A DNA-based voltmeter for organelles

Saminathan A, Devany J, Veetil AT, Suresh B, Pillai KS, Schwake M, Krishnan Y (2020)
Nature Nanotechnology.

Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
 
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DOI
Autor*in
Saminathan, Anand; Devany, John; Veetil, Aneesh Tazhe; Suresh, Bhavyashree; Pillai, Kavya Smitha; Schwake, MichaelUniBi ; Krishnan, Yamuna
Einrichtung
Fakultät für Chemie > Biochemie III
Abstract / Bemerkung
The role of membrane potential in most intracellular organelles remains unexplored because of the lack of suitable tools. Here, we describe Voltair, a fluorescent DNA nanodevice that reports the absolute membrane potential and can be targeted to organelles in live cells. Voltair consists of a voltage-sensitive fluorophore and a reference fluorophore for ratiometry, and acts as an endocytic tracer. Using Voltair, we could measure the membrane potential of different organelles in situ in live cells. Voltair can potentially guide the rational design of biocompatible electronics and enhance our understanding of how membrane potential regulates organelle biology.
Erscheinungsjahr
2020
Zeitschriftentitel
Nature Nanotechnology
eISSN
1748-3395
Page URI
https://pub.uni-bielefeld.de/record/2948754

Zitieren

Saminathan A, Devany J, Veetil AT, et al. A DNA-based voltmeter for organelles. Nature Nanotechnology. 2020.
Saminathan, A., Devany, J., Veetil, A. T., Suresh, B., Pillai, K. S., Schwake, M., & Krishnan, Y. (2020). A DNA-based voltmeter for organelles. Nature Nanotechnology. doi:10.1038/s41565-020-00784-1
Saminathan, Anand, Devany, John, Veetil, Aneesh Tazhe, Suresh, Bhavyashree, Pillai, Kavya Smitha, Schwake, Michael, and Krishnan, Yamuna. 2020. “A DNA-based voltmeter for organelles”. Nature Nanotechnology.
Saminathan, A., Devany, J., Veetil, A. T., Suresh, B., Pillai, K. S., Schwake, M., and Krishnan, Y. (2020). A DNA-based voltmeter for organelles. Nature Nanotechnology.
Saminathan, A., et al., 2020. A DNA-based voltmeter for organelles. Nature Nanotechnology.
A. Saminathan, et al., “A DNA-based voltmeter for organelles”, Nature Nanotechnology, 2020.
Saminathan, A., Devany, J., Veetil, A.T., Suresh, B., Pillai, K.S., Schwake, M., Krishnan, Y.: A DNA-based voltmeter for organelles. Nature Nanotechnology. (2020).
Saminathan, Anand, Devany, John, Veetil, Aneesh Tazhe, Suresh, Bhavyashree, Pillai, Kavya Smitha, Schwake, Michael, and Krishnan, Yamuna. “A DNA-based voltmeter for organelles”. Nature Nanotechnology (2020).
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