A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase

Zachos C, Blanz J, Saftig P, Schwake M (2012)
Traffic 13(8): 1113-1123.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Zachos, Christina; Blanz, Judith; Saftig, Paul; Schwake, MichaelUniBi
Alternativer Titel
A Histidine in LIMP-2 Controls Binding to GC
Abstract / Bemerkung
The lysosomal membrane protein type 2 is a novel identified lysosomal sorting receptor for β-glucocerebrosidase (GC). Mutations in both genes underlie human pathologies causing action myoclonus-renal failure syndrome (AMRF) and Gaucher disease (GD), respectively. We now demonstrate that the lumenal acidification mediated by the vacuolar (H+)-ATPase triggers the dissociation of LIMP-2 and GC in late endosomal/lysosomal compartments. Moreover, we identified a single histidine residue in LIMP-2 that is necessary for LIMP-2 and GC binding. This residue is in close proximity to a proposed coiled-coil domain, which determines the binding to GC and may function as a critical pH sensor.
Erscheinungsjahr
2012
Zeitschriftentitel
Traffic
Band
13
Ausgabe
8
Seite(n)
1113-1123
ISSN
1398-9219
Page URI
https://pub.uni-bielefeld.de/record/2953340

Zitieren

Zachos C, Blanz J, Saftig P, Schwake M. A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase. Traffic. 2012;13(8):1113-1123.
Zachos, C., Blanz, J., Saftig, P., & Schwake, M. (2012). A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase. Traffic, 13(8), 1113-1123. https://doi.org/10.1111/j.1600-0854.2012.01372.x
Zachos, C., Blanz, J., Saftig, P., and Schwake, M. (2012). A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase. Traffic 13, 1113-1123.
Zachos, C., et al., 2012. A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase. Traffic, 13(8), p 1113-1123.
C. Zachos, et al., “A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase”, Traffic, vol. 13, 2012, pp. 1113-1123.
Zachos, C., Blanz, J., Saftig, P., Schwake, M.: A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase. Traffic. 13, 1113-1123 (2012).
Zachos, Christina, Blanz, Judith, Saftig, Paul, and Schwake, Michael. “A Critical Histidine Residue Within LIMP-2 Mediates pH Sensitive Binding to Its Ligand β-Glucocerebrosidase”. Traffic 13.8 (2012): 1113-1123.
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