Protein target highlights in CASP15: Analysis of models by structure providers
Alexander LT, Durairaj J, Kryshtafovych A, Abriata LA, Bayo Y, Bhabha G, Breyton C, Caulton SG, Chen J, Degroux S, Ekiert DC, et al. (2023)
Proteins: Structure, Function, and Bioinformatics .
Zeitschriftenaufsatz
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Autor*in
Alexander, Leila T;
Durairaj, Janani;
Kryshtafovych, Andriy;
Abriata, Luciano A;
Bayo, Yusupha;
Bhabha, Gira;
Breyton, Cecile;
Caulton, Simon G;
Chen, James;
Degroux, Seraphine;
Ekiert, Damian C;
Erlandsen, Benedikte S
Alle
Alle
Einrichtung
Abstract / Bemerkung
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology. © 2023 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.
Erscheinungsjahr
2023
Zeitschriftentitel
Proteins: Structure, Function, and Bioinformatics
eISSN
1097-0134
Page URI
https://pub.uni-bielefeld.de/record/2981627
Zitieren
Alexander LT, Durairaj J, Kryshtafovych A, et al. Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . 2023.
Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., et al. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . https://doi.org/10.1002/prot.26545
Alexander, Leila T, Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A, Bayo, Yusupha, Bhabha, Gira, Breyton, Cecile, et al. 2023. “Protein target highlights in CASP15: Analysis of models by structure providers”. Proteins: Structure, Function, and Bioinformatics .
Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., et al. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics .
Alexander, L.T., et al., 2023. Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics .
L.T. Alexander, et al., “Protein target highlights in CASP15: Analysis of models by structure providers”, Proteins: Structure, Function, and Bioinformatics , 2023.
Alexander, L.T., Durairaj, J., Kryshtafovych, A., Abriata, L.A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S.G., Chen, J., Degroux, S., Ekiert, D.C., Erlandsen, B.S., Freddolino, P.L., Gilzer, D., Greening, C., Grimes, J.M., Grinter, R., Gurusaran, M., Hartmann, M.D., Hitchman, C.J., Keown, J.R., Kropp, A., Kursula, P., Lovering, A.L., Lemaitre, B., Lia, A., Liu, S., Logotheti, M., Lu, S., Markusson, S., Miller, M.D., Minasov, G., Niemann, H., Opazo, F., Phillips, G.N.J., Davies, O.R., Rommelaere, S., Rosas-Lemus, M., Roversi, P., Satchell, K., Smith, N., Wilson, M.A., Wu, K.-L., Xia, X., Xiao, H., Zhang, W., Zhou, Z.H., Fidelis, K., Topf, M., Moult, J., Schwede, T.: Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . (2023).
Alexander, Leila T, Durairaj, Janani, Kryshtafovych, Andriy, Abriata, Luciano A, Bayo, Yusupha, Bhabha, Gira, Breyton, Cecile, Caulton, Simon G, Chen, James, Degroux, Seraphine, Ekiert, Damian C, Erlandsen, Benedikte S, Freddolino, Peter L, Gilzer, Dominic, Greening, Chris, Grimes, Jonathan M, Grinter, Rhys, Gurusaran, Manickam, Hartmann, Marcus D, Hitchman, Charlie J, Keown, Jeremy R, Kropp, Ashleigh, Kursula, Petri, Lovering, Andrew L, Lemaitre, Bruno, Lia, Andrea, Liu, Shiheng, Logotheti, Maria, Lu, Shuze, Markusson, Sigurbjörn, Miller, Mitchell D, Minasov, George, Niemann, Hartmut, Opazo, Felipe, Phillips, George N Jr, Davies, Owen R, Rommelaere, Samuel, Rosas-Lemus, Monica, Roversi, Pietro, Satchell, Karla, Smith, Nathan, Wilson, Mark A, Wu, Kuan-Lin, Xia, Xian, Xiao, Han, Zhang, Wenhua, Zhou, Z Hong, Fidelis, Krzysztof, Topf, Maya, Moult, John, and Schwede, Torsten. “Protein target highlights in CASP15: Analysis of models by structure providers”. Proteins: Structure, Function, and Bioinformatics (2023).
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