Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36

Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, et al. (2013)
Nature 504(7478): 172-176.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Neculai, Dante; Schwake, MichaelUniBi ; Ravichandran, Mani; Zunke, Friederike; Collins, Richard F.; Peters, Judith; Neculai, Mirela; Plumb, Jonathan; Loppnau, Peter; Pizarro, Juan Carlos; Seitova, Alma; Trimble, William S.
Abstract / Bemerkung
Members of the CD36 superfamily of scavenger receptor proteins are important regulators of lipid metabolism and innate immunity. They recognize normal and modified lipoproteins, as well as pathogen-associated molecular patterns. The family consists of three members: SR-BI (which delivers cholesterol to the liver and steroidogenic organs and is a co-receptor for hepatitis C virus), LIMP-2/LGP85 (which mediates lysosomal delivery of beta-glucocerebrosidase and serves as a receptor for enterovirus 71 and coxsackieviruses) and CD36 (a fatty-acid transporter and receptor for phagocytosis of effete cells and Plasmodium-infected erythrocytes). Notably, CD36 is also a receptor for modified lipoproteins and beta-amyloid, and has been implicated in the pathogenesis of atherosclerosis and of Alzheimer's disease(1). Despite their prominent roles in health and disease, understanding the function and abnormalities of the CD36 family members has been hampered by the paucity of information about their structure. Here we determine the crystal structure of LIMP-2 and infer, by homology modelling, the structure of SR-BI and CD36. LIMP-2 shows a helical bundle where beta-glucocerebrosidase binds, and where ligands are most likely to bind to SR-BI and CD36. Remarkably, the crystal structure also shows the existence of a large cavity that traverses the entire length of the molecule. Mutagenesis of SR-BI indicates that the cavity serves as a tunnel through which cholesterol(esters) are delivered from the bound lipoprotein to the outer leaflet of the plasma membrane. We provide evidence supporting a model(2) whereby lipidic constituents of the ligands attached to the receptor surface are handed off to the membrane through the tunnel, accounting for the selective lipid transfer characteristic of SR-BI and CD36.
Page URI


Neculai D, Schwake M, Ravichandran M, et al. Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 2013;504(7478):172-176.
Neculai, D., Schwake, M., Ravichandran, M., Zunke, F., Collins, R. F., Peters, J., Neculai, M., et al. (2013). Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature, 504(7478), 172-176. doi:10.1038/nature12684
Neculai, Dante, Schwake, Michael, Ravichandran, Mani, Zunke, Friederike, Collins, Richard F., Peters, Judith, Neculai, Mirela, et al. 2013. “Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36”. Nature 504 (7478): 172-176.
Neculai, D., Schwake, M., Ravichandran, M., Zunke, F., Collins, R. F., Peters, J., Neculai, M., Plumb, J., Loppnau, P., Pizarro, J. C., et al. (2013). Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature 504, 172-176.
Neculai, D., et al., 2013. Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature, 504(7478), p 172-176.
D. Neculai, et al., “Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36”, Nature, vol. 504, 2013, pp. 172-176.
Neculai, D., Schwake, M., Ravichandran, M., Zunke, F., Collins, R.F., Peters, J., Neculai, M., Plumb, J., Loppnau, P., Pizarro, J.C., Seitova, A., Trimble, W.S., Saftig, P., Grinstein, S., Dhe-Paganon, S.: Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 504, 172-176 (2013).
Neculai, Dante, Schwake, Michael, Ravichandran, Mani, Zunke, Friederike, Collins, Richard F., Peters, Judith, Neculai, Mirela, Plumb, Jonathan, Loppnau, Peter, Pizarro, Juan Carlos, Seitova, Alma, Trimble, William S., Saftig, Paul, Grinstein, Sergio, and Dhe-Paganon, Sirano. “Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36”. Nature 504.7478 (2013): 172-176.

86 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust.
Hou X, Summer R, Chen Z, Tian Y, Ma J, Cui J, Hao X, Guo L, Xu H, Wang H, Liu H., Sci Rep 9(1), 2019
PMID: 30674959
Building a mechanistic mathematical model of hepatitis C virus entry.
Kalemera M, Mincheva D, Grove J, Illingworth CJR., PLoS Comput Biol 15(3), 2019
PMID: 30883541
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui R., Proc Natl Acad Sci U S A 116(28), 2019
PMID: 31239348
Fatty-acid receptor CD36 functions as a hydrogen sulfide-targeted receptor with its Cys333-Cys272 disulfide bond serving as a specific molecular switch to accelerate gastric cancer metastasis.
Wang R, Tao B, Fan Q, Wang S, Chen L, Zhang J, Hao Y, Dong S, Wang Z, Wang W, Cai Y, Li X, Bao T, Wang X, Qiu X, Wang K, Mo X, Kang Y, Wang Z., EBioMedicine 45(), 2019
PMID: 31262715
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D., Nat Commun 10(1), 2019
PMID: 31387993
HDL protects against doxorubicin-induced cardiotoxicity in a scavenger receptor class B type 1-, PI3K-, and Akt-dependent manner.
Durham KK, Chathely KM, Mak KC, Momen A, Thomas CT, Zhao YY, MacDonald ME, Curtis JM, Husain M, Trigatti BL., Am J Physiol Heart Circ Physiol 314(1), 2018
PMID: 28986362
SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux.
Shen WJ, Azhar S, Kraemer FB., Annu Rev Physiol 80(), 2018
PMID: 29125794
The importance of cholesterol in Parkinson's disease.
García-Sanz P, Moratalla R., Mov Disord 33(2), 2018
PMID: 29315826
Scavenger receptor B type 1: expression, molecular regulation, and cholesterol transport function.
Shen WJ, Asthana S, Kraemer FB, Azhar S., J Lipid Res 59(7), 2018
PMID: 29720388
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling.
Samovski D, Dhule P, Pietka T, Jacome-Sosa M, Penrose E, Son NH, Flynn CR, Shoghi KI, Hyrc KL, Goldberg IJ, Gamazon ER, Abumrad NA., Diabetes 67(7), 2018
PMID: 29748289
Identification of a Novel Homozygous Splice-Site Mutation in SCARB2 that Causes Progressive Myoclonus Epilepsy with or without Renal Failure.
He J, Lin H, Li JJ, Su HZ, Wang DN, Lin Y, Wang N, Chen WJ., Chin Med J (Engl) 131(13), 2018
PMID: 29941711
Targeting CD36 as Biomarker for Metastasis Prognostic: How Far from Translation into Clinical Practice?
Enciu AM, Radu E, Popescu ID, Hinescu ME, Ceafalan LC., Biomed Res Int 2018(), 2018
PMID: 30069479
Functions of the Dictyostelium LIMP-2 and CD36 homologues in bacteria uptake, phagolysosome biogenesis and host cell defence.
Sattler N, Bosmani C, Barisch C, Guého A, Gopaldass N, Dias M, Leuba F, Bruckert F, Cosson P, Soldati T., J Cell Sci 131(17), 2018
PMID: 30054386
SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation.
Tsugita M, Morimoto N, Tashiro M, Kinoshita K, Nakayama M., Cell Rep 18(5), 2017
PMID: 28147282
NMR Structure of the C-Terminal Transmembrane Domain of the HDL Receptor, SR-BI, and a Functionally Relevant Leucine Zipper Motif.
Chadwick AC, Jensen DR, Hanson PJ, Lange PT, Proudfoot SC, Peterson FC, Volkman BF, Sahoo D., Structure 25(3), 2017
PMID: 28162952
Identification of Inhibitors of CD36-Amyloid Beta Binding as Potential Agents for Alzheimer's Disease.
Doens D, Valiente PA, Mfuh AM, X T Vo A, Tristan A, Carreño L, Quijada M, Nguyen VT, Perry G, Larionov OV, Lleonart R, Fernández PL., ACS Chem Neurosci 8(6), 2017
PMID: 28150942
SR-BI: A Multifunctional Receptor in Cholesterol Homeostasis and Atherosclerosis.
Linton MF, Tao H, Linton EF, Yancey PG., Trends Endocrinol Metab 28(6), 2017
PMID: 28259375
α-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Kγ in THP-1 Monocytes.
Zingg JM, Azzi A, Meydani M., J Cell Biochem 118(7), 2017
PMID: 28059487
SR-B1 and PDZK1: partners in HDL regulation.
Trigatti BL., Curr Opin Lipidol 28(2), 2017
PMID: 28134663
The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection.
Zhang X, Yang P, Wang N, Zhang J, Li J, Guo H, Yin X, Rao Z, Wang X, Zhang L., Protein Cell 8(8), 2017
PMID: 28447294
A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.
PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J., J Immunol 198(10), 2017
PMID: 28483986
Cell biology in China: Focusing on the lysosome.
Yang C, Wang X., Traffic 18(6), 2017
PMID: 28371106
High-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.
Toomey MB, Lopes RJ, Araújo PM, Johnson JD, Gazda MA, Afonso S, Mota PG, Koch RE, Hill GE, Corbo JC, Carneiro M., Proc Natl Acad Sci U S A 114(20), 2017
PMID: 28465440
Plasmodium P36 determines host cell receptor usage during sporozoite invasion.
Manzoni G, Marinach C, Topçu S, Briquet S, Grand M, Tolle M, Gransagne M, Lescar J, Andolina C, Franetich JF, Zeisel MB, Huby T, Rubinstein E, Snounou G, Mazier D, Nosten F, Baumert TF, Silvie O., Elife 6(), 2017
PMID: 28506360
Scavenger receptor C promotes bacterial clearance in kuruma shrimp Marsupenaeus japonicus by enhancing hemocyte phagocytosis and AMP expression.
Yang MC, Yang HT, Li J, Sun JJ, Bi WJ, Niu GJ, Zhang Q, Shi XZ, Zhao XF, Wang JX., Fish Shellfish Immunol 67(), 2017
PMID: 28602682
CD36 in chronic kidney disease: novel insights and therapeutic opportunities.
Yang X, Okamura DM, Lu X, Chen Y, Moorhead J, Varghese Z, Ruan XZ., Nat Rev Nephrol 13(12), 2017
PMID: 28919632
SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1.
Fung KY, Wang C, Nyegaard S, Heit B, Fairn GD, Lee WL., Front Physiol 8(), 2017
PMID: 29163190
HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study.
Plochberger B, Röhrl C, Preiner J, Rankl C, Brameshuber M, Madl J, Bittman R, Ros R, Sezgin E, Eggeling C, Hinterdorfer P, Stangl H, Schütz GJ., Sci Rep 7(1), 2017
PMID: 29162870
Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.
Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD., Nat Commun 8(1), 2017
PMID: 29199275
The critical role of toll-like receptors--From microbial recognition to autoimmunity: A comprehensive review.
Jiménez-Dalmaroni MJ, Gerswhin ME, Adamopoulos IE., Autoimmun Rev 15(1), 2016
PMID: 26299984
Tryptophan 415 Is Critical for the Cholesterol Transport Functions of Scavenger Receptor BI.
Holme RL, Miller JJ, Nicholson K, Sahoo D., Biochemistry 55(1), 2016
PMID: 26652912
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases.
Marques AR, Mirzaian M, Akiyama H, Wisse P, Ferraz MJ, Gaspar P, Ghauharali-van der Vlugt K, Meijer R, Giraldo P, Alfonso P, Irún P, Dahl M, Karlsson S, Pavlova EV, Cox TM, Scheij S, Verhoek M, Ottenhoff R, van Roomen CP, Pannu NS, van Eijk M, Dekker N, Boot RG, Overkleeft HS, Blommaart E, Hirabayashi Y, Aerts JM., J Lipid Res 57(3), 2016
PMID: 26724485
Zebrafish scarb2a insertional mutant reveals a novel function for the Scarb2/Limp2 receptor in notochord development.
Diaz-Tellez A, Zampedri C, Ramos-Balderas JL, García-Hernández F, Maldonado E., Dev Dyn 245(4), 2016
PMID: 26743566
Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.
Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S., J Biol Chem 291(16), 2016
PMID: 26907692
Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.
Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M., Proc Natl Acad Sci U S A 113(14), 2016
PMID: 27001828
CD36 actions in the heart: Lipids, calcium, inflammation, repair and more?
Abumrad NA, Goldberg IJ., Biochim Biophys Acta 1861(10), 2016
PMID: 27004753
Leishmania amazonensis Engages CD36 to Drive Parasitophorous Vacuole Maturation.
Okuda K, Tong M, Dempsey B, Moore KJ, Gazzinelli RT, Silverman N., PLoS Pathog 12(6), 2016
PMID: 27280707
A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism.
Gomez-Diaz C, Bargeton B, Abuin L, Bukar N, Reina JH, Bartoi T, Graf M, Ong H, Ulbrich MH, Masson JF, Benton R., Nat Commun 7(), 2016
PMID: 27302750
The structural basis for CD36 binding by the malaria parasite.
Hsieh FL, Turner L, Bolla JR, Robinson CV, Lavstsen T, Higgins MK., Nat Commun 7(), 2016
PMID: 27667267
Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36.
Mao B, Huang S, Lu X, Sun W, Zhou Y, Pan X, Yu J, Lai M, Chen B, Zhou Q, Mao S, Bian G, Zhou J, Nakahata T, Ma F., Stem Cell Reports 7(5), 2016
PMID: 27720903
The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity.
Li Y, Chen B, Zou W, Wang X, Wu Y, Zhao D, Sun Y, Liu Y, Chen L, Miao L, Yang C, Wang X., J Cell Biol 215(2), 2016
PMID: 27810910
β-oxidation and rapid metabolism, but not uptake regulate brain eicosapentaenoic acid levels.
Chen CT, Bazinet RP., Prostaglandins Leukot Essent Fatty Acids 92(), 2015
PMID: 24986271
CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding.
Jay AG, Chen AN, Paz MA, Hung JP, Hamilton JA., J Biol Chem 290(8), 2015
PMID: 25555908
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.
Peters J, Rittger A, Weisner R, Knabbe J, Zunke F, Rothaug M, Damme M, Berkovic SF, Blanz J, Saftig P, Schwake M., Biochem Biophys Res Commun 457(3), 2015
PMID: 25576872
Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport.
Dockendorff C, Faloon PW, Yu M, Youngsaye W, Penman M, Nieland TJ, Nag PP, Lewis TA, Pu J, Bennion M, Negri J, Paterson C, Lam G, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M., ACS Med Chem Lett 6(4), 2015
PMID: 26478787
Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.
Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y., Endocrinology 156(6), 2015
PMID: 25807042
Micellar lipid composition affects micelle interaction with class B scavenger receptor extracellular loops.
Goncalves A, Gontero B, Nowicki M, Margier M, Masset G, Amiot MJ, Reboul E., J Lipid Res 56(6), 2015
PMID: 25833688
Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Dockendorff C, Faloon PW, Pu J, Yu M, Johnston S, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M., Bioorg Med Chem Lett 25(10), 2015
PMID: 25900219
Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.
Dockendorff C, Faloon PW, Germain A, Yu M, Youngsaye W, Nag PP, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M., Bioorg Med Chem Lett 25(12), 2015
PMID: 25958245
Role of LIMP-2 in the intracellular trafficking of β-glucosidase in different human cellular models.
Malini E, Zampieri S, Deganuto M, Romanello M, Sechi A, Bembi B, Dardis A., FASEB J 29(9), 2015
PMID: 26018676
Insight into the mechanism of lipids binding and uptake by CD36 receptor.
Tarhda Z, Ibrahimi A., Bioinformation 11(6), 2015
PMID: 26229291
Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.
Blanz J, Zunke F, Markmann S, Damme M, Braulke T, Saftig P, Schwake M., Traffic 16(10), 2015
PMID: 26219725
A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.
Armstrong SM, Sugiyama MG, Fung KY, Gao Y, Wang C, Levy AS, Azizi P, Roufaiel M, Zhu SN, Neculai D, Yin C, Bolz SS, Seidah NG, Cybulsky MI, Heit B, Lee WL., Cardiovasc Res 108(2), 2015
PMID: 26334034
Nanoparticle Targeting and Cholesterol Flux Through Scavenger Receptor Type B-1 Inhibits Cellular Exosome Uptake.
Plebanek MP, Mutharasan RK, Volpert O, Matov A, Gatlin JC, Thaxton CS., Sci Rep 5(), 2015
PMID: 26511855
CD81 and hepatitis C virus (HCV) infection.
Fénéant L, Levy S, Cocquerel L., Viruses 6(2), 2014
PMID: 24509809
Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions.
Shen WJ, Hu J, Hu Z, Kraemer FB, Azhar S., Metabolism 63(7), 2014
PMID: 24854385
Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism.
Pepino MY, Kuda O, Samovski D, Abumrad NA., Annu Rev Nutr 34(), 2014
PMID: 24850384
Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71.
Dang M, Wang X, Wang Q, Wang Y, Lin J, Sun Y, Li X, Zhang L, Lou Z, Wang J, Rao Z., Protein Cell 5(9), 2014
PMID: 24986489
Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Zhao Y, Ren J, Padilla-Parra S, Fry EE, Stuart DI., Nat Commun 5(), 2014
PMID: 25027712
Receptors for enterovirus 71.
Yamayoshi S, Fujii K, Koike S., Emerg Microbes Infect 3(7), 2014
PMID: 26038749
Molecular mechanisms of cellular cholesterol efflux.
Phillips MC., J Biol Chem 289(35), 2014
PMID: 25074931
CD36 and malaria: friends or foes? A decade of data provides some answers.
Cabrera A, Neculai D, Kain KC., Trends Parasitol 30(9), 2014
PMID: 25113859
Protein sorting at the trans-Golgi network.
Guo Y, Sirkis DW, Schekman R., Annu Rev Cell Dev Biol 30(), 2014
PMID: 25150009
The cellular receptor for enterovirus 71.
Liu Y, Rossmann MG., Protein Cell 5(9), 2014
PMID: 25103897
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport.
Kartz GA, Holme RL, Nicholson K, Sahoo D., Biochemistry 53(39), 2014
PMID: 25211142
Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator.
Qing J, Wang Y, Sun Y, Huang J, Yan W, Wang J, Su D, Ni C, Li J, Rao Z, Liu L, Lou Z., PLoS Pathog 10(10), 2014
PMID: 25275585
LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.
Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J., Proc Natl Acad Sci U S A 111(43), 2014
PMID: 25316793
Polyunsaturated fatty acids and their metabolites in brain function and disease.
Bazinet RP, Layé S., Nat Rev Neurosci 15(12), 2014
PMID: 25387473
Mipu1 overexpression protects macrophages from oxLDL-induced foam cell formation and cell apoptosis.
Qu SL, Fan WJ, Zhang C, Guo F, Han D, Pan WJ, Li W, Feng DM, Jiang ZS., DNA Cell Biol 33(12), 2014
PMID: 25141035

21 References

Daten bereitgestellt von Europe PubMed Central.

Scavenger receptors in homeostasis and immunity.
Canton J, Neculai D, Grinstein S., Nat. Rev. Immunol. 13(9), 2013
PMID: 23928573
Mechanism of scavenger receptor class B type I-mediated selective uptake of cholesteryl esters from high density lipoprotein to adrenal cells.
Rodrigueza WV, Thuahnai ST, Temel RE, Lund-Katz S, Phillips MC, Williams DL., J. Biol. Chem. 274(29), 1999
PMID: 10400657
Exoplasmic cysteine Cys384 of the HDL receptor SR-BI is critical for its sensitivity to a small-molecule inhibitor and normal lipid transport activity.
Yu M, Romer KA, Nieland TJ, Xu S, Saenz-Vash V, Penman M, Yesilaltay A, Carr SA, Krieger M., Proc. Natl. Acad. Sci. U.S.A. 108(30), 2011
PMID: 21746906
Assignment of disulfide bridges in bovine CD36.
Rasmussen JT, Berglund L, Rasmussen MS, Petersen TE., Eur. J. Biochem. 257(2), 1998
PMID: 9826197
LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.
Reczek D, Schwake M, Schroder J, Hughes H, Blanz J, Jin X, Brondyk W, Van Patten S, Edmunds T, Saftig P., Cell 131(4), 2007
PMID: 18022370
Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36.
Ryeom SW, Silverstein RL, Scotto A, Sparrow JR., J. Biol. Chem. 271(34), 1996
PMID: 8702796
Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2.
Jimenez-Dalmaroni MJ, Xiao N, Corper AL, Verdino P, Ainge GD, Larsen DS, Painter GF, Rudd PM, Dwek RA, Hoebe K, Beutler B, Wilson IA., PLoS ONE 4(10), 2009
PMID: 19847289
Identification on human CD36 of a domain (155-183) implicated in binding oxidized low-density lipoproteins (Ox-LDL).
Puente Navazo MD, Daviet L, Ninio E, McGregor JL., Arterioscler. Thromb. Vasc. Biol. 16(8), 1996
PMID: 8696943
Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.
Stylianou IM, Svenson KL, VanOrman SK, Langle Y, Millar JS, Paigen B, Rader DJ., PLoS ONE 4(8), 2009
PMID: 19654867
Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux.
Ji Y, Jian B, Wang N, Sun Y, Moya ML, Phillips MC, Rothblat GH, Swaney JB, Tall AR., J. Biol. Chem. 272(34), 1997
PMID: 9261096
Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.
Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T., Proc. Natl. Acad. Sci. U.S.A. 99(24), 2002
PMID: 12438696
Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M., Biochemistry 47(1), 2007
PMID: 18067275

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 24162852
PubMed | Europe PMC

Suchen in

Google Scholar