A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti
Draghi WO, Del Papa MF, Hellweg C, Watt SA, Watt TF, Barsch A, Lozano MJ, Lagares, A. J, Salas ME, Lopez JL, Albicoro FJ, et al. (2016)
SCIENTIFIC REPORTS 6(1): 29278.
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Autor*in
Draghi, W. O.;
Del Papa, M. F.;
Hellweg, C.;
Watt, S. A.;
Watt, T. F.;
Barsch, A.;
Lozano, M. J.;
Lagares, A., Jr.;
Salas, M. E.;
Lopez, J. L.;
Albicoro, F. J.;
Nilsson, J. F.
Alle
Alle
Einrichtung
Abstract / Bemerkung
Abiotic stresses in general and extracellular acidity in particular disturb and limit nitrogen-fixing symbioses between rhizobia and their host legumes. Except for valuable molecular-biological studies on different rhizobia, no consolidated models have been formulated to describe the central physiologic changes that occur in acid-stressed bacteria. We present here an integrated analysis entailing the main cultural, metabolic, and molecular responses of the model bacterium Sinorhizobium meliloti growing under controlled acid stress in a chemostat. A stepwise extracellular acidification of the culture medium had indicated that S. meliloti stopped growing at ca. pH 6.0-6.1. Under such stress the rhizobia increased the O-2 consumption per cell by more than 5-fold. This phenotype, together with an increase in the transcripts for several membrane cytochromes, entails a higher aerobic-respiration rate in the acid-stressed rhizobia. Multivariate analysis of global metabolome data served to unequivocally correlate specific-metabolite profiles with the extracellular pH, showing that at low pH the pentose-phosphate pathway exhibited increases in several transcripts, enzymes, and metabolites. Further analyses should be focused on the time course of the observed changes, its associated intracellular signaling, and on the comparison with the changes that operate during the sub lethal acid-adaptive response (ATR) in rhizobia.
Erscheinungsjahr
2016
Zeitschriftentitel
SCIENTIFIC REPORTS
Band
6
Ausgabe
1
Art.-Nr.
29278
ISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2905122
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Draghi WO, Del Papa MF, Hellweg C, et al. A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti. SCIENTIFIC REPORTS. 2016;6(1): 29278.
Draghi, W. O., Del Papa, M. F., Hellweg, C., Watt, S. A., Watt, T. F., Barsch, A., Lozano, M. J., et al. (2016). A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti. SCIENTIFIC REPORTS, 6(1), 29278. doi:10.1038/srep29278
Draghi, W. O., Del Papa, M. F., Hellweg, C., Watt, S. A., Watt, T. F., Barsch, A., Lozano, M. J., et al. 2016. “A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti”. SCIENTIFIC REPORTS 6 (1): 29278.
Draghi, W. O., Del Papa, M. F., Hellweg, C., Watt, S. A., Watt, T. F., Barsch, A., Lozano, M. J., Lagares, A., J., Salas, M. E., Lopez, J. L., et al. (2016). A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti. SCIENTIFIC REPORTS 6:29278.
Draghi, W.O., et al., 2016. A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti. SCIENTIFIC REPORTS, 6(1): 29278.
W.O. Draghi, et al., “A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti”, SCIENTIFIC REPORTS, vol. 6, 2016, : 29278.
Draghi, W.O., Del Papa, M.F., Hellweg, C., Watt, S.A., Watt, T.F., Barsch, A., Lozano, M.J., Lagares, A., J., Salas, M.E., Lopez, J.L., Albicoro, F.J., Nilsson, J.F., Torres Tejerizo, G.A., Luna, M.F., Pistorio, M., Boiardi, J.L., Pühler, A., Weidner, S., Niehaus, K., Lagares, A.: A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti. SCIENTIFIC REPORTS. 6, : 29278 (2016).
Draghi, W. O., Del Papa, M. F., Hellweg, C., Watt, S. A., Watt, T. F., Barsch, A., Lozano, M. J., Lagares, A., Jr., Salas, M. E., Lopez, J. L., Albicoro, F. J., Nilsson, J. F., Torres Tejerizo, G. A., Luna, M. F., Pistorio, M., Boiardi, J. L., Pühler, Alfred, Weidner, Stefan, Niehaus, Karsten, and Lagares, A. “A consolidated analysis of the physiologic and molecular responses induced under acid stress in the legume-symbiont model-soil bacterium Sinorhizobium meliloti”. SCIENTIFIC REPORTS 6.1 (2016): 29278.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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The COG database: an updated version includes eukaryotes.
Tatusov RL, Fedorova ND, Jackson JD, Jacobs AR, Kiryutin B, Koonin EV, Krylov DM, Mazumder R, Mekhedov SL, Nikolskaya AN, Rao BS, Smirnov S, Sverdlov AV, Vasudevan S, Wolf YI, Yin JJ, Natale DA., BMC Bioinformatics 4(), 2003
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