Origin of serpin-mediated regulation of coagulation and blood pressure

Wang Y, Köster K, Lummer M, Ragg H (2014)
PLoS ONE 9(5): e97879.

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Abstract / Bemerkung
Vertebrates evolved an endothelium-lined hemostatic system and a pump-driven pressurized circulation with a finely-balanced coagulation cascade and elaborate blood pressure control over the past 500 million years. Genome analyses have identified principal components of the ancestral coagulation system, however, how this complex trait was originally regulated is largely unknown. Likewise, little is known about the roots of blood pressure control in vertebrates. Here we studied three members of the serpin superfamily that interfere with procoagulant activity and blood pressure of lampreys, a group of basal vertebrates. Angiotensinogen from these jawless fish was found to fulfill a dual role by operating as a highly selective thrombin inhibitor that is activated by heparin-related glycosaminoglycans, and concurrently by serving as source of effector peptides that activate type 1 angiotensin receptors. Lampreys, uniquely among vertebrates, thus use angiotensinogen for interference with both coagulation and osmo- and pressure regulation. Heparin cofactor II from lampreys, in contrast to its paralogue angiotensinogen, is preferentially activated by dermatan sulfate, suggesting that these two serpins affect different facets of thrombin’s multiple roles. Lampreys also express a lineage-specific serpin with anti-factor Xa activity, which demonstrates that another important procoagulant enzyme is under inhibitory control. Comparative genomics suggests that orthologues of these three serpins were key components of the ancestral hemostatic system. It appears that, early in vertebrate evolution, coagulation and osmo- and pressure regulation crosstalked through antiproteolytically active angiotensinogen, a feature that was lost during vertebrate radiation, though in gnathostomes interplay between these traits is effective.
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PLoS ONE
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9
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5
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e97879
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eISSN
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Article Processing Charge funded by the Deutsche Forschungsgemeinschaft and the Open Access Publication Fund of Bielefeld University.
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Wang Y, Köster K, Lummer M, Ragg H. Origin of serpin-mediated regulation of coagulation and blood pressure. PLoS ONE. 2014;9(5):e97879.
Wang, Y., Köster, K., Lummer, M., & Ragg, H. (2014). Origin of serpin-mediated regulation of coagulation and blood pressure. PLoS ONE, 9(5), e97879. doi:10.1371/journal.pone.0097879
Wang, Y., Köster, K., Lummer, M., and Ragg, H. (2014). Origin of serpin-mediated regulation of coagulation and blood pressure. PLoS ONE 9, e97879.
Wang, Y., et al., 2014. Origin of serpin-mediated regulation of coagulation and blood pressure. PLoS ONE, 9(5), p e97879.
Y. Wang, et al., “Origin of serpin-mediated regulation of coagulation and blood pressure”, PLoS ONE, vol. 9, 2014, pp. e97879.
Wang, Y., Köster, K., Lummer, M., Ragg, H.: Origin of serpin-mediated regulation of coagulation and blood pressure. PLoS ONE. 9, e97879 (2014).
Wang, Yunjie, Köster, Katharina, Lummer, Martina, and Ragg, Hermann. “Origin of serpin-mediated regulation of coagulation and blood pressure”. PLoS ONE 9.5 (2014): e97879.
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2019-09-06T09:18:23Z

4 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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