Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome
Peng B, Geue S, Coman C, Münzer P, Kopczynski D, Has C, Hoffmann N, Manke M-C, Lang F, Sickmann A, Gawaz M, et al. (2018)
Blood 132(5): e1-e12.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Peng, Bing;
Geue, Sascha;
Coman, Cristina;
Münzer, Patrick;
Kopczynski, Dominik;
Has, Canan;
Hoffmann, NilsUniBi
;
Manke, Mailin-Christin;
Lang, Florian;
Sickmann, Albert;
Gawaz, Meinrad;
Borst, Oliver
Alle
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Alle
Einrichtung
Abstract / Bemerkung
Platelet integrity and function critically depend on lipid composition. However, the lipid inventory in platelets was hitherto not quantified. Here, we examined the lipidome of murine platelets using lipid-category tailored protocols on a quantitative lipidomics platform. We could show that the platelet lipidome comprises almost 400 lipid species and covers a concentration range of 7 orders of magnitude. A systematic comparison of the lipidomics network in resting and activated murine platelets, validated in human platelets, revealed that <20% of the platelet lipidome is changed upon activation, involving mainly lipids containing arachidonic acid. Sphingomyelin phosphodiesterase-1 (Smpd1) deficiency resulted in a very specific modulation of the platelet lipidome with an order of magnitude upregulation of lysosphingomyelin (SPC), and subsequent modification of platelet activation and thrombus formation. In conclusion, this first comprehensive quantitative lipidomic analysis of platelets sheds light on novel mechanisms important for platelet function, and has therefore the potential to open novel diagnostic and therapeutic opportunities.
Erscheinungsjahr
2018
Zeitschriftentitel
Blood
Band
132
Ausgabe
5
Seite(n)
e1-e12
ISSN
0006-4971
eISSN
1528-0020
Page URI
https://pub.uni-bielefeld.de/record/2956713
Zitieren
Peng B, Geue S, Coman C, et al. Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood. 2018;132(5):e1-e12.
Peng, B., Geue, S., Coman, C., Münzer, P., Kopczynski, D., Has, C., Hoffmann, N., et al. (2018). Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood, 132(5), e1-e12. https://doi.org/10.1182/blood-2017-12-822890
Peng, Bing, Geue, Sascha, Coman, Cristina, Münzer, Patrick, Kopczynski, Dominik, Has, Canan, Hoffmann, Nils, et al. 2018. “Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome”. Blood 132 (5): e1-e12.
Peng, B., Geue, S., Coman, C., Münzer, P., Kopczynski, D., Has, C., Hoffmann, N., Manke, M. - C., Lang, F., Sickmann, A., et al. (2018). Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood 132, e1-e12.
Peng, B., et al., 2018. Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood, 132(5), p e1-e12.
B. Peng, et al., “Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome”, Blood, vol. 132, 2018, pp. e1-e12.
Peng, B., Geue, S., Coman, C., Münzer, P., Kopczynski, D., Has, C., Hoffmann, N., Manke, M.-C., Lang, F., Sickmann, A., Gawaz, M., Borst, O., Ahrends, R.: Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome. Blood. 132, e1-e12 (2018).
Peng, Bing, Geue, Sascha, Coman, Cristina, Münzer, Patrick, Kopczynski, Dominik, Has, Canan, Hoffmann, Nils, Manke, Mailin-Christin, Lang, Florian, Sickmann, Albert, Gawaz, Meinrad, Borst, Oliver, and Ahrends, Robert. “Identification of key lipids critical for platelet activation by comprehensive analysis of the platelet lipidome”. Blood 132.5 (2018): e1-e12.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
References
Daten bereitgestellt von Europe PubMed Central.
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 29784642
PubMed | Europe PMC
Suchen in