Marking RNA: m6A writers, readers and functions in Arabidopsis

Reichel M, Köster T, Staiger D (2019)
Journal of molecular cell biology.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | E-Veröff. vor dem Druck | Englisch
Abstract / Bemerkung
N6-methyladenosine (m6A) emerges as an important modification in eukaryotic mRNAs. m6A has first been reported in 1974, and its functional significance in mammalian gene regulation and importance for proper development has been well established. An arsenal of writer, eraser, and reader proteins accomplish deposition, removal, and interpretation of the m6A mark, resulting in dynamic function. This led to the concept of an epitranscriptome, the compendium of RNA species with chemical modification of the nucleobases in the cell, in analogy to the epigenome. While m6A has long been known to also exist in plant mRNAs, proteins involved in m6A metabolism have only recently been detected by mutant analysis, homology search, and mRNA interactome capture in the reference plant Arabidopsis thaliana. Dysregulation of the m6A modification causes severe developmental abnormalities of leaves and roots and altered timing of reproductive development. Furthermore, m6A modification affects viral infection. Here, we discuss recent progress in identifying m6A sites transcriptome-wide, in identifying the molecular players involved in writing, removing, and reading the mark, and in assigning functions to this RNA modification in Arabidopsis thaliana. We highlight similarities and differences to m6A modification in mammals and provide an outlook on important questions that remain to be addressed. © The Author(s) 2019. Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS.
Erscheinungsjahr
Zeitschriftentitel
Journal of molecular cell biology
eISSN
PUB-ID

Zitieren

Reichel M, Köster T, Staiger D. Marking RNA: m6A writers, readers and functions in Arabidopsis. Journal of molecular cell biology. 2019.
Reichel, M., Köster, T., & Staiger, D. (2019). Marking RNA: m6A writers, readers and functions in Arabidopsis. Journal of molecular cell biology. doi:10.1093/jmcb/mjz085
Reichel, M., Köster, T., and Staiger, D. (2019). Marking RNA: m6A writers, readers and functions in Arabidopsis. Journal of molecular cell biology.
Reichel, M., Köster, T., & Staiger, D., 2019. Marking RNA: m6A writers, readers and functions in Arabidopsis. Journal of molecular cell biology.
M. Reichel, T. Köster, and D. Staiger, “Marking RNA: m6A writers, readers and functions in Arabidopsis”, Journal of molecular cell biology, 2019.
Reichel, M., Köster, T., Staiger, D.: Marking RNA: m6A writers, readers and functions in Arabidopsis. Journal of molecular cell biology. (2019).
Reichel, Marlene, Köster, Tino, and Staiger, Dorothee. “Marking RNA: m6A writers, readers and functions in Arabidopsis”. Journal of molecular cell biology (2019).

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Quellen

PMID: 31336387
PubMed | Europe PMC

Suchen in

Google Scholar