Protein target highlights in CASP15: Analysis of models by structure providers

Alexander, Leila T; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A; Bayo, Yusupha; Bhabha, Gira; Breyton, Cecile; Caulton, Simon G; Chen, James; Degroux, Seraphine; Ekiert, Damian C; Erlandsen, Benedikte S; Freddolino, Peter L; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D; Hitchman, Charlie J; Keown, Jeremy R; Kropp, Ashleigh; Kursula, Petri; Lovering, Andrew L; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markusson, Sigurbjörn; Miller, Mitchell D; Minasov, George; Niemann, Hartmut; Opazo, Felipe; Phillips, George N Jr; Davies, Owen R; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John; Schwede, Torsten

Protein target highlights in CASP15: Analysis of models by structure providers

Alexander LT, Durairaj J, Kryshtafovych A, Abriata LA, Bayo Y, Bhabha G, Breyton C, Caulton SG, Chen J, Degroux S, Ekiert DC, et al. (2023)
Proteins: Structure, Function, and Bioinformatics .

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DOI

https://doi.org/10.1002/prot.26545

Autor*in

Alexander, Leila T; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A; Bayo, Yusupha; Bhabha, Gira; Breyton, Cecile; Caulton, Simon G; Chen, James; Degroux, Seraphine; Ekiert, Damian C; Erlandsen, Benedikte S
Alle

Einrichtung

Fakultät für Chemie > Biochemie IV

Abstract / Bemerkung

We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology. © 2023 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.

Erscheinungsjahr

2023

Zeitschriftentitel

Proteins: Structure, Function, and Bioinformatics

eISSN

1097-0134

Page URI

https://pub.uni-bielefeld.de/record/2981627

Zitieren

Alexander LT, Durairaj J, Kryshtafovych A, et al. Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . 2023.

Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., et al. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . https://doi.org/10.1002/prot.26545

Alexander, Leila T, Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A, Bayo, Yusupha, Bhabha, Gira, Breyton, Cecile, et al. 2023. “Protein target highlights in CASP15: Analysis of models by structure providers”. Proteins: Structure, Function, and Bioinformatics .

Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., et al. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics .

Alexander, L.T., et al., 2023. Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics .

L.T. Alexander, et al., “Protein target highlights in CASP15: Analysis of models by structure providers”, Proteins: Structure, Function, and Bioinformatics , 2023.

Alexander, L.T., Durairaj, J., Kryshtafovych, A., Abriata, L.A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S.G., Chen, J., Degroux, S., Ekiert, D.C., Erlandsen, B.S., Freddolino, P.L., Gilzer, D., Greening, C., Grimes, J.M., Grinter, R., Gurusaran, M., Hartmann, M.D., Hitchman, C.J., Keown, J.R., Kropp, A., Kursula, P., Lovering, A.L., Lemaitre, B., Lia, A., Liu, S., Logotheti, M., Lu, S., Markusson, S., Miller, M.D., Minasov, G., Niemann, H., Opazo, F., Phillips, G.N.J., Davies, O.R., Rommelaere, S., Rosas-Lemus, M., Roversi, P., Satchell, K., Smith, N., Wilson, M.A., Wu, K.-L., Xia, X., Xiao, H., Zhang, W., Zhou, Z.H., Fidelis, K., Topf, M., Moult, J., Schwede, T.: Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . (2023).

Alexander, Leila T, Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A, Bayo, Yusupha, Bhabha, Gira, Breyton, Cecile, Caulton, Simon G, Chen, James, Degroux, Seraphine, Ekiert, Damian C, Erlandsen, Benedikte S, Freddolino, Peter L, Gilzer, Dominic, Greening, Chris, Grimes, Jonathan M, Grinter, Rhys, Gurusaran, Manickam, Hartmann, Marcus D, Hitchman, Charlie J, Keown, Jeremy R, Kropp, Ashleigh, Kursula, Petri, Lovering, Andrew L, Lemaitre, Bruno, Lia, Andrea, Liu, Shiheng, Logotheti, Maria, Lu, Shuze, Markusson, Sigurbjörn, Miller, Mitchell D, Minasov, George, Niemann, Hartmut, Opazo, Felipe, Phillips, George N Jr, Davies, Owen R, Rommelaere, Samuel, Rosas-Lemus, Monica, Roversi, Pietro, Satchell, Karla, Smith, Nathan, Wilson, Mark A, Wu, Kuan-Lin, Xia, Xian, Xiao, Han, Zhang, Wenhua, Zhou, Z Hong, Fidelis, Krzysztof, Topf, Maya, Moult, John, and Schwede, Torsten. “Protein target highlights in CASP15: Analysis of models by structure providers”. Proteins: Structure, Function, and Bioinformatics (2023).

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