Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes

Simon J, Stammler A, Oldengott J, Bögge H, Glaser T (2020)
Inorganic chemistry 59(19): 14615–14619.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
We have rationally designed a family of dinuclear transition-metal complexes to bind two neighboring phosphate diester groups of DNA. The two metal ions are positioned at the distance of two neighboring phosphate diesters in DNA of 6-7 A by a 1,8-naphthalenediol backbone. Two sterically demanding dipicolylamine pendant arms in the 2 and 7 positions stabilize coordination of the metal ions and prevent coordination to the less exposed nucleobases of DNA. Although the dinuclear NiII2 and CuII2 bind to DNA, inhibit DNA synthesis, and preferentially kill human cancer cells over fast proliferating human stem cells, the DNA binding mode was elusive. Here, we prove the principle phosphate diester binding ability of this family of dinuclear complexes by a new dinuclear NiII2 complex with dibenzimidazolamine pendant arms. The distance of the oxygen atoms of the coordinated phosphate diesters of 6.5 A confirms the initial design and binding ability to two neighboring phosphate diesters of the DNA backbone. Moreover, the facile exchange of coordinated acetates by phosphate diesters indicates a preferential binding to phosphate diesters.
Erscheinungsjahr
2020
Zeitschriftentitel
Inorganic chemistry
Band
59
Ausgabe
19
Seite(n)
14615–14619
eISSN
1520-510X
Page URI
https://pub.uni-bielefeld.de/record/2946322

Zitieren

Simon J, Stammler A, Oldengott J, Bögge H, Glaser T. Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes. Inorganic chemistry. 2020;59(19):14615–14619.
Simon, J., Stammler, A., Oldengott, J., Bögge, H., & Glaser, T. (2020). Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes. Inorganic chemistry, 59(19), 14615–14619. doi:10.1021/acs.inorgchem.0c02644
Simon, J., Stammler, A., Oldengott, J., Bögge, H., and Glaser, T. (2020). Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes. Inorganic chemistry 59, 14615–14619.
Simon, J., et al., 2020. Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes. Inorganic chemistry, 59(19), p 14615–14619.
J. Simon, et al., “Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes”, Inorganic chemistry, vol. 59, 2020, pp. 14615–14619.
Simon, J., Stammler, A., Oldengott, J., Bögge, H., Glaser, T.: Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes. Inorganic chemistry. 59, 14615–14619 (2020).
Simon, Jasmin, Stammler, Anja, Oldengott, Jan, Bögge, Hartmut, and Glaser, Thorsten. “Proof of Phosphate Diester Binding Ability of Cytotoxic DNA-Binding Complexes”. Inorganic chemistry 59.19 (2020): 14615–14619.

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