Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics

Tauch A, Pühler A, Kalinowski J, Thierbach G (2003)
JOURNAL OF BIOTECHNOLOGY 104(1-3): 27-40.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Endogenous plasmids and selectable resistance markers are a fundamental prerequisite for the development of efficient recombinant DNA techniques in industrial microorganisms. In this article, we therefore summarize the current knowledge about endogenous plasmids in amino acid-producing Corynebacterium glutamicum isolates. Screening studies identified a total of 24 different plasmids ranging in size from 2.4 to 95 kb. Although most of the C glutamicum plasmids were cryptic, four plasmids carried resistance determinants against the antibiotics chloramphenicol, tetracycline, streptomycin-spectinomycin, and sulfonamides. Considerable information is now available on the molecular genetic organization of 12 completely sequenced plasmid genomes from C. glutamicum. The deduced mechanism of plasmid DNA replication and the degree of amino acid sequence similarity among replication initiator proteins was the basis for performing a classification of the plasmids into four distinct C. glutamicum plasmid families. (C) 2003 Elsevier B.V. All rights reserved.
Stichworte
Corynebacterium glutamicum; antibiotic resistance gene; plasmid replication; rolling circle replication; theta replication; plasmid family
Erscheinungsjahr
2003
Zeitschriftentitel
JOURNAL OF BIOTECHNOLOGY
Band
104
Ausgabe
1-3
Seite(n)
27-40
ISSN
0168-1656
Page URI
https://pub.uni-bielefeld.de/record/1610254

Zitieren

Tauch A, Pühler A, Kalinowski J, Thierbach G. Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. JOURNAL OF BIOTECHNOLOGY. 2003;104(1-3):27-40.
Tauch, A., Pühler, A., Kalinowski, J., & Thierbach, G. (2003). Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. JOURNAL OF BIOTECHNOLOGY, 104(1-3), 27-40. doi:10.1016/S0168-1656(03)00157-3
Tauch, A., Pühler, A., Kalinowski, J., and Thierbach, G. (2003). Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. JOURNAL OF BIOTECHNOLOGY 104, 27-40.
Tauch, A., et al., 2003. Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. JOURNAL OF BIOTECHNOLOGY, 104(1-3), p 27-40.
A. Tauch, et al., “Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics”, JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pp. 27-40.
Tauch, A., Pühler, A., Kalinowski, J., Thierbach, G.: Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. JOURNAL OF BIOTECHNOLOGY. 104, 27-40 (2003).
Tauch, Andreas, Pühler, Alfred, Kalinowski, Jörn, and Thierbach, G. “Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics”. JOURNAL OF BIOTECHNOLOGY 104.1-3 (2003): 27-40.

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PMID: 12948627
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