A comprehensive comparison of comparative RNA structure prediction approaches

Gardner PP, Giegerich R (2004)
BMC Bioinformatics 5(1): 140.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
URN
urn:nbn:de:0070-pub-17737476
Autor*in
Gardner, Paul P.; Giegerich, RobertUniBi
Einrichtung
Technische Fakultät > AG Praktische Informatik
Centrum für Biotechnologie > Institut für Bioinformatik
Centrum für Biotechnologie > Arbeitsgruppe R. Giegerich
Abstract / Bemerkung
Background: An increasing number of researchers have released novel RNA structure analysis and prediction algorithms for comparative approaches to structure prediction. Yet, independent benchmarking of these algorithms is rarely performed as is now common practice for protein-folding, gene-finding and multiple-sequence-alignment algorithms. Results: Here we evaluate a number of RNA folding algorithms using reliable RNA data-sets and compare their relative performance. Conclusions: We conclude that comparative data can enhance structure prediction but structure-prediction-algorithms vary widely in terms of both sensitivity and selectivity across different lengths and homologies. Furthermore, we outline some directions for future research.
Erscheinungsjahr
2004
Zeitschriftentitel
BMC Bioinformatics
Band
5
Ausgabe
1
Art.-Nr.
140
ISSN
1471-2105
Page URI
https://pub.uni-bielefeld.de/record/1773747

Zitieren

Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.
Gardner, P. P., & Giegerich, R. (2004). A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics, 5(1), 140. https://doi.org/10.1186/1471-2105-5-140
Gardner, Paul P., and Giegerich, Robert. 2004. “A comprehensive comparison of comparative RNA structure prediction approaches”. BMC Bioinformatics 5 (1): 140.
Gardner, P. P., and Giegerich, R. (2004). A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics 5:140.
Gardner, P.P., & Giegerich, R., 2004. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics, 5(1): 140.
P.P. Gardner and R. Giegerich, “A comprehensive comparison of comparative RNA structure prediction approaches”, BMC Bioinformatics, vol. 5, 2004, : 140.
Gardner, P.P., Giegerich, R.: A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 5, : 140 (2004).
Gardner, Paul P., and Giegerich, Robert. “A comprehensive comparison of comparative RNA structure prediction approaches”. BMC Bioinformatics 5.1 (2004): 140.
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