Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes

von Lukowicz H, Poets CF, Peters T, Wilhelm B, Schlarb A, Urschitz MS (2021)
Sleep Medicine 83: 145-150.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
von Lukowicz, Hannah; Poets, Christian F.; Peters, Tobias; Wilhelm, Barbara; Schlarb, AngelikaUniBi; Urschitz, Michael S.
Abstract / Bemerkung
Objectives: To report validation data for the Pupillographic Sleepiness Test (PST) in children and adolescents, evaluate its applicability for diagnosing excessive daytime sleepiness and its relationship to sleepiness-associated outcomes. Methods: A cross-sectional diagnostic test accuracy study was performed. Patients underwent three PST at 9 a.m. (T1), 11 a.m. (T2) and 1 p.m. (T3) plus the Multiple Sleep Latency Test (MSLT) on a single day. Additionally, two neurocognitive tests were performed and three questionnaires about quality of life, sleep-related self-efficacy and behavioural aspects completed. Gender-stratified z-values of the natural logarithm of the Pupillary Unrest Index (z-lnPUI) were correlated to Sleep Latency (SL) and Mean Sleep Latency (MSL) and to variables of neurocognitive tests and questionnaires using Spearman's rank correlation. Cut-off values were determined by receiver operating characteristic (ROC) analysis. Results: 47 patients were recruited (median 10.6 years, range 6e18). Correlation between z-lnPUI and SL was r(T1) = -0.373 (p = 0.011); r(T2) = -0.320 (p = 0.028) and r(T3) = -0.336 (p = 0.022). Correlation between z-lnPUI and MSL was r(T1) = -0.338 (p = 0.020); r(T2) = -0.202 (p = 0.173); r(T3) = -0.117 (p = 0.433). ROC analysis showed an area under the curve of 90.7% and PUI cut-off values of 12.6 mm/min (boys) and 11.6 mm/min (girls). There were moderate correlations between z-lnPUI(T1) and reaction time and omission errors in neurocognitive tests (r = 0.394, p = 0.007 and 0.391, p = 0.008). Conclusions: We found satisfactory correlations between PST and MSLT results. The z-lnPUI(T1) was related to MSL and objective measures of attention ability. Given this accuracy, the PST may be used as a screening tool for evaluating daytime sleepiness in children and adolescents. Corresponding gender-related reference values are now available. (C) 2021 Elsevier B.V. All rights reserved.
Stichworte
Pupillography; Daytime sleepiness; Sleepiness testing; Central nervous; activation; Alertness; Hypersomnia
Erscheinungsjahr
2021
Zeitschriftentitel
Sleep Medicine
Band
83
Seite(n)
145-150
ISSN
1389-9457
eISSN
1878-5506
Page URI
https://pub.uni-bielefeld.de/record/2956296

Zitieren

von Lukowicz H, Poets CF, Peters T, Wilhelm B, Schlarb A, Urschitz MS. Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes. Sleep Medicine. 2021;83:145-150.
von Lukowicz, H., Poets, C. F., Peters, T., Wilhelm, B., Schlarb, A., & Urschitz, M. S. (2021). Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes. Sleep Medicine, 83, 145-150. https://doi.org/10.1016/j.sleep.2021.04.030
von Lukowicz, H., Poets, C. F., Peters, T., Wilhelm, B., Schlarb, A., and Urschitz, M. S. (2021). Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes. Sleep Medicine 83, 145-150.
von Lukowicz, H., et al., 2021. Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes. Sleep Medicine, 83, p 145-150.
H. von Lukowicz, et al., “Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes”, Sleep Medicine, vol. 83, 2021, pp. 145-150.
von Lukowicz, H., Poets, C.F., Peters, T., Wilhelm, B., Schlarb, A., Urschitz, M.S.: Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes. Sleep Medicine. 83, 145-150 (2021).
von Lukowicz, Hannah, Poets, Christian F., Peters, Tobias, Wilhelm, Barbara, Schlarb, Angelika, and Urschitz, Michael S. “Validity of the Pupillographic Sleepiness Test for the diagnosis of daytime sleepiness in children and adolescents and its relationship to sleepiness-associated outcomes”. Sleep Medicine 83 (2021): 145-150.

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