Relative Source Power: A novel method for localizing epileptiform EEG discharges

Scherg M, Schulz R, Berg P, Cho J-H, Bornfleth H, Kural MA, Wörmann F, Bien C, Beniczky S (2021)
Clinical Neurophysiology 133: 9-19.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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Autor*in
Scherg, Michael; Schulz, Reinhard; Berg, Patrick; Cho, Jae-Hyun; Bornfleth, Harald; Kural, Mustafa A; Wörmann, Friedrich ; Bien, ChristianUniBi; Beniczky, Sandor
Abstract / Bemerkung
OBJECTIVE: To validate relative source power (RSP) imaging of extratemporal interictal epileptiform discharges (IEDs).; METHODS: The accuracy of RSP was validated in a cohort of patients with extratemporal focal epilepsy and a confined epileptogenic lesion (<19cm3) using distance to the lesion, concordance with resected area and postoperative outcome. Performance was compared with three conventional methods: voltage maps, equivalent current dipole and a distributed source model.; RESULTS: Thirty-three of 41 consecutive patients (80%) had IED averages suitable for analysis. While the peak negativity in voltage maps localized above the epileptogenic lesion only in 18 cases, RSP-maps matched in 29 cases (88%, p<0.0026). Source localization showed a median distance of 9.8mm from the lesion. Source-regions with 20mm radius included 98% of all source-to-lesion distances. In the 21 surgical cases, outcome showed a sensitivity of 82.35% and specificity of 50% without significant differences between the three source imaging methods.; CONCLUSIONS: RSP-maps provide a rapid, intuitive and more accurate source estimation than voltage maps. At sublobar level, RSP localizes with an accuracy similar to conventional methods and results of previous studies.; SIGNIFICANCE: The definition of a source region with 20mm radius helps in guiding further exploration in extratemporal focal epilepsy. Copyright © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
Erscheinungsjahr
2021
Zeitschriftentitel
Clinical Neurophysiology
Band
133
Seite(n)
9-19
eISSN
1872-8952
Page URI
https://pub.uni-bielefeld.de/record/2959620

Zitieren

Scherg M, Schulz R, Berg P, et al. Relative Source Power: A novel method for localizing epileptiform EEG discharges. Clinical Neurophysiology . 2021;133:9-19.
Scherg, M., Schulz, R., Berg, P., Cho, J. - H., Bornfleth, H., Kural, M. A., Wörmann, F., et al. (2021). Relative Source Power: A novel method for localizing epileptiform EEG discharges. Clinical Neurophysiology , 133, 9-19. https://doi.org/10.1016/j.clinph.2021.10.005
Scherg, Michael, Schulz, Reinhard, Berg, Patrick, Cho, Jae-Hyun, Bornfleth, Harald, Kural, Mustafa A, Wörmann, Friedrich, Bien, Christian, and Beniczky, Sandor. 2021. “Relative Source Power: A novel method for localizing epileptiform EEG discharges”. Clinical Neurophysiology 133: 9-19.
Scherg, M., Schulz, R., Berg, P., Cho, J. - H., Bornfleth, H., Kural, M. A., Wörmann, F., Bien, C., and Beniczky, S. (2021). Relative Source Power: A novel method for localizing epileptiform EEG discharges. Clinical Neurophysiology 133, 9-19.
Scherg, M., et al., 2021. Relative Source Power: A novel method for localizing epileptiform EEG discharges. Clinical Neurophysiology , 133, p 9-19.
M. Scherg, et al., “Relative Source Power: A novel method for localizing epileptiform EEG discharges”, Clinical Neurophysiology , vol. 133, 2021, pp. 9-19.
Scherg, M., Schulz, R., Berg, P., Cho, J.-H., Bornfleth, H., Kural, M.A., Wörmann, F., Bien, C., Beniczky, S.: Relative Source Power: A novel method for localizing epileptiform EEG discharges. Clinical Neurophysiology . 133, 9-19 (2021).
Scherg, Michael, Schulz, Reinhard, Berg, Patrick, Cho, Jae-Hyun, Bornfleth, Harald, Kural, Mustafa A, Wörmann, Friedrich, Bien, Christian, and Beniczky, Sandor. “Relative Source Power: A novel method for localizing epileptiform EEG discharges”. Clinical Neurophysiology 133 (2021): 9-19.
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