Self-assembly of the isolated KCNQ2 subunit interaction domain
Wehling C, Beimgraben C, Gelhaus C, Friedrich T, Saftig P, Grötzinger J, Schwake M (2007)
FEBS Letters 581(8): 1594-1598.
Zeitschriftenaufsatz
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Autor*in
Wehling, Christina;
Beimgraben, Christian;
Gelhaus, Christoph;
Friedrich, Thomas;
Saftig, Paul;
Grötzinger, Joachim;
Schwake, MichaelUniBi 
Einrichtung
Abstract / Bemerkung
Mutations in the KCNQ2 gene cause myokymia and neonatal epilepsy, indicating that this K+ channel regulates the excitability of lower motoneurons and CNS neurons. Little is known about the parameters that direct the assembly of this multimeric molecule and other KCNQ subunits. Here, we show that the carboxy-terminal subunit interaction domain of KCNQ2 autonomously folds and assembles into tetramers. This domain contains a bipartite coiled-coil motif. Whereas structural integrity of the second coiled-coil motif is crucial for tetramer formation, that of the first motif is less important. These data suggest a crucial role of coiled-coil motifs in tetrameric KCNQ channel assembly.
Erscheinungsjahr
2007
Zeitschriftentitel
FEBS Letters
Band
581
Ausgabe
8
Seite(n)
1594-1598
ISSN
00145793
Page URI
https://pub.uni-bielefeld.de/record/2953354
Zitieren
Wehling C, Beimgraben C, Gelhaus C, et al. Self-assembly of the isolated KCNQ2 subunit interaction domain. FEBS Letters. 2007;581(8):1594-1598.
Wehling, C., Beimgraben, C., Gelhaus, C., Friedrich, T., Saftig, P., Grötzinger, J., & Schwake, M. (2007). Self-assembly of the isolated KCNQ2 subunit interaction domain. FEBS Letters, 581(8), 1594-1598. https://doi.org/10.1016/j.febslet.2007.03.024
Wehling, Christina, Beimgraben, Christian, Gelhaus, Christoph, Friedrich, Thomas, Saftig, Paul, Grötzinger, Joachim, and Schwake, Michael. 2007. “Self-assembly of the isolated KCNQ2 subunit interaction domain”. FEBS Letters 581 (8): 1594-1598.
Wehling, C., Beimgraben, C., Gelhaus, C., Friedrich, T., Saftig, P., Grötzinger, J., and Schwake, M. (2007). Self-assembly of the isolated KCNQ2 subunit interaction domain. FEBS Letters 581, 1594-1598.
Wehling, C., et al., 2007. Self-assembly of the isolated KCNQ2 subunit interaction domain. FEBS Letters, 581(8), p 1594-1598.
C. Wehling, et al., “Self-assembly of the isolated KCNQ2 subunit interaction domain”, FEBS Letters, vol. 581, 2007, pp. 1594-1598.
Wehling, C., Beimgraben, C., Gelhaus, C., Friedrich, T., Saftig, P., Grötzinger, J., Schwake, M.: Self-assembly of the isolated KCNQ2 subunit interaction domain. FEBS Letters. 581, 1594-1598 (2007).
Wehling, Christina, Beimgraben, Christian, Gelhaus, Christoph, Friedrich, Thomas, Saftig, Paul, Grötzinger, Joachim, and Schwake, Michael. “Self-assembly of the isolated KCNQ2 subunit interaction domain”. FEBS Letters 581.8 (2007): 1594-1598.
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