Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes

Schwarzbich S, Horstmann Nee Gruschka C, Simon J, Siebe L, Moreth A, Wiegand C, Lavrentieva A, Scheper T, Stammler A, Bögge H, Fischer von Mollard G, et al. (2020)
Inorganic chemistry 59(19): 14464–14477.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Schwarzbich, Sabrina; Horstmann Nee Gruschka, Claudia; Simon, JasminUniBi; Siebe, LenaUniBi; Moreth, Alexander; Wiegand, ChristianeUniBi; Lavrentieva, Antonina; Scheper, Thomas; Stammler, AnjaUniBi; Bögge, HartmutUniBi; Fischer von Mollard, GabrieleUniBi; Glaser, ThorstenUniBi
Alle
Abstract / Bemerkung
Cytostatic metallo-drugs mostly bind to the nucleobases of DNA. A new family of dinuclear transition metal complexes was rationally designed to selectively target the phosphate diesters of the DNA backbone by covalent bonding. The synthesis and characterization of the first dinuclear NiII2 complex of this family are presented, and its DNA binding and interference with DNA synthesis in polymerase chain reaction (PCR) are investigated and compared to those of the analogous CuII2 complex. The NiII2 complex also binds to DNA but forms fewer intermolecular DNA cross-links, while it interferes with DNA synthesis in PCR at lower concentrations than CuII2. To simulate possible competing phosphate-based ligands in vivo, these effects have been studied for both complexes with 100-200-fold excesses of phosphate and ATP, which provided no disturbance. The cytotoxicity of both complexes has been studied for human cancer cells and human stem cells with similar rates of proliferation. CuII2 shows the lowest IC50 values and a remarkable preference for killing the cancer cells. Three different assays show that the CuII2 complex induces apoptosis in cancer cells. These results are discussed to gain insight into the mechanisms of action and demonstrate the potential of this family of dinuclear complexes as anticancer drugs acting by a new binding target.
Erscheinungsjahr
2020
Zeitschriftentitel
Inorganic chemistry
Band
59
Ausgabe
19
Seite(n)
14464–14477
eISSN
1520-510X
Page URI
https://pub.uni-bielefeld.de/record/2946328

Zitieren

Schwarzbich S, Horstmann Nee Gruschka C, Simon J, et al. Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes. Inorganic chemistry. 2020;59(19):14464–14477.
Schwarzbich, S., Horstmann Nee Gruschka, C., Simon, J., Siebe, L., Moreth, A., Wiegand, C., Lavrentieva, A., et al. (2020). Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes. Inorganic chemistry, 59(19), 14464–14477. doi:10.1021/acs.inorgchem.0c02255
Schwarzbich, S., Horstmann Nee Gruschka, C., Simon, J., Siebe, L., Moreth, A., Wiegand, C., Lavrentieva, A., Scheper, T., Stammler, A., Bögge, H., et al. (2020). Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes. Inorganic chemistry 59, 14464–14477.
Schwarzbich, S., et al., 2020. Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes. Inorganic chemistry, 59(19), p 14464–14477.
S. Schwarzbich, et al., “Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes”, Inorganic chemistry, vol. 59, 2020, pp. 14464–14477.
Schwarzbich, S., Horstmann Nee Gruschka, C., Simon, J., Siebe, L., Moreth, A., Wiegand, C., Lavrentieva, A., Scheper, T., Stammler, A., Bögge, H., Fischer von Mollard, G., Glaser, T.: Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes. Inorganic chemistry. 59, 14464–14477 (2020).
Schwarzbich, Sabrina, Horstmann Nee Gruschka, Claudia, Simon, Jasmin, Siebe, Lena, Moreth, Alexander, Wiegand, Christiane, Lavrentieva, Antonina, Scheper, Thomas, Stammler, Anja, Bögge, Hartmut, Fischer von Mollard, Gabriele, and Glaser, Thorsten. “Stronger Cytotoxicity for Cancer Cells Than for Fast Proliferating Human Stem Cells by Rationally Designed Dinuclear Complexes”. Inorganic chemistry 59.19 (2020): 14464–14477.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 32951424
PubMed | Europe PMC

Suchen in

Google Scholar