Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing
Reisch LM, Wegrzyn M, Mielke M, Mehlmann A, Wörmann F, Kißler J, Bien C (2022)
Human Brain Mapping 43: 3293-3305.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Autor*in
Einrichtung
Medizinische Fakultät OWL > AG 104 Epileptologie
Center of Excellence - Cognitive Interaction Technology CITEC > Affektive Neuropsychologie
Fakultät für Psychologie und Sportwissenschaft > Abteilung für Psychologie > Arbeitseinheit 02 - Allgemeine Psychologie II
Fakultät für Psychologie und Sportwissenschaft > Abteilung für Psychologie > Arbeitseinheit 14 - Biopsychologie und Kognitive Neurowissenschaften
Center of Excellence - Cognitive Interaction Technology CITEC > Affektive Neuropsychologie
Fakultät für Psychologie und Sportwissenschaft > Abteilung für Psychologie > Arbeitseinheit 02 - Allgemeine Psychologie II
Fakultät für Psychologie und Sportwissenschaft > Abteilung für Psychologie > Arbeitseinheit 14 - Biopsychologie und Kognitive Neurowissenschaften
Abstract / Bemerkung
Enhanced visual cortex activation by negative compared to neutral stimuli is often attributed to modulating feedback from the amygdala, but evidence from lesion studies is scarce, particularly regarding differential effects of left and right amygdala lesions. Therefore, we compared visual cortex activation by negative and neutral complex scenes in an event-related fMRI study between 40 patients with unilateral temporal lobe resection (TLR; 19 left [lTLR], 21 right [rTLR]), including the amygdala, and 20 healthy controls. We found preserved hemodynamic emotion modulation of visual cortex in rTLR patients and only subtle reductions in lTLR patients. In contrast, rTLR patients showed a significant decrease in visual cortex activation irrespective of picture content. In line with this, healthy controls showed small emotional modulation of the left amygdala only, while their right amygdala was activated equally by negative and neutral pictures. Correlations of activation in amygdala and visual cortex were observed for both negative and neutral pictures in the controls. In both patient groups, this relationship was attenuated ipsilateral to the TLR. Our results support the notion of reentrant mechanisms between amygdala and visual cortex and suggest laterality differences in their emotion-specificity. While right medial temporal lobe structures including the amygdala seem to influence visual processing in general, the left medial temporal lobe appears to contribute specifically to emotion processing. Still, effects of left TLR on visual emotion processing were relatively subtle. Therefore, hemodynamic correlates of visual emotion processing are likely supported by a distributed cerebral network, challenging an amygdalocentric view of emotion processing. © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Erscheinungsjahr
2022
Zeitschriftentitel
Human Brain Mapping
Band
43
Seite(n)
3293-3305
Urheberrecht / Lizenzen
eISSN
1097-0193
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2962324
Zitieren
Reisch LM, Wegrzyn M, Mielke M, et al. Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing. Human Brain Mapping. 2022;43:3293-3305.
Reisch, L. M., Wegrzyn, M., Mielke, M., Mehlmann, A., Wörmann, F., Kißler, J., & Bien, C. (2022). Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing. Human Brain Mapping, 43, 3293-3305. https://doi.org/10.1002/hbm.25852
Reisch, Lea Marie, Wegrzyn, Martin, Mielke, Malena, Mehlmann, Alexandra, Wörmann, Friedrich, Kißler, Johanna, and Bien, Christian. 2022. “Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing”. Human Brain Mapping 43: 3293-3305.
Reisch, L. M., Wegrzyn, M., Mielke, M., Mehlmann, A., Wörmann, F., Kißler, J., and Bien, C. (2022). Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing. Human Brain Mapping 43, 3293-3305.
Reisch, L.M., et al., 2022. Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing. Human Brain Mapping, 43, p 3293-3305.
L.M. Reisch, et al., “Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing”, Human Brain Mapping, vol. 43, 2022, pp. 3293-3305.
Reisch, L.M., Wegrzyn, M., Mielke, M., Mehlmann, A., Wörmann, F., Kißler, J., Bien, C.: Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing. Human Brain Mapping. 43, 3293-3305 (2022).
Reisch, Lea Marie, Wegrzyn, Martin, Mielke, Malena, Mehlmann, Alexandra, Wörmann, Friedrich, Kißler, Johanna, and Bien, Christian. “Effects of left and right medial temporal lobe resections on hemodynamic correlates of negative and neutral scene processing”. Human Brain Mapping 43 (2022): 3293-3305.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International (CC BY-NC-ND 4.0):
Volltext(e)
Access Level
![Open access file OA](https://pub.uni-bielefeld.de/images/access_open.png)
Zuletzt Hochgeladen
2022-09-01T12:35:48Z
MD5 Prüfsumme
b6e78b60693fbff5ec6f741628fbedfa
Daten bereitgestellt von European Bioinformatics Institute (EBI)
Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
References
Daten bereitgestellt von Europe PubMed Central.
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 35384132
PubMed | Europe PMC
Suchen in