Seizure Semiology in Antibody-Associated Autoimmune Encephalitis

Kaaden T, Madlener M, Angstwurm K, Bien C, Bogarin Y, Doppler K, Finke A, Gerner ST, Reimann G, Hausler M, Handreka R, et al. (2022)
Neurology(R) neuroimmunology & neuroinflammation 9(6): e200034 .

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Kaaden, Tillman; Madlener, Marie; Angstwurm, Klemens; Bien, ChristianUniBi; Bogarin, Yuri; Doppler, Kathrin; Finke, Alexander; Gerner, Stefan T; Reimann, Gernot; Hausler, Martin; Handreka, Robert; Hellwig, Kerstin
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Abstract / Bemerkung
BACKGROUND AND OBJECTIVES: To assess seizure characteristics in antibody (ab)-associated autoimmune encephalitis (ab + AE) with the 3 most prevalent abs against N-methyl-d-aspartate receptor (NMDAR), leucine-rich glioma-inactivated protein 1 (LGI1), and glutamic acid decarboxylase (GAD).; METHODS: Multicenter nationwide prospective cohort study of the German Network for Research in Autoimmune Encephalitis.; RESULTS: Three hundred twenty patients with ab + AE were eligible for analysis: 190 NMDAR+, 89 LGI1+, and 41 GAD+. Seizures were present in 113 (60%) NMDAR+, 69 (78%) LGI1+, and 26 (65%) GAD+ patients and as leading symptoms for diagnosis in 53 (28%) NMDAR+, 47 (53%) LGI+, and 20 (49%) GAD+ patients. Bilateral tonic-clonic seizures occurred with almost equal frequency in NMDAR+ (38/51, 75%) and GAD+ (14/20, 70%) patients, while being less common in LGI1+ patients (27/59, 46%). Focal seizures occurred less frequently in NMDAR+ (67/113; 59%) than in LGI1+ (54/69, 78%) or in GAD+ patients (23/26; 88%). An aura with deja-vu phenomenon was nearly specific in GAD+ patients (16/20, 80%). Faciobrachial dystonic seizures (FBDS) were uniquely observed in LGI1+ patients (17/59, 29%). Status epilepticus was reported in one-third of NMDAR+ patients, but only rarely in the 2 other groups. The occurrence of seizures was associated with higher disease severity only in NMDAR+ patients.; DISCUSSION: Seizures are a frequent and diagnostically relevant symptom of ab + AE. Whereas NMDAR+ patients had few localizing semiological features, semiology in LGI1+ and GAD+ patients pointed toward a predominant temporal seizure onset. FBDS are pathognomonic for LGI1 + AE. Status epilepticus seems to be more frequent in NMDAR + AE. Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Erscheinungsjahr
2022
Zeitschriftentitel
Neurology(R) neuroimmunology & neuroinflammation
Band
9
Ausgabe
6
Art.-Nr.
e200034
eISSN
2332-7812
Page URI
https://pub.uni-bielefeld.de/record/2966466

Zitieren

Kaaden T, Madlener M, Angstwurm K, et al. Seizure Semiology in Antibody-Associated Autoimmune Encephalitis. Neurology(R) neuroimmunology & neuroinflammation. 2022;9(6): e200034 .
Kaaden, T., Madlener, M., Angstwurm, K., Bien, C., Bogarin, Y., Doppler, K., Finke, A., et al. (2022). Seizure Semiology in Antibody-Associated Autoimmune Encephalitis. Neurology(R) neuroimmunology & neuroinflammation, 9(6), e200034 . https://doi.org/10.1212/NXI.0000000000200034
Kaaden, Tillman, Madlener, Marie, Angstwurm, Klemens, Bien, Christian, Bogarin, Yuri, Doppler, Kathrin, Finke, Alexander, et al. 2022. “Seizure Semiology in Antibody-Associated Autoimmune Encephalitis”. Neurology(R) neuroimmunology & neuroinflammation 9 (6): e200034 .
Kaaden, T., Madlener, M., Angstwurm, K., Bien, C., Bogarin, Y., Doppler, K., Finke, A., Gerner, S. T., Reimann, G., Hausler, M., et al. (2022). Seizure Semiology in Antibody-Associated Autoimmune Encephalitis. Neurology(R) neuroimmunology & neuroinflammation 9:e200034 .
Kaaden, T., et al., 2022. Seizure Semiology in Antibody-Associated Autoimmune Encephalitis. Neurology(R) neuroimmunology & neuroinflammation, 9(6): e200034 .
T. Kaaden, et al., “Seizure Semiology in Antibody-Associated Autoimmune Encephalitis”, Neurology(R) neuroimmunology & neuroinflammation, vol. 9, 2022, : e200034 .
Kaaden, T., Madlener, M., Angstwurm, K., Bien, C., Bogarin, Y., Doppler, K., Finke, A., Gerner, S.T., Reimann, G., Hausler, M., Handreka, R., Hellwig, K., Kaufmann, M., Kellinghaus, C., Koertvelyessy, P., Kraft, A., Lewerenz, J., Menge, T., Paliantonis, A., von Podewils, F., Pruss, H., Rauer, S., Ringelstein, M., Rostasy, K., Schirotzek, I., Schwabe, J., Sokolowski, P., Suesse, M., Suhs, K.-W., Surges, R., Tauber, S.C., Thaler, F., Bergh, F.T., Urbanek, C., Wandinger, K.-P., Wildemann, B., Mues, S., Zettl, U., Leypoldt, F., Melzer, N., Geis, C., Malter, M., Kunze, A.: Seizure Semiology in Antibody-Associated Autoimmune Encephalitis. Neurology(R) neuroimmunology & neuroinflammation. 9, : e200034 (2022).
Kaaden, Tillman, Madlener, Marie, Angstwurm, Klemens, Bien, Christian, Bogarin, Yuri, Doppler, Kathrin, Finke, Alexander, Gerner, Stefan T, Reimann, Gernot, Hausler, Martin, Handreka, Robert, Hellwig, Kerstin, Kaufmann, Max, Kellinghaus, Christoph, Koertvelyessy, Peter, Kraft, Andrea, Lewerenz, Jan, Menge, Til, Paliantonis, Asterios, von Podewils, Felix, Pruss, Harald, Rauer, Sebastian, Ringelstein, Marius, Rostasy, Kevin, Schirotzek, Ingo, Schwabe, Julia, Sokolowski, Piotr, Suesse, Marie, Suhs, Kurt-Wolfram, Surges, Rainer, Tauber, Simone C, Thaler, Franziska, Bergh, Florian Then, Urbanek, Christian, Wandinger, Klaus-P, Wildemann, Brigitte, Mues, Sigrid, Zettl, Uwe, Leypoldt, Frank, Melzer, Nico, Geis, Christian, Malter, Michael, and Kunze, Albrecht. “Seizure Semiology in Antibody-Associated Autoimmune Encephalitis”. Neurology(R) neuroimmunology & neuroinflammation 9.6 (2022): e200034 .

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