Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort

Creutz I, Busche T, Layer F, Bednarz H, Kalinowski J, Niehaus K (2021)
Travel medicine and infectious disease: 102204.

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Abstract / Bemerkung
BACKGROUND: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) seem to be highly transmissible, often infect otherwise healthy humans and frequently occur in hospital outbreaks.; METHODS: Refugees, living in accommodations in Germany were screened for nasal carriage of S. aureus. The isolates were investigated regarding resistance and virulence, phenotypically and by whole genome data analysis.; RESULTS: 5.6% (9/161) of the refugees are carriers of S. aureus. 2.5% (4/161) are MRSA carriers. Among the refugees, spa-types t021, t084, t304, t991 and t4983 were detected, as well as the new spa-types t18794 and t18795. t304 and t991 are assumed to be local spa-types from the middle east. The isolates are less resistant and marginal biofilm formers. Each isolate has a remarkable set of virulence genes, although genes, encoding for proteins strongly associated with invasive S. aureus infections, like Panton-Valentine leucocidin, were not detected.; CONCLUSION: The detection of strains from the middle east, supports the assumption that strains co-travel with the refugees and persist despite a transition of the host's living conditions. Whole genome data analysis does not permit to finally evaluate a germ's virulence. Nevertheless, an impression of the virulence potential of the strains, regarding skills in colonization, resistance, immune evasion, and host cell damaging can be pictured. Copyright © 2021. Published by Elsevier Ltd.
Erscheinungsjahr
2021
Zeitschriftentitel
Travel medicine and infectious disease
Art.-Nr.
102204
ISSN
1873-0442
Page URI
https://pub.uni-bielefeld.de/record/2959606

Zitieren

Creutz I, Busche T, Layer F, Bednarz H, Kalinowski J, Niehaus K. Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort. Travel medicine and infectious disease. 2021: 102204.
Creutz, I., Busche, T., Layer, F., Bednarz, H., Kalinowski, J., & Niehaus, K. (2021). Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort. Travel medicine and infectious disease, 102204. https://doi.org/10.1016/j.tmaid.2021.102204
Creutz, Ines, Busche, Tobias, Layer, Franziska, Bednarz, Hanna, Kalinowski, Jörn, and Niehaus, Karsten. 2021. “Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort”. Travel medicine and infectious disease: 102204.
Creutz, I., Busche, T., Layer, F., Bednarz, H., Kalinowski, J., and Niehaus, K. (2021). Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort. Travel medicine and infectious disease:102204.
Creutz, I., et al., 2021. Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort. Travel medicine and infectious disease, : 102204.
I. Creutz, et al., “Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort”, Travel medicine and infectious disease, 2021, : 102204.
Creutz, I., Busche, T., Layer, F., Bednarz, H., Kalinowski, J., Niehaus, K.: Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort. Travel medicine and infectious disease. : 102204 (2021).
Creutz, Ines, Busche, Tobias, Layer, Franziska, Bednarz, Hanna, Kalinowski, Jörn, and Niehaus, Karsten. “Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort”. Travel medicine and infectious disease (2021): 102204.

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