How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?
Carrondo MJT, Alves PM, Carinhas N, Glassey J, Hesse F, Merten O-W, Micheletti M, Noll T, Oliveira R, Reichl U, Staby A, et al. (2012)
Biotechnology Journal 7(12): 1522-1529.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Carrondo, Manuel J. T.;
Alves, Paula M.;
Carinhas, Nuno;
Glassey, Jarka;
Hesse, Friedemann;
Merten, Otto-Wilhelm;
Micheletti, Martina;
Noll, ThomasUniBi 
;
Oliveira, Rui;
Reichl, Udo;
Staby, Arne;
Teixeira, Ana P.
Alle
;
Oliveira, Rui;
Reichl, Udo;
Staby, Arne;
Teixeira, Ana P.
Alle
Einrichtung
Abstract / Bemerkung
This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic and industrial backgrounds. The latest ascents in (MC)-C-3 are discussed from a cell culture perspective for industrial process development and production needs. The report concludes with a set of recommendations for targeting (MC)-C-3 research toward the industrial interests. These include issues of importance for biotherapeutics production, miniaturization of measurement techniques and modeling methods.
Stichworte
Stem cells;
Mammalian cells;
Biopharmaceuticals;
Gene therapy;
vectors;
Viral
Erscheinungsjahr
2012
Zeitschriftentitel
Biotechnology Journal
Band
7
Ausgabe
12
Seite(n)
1522-1529
ISSN
1860-6768
Page URI
https://pub.uni-bielefeld.de/record/2553404
Zitieren
Carrondo MJT, Alves PM, Carinhas N, et al. How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal. 2012;7(12):1522-1529.
Carrondo, M. J. T., Alves, P. M., Carinhas, N., Glassey, J., Hesse, F., Merten, O. - W., Micheletti, M., et al. (2012). How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal, 7(12), 1522-1529. doi:10.1002/biot.201200226
Carrondo, Manuel J. T., Alves, Paula M., Carinhas, Nuno, Glassey, Jarka, Hesse, Friedemann, Merten, Otto-Wilhelm, Micheletti, Martina, et al. 2012. “How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?”. Biotechnology Journal 7 (12): 1522-1529.
Carrondo, M. J. T., Alves, P. M., Carinhas, N., Glassey, J., Hesse, F., Merten, O. - W., Micheletti, M., Noll, T., Oliveira, R., Reichl, U., et al. (2012). How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal 7, 1522-1529.
Carrondo, M.J.T., et al., 2012. How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal, 7(12), p 1522-1529.
M.J.T. Carrondo, et al., “How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?”, Biotechnology Journal, vol. 7, 2012, pp. 1522-1529.
Carrondo, M.J.T., Alves, P.M., Carinhas, N., Glassey, J., Hesse, F., Merten, O.-W., Micheletti, M., Noll, T., Oliveira, R., Reichl, U., Staby, A., Teixeira, A.P., Weichert, H., Mandenius, C.-F.: How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology? Biotechnology Journal. 7, 1522-1529 (2012).
Carrondo, Manuel J. T., Alves, Paula M., Carinhas, Nuno, Glassey, Jarka, Hesse, Friedemann, Merten, Otto-Wilhelm, Micheletti, Martina, Noll, Thomas, Oliveira, Rui, Reichl, Udo, Staby, Arne, Teixeira, Ana P., Weichert, Henry, and Mandenius, Carl-Fredrik. “How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?”. Biotechnology Journal 7.12 (2012): 1522-1529.
8 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
On-line soft sensing in upstream bioprocessing.
Randek J, Mandenius CF., Crit Rev Biotechnol 38(1), 2018
PMID: 28423945
Randek J, Mandenius CF., Crit Rev Biotechnol 38(1), 2018
PMID: 28423945
Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation.
Chopda VR, Gomes J, Rathore AS., Biotechnol J 11(1), 2016
PMID: 26647285
Chopda VR, Gomes J, Rathore AS., Biotechnol J 11(1), 2016
PMID: 26647285
Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness.
Konakovsky V, Clemens C, Müller MM, Bechmann J, Berger M, Schlatter S, Herwig C., Bioengineering (Basel) 3(1), 2016
PMID: 28952567
Konakovsky V, Clemens C, Müller MM, Bechmann J, Berger M, Schlatter S, Herwig C., Bioengineering (Basel) 3(1), 2016
PMID: 28952567
Monitoring of an antigen manufacturing process.
Zavatti V, Budman H, Legge R, Tamer M., Bioprocess Biosyst Eng 39(6), 2016
PMID: 26879644
Zavatti V, Budman H, Legge R, Tamer M., Bioprocess Biosyst Eng 39(6), 2016
PMID: 26879644
Process development of a New Haemophilus influenzae type b conjugate vaccine and the use of mathematical modeling to identify process optimization possibilities.
Hamidi A, Kreeftenberg H, V D Pol L, Ghimire S, V D Wielen LA, Ottens M., Biotechnol Prog 32(3), 2016
PMID: 26821825
Hamidi A, Kreeftenberg H, V D Pol L, Ghimire S, V D Wielen LA, Ottens M., Biotechnol Prog 32(3), 2016
PMID: 26821825
Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations.
Mercier SM, Diepenbroek B, Wijffels RH, Streefland M., Trends Biotechnol 32(6), 2014
PMID: 24732022
Mercier SM, Diepenbroek B, Wijffels RH, Streefland M., Trends Biotechnol 32(6), 2014
PMID: 24732022
Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture.
Kempf H, Olmer R, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R., Stem Cell Reports 3(6), 2014
PMID: 25454631
Kempf H, Olmer R, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R., Stem Cell Reports 3(6), 2014
PMID: 25454631
Multivariate data analysis as a PAT tool for early bioprocess development data.
Mercier SM, Diepenbroek B, Dalm MC, Wijffels RH, Streefland M., J Biotechnol 167(3), 2013
PMID: 23871900
Mercier SM, Diepenbroek B, Dalm MC, Wijffels RH, Streefland M., J Biotechnol 167(3), 2013
PMID: 23871900
35 References
Daten bereitgestellt von Europe PubMed Central.
AUTHOR UNKNOWN, 0
Instrumentation of biotechnological processes.
Sonnleitner, Adv. Biochem. Eng. Biotechnol. 66(), 1999
Sonnleitner, Adv. Biochem. Eng. Biotechnol. 66(), 1999
Recent developments in the monitoring, modeling and control of biological production systems.
Mandenius CF., Bioprocess Biosyst Eng 26(6), 2004
PMID: 15597197
Mandenius CF., Bioprocess Biosyst Eng 26(6), 2004
PMID: 15597197
Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative.
Teixeira AP, Oliveira R, Alves PM, Carrondo MJT., Biotechnol. Adv. 27(6), 2009
PMID: 19450676
Teixeira AP, Oliveira R, Alves PM, Carrondo MJT., Biotechnol. Adv. 27(6), 2009
PMID: 19450676
AUTHOR UNKNOWN, 0
AUTHOR UNKNOWN, 0
AUTHOR UNKNOWN, 0
Process analytical technology (PAT) for biopharmaceuticals.
Glassey J, Gernaey KV, Clemens C, Schulz TW, Oliveira R, Striedner G, Mandenius CF., Biotechnol J 6(4), 2011
PMID: 21416609
Glassey J, Gernaey KV, Clemens C, Schulz TW, Oliveira R, Striedner G, Mandenius CF., Biotechnol J 6(4), 2011
PMID: 21416609
Quality-by-design for biotechnology-related pharmaceuticals.
Mandenius CF, Graumann K, Schultz TW, Premstaller A, Olsson IM, Petiot E, Clemens C, Welin M., Biotechnol J 4(5), 2009
PMID: 19418475
Mandenius CF, Graumann K, Schultz TW, Premstaller A, Olsson IM, Petiot E, Clemens C, Welin M., Biotechnol J 4(5), 2009
PMID: 19418475
The use of multidimensional image-based analysis to accurately monitor cell growth in 3D bioreactor culture.
Baradez MO, Marshall D., PLoS ONE 6(10), 2011
PMID: 22028809
Baradez MO, Marshall D., PLoS ONE 6(10), 2011
PMID: 22028809
CellViCAM--Cell viability classification for animal cell cultures using dark field micrographs.
Burgemeister S, Nattkemper TW, Noll T, Hoffrogge R, Flaschel E., J. Biotechnol. 149(4), 2010
PMID: 20655961
Burgemeister S, Nattkemper TW, Noll T, Hoffrogge R, Flaschel E., J. Biotechnol. 149(4), 2010
PMID: 20655961
Evaluation of a genomics platform for cross-species transcriptome analysis of recombinant CHO cells.
Ernst W, Trummer E, Mead J, Bessant C, Strelec H, Katinger H, Hesse F., Biotechnol J 1(6), 2006
PMID: 16892312
Ernst W, Trummer E, Mead J, Bessant C, Strelec H, Katinger H, Hesse F., Biotechnol J 1(6), 2006
PMID: 16892312
Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.
Becker J, Hackl M, Rupp O, Jakobi T, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, Noll T, Puhler A, Tauch A, Brinkrolf K., J. Biotechnol. 156(3), 2011
PMID: 21945585
Becker J, Hackl M, Rupp O, Jakobi T, Schneider J, Szczepanowski R, Bekel T, Borth N, Goesmann A, Grillari J, Kaltschmidt C, Noll T, Puhler A, Tauch A, Brinkrolf K., J. Biotechnol. 156(3), 2011
PMID: 21945585
Flow cytometric monitoring of influenza A virus infection in MDCK cells during vaccine production.
Schulze-Horsel J, Genzel Y, Reichl U., BMC Biotechnol. 8(), 2008
PMID: 18447925
Schulze-Horsel J, Genzel Y, Reichl U., BMC Biotechnol. 8(), 2008
PMID: 18447925
Process engineering of human pluripotent stem cells for clinical application.
Serra M, Brito C, Correia C, Alves PM., Trends Biotechnol. 30(6), 2012
PMID: 22541338
Serra M, Brito C, Correia C, Alves PM., Trends Biotechnol. 30(6), 2012
PMID: 22541338
Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin.
Schwarzer J, Rapp E, Hennig R, Genzel Y, Jordan I, Sandig V, Reichl U., Vaccine 27(32), 2009
PMID: 19410619
Schwarzer J, Rapp E, Hennig R, Genzel Y, Jordan I, Sandig V, Reichl U., Vaccine 27(32), 2009
PMID: 19410619
Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling.
Ritter JB, Wahl AS, Freund S, Genzel Y, Reichl U., BMC Syst Biol 4(), 2010
PMID: 20465796
Ritter JB, Wahl AS, Freund S, Genzel Y, Reichl U., BMC Syst Biol 4(), 2010
PMID: 20465796
Fast filtration for metabolome sampling of suspended animal cells.
Volmer M, Northoff S, Scholz S, Thute T, Buntemeyer H, Noll T., Biotechnol. Lett. 33(3), 2010
PMID: 21072561
Volmer M, Northoff S, Scholz S, Thute T, Buntemeyer H, Noll T., Biotechnol. Lett. 33(3), 2010
PMID: 21072561
A label-free methodology for selective protein quantification by means of absorption measurements.
Hansen SK, Skibsted E, Staby A, Hubbuch J., Biotechnol. Bioeng. 108(11), 2011
PMID: 21755495
Hansen SK, Skibsted E, Staby A, Hubbuch J., Biotechnol. Bioeng. 108(11), 2011
PMID: 21755495
Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.
Mandenius CF, Andersson TB, Alves PM, Batzl-Hartmann C, Bjorquist P, Carrondo MJ, Chesne C, Coecke S, Edsbagge J, Fredriksson JM, Gerlach JC, Heinzle E, Ingelman-Sundberg M, Johansson I, Kuppers-Munther B, Muller-Vieira U, Noor F, Zeilinger K., Altern Lab Anim 39(2), 2011
PMID: 21639679
Mandenius CF, Andersson TB, Alves PM, Batzl-Hartmann C, Bjorquist P, Carrondo MJ, Chesne C, Coecke S, Edsbagge J, Fredriksson JM, Gerlach JC, Heinzle E, Ingelman-Sundberg M, Johansson I, Kuppers-Munther B, Muller-Vieira U, Noor F, Zeilinger K., Altern Lab Anim 39(2), 2011
PMID: 21639679
On-line detection of microbial contaminations in animal cell reactor cultures using an electronic nose device.
Kreij K, Mandenius CF, Clemente JJ, Cunha AE, Monteiro SM, Carrondo MJ, Hesse F, de Los Molinas MM, Wagner R, Merten OW, Geny-Fiamma C, Leger W, Wiesinger-Mayr H, Muller D, Katinger H, Martensson P, Bachinger T, Mitrovics J., Cytotechnology 48(1-3), 2005
PMID: 19003031
Kreij K, Mandenius CF, Clemente JJ, Cunha AE, Monteiro SM, Carrondo MJ, Hesse F, de Los Molinas MM, Wagner R, Merten OW, Geny-Fiamma C, Leger W, Wiesinger-Mayr H, Muller D, Katinger H, Martensson P, Bachinger T, Mitrovics J., Cytotechnology 48(1-3), 2005
PMID: 19003031
Simplified off-gas analyses in animal cell cultures for process monitoring and control purposes.
Aehle M, Kuprijanov A, Schaepe S, Simutis R, Lubbert A., Biotechnol. Lett. 33(11), 2011
PMID: 21744145
Aehle M, Kuprijanov A, Schaepe S, Simutis R, Lubbert A., Biotechnol. Lett. 33(11), 2011
PMID: 21744145
Dynamics of single cell property distributions in Chinese hamster ovary cell cultures monitored and controlled with automated flow cytometry.
Kacmar J, Srienc F., J. Biotechnol. 120(4), 2005
PMID: 16144728
Kacmar J, Srienc F., J. Biotechnol. 120(4), 2005
PMID: 16144728
Synchronous fluorescence spectroscopy as a novel tool to enable PAT applications in bioprocesses.
Teixeira AP, Duarte TM, Carrondo MJ, Alves PM., Biotechnol. Bioeng. 108(8), 2011
PMID: 21391211
Teixeira AP, Duarte TM, Carrondo MJ, Alves PM., Biotechnol. Bioeng. 108(8), 2011
PMID: 21391211
On-line infrared spectroscopy for bioprocess monitoring.
Landgrebe D, Haake C, Hopfner T, Beutel S, Hitzmann B, Scheper T, Rhiel M, Reardon KF., Appl. Microbiol. Biotechnol. 88(1), 2010
PMID: 20652240
Landgrebe D, Haake C, Hopfner T, Beutel S, Hitzmann B, Scheper T, Rhiel M, Reardon KF., Appl. Microbiol. Biotechnol. 88(1), 2010
PMID: 20652240
Soft sensors in bioprocessing: a status report and recommendations.
Luttmann R, Bracewell DG, Cornelissen G, Gernaey KV, Glassey J, Hass VC, Kaiser C, Preusse C, Striedner G, Mandenius CF., Biotechnol J 7(8), 2012
PMID: 22489000
Luttmann R, Bracewell DG, Cornelissen G, Gernaey KV, Glassey J, Hass VC, Kaiser C, Preusse C, Striedner G, Mandenius CF., Biotechnol J 7(8), 2012
PMID: 22489000
Hybrid metabolic flux analysis: combining stoichiometric and statistical constraints to model the formation of complex recombinant products.
Carinhas N, Bernal V, Teixeira AP, Carrondo MJ, Alves PM, Oliveira R., BMC Syst Biol 5(), 2011
PMID: 21352531
Carinhas N, Bernal V, Teixeira AP, Carrondo MJ, Alves PM, Oliveira R., BMC Syst Biol 5(), 2011
PMID: 21352531
Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control.
Teixeira AP, Alves C, Alves PM, Carrondo MJ, Oliveira R., BMC Bioinformatics 8(), 2007
PMID: 17261182
Teixeira AP, Alves C, Alves PM, Carrondo MJ, Oliveira R., BMC Bioinformatics 8(), 2007
PMID: 17261182
AUTHOR UNKNOWN, 0
Review: Mathematical modeling of Protein Chromatograms.
Lienqueo, Chem. Eng. Technol. 35(), 2012
Lienqueo, Chem. Eng. Technol. 35(), 2012
The systematic production of cells for cell therapies.
Kirouac DC, Zandstra PW., Cell Stem Cell 3(4), 2008
PMID: 18940729
Kirouac DC, Zandstra PW., Cell Stem Cell 3(4), 2008
PMID: 18940729
Application of process quality engineering techniques to improve the understanding of the in vitro processing of stem cells for therapeutic use.
Thomas RJ, Hourd PC, Williams DJ., J. Biotechnol. 136(3-4), 2008
PMID: 18672011
Thomas RJ, Hourd PC, Williams DJ., J. Biotechnol. 136(3-4), 2008
PMID: 18672011
High throughput screening for the design and optimization of chromatographic processes: Assessment of model parameter determination from high throughput compatible data.
Susanto, Chem. Eng. Technol. 31(), 2008
Susanto, Chem. Eng. Technol. 31(), 2008
Near-infrared spectroscopy applications in pharmaceutical analysis.
Luypaert J, Massart DL, Vander Heyden Y., Talanta 72(3), 2006
PMID: 19071701
Luypaert J, Massart DL, Vander Heyden Y., Talanta 72(3), 2006
PMID: 19071701
Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches.
Lee HW, Christie A, Liu JJ, Yoon S., Biotechnol. Prog. 28(3), 2012
PMID: 22467629
Lee HW, Christie A, Liu JJ, Yoon S., Biotechnol. Prog. 28(3), 2012
PMID: 22467629
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 22949408
PubMed | Europe PMC
Suchen in
Google Scholar