Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin

Guerrero-Garzon JF, Madland E, Zehl M, Singh M, Rezaei S, Aachmann FL, Courtade G, Urban E, Rückert C, Busche T, Kalinowski J, et al. (2020)
iScience 23(12): 101785.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Guerrero-Garzon, Jaime Felipe; Madland, Eva; Zehl, Martin; Singh, Madhurendra; Rezaei, Shiva; Aachmann, Finn L; Courtade, Gaston; Urban, Ernst; Rückert, ChristianUniBi ; Busche, TobiasUniBi; Kalinowski, JörnUniBi; Cao, Yan-Ru
Alle
Abstract / Bemerkung
Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed investigation revealed, that pre-treatment of cancer cells with a mixture of felipeptins resulted in downregulation of the tumor suppressor Rb, making the cancer cells to proliferate faster. Pre-treatment with felipeptins made cancer cells considerably more sensitive to the anticancer agent doxorubicin and re-sensitized doxorubicin-resistant cells to this drug. Structural characterization and binding experiments showed an interaction between felipeptins resulting in complex formation, which explains their synergistic effect. This discovery may open an alternative avenue in cancer treatment, helping to eliminate quiescent cells that often lead to cancer relapse. © 2020 The Authors.
Erscheinungsjahr
2020
Zeitschriftentitel
iScience
Band
23
Ausgabe
12
Art.-Nr.
101785
ISSN
2589-0042
Page URI
https://pub.uni-bielefeld.de/record/2949422

Zitieren

Guerrero-Garzon JF, Madland E, Zehl M, et al. Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. iScience. 2020;23(12): 101785.
Guerrero-Garzon, J. F., Madland, E., Zehl, M., Singh, M., Rezaei, S., Aachmann, F. L., Courtade, G., et al. (2020). Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. iScience, 23(12), 101785. doi:10.1016/j.isci.2020.101785
Guerrero-Garzon, J. F., Madland, E., Zehl, M., Singh, M., Rezaei, S., Aachmann, F. L., Courtade, G., Urban, E., Rückert, C., Busche, T., et al. (2020). Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. iScience 23:101785.
Guerrero-Garzon, J.F., et al., 2020. Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. iScience, 23(12): 101785.
J.F. Guerrero-Garzon, et al., “Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin”, iScience, vol. 23, 2020, : 101785.
Guerrero-Garzon, J.F., Madland, E., Zehl, M., Singh, M., Rezaei, S., Aachmann, F.L., Courtade, G., Urban, E., Rückert, C., Busche, T., Kalinowski, J., Cao, Y.-R., Jiang, Y., Jiang, C.-L., Selivanova, G., Zotchev, S.B.: Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin. iScience. 23, : 101785 (2020).
Guerrero-Garzon, Jaime Felipe, Madland, Eva, Zehl, Martin, Singh, Madhurendra, Rezaei, Shiva, Aachmann, Finn L, Courtade, Gaston, Urban, Ernst, Rückert, Christian, Busche, Tobias, Kalinowski, Jörn, Cao, Yan-Ru, Jiang, Yi, Jiang, Cheng-Lin, Selivanova, Galina, and Zotchev, Sergey B. “Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin”. iScience 23.12 (2020): 101785.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 33294793
PubMed | Europe PMC

Suchen in

Google Scholar