An environmental bacterial taxon with a large and distinct metabolic repertoire
Wilson MC, Mori T, Rückert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UAE, Heycke N, Schmitt S, Rinke C, et al. (2014)
Nature 506(7486): 58-62.
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Autor*in
Wilson, Micheal C;
Mori, Tetsushi;
Rückert, ChristianUniBi
;
Uria, Agustinus R;
Helf, Maximilian J;
Takada, Kentaro;
Gernert, Christine;
Steffens, Ursula A E;
Heycke, Nina;
Schmitt, Susanne;
Rinke, Christian;
Helfrich, Eric J N
Alle
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Alle
Einrichtung
Abstract / Bemerkung
: Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such 'talented' producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of new drug candidates, but so far it is unknown whether taxa containing talented bacteria indeed exist. Here we report the single-cell- and metagenomics-based discovery of such producers. Two phylotypes of the candidate genus 'Entotheonella' with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei. Almost all bioactive polyketides and peptides known from this animal were attributed to a single phylotype. 'Entotheonella' spp. are widely distributed in sponges and belong to an environmental taxon proposed here as candidate phylum 'Tectomicrobia'. The pronounced bioactivities and chemical uniqueness of 'Entotheonella' compounds provide significant opportunities for ecological studies and drug discovery.
Erscheinungsjahr
2014
Zeitschriftentitel
Nature
Band
506
Ausgabe
7486
Seite(n)
58-62
ISSN
0028-0836
eISSN
1476-4687
Page URI
https://pub.uni-bielefeld.de/record/2653196
Zitieren
Wilson MC, Mori T, Rückert C, et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 2014;506(7486):58-62.
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., et al. (2014). An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature, 506(7486), 58-62. doi:10.1038/nature12959
Wilson, Micheal C, Mori, Tetsushi, Rückert, Christian, Uria, Agustinus R, Helf, Maximilian J, Takada, Kentaro, Gernert, Christine, et al. 2014. “An environmental bacterial taxon with a large and distinct metabolic repertoire”. Nature 506 (7486): 58-62.
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., et al. (2014). An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58-62.
Wilson, M.C., et al., 2014. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature, 506(7486), p 58-62.
M.C. Wilson, et al., “An environmental bacterial taxon with a large and distinct metabolic repertoire”, Nature, vol. 506, 2014, pp. 58-62.
Wilson, M.C., Mori, T., Rückert, C., Uria, A.R., Helf, M.J., Takada, K., Gernert, C., Steffens, U.A.E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E.J.N., Brachmann, A.O., Gurgui, C., Wakimoto, T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.: An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 506, 58-62 (2014).
Wilson, Micheal C, Mori, Tetsushi, Rückert, Christian, Uria, Agustinus R, Helf, Maximilian J, Takada, Kentaro, Gernert, Christine, Steffens, Ursula A E, Heycke, Nina, Schmitt, Susanne, Rinke, Christian, Helfrich, Eric J N, Brachmann, Alexander O, Gurgui, Cristian, Wakimoto, Toshiyuki, Kracht, Matthias, Crüsemann, Max, Hentschel, Ute, Abe, Ikuro, Matsunaga, Shigeki, Kalinowski, Jörn, Takeyama, Haruko, and Piel, Jörn. “An environmental bacterial taxon with a large and distinct metabolic repertoire”. Nature 506.7486 (2014): 58-62.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
UNIPROT
17418 Einträge gefunden, die diesen Artikel zitieren von denen 10 angezeigt werden
CinA-like protein (UNIPROT: W4LA76)
Organism: Candidatus Entotheonella sp. TSY2
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Organism: Candidatus Entotheonella sp. TSY2
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Aminopyrimidine aminohydrolase (UNIPROT: W4LEG3)
Organism: Candidatus Entotheonella sp. TSY2
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Organism: Candidatus Entotheonella sp. TSY2
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UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UNIPROT: W4LU52)
Organism: Candidatus Entotheonella sp. TSY1
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Organism: Candidatus Entotheonella sp. TSY1
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NADH-quinone oxidoreductase subunit H (UNIPROT: W4LYQ0)
Organism: Candidatus Entotheonella sp. TSY1
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Organism: Candidatus Entotheonella sp. TSY1
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Phosphatidylserine decarboxylase (UNIPROT: W4LF03)
Organism: Candidatus Entotheonella sp. TSY1
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Organism: Candidatus Entotheonella sp. TSY1
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Sulfurtransferase (UNIPROT: W4LYM0)
Organism: Candidatus Entotheonella sp. TSY2
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Organism: Candidatus Entotheonella sp. TSY2
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Uncharacterized protein (UNIPROT: W4L1J1)
Organism: Candidatus Entotheonella sp. TSY1
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Organism: Candidatus Entotheonella sp. TSY1
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Uncharacterized protein (UNIPROT: W4L3G1)
Organism: Candidatus Entotheonella sp. TSY1
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Organism: Candidatus Entotheonella sp. TSY1
Download in FASTA format
Uncharacterized protein (UNIPROT: W4L3L0)
Organism: Candidatus Entotheonella sp. TSY1
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Organism: Candidatus Entotheonella sp. TSY1
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EMBL
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Integrated metabolism in sponge-microbe symbiosis revealed by genome-centered metatranscriptomics.
Moitinho-Silva L, Díez-Vives C, Batani G, Esteves AI, Jahn MT, Thomas T., ISME J 11(7), 2017
PMID: 28338677
Moitinho-Silva L, Díez-Vives C, Batani G, Esteves AI, Jahn MT, Thomas T., ISME J 11(7), 2017
PMID: 28338677
Another Look at Pyrroloiminoquinone Alkaloids-Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues.
Lin S, McCauley EP, Lorig-Roach N, Tenney K, Naphen CN, Yang AM, Johnson TA, Hernadez T, Rattan R, Valeriote FA, Crews P., Mar Drugs 15(4), 2017
PMID: 28353633
Lin S, McCauley EP, Lorig-Roach N, Tenney K, Naphen CN, Yang AM, Johnson TA, Hernadez T, Rattan R, Valeriote FA, Crews P., Mar Drugs 15(4), 2017
PMID: 28353633
Cyanobacterial ent-Sterol-Like Natural Products from a Deviated Ubiquinone Pathway.
Moosmann P, Ueoka R, Grauso L, Mangoni A, Morinaka BI, Gugger M, Piel J., Angew Chem Int Ed Engl 56(18), 2017
PMID: 28370791
Moosmann P, Ueoka R, Grauso L, Mangoni A, Morinaka BI, Gugger M, Piel J., Angew Chem Int Ed Engl 56(18), 2017
PMID: 28370791
Mining prokaryotes for antimicrobial compounds: from diversity to function.
Tracanna V, de Jong A, Medema MH, Kuipers OP., FEMS Microbiol Rev 41(3), 2017
PMID: 28402441
Tracanna V, de Jong A, Medema MH, Kuipers OP., FEMS Microbiol Rev 41(3), 2017
PMID: 28402441
Chemical ecology of antibiotic production by actinomycetes.
van der Meij A, Worsley SF, Hutchings MI, van Wezel GP., FEMS Microbiol Rev 41(3), 2017
PMID: 28521336
van der Meij A, Worsley SF, Hutchings MI, van Wezel GP., FEMS Microbiol Rev 41(3), 2017
PMID: 28521336
Predicting the HMA-LMA Status in Marine Sponges by Machine Learning.
Moitinho-Silva L, Steinert G, Nielsen S, Hardoim CCP, Wu YC, McCormack GP, López-Legentil S, Marchant R, Webster N, Thomas T, Hentschel U., Front Microbiol 8(), 2017
PMID: 28533766
Moitinho-Silva L, Steinert G, Nielsen S, Hardoim CCP, Wu YC, McCormack GP, López-Legentil S, Marchant R, Webster N, Thomas T, Hentschel U., Front Microbiol 8(), 2017
PMID: 28533766
Bioactive Natural Products of Marine Sponges from the Genus Hyrtios.
Shady NH, El-Hossary EM, Fouad MA, Gulder TAM, Kamel MS, Abdelmohsen UR., Molecules 22(5), 2017
PMID: 28492499
Shady NH, El-Hossary EM, Fouad MA, Gulder TAM, Kamel MS, Abdelmohsen UR., Molecules 22(5), 2017
PMID: 28492499
Screening and identification of novel biologically active natural compounds.
Newman D., F1000Res 6(), 2017
PMID: 28649374
Newman D., F1000Res 6(), 2017
PMID: 28649374
Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.
Miller IJ, Chevrette MG, Kwan JC., Mar Drugs 15(6), 2017
PMID: 28587290
Miller IJ, Chevrette MG, Kwan JC., Mar Drugs 15(6), 2017
PMID: 28587290
Bioprospecting challenges in unusual environments.
Tanner K, Vilanova C, Porcar M., Microb Biotechnol 10(4), 2017
PMID: 28612429
Tanner K, Vilanova C, Porcar M., Microb Biotechnol 10(4), 2017
PMID: 28612429
Antimicrobial Potential of Bacteria Associated with Marine Sea Slugs from North Sulawesi, Indonesia.
Böhringer N, Fisch KM, Schillo D, Bara R, Hertzer C, Grein F, Eisenbarth JH, Kaligis F, Schneider T, Wägele H, König GM, Schäberle TF., Front Microbiol 8(), 2017
PMID: 28659904
Böhringer N, Fisch KM, Schillo D, Bara R, Hertzer C, Grein F, Eisenbarth JH, Kaligis F, Schneider T, Wägele H, König GM, Schäberle TF., Front Microbiol 8(), 2017
PMID: 28659904
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights.
Masschelein J, Jenner M, Challis GL., Nat Prod Rep 34(7), 2017
PMID: 28650032
Masschelein J, Jenner M, Challis GL., Nat Prod Rep 34(7), 2017
PMID: 28650032
Novel approaches in function-driven single-cell genomics.
Doud DFR, Woyke T., FEMS Microbiol Rev 41(4), 2017
PMID: 28591840
Doud DFR, Woyke T., FEMS Microbiol Rev 41(4), 2017
PMID: 28591840
Form Follows Function: Designer Chemistry at the 52nd Bürgenstock Conference.
Heretsch P., Angew Chem Int Ed Engl 56(31), 2017
PMID: 28675614
Heretsch P., Angew Chem Int Ed Engl 56(31), 2017
PMID: 28675614
Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges.
Ellis GA, Thomas CS, Chanana S, Adnani N, Szachowicz E, Braun DR, Harper MK, Wyche TP, Bugni TS., PLoS One 12(7), 2017
PMID: 28692665
Ellis GA, Thomas CS, Chanana S, Adnani N, Szachowicz E, Braun DR, Harper MK, Wyche TP, Bugni TS., PLoS One 12(7), 2017
PMID: 28692665
Buwchitin: A Ruminal Peptide with Antimicrobial Potential against Enterococcus faecalis.
Oyama LB, Crochet JA, Edwards JE, Girdwood SE, Cookson AR, Fernandez-Fuentes N, Hilpert K, Golyshin PN, Golyshina OV, Privé F, Hess M, Mantovani HC, Creevey CJ, Huws SA., Front Chem 5(), 2017
PMID: 28748180
Oyama LB, Crochet JA, Edwards JE, Girdwood SE, Cookson AR, Fernandez-Fuentes N, Hilpert K, Golyshin PN, Golyshina OV, Privé F, Hess M, Mantovani HC, Creevey CJ, Huws SA., Front Chem 5(), 2017
PMID: 28748180
Present and Future of Culturing Bacteria.
Overmann J, Abt B, Sikorski J., Annu Rev Microbiol 71(), 2017
PMID: 28731846
Overmann J, Abt B, Sikorski J., Annu Rev Microbiol 71(), 2017
PMID: 28731846
Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017.
Montenegro J, Phipps RJ., Chem Commun (Camb) 53(72), 2017
PMID: 28837191
Montenegro J, Phipps RJ., Chem Commun (Camb) 53(72), 2017
PMID: 28837191
Zeamide, a Glycosylinositol Phosphorylceramide with the Novel Core Arap(1β→6)Ins Motif from the Marine Sponge Svenzea zeai.
Della Sala G, Teta R, Esposito G, Pawlik JR, Mangoni A, Costantino V., Molecules 22(9), 2017
PMID: 28862696
Della Sala G, Teta R, Esposito G, Pawlik JR, Mangoni A, Costantino V., Molecules 22(9), 2017
PMID: 28862696
The sponge microbiome project.
Moitinho-Silva L, Nielsen S, Amir A, Gonzalez A, Ackermann GL, Cerrano C, Astudillo-Garcia C, Easson C, Sipkema D, Liu F, Steinert G, Kotoulas G, McCormack GP, Feng G, Bell JJ, Vicente J, Björk JR, Montoya JM, Olson JB, Reveillaud J, Steindler L, Pineda MC, Marra MV, Ilan M, Taylor MW, Polymenakou P, Erwin PM, Schupp PJ, Simister RL, Knight R, Thacker RW, Costa R, Hill RT, Lopez-Legentil S, Dailianis T, Ravasi T, Hentschel U, Li Z, Webster NS, Thomas T., Gigascience 6(10), 2017
PMID: 29020741
Moitinho-Silva L, Nielsen S, Amir A, Gonzalez A, Ackermann GL, Cerrano C, Astudillo-Garcia C, Easson C, Sipkema D, Liu F, Steinert G, Kotoulas G, McCormack GP, Feng G, Bell JJ, Vicente J, Björk JR, Montoya JM, Olson JB, Reveillaud J, Steindler L, Pineda MC, Marra MV, Ilan M, Taylor MW, Polymenakou P, Erwin PM, Schupp PJ, Simister RL, Knight R, Thacker RW, Costa R, Hill RT, Lopez-Legentil S, Dailianis T, Ravasi T, Hentschel U, Li Z, Webster NS, Thomas T., Gigascience 6(10), 2017
PMID: 29020741
The trajectory of microbial single-cell sequencing.
Woyke T, Doud DFR, Schulz F., Nat Methods 14(11), 2017
PMID: 29088131
Woyke T, Doud DFR, Schulz F., Nat Methods 14(11), 2017
PMID: 29088131
Marine microbiome as source of natural products.
de la Calle F., Microb Biotechnol 10(6), 2017
PMID: 29076296
de la Calle F., Microb Biotechnol 10(6), 2017
PMID: 29076296
Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs).
Benjdia A, Balty C, Berteau O., Front Chem 5(), 2017
PMID: 29167789
Benjdia A, Balty C, Berteau O., Front Chem 5(), 2017
PMID: 29167789
Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology.
Grubbs KJ, Bleich RM, Santa Maria KC, Allen SE, Farag S, AgBiome Team, Shank EA, Bowers AA., mSystems 2(6), 2017
PMID: 29152584
Grubbs KJ, Bleich RM, Santa Maria KC, Allen SE, Farag S, AgBiome Team, Shank EA, Bowers AA., mSystems 2(6), 2017
PMID: 29152584
Cyclic azole-homologated peptides from Marine sponges.
Molinski TF., Org Biomol Chem 16(1), 2017
PMID: 29210421
Molinski TF., Org Biomol Chem 16(1), 2017
PMID: 29210421
Comparative Metagenomics Reveals the Distinctive Adaptive Features of the Spongia officinalis Endosymbiotic Consortium.
Karimi E, Ramos M, Gonçalves JMS, Xavier JR, Reis MP, Costa R., Front Microbiol 8(), 2017
PMID: 29312205
Karimi E, Ramos M, Gonçalves JMS, Xavier JR, Reis MP, Costa R., Front Microbiol 8(), 2017
PMID: 29312205
Metabolic profiling as a tool for prioritizing antimicrobial compounds.
Wu C, Choi YH, van Wezel GP., J Ind Microbiol Biotechnol 43(2-3), 2016
PMID: 26335567
Wu C, Choi YH, van Wezel GP., J Ind Microbiol Biotechnol 43(2-3), 2016
PMID: 26335567
Leveraging ecological theory to guide natural product discovery.
Smanski MJ, Schlatter DC, Kinkel LL., J Ind Microbiol Biotechnol 43(2-3), 2016
PMID: 26434742
Smanski MJ, Schlatter DC, Kinkel LL., J Ind Microbiol Biotechnol 43(2-3), 2016
PMID: 26434742
Lichens as natural sources of biotechnologically relevant bacteria.
Suzuki MT, Parrot D, Berg G, Grube M, Tomasi S., Appl Microbiol Biotechnol 100(2), 2016
PMID: 26549239
Suzuki MT, Parrot D, Berg G, Grube M, Tomasi S., Appl Microbiol Biotechnol 100(2), 2016
PMID: 26549239
Culture-independent discovery of natural products from soil metagenomes.
Katz M, Hover BM, Brady SF., J Ind Microbiol Biotechnol 43(2-3), 2016
PMID: 26586404
Katz M, Hover BM, Brady SF., J Ind Microbiol Biotechnol 43(2-3), 2016
PMID: 26586404
A New N-Acyl Homoserine Lactone Synthase in an Uncultured Symbiont of the Red Sea Sponge Theonella swinhoei.
Britstein M, Devescovi G, Handley KM, Malik A, Haber M, Saurav K, Teta R, Costantino V, Burgsdorf I, Gilbert JA, Sher N, Venturi V, Steindler L., Appl Environ Microbiol 82(4), 2016
PMID: 26655754
Britstein M, Devescovi G, Handley KM, Malik A, Haber M, Saurav K, Teta R, Costantino V, Burgsdorf I, Gilbert JA, Sher N, Venturi V, Steindler L., Appl Environ Microbiol 82(4), 2016
PMID: 26655754
Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products.
Zarins-Tutt JS, Barberi TT, Gao H, Mearns-Spragg A, Zhang L, Newman DJ, Goss RJ., Nat Prod Rep 33(1), 2016
PMID: 26538321
Zarins-Tutt JS, Barberi TT, Gao H, Mearns-Spragg A, Zhang L, Newman DJ, Goss RJ., Nat Prod Rep 33(1), 2016
PMID: 26538321
Antibacterial drug discovery in the resistance era.
Brown ED, Wright GD., Nature 529(7586), 2016
PMID: 26791724
Brown ED, Wright GD., Nature 529(7586), 2016
PMID: 26791724
New marine natural products from sponges (Porifera) of the order Dictyoceratida (2001 to 2012); a promising source for drug discovery, exploration and future prospects.
Mehbub MF, Perkins MV, Zhang W, Franco CMM., Biotechnol Adv 34(5), 2016
PMID: 26802363
Mehbub MF, Perkins MV, Zhang W, Franco CMM., Biotechnol Adv 34(5), 2016
PMID: 26802363
Increasing the Richness of Culturable Arsenic-Tolerant Bacteria from Theonella swinhoei by Addition of Sponge Skeleton to the Growth Medium.
Keren R, Lavy A, Ilan M., Microb Ecol 71(4), 2016
PMID: 26809776
Keren R, Lavy A, Ilan M., Microb Ecol 71(4), 2016
PMID: 26809776
Goodbye to brute force in antibiotic discovery?
Kolter R, van Wezel GP., Nat Microbiol 1(), 2016
PMID: 27571977
Kolter R, van Wezel GP., Nat Microbiol 1(), 2016
PMID: 27571977
Biosynthesis of polyketides by trans-AT polyketide synthases.
Helfrich EJ, Piel J., Nat Prod Rep 33(2), 2016
PMID: 26689670
Helfrich EJ, Piel J., Nat Prod Rep 33(2), 2016
PMID: 26689670
Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity.
Hayata A, Itoh H, Matsutaka S, Inoue M., Chemistry (), 2016
PMID: 26833801
Hayata A, Itoh H, Matsutaka S, Inoue M., Chemistry (), 2016
PMID: 26833801
Marine natural products.
Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR., Nat Prod Rep 33(3), 2016
PMID: 26837534
Blunt JW, Copp BR, Keyzers RA, Munro MH, Prinsep MR., Nat Prod Rep 33(3), 2016
PMID: 26837534
Informatic analysis reveals Legionella as a source of novel natural products.
Johnston CW, Plumb J, Li X, Grinstein S, Magarvey NA., Synth Syst Biotechnol 1(2), 2016
PMID: 29062936
Johnston CW, Plumb J, Li X, Grinstein S, Magarvey NA., Synth Syst Biotechnol 1(2), 2016
PMID: 29062936
Increasing Metagenomic Resolution of Microbiome Interactions Through Functional Phylogenomics and Bacterial Sub-Communities.
Cibrián-Jaramillo A, Barona-Gómez F., Front Genet 7(), 2016
PMID: 26904093
Cibrián-Jaramillo A, Barona-Gómez F., Front Genet 7(), 2016
PMID: 26904093
Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.
Kanakkanthara A, Northcote PT, Miller JH., Nat Prod Rep 33(4), 2016
PMID: 26867978
Kanakkanthara A, Northcote PT, Miller JH., Nat Prod Rep 33(4), 2016
PMID: 26867978
Culture-independent method for identification of microbial enzyme-encoding genes by activity-based single-cell sequencing using a water-in-oil microdroplet platform.
Nakamura K, Iizuka R, Nishi S, Yoshida T, Hatada Y, Takaki Y, Iguchi A, Yoon DH, Sekiguchi T, Shoji S, Funatsu T., Sci Rep 6(), 2016
PMID: 26915788
Nakamura K, Iizuka R, Nishi S, Yoshida T, Hatada Y, Takaki Y, Iguchi A, Yoon DH, Sekiguchi T, Shoji S, Funatsu T., Sci Rep 6(), 2016
PMID: 26915788
Advanced tools in marine natural drug discovery.
Zhang G, Li J, Zhu T, Gu Q, Li D., Curr Opin Biotechnol 42(), 2016
PMID: 26954946
Zhang G, Li J, Zhu T, Gu Q, Li D., Curr Opin Biotechnol 42(), 2016
PMID: 26954946
Delta-proteobacterial SAR324 group in hydrothermal plumes on the South Mid-Atlantic Ridge.
Cao H, Dong C, Bougouffa S, Li J, Zhang W, Shao Z, Bajic VB, Qian PY., Sci Rep 6(), 2016
PMID: 26953077
Cao H, Dong C, Bougouffa S, Li J, Zhang W, Shao Z, Bajic VB, Qian PY., Sci Rep 6(), 2016
PMID: 26953077
Sample Processing Impacts the Viability and Cultivability of the Sponge Microbiome.
Esteves AI, Amer N, Nguyen M, Thomas T., Front Microbiol 7(), 2016
PMID: 27242673
Esteves AI, Amer N, Nguyen M, Thomas T., Front Microbiol 7(), 2016
PMID: 27242673
Evolving medicinal chemistry strategies in antibiotic discovery.
Pawlowski AC, Johnson JW, Wright GD., Curr Opin Biotechnol 42(), 2016
PMID: 27116217
Pawlowski AC, Johnson JW, Wright GD., Curr Opin Biotechnol 42(), 2016
PMID: 27116217
Inhabitancy of active Nitrosopumilus-like ammonia-oxidizing archaea and Nitrospira nitrite-oxidizing bacteria in the sponge Theonella swinhoei.
Feng G, Sun W, Zhang F, Karthik L, Li Z., Sci Rep 6(), 2016
PMID: 27113140
Feng G, Sun W, Zhang F, Karthik L, Li Z., Sci Rep 6(), 2016
PMID: 27113140
Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds.
Indraningrat AA, Smidt H, Sipkema D., Mar Drugs 14(5), 2016
PMID: 27144573
Indraningrat AA, Smidt H, Sipkema D., Mar Drugs 14(5), 2016
PMID: 27144573
Origin of Chemical Diversity in Prochloron-Tunicate Symbiosis.
Lin Z, Torres JP, Tianero MD, Kwan JC, Schmidt EW., Appl Environ Microbiol 82(12), 2016
PMID: 27037119
Lin Z, Torres JP, Tianero MD, Kwan JC, Schmidt EW., Appl Environ Microbiol 82(12), 2016
PMID: 27037119
Calyculin: Nature's way of making the sponge-derived cytotoxin.
Wakimoto T, Egami Y, Abe I., Nat Prod Rep 33(6), 2016
PMID: 26923942
Wakimoto T, Egami Y, Abe I., Nat Prod Rep 33(6), 2016
PMID: 26923942
The evolution of genome mining in microbes - a review.
Ziemert N, Alanjary M, Weber T., Nat Prod Rep 33(8), 2016
PMID: 27272205
Ziemert N, Alanjary M, Weber T., Nat Prod Rep 33(8), 2016
PMID: 27272205
Lanthanides: New life metals?
Chistoserdova L., World J Microbiol Biotechnol 32(8), 2016
PMID: 27357406
Chistoserdova L., World J Microbiol Biotechnol 32(8), 2016
PMID: 27357406
Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics.
Crone WJ, Vior NM, Santos-Aberturas J, Schmitz LG, Leeper FJ, Truman AW., Angew Chem Int Ed Engl 55(33), 2016
PMID: 27374993
Crone WJ, Vior NM, Santos-Aberturas J, Schmitz LG, Leeper FJ, Truman AW., Angew Chem Int Ed Engl 55(33), 2016
PMID: 27374993
Antibiotic drug discovery.
Wohlleben W, Mast Y, Stegmann E, Ziemert N., Microb Biotechnol 9(5), 2016
PMID: 27470984
Wohlleben W, Mast Y, Stegmann E, Ziemert N., Microb Biotechnol 9(5), 2016
PMID: 27470984
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.
Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N., Nat Biotechnol 34(8), 2016
PMID: 27504778
Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N., Nat Biotechnol 34(8), 2016
PMID: 27504778
Toward Accurate and Quantitative Comparative Metagenomics.
Nayfach S, Pollard KS., Cell 166(5), 2016
PMID: 27565341
Nayfach S, Pollard KS., Cell 166(5), 2016
PMID: 27565341
Developing Techniques for the Utilization of Planctomycetes As Producers of Bioactive Molecules.
Jeske O, Surup F, Ketteniß M, Rast P, Förster B, Jogler M, Wink J, Jogler C., Front Microbiol 7(), 2016
PMID: 27594849
Jeske O, Surup F, Ketteniß M, Rast P, Förster B, Jogler M, Wink J, Jogler C., Front Microbiol 7(), 2016
PMID: 27594849
New Genomic Insights into "Entotheonella" Symbionts in Theonella swinhoei: Mixotrophy, Anaerobic Adaptation, Resilience, and Interaction.
Liu F, Li J, Feng G, Li Z., Front Microbiol 7(), 2016
PMID: 27610106
Liu F, Li J, Feng G, Li Z., Front Microbiol 7(), 2016
PMID: 27610106
HydDB: A web tool for hydrogenase classification and analysis.
Søndergaard D, Pedersen CN, Greening C., Sci Rep 6(), 2016
PMID: 27670643
Søndergaard D, Pedersen CN, Greening C., Sci Rep 6(), 2016
PMID: 27670643
Single sample resolution of rare microbial dark matter in a marine invertebrate metagenome.
Miller IJ, Weyna TR, Fong SS, Lim-Fong GE, Kwan JC., Sci Rep 6(), 2016
PMID: 27681823
Miller IJ, Weyna TR, Fong SS, Lim-Fong GE, Kwan JC., Sci Rep 6(), 2016
PMID: 27681823
Synthetic Biology of Natural Products.
Breitling R, Takano E., Cold Spring Harb Perspect Biol 8(10), 2016
PMID: 27503995
Breitling R, Takano E., Cold Spring Harb Perspect Biol 8(10), 2016
PMID: 27503995
Metagenomic Analysis of the Sponge Discodermia Reveals the Production of the Cyanobacterial Natural Product Kasumigamide by 'Entotheonella'.
Nakashima Y, Egami Y, Kimura M, Wakimoto T, Abe I., PLoS One 11(10), 2016
PMID: 27732651
Nakashima Y, Egami Y, Kimura M, Wakimoto T, Abe I., PLoS One 11(10), 2016
PMID: 27732651
Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen.
Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein PC., mSystems 1(6), 2016
PMID: 28028548
Garg N, Zeng Y, Edlund A, Melnik AV, Sanchez LM, Mohimani H, Gurevich A, Miao V, Schiffler S, Lim YW, Luzzatto-Knaan T, Cai S, Rohwer F, Pevzner PA, Cichewicz RH, Alexandrov T, Dorrestein PC., mSystems 1(6), 2016
PMID: 28028548
The multicellular nature of filamentous heterocyst-forming cyanobacteria.
Herrero A, Stavans J, Flores E., FEMS Microbiol Rev 40(6), 2016
PMID: 28204529
Herrero A, Stavans J, Flores E., FEMS Microbiol Rev 40(6), 2016
PMID: 28204529
An Enrichment of CRISPR and Other Defense-Related Features in Marine Sponge-Associated Microbial Metagenomes.
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Newman DJ., Front Microbiol 7(), 2016
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Complete genome sequence of the actinomycete Actinoalloteichus hymeniacidonis type strain HPA 177T isolated from a marine sponge.
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PMID: 28031775
Schaffert L, Albersmeier A, Winkler A, Kalinowski J, Zotchev SB, Rückert C., Stand Genomic Sci 11(), 2016
PMID: 28031775
The surprisingly complex immune gene repertoire of a simple sponge, exemplified by the NLR genes: a capacity for specificity?
Degnan SM., Dev Comp Immunol 48(2), 2015
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Degnan SM., Dev Comp Immunol 48(2), 2015
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Fast and sensitive protein alignment using DIAMOND.
Buchfink B, Xie C, Huson DH., Nat Methods 12(1), 2015
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Buchfink B, Xie C, Huson DH., Nat Methods 12(1), 2015
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Diversity and bioprospecting of culturable actinomycetes from marine sediment of the Yellow Sea, China.
Xiong ZQ, Liu QX, Pan ZL, Zhao N, Feng ZX, Wang Y., Arch Microbiol 197(2), 2015
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Cooperation and selfishness both occur during molecular evolution.
Penny D., Biol Direct 10(), 2015
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Function-driven single-cell genomics.
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A new antibiotic kills pathogens without detectable resistance.
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Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K., Nature 517(7535), 2015
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The re-emergence of natural products for drug discovery in the genomics era.
Harvey AL, Edrada-Ebel R, Quinn RJ., Nat Rev Drug Discov 14(2), 2015
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Harvey AL, Edrada-Ebel R, Quinn RJ., Nat Rev Drug Discov 14(2), 2015
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Nurdiani D, Ito M, Maruyama T, Terahara T, Mori T, Ugawa S, Takeyama H., J Biosci Bioeng 120(2), 2015
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Hedlund BP, Dodsworth JA, Staley JT., Syst Appl Microbiol 38(4), 2015
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Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.
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Hexacyclopeptides secreted by an endophytic fungus Fusarium solani N06 act as crosstalk molecules in Narcissus tazetta.
Wang WX, Kusari S, Sezgin S, Lamshöft M, Kusari P, Kayser O, Spiteller M., Appl Microbiol Biotechnol 99(18), 2015
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Crystal Structure of Okadaic Acid Binding Protein 2.1: A Sponge Protein Implicated in Cytotoxin Accumulation.
Ehara H, Makino M, Kodama K, Konoki K, Ito T, Sekine S, Fukuzawa S, Yokoyama S, Tachibana K., Chembiochem 16(10), 2015
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Ehara H, Makino M, Kodama K, Konoki K, Ito T, Sekine S, Fukuzawa S, Yokoyama S, Tachibana K., Chembiochem 16(10), 2015
PMID: 25965326
Emerging concepts promising new horizons for marine biodiscovery and synthetic biology.
Reen FJ, Gutiérrez-Barranquero JA, Dobson AD, Adams C, O'Gara F., Mar Drugs 13(5), 2015
PMID: 25984990
Reen FJ, Gutiérrez-Barranquero JA, Dobson AD, Adams C, O'Gara F., Mar Drugs 13(5), 2015
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Endophytic and epiphytic microbes as "sources" of bioactive agents.
Newman DJ, Cragg GM., Front Chem 3(), 2015
PMID: 26052511
Newman DJ, Cragg GM., Front Chem 3(), 2015
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13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus.
Gverzdys T, Hart MK, Pimentel-Elardo S, Tranmer G, Nodwell JR., J Antibiot (Tokyo) 68(11), 2015
PMID: 26014719
Gverzdys T, Hart MK, Pimentel-Elardo S, Tranmer G, Nodwell JR., J Antibiot (Tokyo) 68(11), 2015
PMID: 26014719
Isolation and Total Synthesis of Kirkamide, an Aminocyclitol from an Obligate Leaf Nodule Symbiont.
Sieber S, Carlier A, Neuburger M, Grabenweger G, Eberl L, Gademann K., Angew Chem Int Ed Engl 54(27), 2015
PMID: 26033226
Sieber S, Carlier A, Neuburger M, Grabenweger G, Eberl L, Gademann K., Angew Chem Int Ed Engl 54(27), 2015
PMID: 26033226
In Silico Analysis of the Metabolic Potential and Niche Specialization of Candidate Phylum "Latescibacteria" (WS3).
Youssef NH, Farag IF, Rinke C, Hallam SJ, Woyke T, Elshahed MS., PLoS One 10(6), 2015
PMID: 26039074
Youssef NH, Farag IF, Rinke C, Hallam SJ, Woyke T, Elshahed MS., PLoS One 10(6), 2015
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Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation.
Wu C, Zacchetti B, Ram AF, van Wezel GP, Claessen D, Hae Choi Y., Sci Rep 5(), 2015
PMID: 26040782
Wu C, Zacchetti B, Ram AF, van Wezel GP, Claessen D, Hae Choi Y., Sci Rep 5(), 2015
PMID: 26040782
Discovery of microbial natural products by activation of silent biosynthetic gene clusters.
Rutledge PJ, Challis GL., Nat Rev Microbiol 13(8), 2015
PMID: 26119570
Rutledge PJ, Challis GL., Nat Rev Microbiol 13(8), 2015
PMID: 26119570
Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms.
Flórez LV, Biedermann PH, Engl T, Kaltenpoth M., Nat Prod Rep 32(7), 2015
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Kell D, Potgieter M, Pretorius E., F1000Res 4(), 2015
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Marine Structural Biomaterials in Medical Biomimicry.
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Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.
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The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms.
Reen FJ, Romano S, Dobson AD, O'Gara F., Mar Drugs 13(8), 2015
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Mass spectrometry tools and workflows for revealing microbial chemistry.
Luzzatto-Knaan T, Melnik AV, Dorrestein PC., Analyst 140(15), 2015
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Electrical Retrieval of Living Microorganisms from Cryopreserved Marine Sponges Using a Potential-Controlled Electrode.
Koyama S, Nishi S, Tokuda M, Uemura M, Ishikawa Y, Seya T, Chow S, Ise Y, Hatada Y, Fujiwara Y, Tsubouchi T., Mar Biotechnol (NY) 17(5), 2015
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Koyama S, Nishi S, Tokuda M, Uemura M, Ishikawa Y, Seya T, Chow S, Ise Y, Hatada Y, Fujiwara Y, Tsubouchi T., Mar Biotechnol (NY) 17(5), 2015
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Targeted metagenomics as a tool to tap into marine natural product diversity for the discovery and production of drug candidates.
Trindade M, van Zyl LJ, Navarro-Fernández J, Abd Elrazak A., Front Microbiol 6(), 2015
PMID: 26379658
Trindade M, van Zyl LJ, Navarro-Fernández J, Abd Elrazak A., Front Microbiol 6(), 2015
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Minimum Information about a Biosynthetic Gene cluster.
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Computational approaches to natural product discovery.
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Monodisperse Picoliter Droplets for Low-Bias and Contamination-Free Reactions in Single-Cell Whole Genome Amplification.
Nishikawa Y, Hosokawa M, Maruyama T, Yamagishi K, Mori T, Takeyama H., PLoS One 10(9), 2015
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Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach.
Adnani N, Vazquez-Rivera E, Adibhatla SN, Ellis GA, Braun DR, Bugni TS., Mar Drugs 13(10), 2015
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A new benzofuran glycoside and indole alkaloids from a sponge-associated rare actinomycete, Amycolatopsis sp.
Kwon Y, Kim SH, Shin Y, Bae M, Kim BY, Lee SK, Oh KB, Shin J, Oh DC., Mar Drugs 12(4), 2014
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Recent advances in genome-based polyketide discovery.
Helfrich EJ, Reiter S, Piel J., Curr Opin Biotechnol 29(), 2014
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Proteomics meets blue biotechnology: a wealth of novelties and opportunities.
Hartmann EM, Durighello E, Pible O, Nogales B, Beltrametti F, Bosch R, Christie-Oleza JA, Armengaud J., Mar Genomics 17(), 2014
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In situ detection of antibiotic amphotericin B produced in Streptomyces nodosus using Raman microspectroscopy.
Miyaoka R, Hosokawa M, Ando M, Mori T, Hamaguchi HO, Takeyama H., Mar Drugs 12(5), 2014
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Miyaoka R, Hosokawa M, Ando M, Mori T, Hamaguchi HO, Takeyama H., Mar Drugs 12(5), 2014
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Pidot S, Ishida K, Cyrulies M, Hertweck C., Angew Chem Int Ed Engl 53(30), 2014
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The re-emerging role of microbial natural products in antibiotic discovery.
Genilloud O., Antonie Van Leeuwenhoek 106(1), 2014
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Watson JR, Brennan TC, Degnan BM, Degnan SM, Krömer JO., Mar Drugs 12(6), 2014
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Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.
Wakimoto T, Egami Y, Nakashima Y, Wakimoto Y, Mori T, Awakawa T, Ito T, Kenmoku H, Asakawa Y, Piel J, Abe I., Nat Chem Biol 10(8), 2014
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Wakimoto T, Egami Y, Nakashima Y, Wakimoto Y, Mori T, Awakawa T, Ito T, Kenmoku H, Asakawa Y, Piel J, Abe I., Nat Chem Biol 10(8), 2014
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Revealing microbial functional activities in the Red Sea sponge Stylissa carteri by metatranscriptomics.
Moitinho-Silva L, Seridi L, Ryu T, Voolstra CR, Ravasi T, Hentschel U., Environ Microbiol 16(12), 2014
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Quantification of bacterial and archaeal symbionts in high and low microbial abundance sponges using real-time PCR.
Bayer K, Kamke J, Hentschel U., FEMS Microbiol Ecol 89(3), 2014
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Diversity and biotechnological potential of microorganisms associated with marine sponges.
Fuerst JA., Appl Microbiol Biotechnol 98(17), 2014
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Natural products: Sponge symbionts play defense.
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Recent advances in genomic DNA sequencing of microbial species from single cells.
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Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.
Mehbub MF, Lei J, Franco C, Zhang W., Mar Drugs 12(8), 2014
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Mining the metabiome: identifying novel natural products from microbial communities.
Milshteyn A, Schneider JS, Brady SF., Chem Biol 21(9), 2014
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Production of avaroferrin and putrebactin by heterologous expression of a deep-sea metagenomic DNA.
Fujita MJ, Sakai R., Mar Drugs 12(9), 2014
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GeoChip-based insights into the microbial functional gene repertoire of marine sponges (high microbial abundance, low microbial abundance) and seawater.
Bayer K, Moitinho-Silva L, Brümmer F, Cannistraci CV, Ravasi T, Hentschel U., FEMS Microbiol Ecol 90(3), 2014
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Pezizomycotina dominates the fungal communities of South China Sea sponges Theonella swinhoei and Xestospongia testudinaria.
Jin L, Liu F, Sun W, Zhang F, Karuppiah V, Li Z., FEMS Microbiol Ecol 90(3), 2014
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Think laterally: horizontal gene transfer from symbiotic microbes may extend the phenotype of marine sessile hosts.
Degnan SM., Front Microbiol 5(), 2014
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Characterisation of non-autoinducing tropodithietic Acid (TDA) production from marine sponge Pseudovibrio species.
Harrington C, Reen FJ, Mooij MJ, Stewart FA, Chabot JB, Guerra AF, Glöckner FO, Nielsen KF, Gram L, Dobson AD, Adams C, O'Gara F., Mar Drugs 12(12), 2014
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