Evaluating the predictability of conformational switching in RNA
Voss B, Meyer C, Giegerich R (2004)
Bioinformatics 20(10): 1573-1582.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
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Autor*in
Voss, Björn;
Meyer, Carsten;
Giegerich, RobertUniBi
Einrichtung
Abstract / Bemerkung
Motivation: There are various cases where the biological function of an RNA molecule involves a reversible change of conformation. paRNAss is a software approach to the prediction of such structural switching in RNA. It is based on three hypotheses about the secondary structure space of a switching RNA molecule that can be evaluated by RNA folding and structure comparison. In the positive case, the predicted structural switching must be verified experimentally. Results: After reviewing the strategy used in paRNAss, we present recent improvements on the algorithmic level of the approach, and the results of an evaluation procedure, comprising 1500 RNA sequences. It could be shown that the paRNAss approach performs well on known examples for conformational switching in RNA. The overall number of positive predictions was small, whereas for human 3' UTRs, representing regulatory important regions, it was substantially higher than for arbitrary natural and random sequences.
Erscheinungsjahr
2004
Zeitschriftentitel
Bioinformatics
Band
20
Ausgabe
10
Seite(n)
1573-1582
ISSN
1367-4803
eISSN
1460-2059
Page URI
https://pub.uni-bielefeld.de/record/1607419
Zitieren
Voss B, Meyer C, Giegerich R. Evaluating the predictability of conformational switching in RNA. Bioinformatics. 2004;20(10):1573-1582.
Voss, B., Meyer, C., & Giegerich, R. (2004). Evaluating the predictability of conformational switching in RNA. Bioinformatics, 20(10), 1573-1582. https://doi.org/10.1093/bioinformatics/bth129
Voss, Björn, Meyer, Carsten, and Giegerich, Robert. 2004. “Evaluating the predictability of conformational switching in RNA”. Bioinformatics 20 (10): 1573-1582.
Voss, B., Meyer, C., and Giegerich, R. (2004). Evaluating the predictability of conformational switching in RNA. Bioinformatics 20, 1573-1582.
Voss, B., Meyer, C., & Giegerich, R., 2004. Evaluating the predictability of conformational switching in RNA. Bioinformatics, 20(10), p 1573-1582.
B. Voss, C. Meyer, and R. Giegerich, “Evaluating the predictability of conformational switching in RNA”, Bioinformatics, vol. 20, 2004, pp. 1573-1582.
Voss, B., Meyer, C., Giegerich, R.: Evaluating the predictability of conformational switching in RNA. Bioinformatics. 20, 1573-1582 (2004).
Voss, Björn, Meyer, Carsten, and Giegerich, Robert. “Evaluating the predictability of conformational switching in RNA”. Bioinformatics 20.10 (2004): 1573-1582.
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