Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae

Dalal A, Vishwakarma A, Singh NK, Gudla T, Bhattacharyya MK, Padmasree K, Viehhauser A, Dietz K-J, Kirti PB (2014)
FEBS Letters 588(4): 584-593.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Brassica juncea annexin-3 (BjAnn3) was functionally characterized for its ability to modulate H(2)O(2-)mediated oxidative stress in Saccharomyces cerevisiae. BjAnn3 showed a significant protective role in cellular-defense against oxidative stress and partially alleviated inhibition of mitochondrial respiration in presence of exogenously applied H2O2. Heterologous expression of BjAnn3 protected membranes from oxidative stress-mediated damage and positively regulated antioxidant gene expression for ROS detoxification. We conclude that, BjAnn3 partially counteracts the effects of thioredoxin peroxidase 1 (TSA1) deficiency and aids in cellular-protection across kingdoms. Despite partial compensation of TSA1 by BjAnn3 in cell-viability tests, the over-complementation in ROS-related features suggests the existence of both redundant (e. g. ROS detoxification) and distinct features (e. g. membrane protection versus proximity-based redox regulator) of both proteins. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Stichworte
Saccharomyces cerevisiae; Thioredoxin peroxidase 1; Brassica juncea annexin-3; Oxidative stress; Cross talk; Complementation
Erscheinungsjahr
2014
Zeitschriftentitel
FEBS Letters
Band
588
Ausgabe
4
Seite(n)
584-593
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/2664302

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Dalal A, Vishwakarma A, Singh NK, et al. Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae. FEBS Letters. 2014;588(4):584-593.
Dalal, A., Vishwakarma, A., Singh, N. K., Gudla, T., Bhattacharyya, M. K., Padmasree, K., Viehhauser, A., et al. (2014). Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae. FEBS Letters, 588(4), 584-593. doi:10.1016/j.febslet.2014.01.006
Dalal, A., Vishwakarma, A., Singh, N. K., Gudla, T., Bhattacharyya, M. K., Padmasree, K., Viehhauser, A., Dietz, K. - J., and Kirti, P. B. (2014). Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae. FEBS Letters 588, 584-593.
Dalal, A., et al., 2014. Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae. FEBS Letters, 588(4), p 584-593.
A. Dalal, et al., “Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae”, FEBS Letters, vol. 588, 2014, pp. 584-593.
Dalal, A., Vishwakarma, A., Singh, N.K., Gudla, T., Bhattacharyya, M.K., Padmasree, K., Viehhauser, A., Dietz, K.-J., Kirti, P.B.: Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae. FEBS Letters. 588, 584-593 (2014).
Dalal, Ahan, Vishwakarma, Abhaypratap, Singh, Naveen Kumar, Gudla, Triveni, Bhattacharyya, Mrinal Kanti, Padmasree, Kollipara, Viehhauser, Andrea, Dietz, Karl-Josef, and Kirti, Pulugurtha Bharadwaja. “Attenuation of hydrogen peroxide-mediated oxidative stress by Brassica juncea annexin-3 counteracts thiol-specific antioxidant (TSA1) deficiency in Saccharomyces cerevisiae”. FEBS Letters 588.4 (2014): 584-593.

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