Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits

Valkova C, Albrizio M, Roder IV, Schwake M, Betto R, Rudolf R, Kaether C (2011)
Proceedings of the National Academy of Sciences 108(2): 621-625.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Valkova, C.; Albrizio, M.; Roder, I. V.; Schwake, MichaelUniBi ; Betto, R.; Rudolf, R.; Kaether, C.
Abstract / Bemerkung
The nicotinic acetylcholine receptor of skeletal muscle is composed of five subunits that are assembled in a stepwise manner. Quality control mechanisms ensure that only fully assembled receptors reach the cell surface. Here, we show that Rer1, a putative Golgi-ER retrieval receptor, is involved in the biogenesis of acetylcholine receptors. Rer1 is expressed in the early secretory pathway in the myoblast line C2C12 and in mouse skeletal muscle, and up-regulated during myogenesis. Upon down-regulation of Rer1 in C2C12 cells, unassembled acetylcholine receptor α-subunits escape from the ER and are transported to the plasma membrane and lysosomes, where they are degraded. As a result, the amount of fully assembled receptor at the cell surface is reduced. In vivo Rer1 knockdown and genetic inactivation of one Rer1 allele lead to significantly smaller neuromuscular junctions in mice. Our data show that Rer1 is a functionally important unique factor that controls surface expression of muscle acetylcholine receptors by localizing unassembled α-subunits to the early secretory pathway.
Erscheinungsjahr
2011
Zeitschriftentitel
Proceedings of the National Academy of Sciences
Band
108
Ausgabe
2
Seite(n)
621-625
ISSN
0027-8424
eISSN
1091-6490
Page URI
https://pub.uni-bielefeld.de/record/2953345

Zitieren

Valkova C, Albrizio M, Roder IV, et al. Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits. Proceedings of the National Academy of Sciences. 2011;108(2):621-625.
Valkova, C., Albrizio, M., Roder, I. V., Schwake, M., Betto, R., Rudolf, R., & Kaether, C. (2011). Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits. Proceedings of the National Academy of Sciences, 108(2), 621-625. https://doi.org/10.1073/pnas.1001624108
Valkova, C., Albrizio, M., Roder, I. V., Schwake, M., Betto, R., Rudolf, R., and Kaether, C. (2011). Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits. Proceedings of the National Academy of Sciences 108, 621-625.
Valkova, C., et al., 2011. Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits. Proceedings of the National Academy of Sciences, 108(2), p 621-625.
C. Valkova, et al., “Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits”, Proceedings of the National Academy of Sciences, vol. 108, 2011, pp. 621-625.
Valkova, C., Albrizio, M., Roder, I.V., Schwake, M., Betto, R., Rudolf, R., Kaether, C.: Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits. Proceedings of the National Academy of Sciences. 108, 621-625 (2011).
Valkova, C., Albrizio, M., Roder, I. V., Schwake, Michael, Betto, R., Rudolf, R., and Kaether, C. “Sorting receptor Rer1 controls surface expression of muscle acetylcholine receptors by ER retention of unassembled α-subunits”. Proceedings of the National Academy of Sciences 108.2 (2011): 621-625.

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