pühler, Alfred, and Beutin, Lothar. “Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7”. Infection and Immunity 76.12 (2008): 5466-5477.

31 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Bad Phages in Good Bacteria: Role of the Mysterious orf63 of λ and Shiga Toxin-Converting Φ24B Bacteriophages.
Dydecka A, Bloch S, Rizvi A, Perez S, Nejman-Falenczyk B, Topka G, Gasior T, Necel A, Wegrzyn G, Donaldson LW, Wegrzyn A., Front Microbiol 8(), 2017
PMID: 28890713
The Role of the Exo-Xis Region in Oxidative Stress-Mediated Induction of Shiga Toxin-Converting Prophages.
Licznerska K, Dydecka A, Bloch S, Topka G, Nejman-Faleńczyk B, Węgrzyn A, Węgrzyn G., Oxid Med Cell Longev 2016(), 2016
PMID: 26798427
Comparative Genomic Analysis of Escherichia coli O157:H7 Isolated from Super-Shedder and Low-Shedder Cattle.
Munns KD, Zaheer R, Xu Y, Stanford K, Laing CR, Gannon VP, Selinger LB, McAllister TA., PLoS One 11(3), 2016
PMID: 27018858
Detection of pathogenic Campylobacter, E. coli O157:H7 and Salmonella spp. in wastewater by PCR assay.
Bonetta S, Pignata C, Lorenzi E, De Ceglia M, Meucci L, Bonetta S, Gilli G, Carraro E., Environ Sci Pollut Res Int 23(15), 2016
PMID: 27106076
Perspectives on super-shedding of Escherichia coli O157:H7 by cattle.
Munns KD, Selinger LB, Stanford K, Guan L, Callaway TR, McAllister TA., Foodborne Pathog Dis 12(2), 2015
PMID: 25514549
Defects in RNA polyadenylation impair both lysogenization by and lytic development of Shiga toxin-converting bacteriophages.
Nowicki D, Bloch S, Nejman-Faleńczyk B, Szalewska-Pałasz A, Węgrzyn A, Węgrzyn G., J Gen Virol 96(pt 7), 2015
PMID: 25711968
UV-Sensitivity of Shiga Toxin-Converting Bacteriophage Virions Φ24B, 933W, P22, P27 and P32.
Bloch S, Nejman-Faleńczyk B, Topka G, Dydecka A, Licznerska K, Narajczyk M, Necel A, Węgrzyn A, Węgrzyn G., Toxins (Basel) 7(9), 2015
PMID: 26402701
Free Shiga toxin 1-encoding bacteriophages are less prevalent than Shiga toxin 2 phages in extraintestinal environments.
Grau-Leal F, Quirós P, Martínez-Castillo A, Muniesa M., Environ Microbiol 17(11), 2015
PMID: 26373580
The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage.
Ogura Y, Mondal SI, Islam MR, Mako T, Arisawa K, Katsura K, Ooka T, Gotoh Y, Murase K, Ohnishi M, Hayashi T., Sci Rep 5(), 2015
PMID: 26567959
Phylogenetic characterization of Escherichia coli O157 : H7 based on IS629 distribution and Shiga toxin genotype.
Stanton E, Park D, Döpfer D, Ivanek R, Kaspar CW., Microbiology 160(pt 3), 2014
PMID: 24425770
Serotype-conversion in Shigella flexneri: identification of a novel bacteriophage, Sf101, from a serotype 7a strain.
Jakhetia R, Marri A, Ståhle J, Widmalm G, Verma NK., BMC Genomics 15(), 2014
PMID: 25174528
Evolution of the Stx2-encoding prophage in persistent bovine Escherichia coli O157:H7 strains.
Park D, Stanton E, Ciezki K, Parrell D, Bozile M, Pike D, Forst SA, Jeong KC, Ivanek R, Döpfer D, Kaspar CW., Appl Environ Microbiol 79(5), 2013
PMID: 23275514
Lineage and genogroup-defining single nucleotide polymorphisms of Escherichia coli O157:H7.
Jung WK, Bono JL, Clawson ML, Leopold SR, Shringi S, Besser TE., Appl Environ Microbiol 79(22), 2013
PMID: 24014531
Phylogenetically related Argentinean and Australian Escherichia coli O157 isolates are distinguished by virulence clades and alternative Shiga toxin 1 and 2 prophages.
Mellor GE, Sim EM, Barlow RS, D'Astek BA, Galli L, Chinen I, Rivas M, Gobius KS., Appl Environ Microbiol 78(13), 2012
PMID: 22544241
Comparative genomics of Shiga toxin encoding bacteriophages.
Smith DL, Rooks DJ, Fogg PC, Darby AC, Thomson NR, McCarthy AJ, Allison HE., BMC Genomics 13(), 2012
PMID: 22799768
Spread of a distinct Stx2-encoding phage prototype among Escherichia coli O104:H4 strains from outbreaks in Germany, Norway, and Georgia.
Beutin L, Hammerl JA, Strauch E, Reetz J, Dieckmann R, Kelner-Burgos Y, Martin A, Miko A, Strockbine NA, Lindstedt BA, Horn D, Monse H, Huettel B, Müller I, Stüber K, Reinhardt R., J Virol 86(19), 2012
PMID: 22811533
Carriage of stx2a differentiates clinical and bovine-biased strains of Escherichia coli O157.
Shringi S, Schmidt C, Katherine K, Brayton KA, Hancock DD, Besser TE., PLoS One 7(12), 2012
PMID: 23240045
Development of a PCR protocol for the detection of Escherichia coli O157:H7 and Salmonella spp. in surface water.
Bonetta S, Borelli E, Bonetta S, Conio O, Palumbo F, Carraro E., Environ Monit Assess 177(1-4), 2011
PMID: 20714926
Genome signatures of Escherichia coli O157:H7 isolates from the bovine host reservoir.
Eppinger M, Mammel MK, Leclerc JE, Ravel J, Cebula TA., Appl Environ Microbiol 77(9), 2011
PMID: 21421787
Genomic anatomy of Escherichia coli O157:H7 outbreaks.
Eppinger M, Mammel MK, Leclerc JE, Ravel J, Cebula TA., Proc Natl Acad Sci U S A 108(50), 2011
PMID: 22135463
Differences in adherence and virulence gene expression between two outbreak strains of enterohaemorrhagic Escherichia coli O157 : H7.
Abu-Ali GS, Ouellette LM, Henderson ST, Whittam TS, Manning SD., Microbiology 156(pt 2), 2010
PMID: 19892762
Lineage and host source are both correlated with levels of Shiga toxin 2 production by Escherichia coli O157:H7 strains.
Zhang Y, Laing C, Zhang Z, Hallewell J, You C, Ziebell K, Johnson RP, Kropinski AM, Thomas JE, Karmali M, Gannon VP., Appl Environ Microbiol 76(2), 2010
PMID: 19948861
Increased adherence and expression of virulence genes in a lineage of Escherichia coli O157:H7 commonly associated with human infections.
Abu-Ali GS, Ouellette LM, Henderson ST, Lacher DW, Riordan JT, Whittam TS, Manning SD., PLoS One 5(4), 2010
PMID: 20422047
Quantification of Shiga toxin-converting bacteriophages in wastewater and in fecal samples by real-time quantitative PCR.
Imamovic L, Ballesté E, Jofre J, Muniesa M., Appl Environ Microbiol 76(17), 2010
PMID: 20622134
Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence.
Kulasekara BR, Jacobs M, Zhou Y, Wu Z, Sims E, Saenphimmachak C, Rohmer L, Ritchie JM, Radey M, McKevitt M, Freeman TL, Hayden H, Haugen E, Gillett W, Fong C, Chang J, Beskhlebnaya V, Waldor MK, Samadpour M, Whittam TS, Kaul R, Brittnacher M, Miller SI., Infect Immun 77(9), 2009
PMID: 19564389

55 References

Daten bereitgestellt von Europe PubMed Central.

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ., Nucleic Acids Res. 25(17), 1997
PMID: 9254694
The InterPro database, an integrated documentation resource for protein families, domains and functional sites.
Apweiler R, Attwood TK, Bairoch A, Bateman A, Birney E, Biswas M, Bucher P, Cerutti L, Corpet F, Croning MD, Durbin R, Falquet L, Fleischmann W, Gouzy J, Hermjakob H, Hulo N, Jonassen I, Kahn D, Kanapin A, Karavidopoulou Y, Lopez R, Marx B, Mulder NJ, Oinn TM, Pagni M, Servant F, Sigrist CJ, Zdobnov EM., Nucleic Acids Res. 29(1), 2001
PMID: 11125043
The Pfam protein families database.
Bateman A, Birney E, Cerruti L, Durbin R, Etwiller L, Eddy SR, Griffiths-Jones S, Howe KL, Marshall M, Sonnhammer EL., Nucleic Acids Res. 30(1), 2002
PMID: 11752314
Characteristics and association with disease of two major subclones of Shiga toxin (Verocytotoxin)-producing strains of Escherichia coli (STEC) O157 that are present among isolates from patients in Germany.
Beutin L, Kaulfuss S, Cheasty T, Brandenburg B, Zimmermann S, Gleier K, Willshaw GA, Smith HR., Diagn. Microbiol. Infect. Dis. 44(4), 2002
PMID: 12543538
Shiga toxin-mediated hemolytic uremic syndrome: time to change the diagnostic paradigm?
Bielaszewska M, Kock R, Friedrich AW, von Eiff C, Zimmerhackl LB, Karch H, Mellmann A., PLoS ONE 2(10), 2007
PMID: 17925872
Isolation and characterization of sorbitol-fermenting Shiga toxin (Verocytotoxin)-producing Escherichia coli O157:H- strains in the Czech Republic.
Bielaszewska M, Schmidt H, Karmali MA, Khakhria R, Janda J, Blahova K, Karch H., J. Clin. Microbiol. 36(7), 1998
PMID: 9650984
The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003.
Boeckmann B, Bairoch A, Apweiler R, Blatter MC, Estreicher A, Gasteiger E, Martin MJ, Michoud K, O'Donovan C, Phan I, Pilbout S, Schneider M., Nucleic Acids Res. 31(1), 2003
PMID: 12520024

AUTHOR UNKNOWN, 1988
The Shiga toxin 1-converting bacteriophage BP-4795 encodes an NleA-like type III effector protein.
Creuzburg K, Recktenwald J, Kuhle V, Herold S, Hensel M, Schmidt H., J. Bacteriol. 187(24), 2005
PMID: 16321954
Assembling genomic DNA sequences with PHRAP.
de la Bastide M, McCombie WR., Curr Protoc Bioinformatics Chapter 11(), 2007
PMID: 18428783

AUTHOR UNKNOWN, 2007
Base-calling of automated sequencer traces using phred. I. Accuracy assessment.
Ewing B, Hillier L, Wendl MC, Green P., Genome Res. 8(3), 1998
PMID: 9521921
Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms.
Friedrich AW, Bielaszewska M, Zhang WL, Pulz M, Kuczius T, Ammon A, Karch H., J. Infect. Dis. 185(1), 2001
PMID: 11756984
Shiga toxin 1c-producing Escherichia coli strains: phenotypic and genetic characterization and association with human disease.
Friedrich AW, Borell J, Bielaszewska M, Fruth A, Tschape H, Karch H., J. Clin. Microbiol. 41(6), 2003
PMID: 12791863
Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli.
Gilmour MW, Tabor H, Wang G, Clark CG, Tracz DM, Olson AB, Mascarenhas M, Karmali MA, Mailman T, Ng LK., J. Clin. Microbiol. 45(11), 2007
PMID: 17804662
Consed: a graphical tool for sequence finishing.
Gordon D, Abajian C, Green P., Genome Res. 8(3), 1998
PMID: 9521923
Automated finishing with autofinish.
Gordon D, Desmarais C, Green P., Genome Res. 11(4), 2001
PMID: 11282977
TIGRFAMs: a protein family resource for the functional identification of proteins.
Haft DH, Loftus BJ, Richardson DL, Yang F, Eisen JA, Paulsen IT, White O., Nucleic Acids Res. 29(1), 2001
PMID: 11125044
Shiga toxin-encoding bacteriophages--genomes in motion.
Herold S, Karch H, Schmidt H., Int. J. Med. Microbiol. 294(2-3), 2004
PMID: 15493821

AUTHOR UNKNOWN, 2006
KEGG: kyoto encyclopedia of genes and genomes.
Kanehisa M, Goto S., Nucleic Acids Res. 28(1), 2000
PMID: 10592173

AUTHOR UNKNOWN, 1997
Detection of various variant verotoxin genes in Escherichia coli by polymerase chain reaction.
Lin Z, Kurazono H, Yamasaki S, Takeda Y., Microbiol. Immunol. 37(7), 1993
PMID: 8231968
REGANOR: a gene prediction server for prokaryotic genomes and a database of high quality gene predictions for prokaryotes.
Linke B, McHardy AC, Neuweger H, Krause L, Meyer F., Appl. Bioinformatics 5(3), 2006
PMID: 16922601
Food-related illness and death in the United States.
Mead PS, Slutsker L, Dietz V, McCaig LF, Bresee JS, Shapiro C, Griffin PM, Tauxe RV., Emerging Infect. Dis. 5(5), 1999
PMID: 10511517
GenDB--an open source genome annotation system for prokaryote genomes.
Meyer F, Goesmann A, McHardy AC, Bartels D, Bekel T, Clausen J, Kalinowski J, Linke B, Rupp O, Giegerich R, Puhler A., Nucleic Acids Res. 31(8), 2003
PMID: 12682369
Subtyping of Shiga toxin 2 variants in human-derived Shiga toxin-producing Escherichia coli strains isolated in Japan.
Nakao H, Kimura K, Murakami H, Maruyama T, Takeda T., FEMS Immunol. Med. Microbiol. 34(4), 2002
PMID: 12443829
Genomic diversity of enterohemorrhagic Escherichia coli O157 revealed by whole genome PCR scanning.
Ohnishi M, Terajima J, Kurokawa K, Nakayama K, Murata T, Tamura K, Ogura Y, Watanabe H, Hayashi T., Proc. Natl. Acad. Sci. U.S.A. 99(26), 2002
PMID: 12481030
Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002.
Rangel JM, Sparling PH, Crowe C, Griffin PM, Swerdlow DL., Emerging Infect. Dis. 11(4), 2005
PMID: 15829201
Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread.
Santapaola D, Del Chierico F, Petrucca A, Uzzau S, Casalino M, Colonna B, Sessa R, Berlutti F, Nicoletti M., J. Bacteriol. 188(4), 2006
PMID: 16452446

AUTHOR UNKNOWN, 2005
Shiga-toxin-converting bacteriophages.
Schmidt H., Res. Microbiol. 152(8), 2001
PMID: 11686382
Characterization of a Shiga toxin-encoding temperate bacteriophage of Shigella sonnei.
Strauch E, Lurz R, Beutin L., Infect. Immun. 69(12), 2001
PMID: 11705937
Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli.
Wagner PL, Livny J, Neely MN, Acheson DW, Friedman DI, Waldor MK., Mol. Microbiol. 44(4), 2002
PMID: 12010491
Verocytotoxin-producing Escherichia coli (VTEC) O157 and other VTEC from human infections in England and Wales: 1995-1998.
Willshaw GA, Cheasty T, Smith HR, O'Brien SJ, Adak GK., J. Med. Microbiol. 50(2), 2001
PMID: 11211220
Vero cytotoxin-producing Escherichia coli O157 outbreaks in England and Wales, 1995: phenotypic methods and genotypic subtyping.
Willshaw GA, Smith HR, Cheasty T, Wall PG, Rowe B., Emerging Infect. Dis. 3(4), 1997
PMID: 9366610
Transcriptional analysis of genes encoding Shiga toxin 2 and its variants in Escherichia coli.
Zhang W, Bielaszewska M, Friedrich AW, Kuczius T, Karch H., Appl. Environ. Microbiol. 71(1), 2005
PMID: 15640236
Genotypic characterization and prevalence of virulence factors among Canadian Escherichia coli O157:H7 strains.
Ziebell K, Steele M, Zhang Y, Benson A, Taboada EN, Laing C, McEwen S, Ciebin B, Johnson R, Gannon V., Appl. Environ. Microbiol. 74(14), 2008
PMID: 18487402
OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence.
Zurawski DV, Mitsuhata C, Mumy KL, McCormick BA, Maurelli AT., Infect. Immun. 74(10), 2006
PMID: 16988276
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