Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center

Cloppenborg T, Mertens M, Hopf J, Kalbhenn T, Bien C, Wörmann F, Polster T (2021)
Epilepsy & Behavior 124: 108274.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Cloppenborg, Thomas; Mertens, Markus; Hopf, Johanna ; Kalbhenn, Thilo; Bien, ChristianUniBi; Wörmann, Friedrich ; Polster, Tilman
Abstract / Bemerkung
Objective: Presurgical evaluation has no established routine to assess reading competence and to identify essential "not to resect" reading areas. Functional models describe a visual word form area (VWFA) located in the midfusiform gyrus in the dominant ventral occipito-temporal cortex (vOTC) as essential for reading. We demonstrate the relevance and feasibility of invasive VWFA-mapping. Methods: Four patients with epilepsy received invasive VWFA-mapping via left temporo-basal strip electrodes. Co-registration of the results and additional data from the literature led to the definition of a region of interest (ROI) for a retrospective assessment of postoperative reading deficits by a standardized telephone-interview in patients with resections in this ROI between 2004 and 2018. Results: Electrical cortical stimulation disturbed whole word recognition and reading in four patients with structural epilepsy. Stimulation results showed distribution in the basal temporal lobe (dorsal mesencephalon to preoccipital notch). We identified 34 patients with resections in the ROI of the dominant hemisphere. Of these, 15 (44.1%) showed a postoperative reading deficit with a mean duration of 18.2 months (+/-32.4, 0.5-122). Six patients suffered from letter-by-letter (LBL) reading. Two patients had permanent LBL reading after resection in the ROI. Significance: We present evidence on the functional relevance of the vOTC for reading by (1) extra operative cortical stimulation of the VWFA and by (2) a retrospective case study of reading deficits in patients operated in this area. Reading assessments and data concerning essential reading structures should be included in the presurgical evaluation of patients with lesions in the left vOTC. (c) 2021 Elsevier Inc. All rights reserved.
Stichworte
Epilepsy surgery; Visual word form area; Reading; Letter-by-letter; reading; Ventral occipito-temporal cortex
Erscheinungsjahr
2021
Zeitschriftentitel
Epilepsy & Behavior
Band
124
Art.-Nr.
108274
ISSN
1525-5050
eISSN
1525-5069
Page URI
https://pub.uni-bielefeld.de/record/2957733

Zitieren

Cloppenborg T, Mertens M, Hopf J, et al. Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center. Epilepsy & Behavior. 2021;124: 108274.
Cloppenborg, T., Mertens, M., Hopf, J., Kalbhenn, T., Bien, C., Wörmann, F., & Polster, T. (2021). Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center. Epilepsy & Behavior, 124, 108274. https://doi.org/10.1016/j.yebeh.2021.108274
Cloppenborg, T., Mertens, M., Hopf, J., Kalbhenn, T., Bien, C., Wörmann, F., and Polster, T. (2021). Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center. Epilepsy & Behavior 124:108274.
Cloppenborg, T., et al., 2021. Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center. Epilepsy & Behavior, 124: 108274.
T. Cloppenborg, et al., “Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center”, Epilepsy & Behavior, vol. 124, 2021, : 108274.
Cloppenborg, T., Mertens, M., Hopf, J., Kalbhenn, T., Bien, C., Wörmann, F., Polster, T.: Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center. Epilepsy & Behavior. 124, : 108274 (2021).
Cloppenborg, Thomas, Mertens, Markus, Hopf, Johanna, Kalbhenn, Thilo, Bien, Christian, Wörmann, Friedrich, and Polster, Tilman. “Reading and the visual word form area (VWFA)-Management and clinical experience at one epilepsy surgery center”. Epilepsy & Behavior 124 (2021): 108274.

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