Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation

Rückert C, Pühler A, Kalinowski J (2003)
JOURNAL OF BIOTECHNOLOGY 104(1-3): 213-228.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
DOI
Autor*in
Rückert, ChristianUniBi ; Pühler, AlfredUniBi ; Kalinowski, JörnUniBi
Einrichtung
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Fakultät für Biologie
Centrum für Biotechnologie > Arbeitsgruppe J. Kalinowski
Centrum für Biotechnologie > Arbeitsgruppe A. Pühler
Abstract / Bemerkung
The genome sequence of Corynebacterium glutamicum. a gram-positive soil bacterium widely used as an amino acid producer, was analyzed by a similarity-based approach to elucidate the pathway for the biosynthesis Of L-methionine. The functions of candidate ORFs were derived by gene deletion and, if necessary, by homologous complementation of suitable mutants. Of nine candidate ORFs (four of which were known previously), seven ORFs (cg0754 (metX), cg0755 (met Y), cg1290 (metE), cg1702 (metH), cg2383 (metf), cg2536 (aecD), and eg2687 (metB)) were demonstrated to be part of the pathway while two others (cg0961 and cg3086) could be excluded. C glutamicum synthesizes methionine in three, respectively four steps, starting from homoserine. C glutamicum possesses two genes with similarity to homoserine acetyltransferases but only MetX can act as such while Cg0961 catalyzes a different, unknown reaction. For the incorporation of the sulfur moiety, the known functions of MetY and MetB could be confirmed and AecD was proven to be the only functional cystathionine beta-lyase in C glutamicum, while Cg3086 can act neither as cystathionine gamma-synthase nor as cystathionine beta-lyase. Finally, MetE and MetH, which catalyze the conversion of L-homocysteine to L-methionine, could be newly identified, together with MetF which provides the necessary N-5-methyltetrahydrofolate. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Stichworte
analysis; methionine biosynthesis; Corynebacterium glutamicum; genome; met genes
Erscheinungsjahr
2003
Zeitschriftentitel
JOURNAL OF BIOTECHNOLOGY
Band
104
Ausgabe
1-3
Seite(n)
213-228
ISSN
0168-1656
Page URI
https://pub.uni-bielefeld.de/record/1610269

Zitieren

Rückert C, Pühler A, Kalinowski J. Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation. JOURNAL OF BIOTECHNOLOGY. 2003;104(1-3):213-228.
Rückert, C., Pühler, A., & Kalinowski, J. (2003). Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation. JOURNAL OF BIOTECHNOLOGY, 104(1-3), 213-228. https://doi.org/10.1016/S0168-1656(03)00158-5
Rückert, Christian, Pühler, Alfred, and Kalinowski, Jörn. 2003. “Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation”. JOURNAL OF BIOTECHNOLOGY 104 (1-3): 213-228.
Rückert, C., Pühler, A., and Kalinowski, J. (2003). Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation. JOURNAL OF BIOTECHNOLOGY 104, 213-228.
Rückert, C., Pühler, A., & Kalinowski, J., 2003. Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation. JOURNAL OF BIOTECHNOLOGY, 104(1-3), p 213-228.
C. Rückert, A. Pühler, and J. Kalinowski, “Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation”, JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pp. 213-228.
Rückert, C., Pühler, A., Kalinowski, J.: Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation. JOURNAL OF BIOTECHNOLOGY. 104, 213-228 (2003).
Rückert, Christian, Pühler, Alfred, and Kalinowski, Jörn. “Genome-wide analysis of the L-methionine biosynthetic pathway in Corynebacterium glutamicum by targeted gene deletion and homologous complementation”. JOURNAL OF BIOTECHNOLOGY 104.1-3 (2003): 213-228.

46 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

RNase E/G-dependent degradation of metE mRNA, encoding methionine synthase, in Corynebacterium glutamicum.
Endo S, Maeda T, Kawame T, Iwai N, Wachi M., J Gen Appl Microbiol 65(1), 2019
PMID: 29984738
Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) of Corynebacterium glutamicum Enhances l-Threonine Biosynthesis.
Petit C, Kim Y, Lee SK, Brown J, Larsen E, Ronning DR, Suh JW, Kang CM., ACS Omega 3(1), 2018
PMID: 30023797
Metabolic engineering of Corynebacterium glutamicum ATCC13032 to produce S-adenosyl-L-methionine.
Han G, Hu X, Qin T, Li Y, Wang X., Enzyme Microb Technol 83(), 2016
PMID: 26777246
A novel esterase subfamily with α/β-hydrolase fold suggested by structures of two bacterial enzymes homologous to L-homoserine O-acetyl transferases.
Tölzer C, Pal S, Watzlawick H, Altenbuchner J, Niefind K., FEBS Lett 590(1), 2016
PMID: 26787467
Discovering novel enzymes by functional screening of plurigenomic libraries from alga-associated Flavobacteriia and Gammaproteobacteria.
Martin M, Vandermies M, Joyeux C, Martin R, Barbeyron T, Michel G, Vandenbol M., Microbiol Res 186-187(), 2016
PMID: 27242143
Corynebacterium glutamicum methionine sulfoxide reductase A uses both mycoredoxin and thioredoxin for regeneration and oxidative stress resistance.
Si M, Zhang L, Chaudhry MT, Ding W, Xu Y, Chen C, Akbar A, Shen X, Liu SJ., Appl Environ Microbiol 81(8), 2015
PMID: 25681179
Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi.
Zhuang WQ, Yi S, Bill M, Brisson VL, Feng X, Men Y, Conrad ME, Tang YJ, Alvarez-Cohen L., Proc Natl Acad Sci U S A 111(17), 2014
PMID: 24733917
Bacterial methionine biosynthesis.
Ferla MP, Patrick WM., Microbiology 160(pt 8), 2014
PMID: 24939187
Transcriptional response of Corynebacterium glutamicum ATCC 13032 to hydrogen peroxide stress and characterization of the OxyR regulon.
Milse J, Petri K, Rückert C, Kalinowski J., J Biotechnol 190(), 2014
PMID: 25107507
Construction of a prophage-free variant of Corynebacterium glutamicum ATCC 13032 for use as a platform strain for basic research and industrial biotechnology.
Baumgart M, Unthan S, Rückert C, Sivalingam J, Grünberger A, Kalinowski J, Bott M, Noack S, Frunzke J., Appl Environ Microbiol 79(19), 2013
PMID: 23892752
Enzymatic synthesis of S-adenosylhomocysteine: immobilization of recombinant S-adenosylhomocysteine hydrolase from Corynebacterium glutamicum (ATCC 13032).
Lozada-Ramírez JD, Sánchez-Ferrer A, García-Carmona F., Appl Microbiol Biotechnol 93(6), 2012
PMID: 22202964
GntR-type transcriptional regulator PckR negatively regulates the expression of phosphoenolpyruvate carboxykinase in Corynebacterium glutamicum.
Hyeon JE, Kang DH, Kim YI, You SK, Han SO., J Bacteriol 194(9), 2012
PMID: 22366416
Transcriptional regulation of the operon encoding stress-responsive ECF sigma factor SigH and its anti-sigma factor RshA, and control of its regulatory network in Corynebacterium glutamicum.
Busche T, Silar R, Pičmanová M, Pátek M, Kalinowski J., BMC Genomics 13(), 2012
PMID: 22943411
Global regulation of the response to sulfur availability in the cheese-related bacterium Brevibacterium aurantiacum.
Forquin MP, Hébert A, Roux A, Aubert J, Proux C, Heilier JF, Landaud S, Junot C, Bonnarme P, Martin-Verstraete I., Appl Environ Microbiol 77(4), 2011
PMID: 21169450
β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents.
De Pascale G, Nazi I, Harrison PH, Wright GD., J Antibiot (Tokyo) 64(7), 2011
PMID: 21522158
Genome-enabled determination of amino acid biosynthesis in Xanthomonas campestris pv. campestris and identification of biosynthetic pathways for alanine, glycine, and isoleucine by 13C-isotopologue profiling.
Schatschneider S, Vorhölter FJ, Rückert C, Becker A, Eisenreich W, Pühler A, Niehaus K., Mol Genet Genomics 286(3-4), 2011
PMID: 21853248
Detection of D-ornithine extracellularly produced by Corynebacterium glutamicum ATCC 13032::argF.
Matsui D, Oikawa T., Biosci Biotechnol Biochem 74(12), 2010
PMID: 21187642
Adaptation of Corynebacterium glutamicum to salt-stress conditions.
Fränzel B, Trötschel C, Rückert C, Kalinowski J, Poetsch A, Wolters DA., Proteomics 10(3), 2010
PMID: 19950167
Crystallization and preliminary crystallographic analysis of cgHle, a homoserine acetyltransferase homologue, from Corynebacterium glutamicum.
Tölzer C, Pal S, Watzlawick H, Altenbuchner J, Niefind K., Acta Crystallogr Sect F Struct Biol Cryst Commun 65(pt 1), 2009
PMID: 19153452
The cmaR gene of Corynebacterium ammoniagenes performs a novel regulatory role in the metabolism of sulfur-containing amino acids.
Lee SM, Hwang BJ, Kim Y, Lee HS., Microbiology 155(pt 6), 2009
PMID: 19383689
FMM: a web server for metabolic pathway reconstruction and comparative analysis.
Chou CH, Chang WC, Chiu CM, Huang CC, Huang HD., Nucleic Acids Res 37(web server issue), 2009
PMID: 19401437
Towards systems metabolic engineering of microorganisms for amino acid production.
Park JH, Lee SY., Curr Opin Biotechnol 19(5), 2008
PMID: 18760356
The dual transcriptional regulator CysR in Corynebacterium glutamicum ATCC 13032 controls a subset of genes of the McbR regulon in response to the availability of sulphide acceptor molecules.
Rückert C, Milse J, Albersmeier A, Koch DJ, Pühler A, Kalinowski J., BMC Genomics 9(), 2008
PMID: 18854009
Physiological response of Corynebacterium glutamicum to oxidative stress induced by deletion of the transcriptional repressor McbR.
Krömer JO, Bolten CJ, Heinzle E, Schröder H, Wittmann C., Microbiology 154(pt 12), 2008
PMID: 19047758
A proteomic study of Corynebacterium glutamicum AAA+ protease FtsH.
Lüdke A, Krämer R, Burkovski A, Schluesener D, Poetsch A., BMC Microbiol 7(), 2007
PMID: 17254330
Characteristics of methionine production by an engineered Corynebacterium glutamicum strain.
Park SD, Lee JY, Sim SY, Kim Y, Lee HS., Metab Eng 9(4), 2007
PMID: 17604670
The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum.
Gaigalat L, Schlüter JP, Hartmann M, Mormann S, Tauch A, Pühler A, Kalinowski J., BMC Mol Biol 8(), 2007
PMID: 18005413
Bioinformatic evaluation of L-arginine catabolic pathways in 24 cyanobacteria and transcriptional analysis of genes encoding enzymes of L-arginine catabolism in the cyanobacterium Synechocystis sp. PCC 6803.
Schriek S, Rückert C, Staiger D, Pistorius EK, Michel KP., BMC Genomics 8(), 2007
PMID: 18045455
Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains.
Krömer JO, Heinzle E, Schröder H, Wittmann C., J Bacteriol 188(2), 2006
PMID: 16385051
Emerging Corynebacterium glutamicum systems biology.
Wendisch VF, Bott M, Kalinowski J, Oldiges M, Wiechert W., J Biotechnol 124(1), 2006
PMID: 16406159
Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum.
Krömer JO, Wittmann C, Schröder H, Heinzle E., Metab Eng 8(4), 2006
PMID: 16621639
Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase.
Oikawa T, Tauch A, Schaffer S, Fujioka T., J Biotechnol 125(4), 2006
PMID: 16707184
Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway.
Mormann S, Lömker A, Rückert C, Gaigalat L, Tauch A, Pühler A, Kalinowski J., BMC Genomics 7(), 2006
PMID: 16901339
Methionine production by fermentation.
Kumar D, Gomes J., Biotechnol Adv 23(1), 2005
PMID: 15610965
Single-gene knockout of a novel regulatory element confers ethionine resistance and elevates methionine production in Corynebacterium glutamicum.
Mampel J, Schröder H, Haefner S, Sauer U., Appl Microbiol Biotechnol 68(2), 2005
PMID: 15668756
The McbR repressor modulated by the effector substance S-adenosylhomocysteine controls directly the transcription of a regulon involved in sulphur metabolism of Corynebacterium glutamicum ATCC 13032.
Rey DA, Nentwich SS, Koch DJ, Rückert C, Pühler A, Tauch A, Kalinowski J., Mol Microbiol 56(4), 2005
PMID: 15853877
Characterization of methionine export in Corynebacterium glutamicum.
Trötschel C, Deutenberg D, Bathe B, Burkovski A, Krämer R., J Bacteriol 187(11), 2005
PMID: 15901702
Rational design of a Corynebacterium glutamicum pantothenate production strain and its characterization by metabolic flux analysis and genome-wide transcriptional profiling.
Hüser AT, Chassagnole C, Lindley ND, Merkamm M, Guyonvarch A, Elisáková V, Pátek M, Kalinowski J, Brune I, Pühler A, Tauch A., Appl Environ Microbiol 71(6), 2005
PMID: 15933028
Systems biotechnology for strain improvement.
Lee SY, Lee DY, Kim TY., Trends Biotechnol 23(7), 2005
PMID: 15923052
Evolutionary plasticity of methionine biosynthesis.
Gophna U, Bapteste E, Doolittle WF, Biran D, Ron EZ., Gene 355(), 2005
PMID: 16046084
Functional genomics and expression analysis of the Corynebacterium glutamicum fpr2-cysIXHDNYZ gene cluster involved in assimilatory sulphate reduction.
Rückert C, Koch DJ, Rey DA, Albersmeier A, Mormann S, Pühler A, Kalinowski J., BMC Genomics 6(), 2005
PMID: 16159395
The transcriptional regulator SsuR activates expression of the Corynebacterium glutamicum sulphonate utilization genes in the absence of sulphate.
Koch DJ, Rückert C, Albersmeier A, Hüser AT, Tauch A, Pühler A, Kalinowski J., Mol Microbiol 58(2), 2005
PMID: 16194234
Role of the ssu and seu genes of Corynebacterium glutamicum ATCC 13032 in utilization of sulfonates and sulfonate esters as sulfur sources.
Koch DJ, Rückert C, Rey DA, Mix A, Pühler A, Kalinowski J., Appl Environ Microbiol 71(10), 2005
PMID: 16204527
Cometabolism of a nongrowth substrate: L-serine utilization by Corynebacterium glutamicum.
Netzer R, Peters-Wendisch P, Eggeling L, Sahm H., Appl Environ Microbiol 70(12), 2004
PMID: 15574911
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.
Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Krämer R, Linke B, McHardy AC, Meyer F, Möckel B, Pfefferle W, Pühler A, Rey DA, Rückert C, Rupp O, Sahm H, Wendisch VF, Wiegräbe I, Tauch A., J Biotechnol 104(1-3), 2003
PMID: 12948626
Development of a Corynebacterium glutamicum DNA microarray and validation by genome-wide expression profiling during growth with propionate as carbon source.
Hüser AT, Becker A, Brune I, Dondrup M, Kalinowski J, Plassmeier J, Pühler A, Wiegräbe I, Tauch A., J Biotechnol 106(2-3), 2003
PMID: 14651867

49 References

Daten bereitgestellt von Europe PubMed Central.

The methionine biosynthetic pathway from homoserine in Pseudomonas putida involves the metW, metX, metZ, metH and metE gene products.
Alaminos M, Ramos JL., Arch. Microbiol. 176(1-2), 2001
PMID: 11479715
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ., Nucleic Acids Res. 25(17), 1997
PMID: 9254694
Structure and organization of the rrnD operon of 'Brevibacterium lactofermentum': analysis of the 16S rRNA gene.
Amador E, Castro JM, Correia A, Martin JF., Microbiology (Reading, Engl.) 145 ( Pt 4)(), 1999
PMID: 10220171
A C-terminal deletion in Corynebacterium glutamicum homoserine dehydrogenase abolishes allosteric inhibition by L-threonine.
Archer JA, Solow-Cordero DE, Sinskey AJ., Gene 107(1), 1991
PMID: 1743520

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).
Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA., Nature 417(6885), 2002
PMID: 12000953
Homoserine O-acetyltransferase, involved in the Leptospira meyeri methionine biosynthetic pathway, is not feedback inhibited.
Bourhy P, Martel A, Margarita D, Saint Girons I, Belfaiza J., J. Bacteriol. 179(13), 1997
PMID: 9209059
Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle.
Claes WA, Puhler A, Kalinowski J., J. Bacteriol. 184(10), 2002
PMID: 11976302
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG., Nature 393(6685), 1998
PMID: 9634230
Massive gene decay in the leprosy bacillus.
Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honore N, Garnier T, Churcher C, Harris D, Mungall K, Basham D, Brown D, Chillingworth T, Connor R, Davies RM, Devlin K, Duthoy S, Feltwell T, Fraser A, Hamlin N, Holroyd S, Hornsby T, Jagels K, Lacroix C, Maclean J, Moule S, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutherford KM, Rutter S, Seeger K, Simon S, Simmonds M, Skelton J, Squares R, Squares S, Stevens K, Taylor K, Whitehead S, Woodward JR, Barrell BG., Nature 409(6823), 2001
PMID: 11234002
Mutants of Escherichia coli requiring methionine or vitamin B12.
DAVIS BD, MINGIOLI ES., J. Bacteriol. 60(1), 1950
PMID: 15436457
Expression of the Corynebacterium glutamicum panD gene encoding L-aspartate-alpha-decarboxylase leads to pantothenate overproduction in Escherichia coli.
Dusch N, Puhler A, Kalinowski J., Appl. Environ. Microbiol. 65(4), 1999
PMID: 10103247
Differential plasmid rescue from transgenic mouse DNAs into Escherichia coli methylation-restriction mutants.
Grant SG, Jessee J, Bloom FR, Hanahan D., Proc. Natl. Acad. Sci. U.S.A. 87(12), 1990
PMID: 2162051
Biosynthesis of methionine
Greene, 1996
Proteome analysis of Corynebacterium glutamicum.
Hermann T, Pfefferle W, Baumann C, Busker E, Schaffer S, Bott M, Sahm H, Dusch N, Kalinowski J, Puhler A, Bendt AK, Kramer R, Burkovski A., Electrophoresis 22(9), 2001
PMID: 11425227
Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.
Horton RM, Hunt HD, Ho SN, Pullen JK, Pease LR., Gene 77(1), 1989
PMID: 2744488
Analysis of Corynebacterium glutamicum methionine biosynthetic pathway: isolation and analysis of metB encoding cystathionine gamma-synthase.
Hwang BJ, Kim Y, Kim HB, Hwang HJ, Kim JH, Lee HS., Mol. Cells 9(3), 1999
PMID: 10420990
Corynebacterium glutamicum utilizes both transsulfuration and direct sulfhydrylation pathways for methionine biosynthesis.
Hwang BJ, Yeom HJ, Kim Y, Lee HS., J. Bacteriol. 184(5), 2002
PMID: 11844756
Evolutionary recruitment of biochemically specialized subdivisions of Family I within the protein superfamily of aminotransferases.
Jensen RA, Gu W., J. Bacteriol. 178(8), 1996
PMID: 8636014
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.
Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Kramer R, Linke B, McHardy AC, Meyer F, Mockel B, Pfefferle W, Puhler A, Rey DA, Ruckert C, Rupp O, Sahm H, Wendisch VF, Wiegrabe I, Tauch A., J. Biotechnol. 104(1-3), 2003
PMID: 12948626
The KEGG databases at GenomeNet.
Kanehisa M, Goto S, Kawashima S, Nakaya A., Nucleic Acids Res. 30(1), 2002
PMID: 11752249
Production of O-acetyl-l-homoserine by methionine analog-resistant mutants and regulation of homoserine-O-transacetylase in Corynebacterium glutamicum
Kase, Agr. Biol. Chem. 38(10), 1974
The regulation of l-methionine synthesis and the properties of cystathionine-γ-synthase and β-cystathionase in Corynebacterium glutamicum
Kase, Agr. Biol. Chem. 38(11), 1974
Methionine biosynthesis by analog-resistant mutants of Corynebacterium glutamicum
Kase, Agr. Biol. Chem. 39(), 1975
Nucleotide sequence of the Saccharomyces cerevisiae MET25 gene.
Kerjan P, Cherest H, Surdin-Kerjan Y., Nucleic Acids Res. 14(20), 1986
PMID: 3022238
Properties of the Corynebacterium glutamicum metC gene encoding cystathionine beta-lyase.
Kim JW, Kim HJ, Kim Y, Lee MS, Lee HS., Mol. Cells 11(2), 2001
PMID: 11355704
Amino acid fermentation. I. Production of l-glutamic acid by various microorganisms
Kinoshita, Appl. Microbiol. 3(), 1957
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Laemmli UK., Nature 227(5259), 1970
PMID: 5432063
The MET2 gene of Saccharomyces cerevisiae: molecular cloning and nucleotide sequence.
Langin T, Faugeron G, Goyon C, Nicolas A, Rossignol JL., Gene 49(3), 1986
PMID: 3552887
Amino acids—technical production and use
Leuchtenberger, 1996
Human cystathionine gamma-lyase: developmental and in vitro expression of two isoforms.
Levonen AL, Lapatto R, Saksela M, Raivio KO., Biochem. J. 347 Pt 1(), 2000
PMID: 10727430
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.
McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK., Nature 413(6858), 2001
PMID: 11677609
Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae.
Ono B, Tanaka K, Naito K, Heike C, Shinoda S, Yamamoto S, Ohmori S, Oshima T, Toh-e A., J. Bacteriol. 174(10), 1992
PMID: 1577698
Isolation and analysis of metA, a methionine biosynthetic gene encoding homoserine acetyltransferase in corynebacterium glutamicum.
Park SD, Lee JY, Kim Y, Kim JH, Lee HS., Mol. Cells 8(3), 1998
PMID: 9666465
Probability-based protein identification by searching sequence databases using mass spectrometry data.
Perkins DN, Pappin DJ, Creasy DM, Cottrell JS., Electrophoresis 20(18), 1999
PMID: 10612281
Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum.
Peters-Wendisch PG, Schiel B, Wendisch VF, Katsoulidis E, Mockel B, Sahm H, Eikmanns BJ., J. Mol. Microbiol. Biotechnol. 3(2), 2001
PMID: 11321586
The putative transcriptional repressor McbR, member of the TetR-family, is involved in the regulation of the metabolic network directing the synthesis of sulfur containing amino acids in Corynebacterium glutamicum.
Rey DA, Puhler A, Kalinowski J., J. Biotechnol. 103(1), 2003
PMID: 12770504
The Corynebacterium glutamicum aecD gene encodes a C-S lyase with alpha, beta-elimination activity that degrades aminoethylcysteine.
Rossol I, Puhler A., J. Bacteriol. 174(9), 1992
PMID: 1569026
Pathway analysis and metabolic engineering in Corynebacterium glutamicum.
Sahm H, Eggeling L, de Graaf AA., Biol. Chem. 381(9-10), 2000
PMID: 11076021

Sambrook, 1989
Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum.
Schafer A, Tauch A, Jager W, Kalinowski J, Thierbach G, Puhler A., Gene 145(1), 1994
PMID: 8045426
Manipulation of Corynebacterium glutamicum by gene disruption and replacement
Schwarzer, Biotechnology 9(), 1991
Strategy to sequence the genome of Corynebacterium glutamicum ATCC 13032: use of a cosmid and a bacterial artificial chromosome library.
Tauch A, Homann I, Mormann S, Ruberg S, Billault A, Bathe B, Brand S, Brockmann-Gretza O, Ruckert C, Schischka N, Wrenger C, Hoheisel J, Mockel B, Huthmacher K, Pfefferle W, Puhler A, Kalinowski J., J. Biotechnol. 95(1), 2002
PMID: 11879709
Efficient electrotransformation of corynebacterium diphtheriae with a mini-replicon derived from the Corynebacterium glutamicum plasmid pGA1.
Tauch A, Kirchner O, Loffler B, Gotker S, Puhler A, Kalinowski J., Curr. Microbiol. 45(5), 2002
PMID: 12232668
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG., Nucleic Acids Res. 25(24), 1997
PMID: 9396791
Purification, characterization and identification of cysteine desulfhydrase of Corynebacterium glutamicum, and its relationship to cysteine production.
Wada M, Awano N, Haisa K, Takagi H, Nakamori S., FEMS Microbiol. Lett. 217(1), 2002
PMID: 12445652
Electrotransformation of intact and osmotically sensitive cells of Corynebacterium glutamicum
Wolf, Appl. Microbiol. Biotechnol. 30(), 1989
MalY of Escherichia coli is an enzyme with the activity of a beta C-S lyase (cystathionase).
Zdych E, Peist R, Reidl J, Boos W., J. Bacteriol. 177(17), 1995
PMID: 7665481
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 12948640
PubMed | Europe PMC

Suchen in

Google Scholar