Viennamycins: Lipopeptides Produced by a Streptomyces sp.

Bekiesch P, Zehl M, Domingo-Contreras E, Martin J, Perez-Victoria I, Reyes F, Kaplan A, Rückert C, Busche T, Kalinowski J, Zotchev SB (2020)
Journal of natural products 83(8): 2381–2389.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Bekiesch, Paulina; Zehl, Martin; Domingo-Contreras, Elizabeth; Martin, Jesus; Perez-Victoria, Ignacio; Reyes, Fernando; Kaplan, Arthur; Rückert, ChristianUniBi ; Busche, TobiasUniBi; Kalinowski, JörnUniBi; Zotchev, Sergey B
Abstract / Bemerkung
Extracts from Streptomyces sp. S4.7 isolated from the rhizosphere of edelweiss, an alpine medicinal plant, exhibited activity against Gram-positive bacteria. LC-HRMS analyses of the extracts resulted in the detection of two unknown, structurally related lipopeptides that were assumed to be responsible for the antibiotic activity. LC-MS guided isolation and structure elucidation of viennamycins A and B (1 and 2) by HR-MS/MS, 1D and 2D NMR, and Marfey's analyses revealed them to be novel compounds, with viennamycin A containing cysteic acid, a unique feature for lipopeptides. Tests for antibacterial, antifungal, and cytotoxic activities of purified viennamycins, both with and without divalent cations, did not reveal any bioactivity, suggesting that their biological function, which could not be determined in the tests used, is atypical for lipopeptides. The genome of Streptomyces sp. S4.7 was sequenced and analyzed, revealing the viennamycin biosynthetic gene cluster. Detailed bioinformatics-based analysis of the viennamycin gene cluster allowed elucidation of the biosynthetic pathway for these lipopeptides.
Erscheinungsjahr
2020
Zeitschriftentitel
Journal of natural products
Band
83
Ausgabe
8
Seite(n)
2381–2389
eISSN
1520-6025
Page URI
https://pub.uni-bielefeld.de/record/2945532

Zitieren

Bekiesch P, Zehl M, Domingo-Contreras E, et al. Viennamycins: Lipopeptides Produced by a Streptomyces sp. Journal of natural products. 2020;83(8):2381–2389.
Bekiesch, P., Zehl, M., Domingo-Contreras, E., Martin, J., Perez-Victoria, I., Reyes, F., Kaplan, A., et al. (2020). Viennamycins: Lipopeptides Produced by a Streptomyces sp. Journal of natural products, 83(8), 2381–2389. doi:10.1021/acs.jnatprod.0c00152
Bekiesch, P., Zehl, M., Domingo-Contreras, E., Martin, J., Perez-Victoria, I., Reyes, F., Kaplan, A., Rückert, C., Busche, T., Kalinowski, J., et al. (2020). Viennamycins: Lipopeptides Produced by a Streptomyces sp. Journal of natural products 83, 2381–2389.
Bekiesch, P., et al., 2020. Viennamycins: Lipopeptides Produced by a Streptomyces sp. Journal of natural products, 83(8), p 2381–2389.
P. Bekiesch, et al., “Viennamycins: Lipopeptides Produced by a Streptomyces sp.”, Journal of natural products, vol. 83, 2020, pp. 2381–2389.
Bekiesch, P., Zehl, M., Domingo-Contreras, E., Martin, J., Perez-Victoria, I., Reyes, F., Kaplan, A., Rückert, C., Busche, T., Kalinowski, J., Zotchev, S.B.: Viennamycins: Lipopeptides Produced by a Streptomyces sp. Journal of natural products. 83, 2381–2389 (2020).
Bekiesch, Paulina, Zehl, Martin, Domingo-Contreras, Elizabeth, Martin, Jesus, Perez-Victoria, Ignacio, Reyes, Fernando, Kaplan, Arthur, Rückert, Christian, Busche, Tobias, Kalinowski, Jörn, and Zotchev, Sergey B. “Viennamycins: Lipopeptides Produced by a Streptomyces sp.”. Journal of natural products 83.8 (2020): 2381–2389.

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