Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality

Fauser S, Elger CE, Wörmann F, Bien C (2021)
Epilepsia.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA 1.09 MB
Autor*in
Fauser, Susanne; Elger, Christian E; Wörmann, Friedrich; Bien, ChristianUniBi
Abstract / Bemerkung
OBJECTIVE: Rasmussen encephalitis (RE) is a progressive and destructive inflammatory disease of one hemisphere. Its cause is unknown. We investigated comorbidity and laterality factors that might predispose to RE.; METHODS: We retrospectively compared the histories of 160 RE patients to those with genetic generalized epilepsy (n=154) and those with focal cortical dysplasia Type II (FCD II; n=148).; RESULTS: The median/mean age at symptom onset in RE was 7/10years (range = 1-53years), and 58.1% of the patients were female. The female sex predominated in RE patients, with age > 7years at disease manifestation. The left hemisphere was affected in 65.6%. Perinatal complications (preterm birth, twin pregnancies, early acquired brain lesions) were more frequent in RE than in control patients. Ipsilateral facial autoimmune conditions (scleroderma en coup de sabre, uveitis, or chorioretinitis) were only observed in RE patients (6.9%). Onset of RE was more frequently associated with fever than that of FCD II. In 33.1% of RE patients, ≥1 potential risk factor was found. Interestingly, 11.9% of patients had one-sided early brain lesions or facial autoimmune lesions ipsilateral to subsequent RE; none had such a lesion contralaterally.; SIGNIFICANCE: Perinatal complications and facial autoimmune conditions may act as predisposing factors for RE. Fever might trigger RE manifestation. Further genetic or infectious contributors may be identified in the future. Single or combined hits may be required to elicit or facilitate the start of the disease. Ipsilateral early comorbid lesions or facial autoimmune processes might in part explain the enigmatic unilaterality of RE. © 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
Erscheinungsjahr
2021
Zeitschriftentitel
Epilepsia
eISSN
1528-1167
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Universität Bielefeld im Rahmen des DEAL-Vertrags gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2959610

Zitieren

Fauser S, Elger CE, Wörmann F, Bien C. Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality. Epilepsia. 2021.
Fauser, S., Elger, C. E., Wörmann, F., & Bien, C. (2021). Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality. Epilepsia. https://doi.org/10.1111/epi.17131
Fauser, Susanne, Elger, Christian E, Wörmann, Friedrich, and Bien, Christian. 2021. “Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality”. Epilepsia.
Fauser, S., Elger, C. E., Wörmann, F., and Bien, C. (2021). Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality. Epilepsia.
Fauser, S., et al., 2021. Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality. Epilepsia.
S. Fauser, et al., “Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality”, Epilepsia, 2021.
Fauser, S., Elger, C.E., Wörmann, F., Bien, C.: Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality. Epilepsia. (2021).
Fauser, Susanne, Elger, Christian E, Wörmann, Friedrich, and Bien, Christian. “Rasmussen encephalitis: Predisposing factors and their potential role in unilaterality”. Epilepsia (2021).
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Creative Commons Namensnennung-Nicht kommerziell 4.0 International (CC BY-NC 4.0):
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2022-07-06T13:17:31Z
MD5 Prüfsumme
00a63a54cb3899321edf19011702bdc9

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 34820830
PubMed | Europe PMC

Suchen in

Google Scholar