Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes
Fernandez-Gonzalez C, Gil JA, Mateos LM, Schwarzer A, Schafer A, Kalinowski J, Pühler A, Martin JF (1996)
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 46(5-6): 554-558.
Zeitschriftenaufsatz
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Autor*in
Fernandez-Gonzalez, C.;
Gil, J.A.;
Mateos, L. M.;
Schwarzer, A.;
Schafer, A.;
Kalinowski, JörnUniBi;
Pühler, AlfredUniBi 
;
Martin, J. F.
;
Martin, J. F.Einrichtung
Abstract / Bemerkung
The mobilization of plasmids from gram-negative Escherichia coli to gram-positive Brevibacterium lactofermentum, mediated by P-type transfer functions, was used to construct disrupted mutants blocked specifically in the homoserine branch of the aspartate pathway. The mutant strain B. lactofermentum R31 showed an efficiency of conjugal transfer two to three orders of magnitude higher than that of the wild-type strain B. lactofermentum ATCC 13869. The hom- and thrB-disrupted mutants of B. lactofermentum ATCC 13869 were lysine overproducers. B. lactofermentum R31 mutants do not overproduce lysine because R31 is an alanine-overproducing strain and channels the pyruvate needed for lysine biosynthesis to the production of alanine.
Erscheinungsjahr
1996
Zeitschriftentitel
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Band
46
Ausgabe
5-6
Seite(n)
554-558
ISSN
0175-7598
eISSN
1432-0614
Page URI
https://pub.uni-bielefeld.de/record/1637976
Zitieren
Fernandez-Gonzalez C, Gil JA, Mateos LM, et al. Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 1996;46(5-6):554-558.
Fernandez-Gonzalez, C., Gil, J. A., Mateos, L. M., Schwarzer, A., Schafer, A., Kalinowski, J., Pühler, A., et al. (1996). Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 46(5-6), 554-558. https://doi.org/10.1007/s002530050860
Fernandez-Gonzalez, C., Gil, J.A., Mateos, L. M., Schwarzer, A., Schafer, A., Kalinowski, Jörn, Pühler, Alfred, and Martin, J. F. 1996. “Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 46 (5-6): 554-558.
Fernandez-Gonzalez, C., Gil, J. A., Mateos, L. M., Schwarzer, A., Schafer, A., Kalinowski, J., Pühler, A., and Martin, J. F. (1996). Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 46, 554-558.
Fernandez-Gonzalez, C., et al., 1996. Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 46(5-6), p 554-558.
C. Fernandez-Gonzalez, et al., “Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes”, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 46, 1996, pp. 554-558.
Fernandez-Gonzalez, C., Gil, J.A., Mateos, L.M., Schwarzer, A., Schafer, A., Kalinowski, J., Pühler, A., Martin, J.F.: Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 46, 554-558 (1996).
Fernandez-Gonzalez, C., Gil, J.A., Mateos, L. M., Schwarzer, A., Schafer, A., Kalinowski, Jörn, Pühler, Alfred, and Martin, J. F. “Construction of L-lysine-overproducing strains of Brevibacterium lactofermentum by targeted disruption of the hom and thrB genes”. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 46.5-6 (1996): 554-558.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
9 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
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NrdH-redoxin of Mycobacterium tuberculosis and Corynebacterium glutamicum dimerizes at high protein concentration and exclusively receives electrons from thioredoxin reductase.
Van Laer K, Dziewulska AM, Fislage M, Wahni K, Hbeddou A, Collet JF, Versées W, Mateos LM, Tamu Dufe V, Messens J., J Biol Chem 288(11), 2013
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Efflux permease CgAcr3-1 of Corynebacterium glutamicum is an arsenite-specific antiporter.
Villadangos AF, Fu HL, Gil JA, Messens J, Rosen BP, Mateos LM., J Biol Chem 287(1), 2012
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Villadangos AF, Fu HL, Gil JA, Messens J, Rosen BP, Mateos LM., J Biol Chem 287(1), 2012
PMID: 22102279
Metabolic pathways and fermentative production of L-aspartate family amino acids.
Park JH, Lee SY., Biotechnol J 5(6), 2010
PMID: 20518059
Park JH, Lee SY., Biotechnol J 5(6), 2010
PMID: 20518059
Evolution of metal(loid) binding sites in transcriptional regulators.
Ordóñez E, Thiyagarajan S, Cook JD, Stemmler TL, Gil JA, Mateos LM, Rosen BP., J Biol Chem 283(37), 2008
PMID: 18591244
Ordóñez E, Thiyagarajan S, Cook JD, Stemmler TL, Gil JA, Mateos LM, Rosen BP., J Biol Chem 283(37), 2008
PMID: 18591244
Characterization and chromosomal organization of the murD-murC-ftsQ region of Corynebacterium glutamicum ATCC 13869.
Ramos A, Honrubia MP, Vega D, Ayala JA, Bouhss A, Mengin-Lecreulx D, Gil JA., Res Microbiol 155(3), 2004
PMID: 15059630
Ramos A, Honrubia MP, Vega D, Ayala JA, Bouhss A, Mengin-Lecreulx D, Gil JA., Res Microbiol 155(3), 2004
PMID: 15059630
Streptomyces lividans and Brevibacterium lactofermentum as heterologous hosts for the production of X22 xylanase from Aspergillus nidulans.
Díaz M, Adham SA, Ramón D, Gil JA, Santamaría RI., Appl Microbiol Biotechnol 65(4), 2004
PMID: 15168093
Díaz M, Adham SA, Ramón D, Gil JA, Santamaría RI., Appl Microbiol Biotechnol 65(4), 2004
PMID: 15168093
Optimization of industrial bacterial strains via mutation analysis: a high-throughput DNA sequencing and bioinformatic approach.
Brett D, Droege M, Weber-Lehmann J., IEEE Eng Med Biol Mag 23(4), 2004
PMID: 15508388
Brett D, Droege M, Weber-Lehmann J., IEEE Eng Med Biol Mag 23(4), 2004
PMID: 15508388
Construction of a xylanase-producing strain of Brevibacterium lactofermentum by stable integration of an engineered xysA gene from Streptomyces halstedii JM8.
Adham SA, Campelo AB, Ramos A, Gil JA., Appl Environ Microbiol 67(12), 2001
PMID: 11722888
Adham SA, Campelo AB, Ramos A, Gil JA., Appl Environ Microbiol 67(12), 2001
PMID: 11722888
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Daten bereitgestellt von Europe PubMed Central.
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