TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems

Tauch A, Pühler A, Kalinowski J, Thierbach G (2000)
PLASMID 44(3): 285-291.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
The complete nucleotide sequence of the tetracycline resistance plasmid pAG1 from the gram-positive soil bacterium Corynebacterium glutamicum 22243 (formerly Corynebacterium melassecola 22243) was determined. The R-plasmid has a size of 19,751 bp and contains at least 18 complete open reading frames. The resistance determinant of pAG1 revealed homology to gram-negative tetracycline efflux and repressor system of Tet classes A through J. The highest levels of amino acid sequence similarity were observed to the transmembrane tetracycline efflux protein TetA(A) and to the tetracycline repressor TetR(A) of transposon Tn1721 with 64 and 56% similarity, respectively. This is the first time a repressor-regulated tet gene has been found in gram-positive bacteria. A new class of tetracycline resistance;Ind repressor proteins, termed TetA(Z) and TetR(Z), is proposed. (C) 2000 Academic Press.
Erscheinungsjahr
2000
Zeitschriftentitel
PLASMID
Band
44
Ausgabe
3
Seite(n)
285-291
ISSN
0147-619X
Page URI
https://pub.uni-bielefeld.de/record/1618501

Zitieren

Tauch A, Pühler A, Kalinowski J, Thierbach G. TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems. PLASMID. 2000;44(3):285-291.
Tauch, A., Pühler, A., Kalinowski, J., & Thierbach, G. (2000). TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems. PLASMID, 44(3), 285-291. doi:10.1006/plas.2000.1489
Tauch, A., Pühler, A., Kalinowski, J., and Thierbach, G. (2000). TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems. PLASMID 44, 285-291.
Tauch, A., et al., 2000. TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems. PLASMID, 44(3), p 285-291.
A. Tauch, et al., “TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems”, PLASMID, vol. 44, 2000, pp. 285-291.
Tauch, A., Pühler, A., Kalinowski, J., Thierbach, G.: TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems. PLASMID. 44, 285-291 (2000).
Tauch, Andreas, Pühler, Alfred, Kalinowski, Jörn, and Thierbach, G. “TetZ, a new tetracycline resistance determinant discovered in gram-positive bacteria, shows high homology to gram-negative regulated efflux systems”. PLASMID 44.3 (2000): 285-291.

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