A DNA-based voltmeter for organelles

Saminathan, Anand; Devany, John; Veetil, Aneesh Tazhe; Suresh, Bhavyashree; Pillai, Kavya Smitha; Schwake, Michael; Krishnan, Yamuna

A DNA-based voltmeter for organelles

Saminathan A, Devany J, Veetil AT, Suresh B, Pillai KS, Schwake M, Krishnan Y (2020)
Nature Nanotechnology.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch

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DOI

https://doi.org/10.1038/s41565-020-00784-1

Autor*in

Saminathan, Anand; Devany, John; Veetil, Aneesh Tazhe; Suresh, Bhavyashree; Pillai, Kavya Smitha; Schwake, Michael^UniBi ; Krishnan, Yamuna

Einrichtung

Fakultät für Chemie > Biochemie III

Abstract / Bemerkung

The role of membrane potential in most intracellular organelles remains unexplored because of the lack of suitable tools. Here, we describe Voltair, a fluorescent DNA nanodevice that reports the absolute membrane potential and can be targeted to organelles in live cells. Voltair consists of a voltage-sensitive fluorophore and a reference fluorophore for ratiometry, and acts as an endocytic tracer. Using Voltair, we could measure the membrane potential of different organelles in situ in live cells. Voltair can potentially guide the rational design of biocompatible electronics and enhance our understanding of how membrane potential regulates organelle biology.

Erscheinungsjahr

2020

Zeitschriftentitel

Nature Nanotechnology

eISSN

1748-3395

Page URI

https://pub.uni-bielefeld.de/record/2948754

Zitieren

Saminathan A, Devany J, Veetil AT, et al. A DNA-based voltmeter for organelles. Nature Nanotechnology. 2020.

Saminathan, A., Devany, J., Veetil, A. T., Suresh, B., Pillai, K. S., Schwake, M., & Krishnan, Y. (2020). A DNA-based voltmeter for organelles. Nature Nanotechnology. doi:10.1038/s41565-020-00784-1

Saminathan, Anand, Devany, John, Veetil, Aneesh Tazhe, Suresh, Bhavyashree, Pillai, Kavya Smitha, Schwake, Michael, and Krishnan, Yamuna. 2020. “A DNA-based voltmeter for organelles”. Nature Nanotechnology.

Saminathan, A., Devany, J., Veetil, A. T., Suresh, B., Pillai, K. S., Schwake, M., and Krishnan, Y. (2020). A DNA-based voltmeter for organelles. Nature Nanotechnology.

Saminathan, A., et al., 2020. A DNA-based voltmeter for organelles. Nature Nanotechnology.

A. Saminathan, et al., “A DNA-based voltmeter for organelles”, Nature Nanotechnology, 2020.

Saminathan, A., Devany, J., Veetil, A.T., Suresh, B., Pillai, K.S., Schwake, M., Krishnan, Y.: A DNA-based voltmeter for organelles. Nature Nanotechnology. (2020).

Saminathan, Anand, Devany, John, Veetil, Aneesh Tazhe, Suresh, Bhavyashree, Pillai, Kavya Smitha, Schwake, Michael, and Krishnan, Yamuna. “A DNA-based voltmeter for organelles”. Nature Nanotechnology (2020).

Daten bereitgestellt von European Bioinformatics Institute (EBI)