Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study.

Grewe P, Schulz R, Woermann FG, Brandt C, Doll A, Schoppe M, Tomka-Hoffmeister M, Bien CG (2019)
Seizure 67: 30-37.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
PURPOSE: To investigate the very long-term (i.e., ≥15 years) seizure, cognitive and psycho-social outcomes in resected patients (RP) with TLE compared to control patients not having undergone epilepsy surgery.; METHODS: We applied a multiple case-study design including three non-resected patients (NRP) who were compared to a group of six RP. The latter were matched to the NRP according to clinical-demographic data. Outcome measures were various seizure, cognitive, and psycho-social variables.; RESULTS: Patients were 56-72 years old. Seizure and AED outcome was more favourable among RP. RP reported better self-perceived overall health but higher subjective memory complaints. Upon formal neuropsychological testing, RP presented with lower verbal memory scores. Very long-term memory decline was evident in left-sided RP with good baseline memory scores, while RP with lower baseline performance, right-sided RP and NRP remained stable. Seizure-freedom had remarkable effects on the relationship between objective and subjective outcome: seizure-free patients, in general, subjectively reported the best psychosocial and cognitive outcome - irrespective of neuropsychological test results.; CONCLUSION: Our study suggests positive effects of TLE surgery in the very long-term course of ≥15 years postoperatively. Long-term seizure-freedom appears to have the strongest impact on patients' subjectively perceived psycho-social and cognitive outcome and may even outweigh actual memory disturbances and/or decline. Overall, our data do not support the assumption of a generally accelerated cognitive decline in patients with TLE. Copyright © 2019 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Erscheinungsjahr
2019
Zeitschriftentitel
Seizure
Band
67
Seite(n)
30-37
ISSN
1532-2688
Page URI
https://pub.uni-bielefeld.de/record/2934553

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Grewe P, Schulz R, Woermann FG, et al. Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. Seizure. 2019;67:30-37.
Grewe, P., Schulz, R., Woermann, F. G., Brandt, C., Doll, A., Schoppe, M., Tomka-Hoffmeister, M., et al. (2019). Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. Seizure, 67, 30-37. doi:10.1016/j.seizure.2019.02.015
Grewe, P., Schulz, R., Woermann, F. G., Brandt, C., Doll, A., Schoppe, M., Tomka-Hoffmeister, M., and Bien, C. G. (2019). Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. Seizure 67, 30-37.
Grewe, P., et al., 2019. Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. Seizure, 67, p 30-37.
P. Grewe, et al., “Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study.”, Seizure, vol. 67, 2019, pp. 30-37.
Grewe, P., Schulz, R., Woermann, F.G., Brandt, C., Doll, A., Schoppe, M., Tomka-Hoffmeister, M., Bien, C.G.: Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study. Seizure. 67, 30-37 (2019).
Grewe, Philip, Schulz, Raimund, Woermann, F G, Brandt, C, Doll, Anna, Schoppe, Mike, Tomka-Hoffmeister, M, and Bien, C G. “Very long-term outcome in resected and non-resected patients with temporal lobe epilepsy with medial temporal lobe sclerosis: A multiple case-study.”. Seizure 67 (2019): 30-37.

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