Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae

Hansmeier N, Chao TC, Kalinowski J, Pühler A, Tauch A (2006)
PROTEOMICS 6(8): 2465-2476.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Secreted proteins of the human pathogen Corynebacterium diphtheriae might be involved in important pathogen-host cell interactions. Here, we present the first systematic reference map of the extracellular and cell surface proteome fractions of the type strain C. diphtheriae C7(s)(-)(tox-). The analysis window of 2-DE covered the pI range from 3 to 10 along with a MW range from 8 to 150 kDa. Computational analysis of the 2-D gels detected almost 150 protein spots in the extracellular proteome fraction and about 80 protein spots of the cell surface proteome. MALDI-TOF-MS and PMF with trypsin unambiguously identified 107 extracellular protein spots and 53 protein spots of the cell surface, representing in total 85 different proteins of C. diphtheriae C7(s)(-)(tox-). Several of the identified proteins are encoded by pathogenicity islands and might represent virulence factors of C. diphtheriae. Additionally, four solute-binding proteins (HmuT Irp6A, CiuA, and FrgD) of different iron ABC transporters were identified, with the hitherto uncharacterized FrgD protein being the most abundant one of the cell surface proteome of C. diphtheriae C7(s)(-)(tox-).
two-dimensional gel electrophoresis; extracellular proteome map; metabolism; virulence factors; iron; Corynebacterium diphtheriae
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Hansmeier N, Chao TC, Kalinowski J, Pühler A, Tauch A. Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae. PROTEOMICS. 2006;6(8):2465-2476.
Hansmeier, N., Chao, T. C., Kalinowski, J., Pühler, A., & Tauch, A. (2006). Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae. PROTEOMICS, 6(8), 2465-2476.
Hansmeier, N., Chao, T. C., Kalinowski, Jörn, Pühler, Alfred, and Tauch, Andreas. 2006. “Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae”. PROTEOMICS 6 (8): 2465-2476.
Hansmeier, N., Chao, T. C., Kalinowski, J., Pühler, A., and Tauch, A. (2006). Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae. PROTEOMICS 6, 2465-2476.
Hansmeier, N., et al., 2006. Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae. PROTEOMICS, 6(8), p 2465-2476.
N. Hansmeier, et al., “Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae”, PROTEOMICS, vol. 6, 2006, pp. 2465-2476.
Hansmeier, N., Chao, T.C., Kalinowski, J., Pühler, A., Tauch, A.: Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae. PROTEOMICS. 6, 2465-2476 (2006).
Hansmeier, N., Chao, T. C., Kalinowski, Jörn, Pühler, Alfred, and Tauch, Andreas. “Mapping and comprehensive analysis of the extracellular and cell surface proteome of the human pathogen Corynebacterium diphtheriae”. PROTEOMICS 6.8 (2006): 2465-2476.

32 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

More than a Toxin: Protein Inventory of Clostridium tetani Toxoid Vaccines.
Möller J, Kraner ME, Burkovski A., Proteomes 7(2), 2019
PMID: 30988272
From the wound to the bench: exoproteome interplay between wound-colonizing Staphylococcus aureus strains and co-existing bacteria.
García-Pérez AN, de Jong A, Junker S, Becher D, Chlebowicz MA, Duipmans JC, Jonkman MF, van Dijl JM., Virulence 9(1), 2018
PMID: 29233035
Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach.
Sharma A, Ponmariappan S, Sarita R, Alam SI, Kamboj DV, Shukla S., Curr Microbiol 75(5), 2018
PMID: 29332140
Adhesion properties of toxigenic corynebacteria.
Ott L., AIMS Microbiol 4(1), 2018
PMID: 31294205
Surface and Extracellular Proteome of the Emerging Pathogen Corynebacterium ulcerans.
Bittel M, Gastiger S, Amin B, Hofmann J, Burkovski A., Proteomes 6(2), 2018
PMID: 29673200
The naringenin-induced exoproteome of Rhizobium etli CE3.
Meneses N, Taboada H, Dunn MF, Vargas MDC, Buchs N, Heller M, Encarnación S., Arch Microbiol 199(5), 2017
PMID: 28255691
Proteomics dedicated to biofilmology: What have we learned from a decade of research?
Khemiri A, Jouenne T, Cosette P., Med Microbiol Immunol 205(1), 2016
PMID: 26068406
Adherence and invasive properties of Corynebacterium diphtheriae strains correlates with the predicted membrane-associated and secreted proteome.
Sangal V, Blom J, Sutcliffe IC, von Hunolstein C, Burkovski A, Hoskisson PA., BMC Genomics 16(), 2015
PMID: 26452736
Selenium effects on the metabolism of a Se-metabolizing Lactobacillus reuteri: analysis of envelope-enriched and extracellular proteomes.
Mangiapane E, Lamberti C, Pessione A, Galano E, Amoresano A, Pessione E., Mol Biosyst 10(6), 2014
PMID: 24481235
SecDF as part of the Sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins.
Vörös A, Simm R, Slamti L, McKay MJ, Hegna IK, Nielsen-LeRoux C, Hassan KA, Paulsen IT, Lereclus D, Økstad OA, Molloy MP, Kolstø AB., PLoS One 9(8), 2014
PMID: 25083861
Induction of the NFκ-B signal transduction pathway in response to Corynebacterium diphtheriae infection.
Ott L, Scholz B, Höller M, Hasselt K, Ensser A, Burkovski A., Microbiology 159(pt 1), 2013
PMID: 23125120
Corynebacterium diphtheriae 67-72p hemagglutinin, characterized as the protein DIP0733, contributes to invasion and induction of apoptosis in HEp-2 cells.
Sabbadini PS, Assis MC, Trost E, Gomes DL, Moreira LO, Dos Santos CS, Pereira GA, Nagao PE, Azevedo VA, Hirata Júnior R, Dos Santos AL, Tauch A, Mattos-Guaraldi AL., Microb Pathog 52(3), 2012
PMID: 22239957
Exoproteomics: exploring the world around biological systems.
Armengaud J, Christie-Oleza JA, Clair G, Malard V, Duport C., Expert Rev Proteomics 9(5), 2012
PMID: 23194272
Proteomics and transcriptomics characterization of bile stress response in probiotic Lactobacillus rhamnosus GG.
Koskenniemi K, Laakso K, Koponen J, Kankainen M, Greco D, Auvinen P, Savijoki K, Nyman TA, Surakka A, Salusjärvi T, de Vos WM, Tynkkynen S, Kalkkinen N, Varmanen P., Mol Cell Proteomics 10(2), 2011
PMID: 21078892
Identification of Corynebacterium diphtheriae gene involved in adherence to epithelial cells.
Kolodkina V, Denisevich T, Titov L., Infect Genet Evol 11(2), 2011
PMID: 21111065
A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis.
Pacheco LG, Slade SE, Seyffert N, Santos AR, Castro TL, Silva WM, Santos AV, Santos SG, Farias LM, Carvalho MA, Pimenta AM, Meyer R, Silva A, Scrivens JH, Oliveira SC, Miyoshi A, Dowson CG, Azevedo V., BMC Microbiol 11(1), 2011
PMID: 21241507
Proteomics of corynebacteria: From biotechnology workhorses to pathogens.
Poetsch A, Haussmann U, Burkovski A., Proteomics 11(15), 2011
PMID: 21674800
Corynebacterium diphtheriae invasion-associated protein (DIP1281) is involved in cell surface organization, adhesion and internalization in epithelial cells.
Ott L, Höller M, Gerlach RG, Hensel M, Rheinlaender J, Schäffer TE, Burkovski A., BMC Microbiol 10(), 2010
PMID: 20051108
Expression and purification of the immunogenically active fragment B of the Park Williams 8 Corynebacterium diphtheriae strain toxin.
Nascimento DV, Lemes EM, Queiroz JL, Silva JG, Nascimento HJ, Silva ED, Hirata R, Dias AA, Santos CS, Pereira GM, Mattos-Guaraldi AL, Armoa GR., Braz J Med Biol Res 43(5), 2010
PMID: 20490433
Genome organization and pathogenicity of Corynebacterium diphtheriae C7(-) and PW8 strains.
Iwaki M, Komiya T, Yamamoto A, Ishiwa A, Nagata N, Arakawa Y, Takahashi M., Infect Immun 78(9), 2010
PMID: 20547743
The extracellular proteome of Rhizobium etli CE3 in exponential and stationary growth phase.
Meneses N, Mendoza-Hernández G, Encarnación S., Proteome Sci 8(), 2010
PMID: 20942974
Immunoproteomic analysis of Bordetella pertussis and identification of new immunogenic proteins.
Altindiş E, Tefon BE, Yildirim V, Ozcengiz E, Becher D, Hecker M, Ozcengiz G., Vaccine 27(4), 2009
PMID: 19028538
Analysis of the secretome of the soybean symbiont Bradyrhizobium japonicum.
Hempel J, Zehner S, Göttfert M, Patschkowski T., J Biotechnol 140(1-2), 2009
PMID: 19095018
Campylobacter proteomics: guidelines, challenges and future perspectives.
Scott NE, Cordwell SJ., Expert Rev Proteomics 6(1), 2009
PMID: 19210127
Scanning the Corynebacterium glutamicum R genome for high-efficiency secretion signal sequences.
Watanabe K, Tsuchida Y, Okibe N, Teramoto H, Suzuki N, Inui M, Yukawa H., Microbiology 155(pt 3), 2009
PMID: 19246745
Diminished exoproteome of Frankia spp. in culture and symbiosis.
Mastronunzio JE, Huang Y, Benson DR., Appl Environ Microbiol 75(21), 2009
PMID: 19749056
Application of proteomics in biotechnology--microbial proteomics.
Josic D, Kovac S., Biotechnol J 3(4), 2008
PMID: 18320565

77 References

Daten bereitgestellt von Europe PubMed Central.

Pappenheimer, Ann. Rev. Biochem. 46(), 1977

Holmes, J. Infect. Dis. 181(), 2000

Hadfield, J. Infect. Dis. 181(), 2000
Diphtheria remains a threat to health in the developing world--an overview.
Mattos-Guaraldi AL, Moreira LO, Damasco PV, Hirata Junior R., Mem. Inst. Oswaldo Cruz 98(8), 2003
PMID: 15049077
Coordinate regulation of siderophore and diphtheria toxin production by iron in Corynebacterium diphtheriae.
Tai SP, Krafft AE, Nootheti P, Holmes RK., Microb. Pathog. 9(4), 1990
PMID: 2151460
Molecular epidemiology of diphtheria in Russia, 1985-1994.
Popovic T, Kombarova SY, Reeves MW, Nakao H, Mazurova IK, Wharton M, Wachsmuth IK, Wenger JD., J. Infect. Dis. 174(5), 1996
PMID: 8896510
Diphtheria in the former Soviet Union: reemergence of a pandemic disease.
Vitek CR, Wharton M., Emerging Infect. Dis. 4(4), 1998
PMID: 9866730

Popovic, J. Infect. Dis. 181(), 2000
The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.
Cerdeno-Tarraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG, Parkhill J., Nucleic Acids Res. 31(22), 2003
PMID: 14602910
Comprehensive analysis of the extracellular proteins from Xanthomonas campestris pv. campestris B100.
Watt SA, Wilke A, Patschkowski T, Niehaus K., Proteomics 5(1), 2005
PMID: 15619296
Probability-based protein identification by searching sequence databases using mass spectrometry data.
Perkins DN, Pappin DJ, Creasy DM, Cottrell JS., Electrophoresis 20(18), 1999
PMID: 10612281

Link, 1998
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.
Nielsen H, Engelbrecht J, Brunak S, von Heijne G., Protein Eng. 10(1), 1997
PMID: 9051728
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A, Larsson B, von Heijne G, Sonnhammer EL., J. Mol. Biol. 305(3), 2001
PMID: 11152613
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ., Nucleic Acids Res. 25(17), 1997
PMID: 9254694
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.
Nielsen H, Engelbrecht J, Brunak S, von Heijne G., Int J Neural Syst 8(5-6), 1997
PMID: 10065837

Hansmeier, 2006
Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens.
Jungblut PR, Schaible UE, Mollenkopf HJ, Zimny-Arndt U, Raupach B, Mattow J, Halada P, Lamer S, Hagens K, Kaufmann SH., Mol. Microbiol. 33(6), 1999
PMID: 10510226
Helicobacter pylori vaccine development based on combined subproteome analysis.
Bumann D, Jungblut PR, Meyer TF., Proteomics 4(10), 2004
PMID: 15378757

Halligan, Nucleic Acids Res. 1(), 2004
Two-dimensional reference map of Agrobacterium tumefaciens proteins.
Rosen R, Sacher A, Shechter N, Becher D, Buttner K, Biran D, Hecker M, Ron EZ., Proteomics 4(4), 2004
PMID: 15048987

Hartmann, J. Arch. Microbiol. 182(), 2004
The Tat protein export pathway.
Berks BC, Sargent F, Palmer T., Mol. Microbiol. 35(2), 2000
PMID: 10652088
The Tat protein translocation pathway and its role in microbial physiology.
Berks BC, Palmer T, Sargent F., Adv. Microb. Physiol. 47(), 2003
PMID: 14560665
Prokaryotic utilization of the twin-arginine translocation pathway: a genomic survey.
Dilks K, Rose RW, Hartmann E, Pohlschroder M., J. Bacteriol. 185(4), 2003
PMID: 12562823
DOLOP--database of bacterial lipoproteins.
Madan Babu M, Sankaran K., Bioinformatics 18(4), 2002
PMID: 12016064
The PEDANT genome database.
Frishman D, Mokrejs M, Kosykh D, Kastenmuller G, Kolesov G, Zubrzycki I, Gruber C, Geier B, Kaps A, Albermann K, Volz A, Wagner C, Fellenberg M, Heumann K, Mewes HW., Nucleic Acids Res. 31(1), 2003
PMID: 12519983
The complete general secretory pathway in gram-negative bacteria.
Pugsley AP., Microbiol. Rev. 57(1), 1993
PMID: 8096622
Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome.
Tjalsma H, Bolhuis A, Jongbloed JD, Bron S, van Dijl JM., Microbiol. Mol. Biol. Rev. 64(3), 2000
PMID: 10974125
Inter- and intraclonal diversity of the Pseudomonas aeruginosa proteome manifests within the secretome.
Wehmhoner D, Haussler S, Tummler B, Jansch L, Bredenbruch F, Wehland J, Steinmetz I., J. Bacteriol. 185(19), 2003
PMID: 13129952
Characterization of a periplasmic peptidyl-prolyl cis-trans isomerase in Erwinia chrysanthemi.
Pissavin C, Hugouvieux-Cotte-Pattat N., FEMS Microbiol. Lett. 157(1), 1997
PMID: 9418240
Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro.
Manca C, Paul S, Barry CE 3rd, Freedman VH, Kaplan G., Infect. Immun. 67(1), 1999
PMID: 9864198

Rao, Micobiology 149(), 2003
Role of catalase in Campylobacter jejuni intracellular survival.
Day WA Jr, Sajecki JL, Pitts TM, Joens LA., Infect. Immun. 68(11), 2000
PMID: 11035743
SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis.
Braunstein M, Espinosa BJ, Chan J, Belisle JT, Jacobs WR Jr., Mol. Microbiol. 48(2), 2003
PMID: 12675804
A genomic perspective on protein families.
Tatusov RL, Koonin EV, Lipman DJ., Science 278(5338), 1997
PMID: 9381173

Malloy, Am. J. Physiol. Lung Cell Mol. Physiol. 288(), 2005
Comparative analysis of the roles of HtrA-like surface proteases in two virulent Staphylococcus aureus strains.
Rigoulay C, Entenza JM, Halpern D, Widmer E, Moreillon P, Poquet I, Gruss A., Infect. Immun. 73(1), 2005
PMID: 15618196
Assembly of pili on the surface of Corynebacterium diphtheriae.
Ton-That H, Schneewind O., Mol. Microbiol. 50(4), 2003
PMID: 14622427
Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif.
Ton-That H, Liu G, Mazmanian SK, Faull KF, Schneewind O., Proc. Natl. Acad. Sci. U.S.A. 96(22), 1999
PMID: 10535938
An embarrassment of sortases - a richness of substrates?
Pallen MJ, Lam AC, Antonio M, Dunbar K., Trends Microbiol. 9(3), 2001
PMID: 11239768

Yellaboina, BMC Microbiol. 38(), 2004
Neuraminidase of Corynebacterium diphtheriae.
Moriyama T, Barksdale L., J. Bacteriol. 94(5), 1967
PMID: 4964482
Trans-sialidase activity for sialic acid incorporation on Corynebacterium diphtheriae.
Mattos-Guaraldi AL, Formiga LC, Andrade AF., FEMS Microbiol. Lett. 168(2), 1998
PMID: 9835025
Properties of sialidase isolated from Actinomyces viscosus DSM 43798.
Teufel M, Roggentin P, Schauer R., Biol. Chem. Hoppe-Seyler 370(5), 1989
PMID: 2742753
Oxidative stress responses in Escherichia coli and Salmonella typhimurium.
Farr SB, Kogoma T., Microbiol. Rev. 55(4), 1991
PMID: 1779927
Identification and role in virulence of putative iron acquisition genes from Corynebacterium pseudotuberculosis.
Billington SJ, Esmay PA, Songer JG, Jost BH., FEMS Microbiol. Lett. 208(1), 2002
PMID: 11934492

Zasada, Ann. Clin. Microbiol. Antimicrob. 4(), 2005
Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.
Nishio Y, Nakamura Y, Kawarabayasi Y, Usuda Y, Kimura E, Sugimoto S, Matsui K, Yamagishi A, Kikuchi H, Ikeo K, Gojobori T., Genome Res. 13(7), 2003
PMID: 12840036
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG., Nature 393(6685), 1998
PMID: 9634230
The complete genome sequence of Mycobacterium bovis.
Garnier T, Eiglmeier K, Camus JC, Medina N, Mansoor H, Pryor M, Duthoy S, Grondin S, Lacroix C, Monsempe C, Simon S, Harris B, Atkin R, Doggett J, Mayes R, Keating L, Wheeler PR, Parkhill J, Barrell BG, Cole ST, Gordon SV, Hewinson RG., Proc. Natl. Acad. Sci. U.S.A. 100(13), 2003
PMID: 12788972
The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.
Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Kramer R, Linke B, McHardy AC, Meyer F, Mockel B, Pfefferle W, Puhler A, Rey DA, Ruckert C, Rupp O, Sahm H, Wendisch VF, Wiegrabe I, Tauch A., J. Biotechnol. 104(1-3), 2003
PMID: 12948626
The complete genome sequence of Propionibacterium acnes, a commensal of human skin.
Bruggemann H, Henne A, Hoster F, Liesegang H, Wiezer A, Strittmatter A, Hujer S, Durre P, Gottschalk G., Science 305(5684), 2004
PMID: 15286373
The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403.
Bolotin A, Wincker P, Mauger S, Jaillon O, Malarme K, Weissenbach J, Ehrlich SD, Sorokin A., Genome Res. 11(5), 2001
PMID: 11337471
Massive gene decay in the leprosy bacillus.
Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honore N, Garnier T, Churcher C, Harris D, Mungall K, Basham D, Brown D, Chillingworth T, Connor R, Davies RM, Devlin K, Duthoy S, Feltwell T, Fraser A, Hamlin N, Holroyd S, Hornsby T, Jagels K, Lacroix C, Maclean J, Moule S, Murphy L, Oliver K, Quail MA, Rajandream MA, Rutherford KM, Rutter S, Seeger K, Simon S, Simmonds M, Skelton J, Squares R, Squares S, Stevens K, Taylor K, Whitehead S, Woodward JR, Barrell BG., Nature 409(6823), 2001
PMID: 11234002
Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species.
Fouts DE, Mongodin EF, Mandrell RE, Miller WG, Rasko DA, Ravel J, Brinkac LM, DeBoy RT, Parker CT, Daugherty SC, Dodson RJ, Durkin AS, Madupu R, Sullivan SA, Shetty JU, Ayodeji MA, Shvartsbeyn A, Schatz MC, Badger JH, Fraser CM, Nelson KE., PLoS Biol. 3(1), 2005
PMID: 15660156
Cloning and nucleotide sequence of the N-acetylmuramidase M1-encoding gene from Streptomyces globisporus.
Lichenstein HS, Hastings AE, Langley KE, Mendiaz EA, Rohde MF, Elmore R, Zukowski MM., Gene 88(1), 1990
PMID: 2341041

Bentley, Nature 417(), 2002
The complete genomic sequence of Nocardia farcinica IFM 10152.
Ishikawa J, Yamashita A, Mikami Y, Hoshino Y, Kurita H, Hotta K, Shiba T, Hattori M., Proc. Natl. Acad. Sci. U.S.A. 101(41), 2004
PMID: 15466710
Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment.
Moran MA, Buchan A, Gonzalez JM, Heidelberg JF, Whitman WB, Kiene RP, Henriksen JR, King GM, Belas R, Fuqua C, Brinkac L, Lewis M, Johri S, Weaver B, Pai G, Eisen JA, Rahe E, Sheldon WM, Ye W, Miller TR, Carlton J, Rasko DA, Paulsen IT, Ren Q, Daugherty SC, Deboy RT, Dodson RJ, Durkin AS, Madupu R, Nelson WC, Sullivan SA, Rosovitz MJ, Haft DH, Selengut J, Ward N., Nature 432(7019), 2004
PMID: 15602564
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.
Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M., Proc. Natl. Acad. Sci. U.S.A. 98(21), 2001
PMID: 11572948

Beres, Proc. Natl. Acad. Sci. USA 99(), 2002

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