An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana

Streitner C, Köster T, Simpson CG, Shaw P, Danisman S, Brown JWS, Staiger D (2012)
Nucleic acids research 40(22): 11240-11255.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Streitner, Corinna; Köster, TinoUniBi ; Simpson, Craig G.; Shaw, Paul; Danisman, SelahattinUniBi; Brown, John W. S.; Staiger, DorotheeUniBi
Abstract / Bemerkung
Alternative splicing (AS) of pre-mRNAs is an important regulatory mechanism shaping the transcriptome. In plants, only few RNA-binding proteins are known to affect AS. Here, we show that the glycine-rich RNA-binding protein AtGRP7 influences AS in Arabidopsis thaliana. Using a high-resolution RT-PCR-based AS panel, we found significant changes in the ratios of AS isoforms for 59 of 288 analyzed AS events upon ectopic AtGRP7 expression. In particular, AtGRP7 affected the choice of alternative 5' splice sites preferentially. About half of the events are also influenced by the paralog AtGRP8, indicating that AtGRP7 and AtGRP8 share a network of downstream targets. For 10 events, the AS patterns were altered in opposite directions in plants with elevated AtGRP7 level or lacking AtGRP7. Importantly, RNA immunoprecipitation from plant extracts showed that several transcripts are bound by AtGRP7 in vivo and indeed represent direct targets. Furthermore, the effect of AtGRP7 on these AS events was abrogated by mutation of a single arginine that is required for its RNA-binding activity. This indicates that AtGRP7 impacts AS of these transcripts via direct interaction. As several of the AS events are also controlled by other splicing regulators, our data begin to provide insights into an AS network in Arabidopsis.
Erscheinungsjahr
2012
Zeitschriftentitel
Nucleic acids research
Band
40
Ausgabe
22
Seite(n)
11240-11255
ISSN
0305-1048
eISSN
1362-4962
Page URI
https://pub.uni-bielefeld.de/record/2548847

Zitieren

Streitner C, Köster T, Simpson CG, et al. An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana. Nucleic acids research. 2012;40(22):11240-11255.
Streitner, C., Köster, T., Simpson, C. G., Shaw, P., Danisman, S., Brown, J. W. S., & Staiger, D. (2012). An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana. Nucleic acids research, 40(22), 11240-11255. doi:10.1093/nar/gks873
Streitner, Corinna, Köster, Tino, Simpson, Craig G., Shaw, Paul, Danisman, Selahattin, Brown, John W. S., and Staiger, Dorothee. 2012. “An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana”. Nucleic acids research 40 (22): 11240-11255.
Streitner, C., Köster, T., Simpson, C. G., Shaw, P., Danisman, S., Brown, J. W. S., and Staiger, D. (2012). An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana. Nucleic acids research 40, 11240-11255.
Streitner, C., et al., 2012. An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana. Nucleic acids research, 40(22), p 11240-11255.
C. Streitner, et al., “An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana”, Nucleic acids research, vol. 40, 2012, pp. 11240-11255.
Streitner, C., Köster, T., Simpson, C.G., Shaw, P., Danisman, S., Brown, J.W.S., Staiger, D.: An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana. Nucleic acids research. 40, 11240-11255 (2012).
Streitner, Corinna, Köster, Tino, Simpson, Craig G., Shaw, Paul, Danisman, Selahattin, Brown, John W. S., and Staiger, Dorothee. “An hnRNP-like RNA-binding protein affects alternative splicing by in vivo interaction with transcripts in Arabidopsis thaliana”. Nucleic acids research 40.22 (2012): 11240-11255.

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Daten bereitgestellt von Europe PubMed Central.

On the move through time - a historical review of plant clock research.
Johansson M, Köster T., Plant Biol (Stuttg) 21 Suppl 1(), 2019
PMID: 29607587
Gene regulatory network and abundant genetic variation play critical roles in heading stage of polyploidy wheat.
Shi C, Zhao L, Zhang X, Lv G, Pan Y, Chen F., BMC Plant Biol 19(1), 2019
PMID: 30606101
The Plant Circadian Oscillator.
McClung CR., Biology (Basel) 8(1), 2019
PMID: 30870980
Genome-Wide Association Analyses Reveal the Importance of Alternative Splicing in Diversifying Gene Function and Regulating Phenotypic Variation in Maize.
Chen Q, Han Y, Liu H, Wang X, Sun J, Zhao B, Li W, Tian J, Liang Y, Yan J, Yang X, Tian F., Plant Cell 30(7), 2018
PMID: 29967286
Roles of pre-mRNA splicing and polyadenylation in plant development.
Deng X, Cao X., Curr Opin Plant Biol 35(), 2017
PMID: 27866125
Ectopic Expression of Plant RNA Chaperone Offering Multiple Stress Tolerance in E. coli.
Jabeen B, Naqvi SM, Mahmood T, Sultana T, Arif M, Khan F., Mol Biotechnol 59(2-3), 2017
PMID: 28138902
Splicing-related genes are alternatively spliced upon changes in ambient temperatures in plants.
Verhage L, Severing EI, Bucher J, Lammers M, Busscher-Lange J, Bonnema G, Rodenburg N, Proveniers MC, Angenent GC, Immink RG., PLoS One 12(3), 2017
PMID: 28257507
Natural haplotypes of FLM non-coding sequences fine-tune flowering time in ambient spring temperatures in Arabidopsis.
Lutz U, Nussbaumer T, Spannagl M, Diener J, Mayer KF, Schwechheimer C., Elife 6(), 2017
PMID: 28294941
A Global View of RNA-Protein Interactions Identifies Post-transcriptional Regulators of Root Hair Cell Fate.
Foley SW, Gosai SJ, Wang D, Selamoglu N, Sollitti AC, Köster T, Steffen A, Lyons E, Daldal F, Garcia BA, Staiger D, Deal RB, Gregory BD., Dev Cell 41(2), 2017
PMID: 28441533
RNA-Binding Proteins Revisited - The Emerging Arabidopsis mRNA Interactome.
Köster T, Marondedze C, Meyer K, Staiger D., Trends Plant Sci 22(6), 2017
PMID: 28412036
A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing.
Zhang R, Calixto CPG, Marquez Y, Venhuizen P, Tzioutziou NA, Guo W, Spensley M, Entizne JC, Lewandowska D, Ten Have S, Frei Dit Frey N, Hirt H, James AB, Nimmo HG, Barta A, Kalyna M, Brown JWS., Nucleic Acids Res 45(9), 2017
PMID: 28402429
Structural disorder in plant proteins: where plasticity meets sessility.
Covarrubias AA, Cuevas-Velazquez CL, Romero-Pérez PS, Rendón-Luna DF, Chater CCC., Cell Mol Life Sci 74(17), 2017
PMID: 28643166
RNA structure, binding, and coordination in Arabidopsis.
Foley SW, Kramer MC, Gregory BD., Wiley Interdiscip Rev RNA 8(5), 2017
PMID: 28660659
The 'how' and 'where' of plant microRNAs.
Yu Y, Jia T, Chen X., New Phytol 216(4), 2017
PMID: 29048752
Adaptation of iCLIP to plants determines the binding landscape of the clock-regulated RNA-binding protein AtGRP7.
Meyer K, Köster T, Nolte C, Weinholdt C, Lewinski M, Grosse I, Staiger D., Genome Biol 18(1), 2017
PMID: 29084609
Identification of potential cargo proteins of transportin protein AtTRN1 in Arabidopsis thaliana.
Yan B, Wang X, Wang Z, Chen N, Mu C, Mao K, Han L, Zhang W, Liu H., Plant Cell Rep 35(3), 2016
PMID: 26650834
The LSM1-7 Complex Differentially Regulates Arabidopsis Tolerance to Abiotic Stress Conditions by Promoting Selective mRNA Decapping.
Perea-Resa C, Carrasco-López C, Catalá R, Turečková V, Novak O, Zhang W, Sieburth L, Jiménez-Gómez JM, Salinas J., Plant Cell 28(2), 2016
PMID: 26764377
Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold.
Zhu X, Bührer C, Wellmann S., Cell Mol Life Sci 73(20), 2016
PMID: 27147467
miRNA Biogenesis: A Dynamic Pathway.
Achkar NP, Cambiagno DA, Manavella PA., Trends Plant Sci 21(12), 2016
PMID: 27793495
K-homology nuclear ribonucleoproteins regulate floral organ identity and determinacy in arabidopsis.
Rodríguez-Cazorla E, Ripoll JJ, Andújar A, Bailey LJ, Martínez-Laborda A, Yanofsky MF, Vera A., PLoS Genet 11(2), 2015
PMID: 25658099
RNA around the clock - regulation at the RNA level in biological timing.
Nolte C, Staiger D., Front Plant Sci 6(), 2015
PMID: 25999975
AtRTD - a comprehensive reference transcript dataset resource for accurate quantification of transcript-specific expression in Arabidopsis thaliana.
Zhang R, Calixto CP, Tzioutziou NA, James AB, Simpson CG, Guo W, Marquez Y, Kalyna M, Patro R, Eyras E, Barta A, Nimmo HG, Brown JW., New Phytol 208(1), 2015
PMID: 26111100
Salicylic acid-dependent and -independent impact of an RNA-binding protein on plant immunity.
Hackmann C, Korneli C, Kutyniok M, Köster T, Wiedenlübbert M, Müller C, Staiger D., Plant Cell Environ 37(3), 2014
PMID: 23961939
The SERRATE protein is involved in alternative splicing in Arabidopsis thaliana.
Raczynska KD, Stepien A, Kierzkowski D, Kalak M, Bajczyk M, McNicol J, Simpson CG, Szweykowska-Kulinska Z, Brown JW, Jarmolowski A., Nucleic Acids Res 42(2), 2014
PMID: 24137006
A glycine-rich RNA-binding protein affects gibberellin biosynthesis in Arabidopsis.
Löhr B, Streitner C, Steffen A, Lange T, Staiger D., Mol Biol Rep 41(1), 2014
PMID: 24281950
Arabidopsis PTB1 and PTB2 proteins negatively regulate splicing of a mini-exon splicing reporter and affect alternative splicing of endogenous genes differentially.
Simpson CG, Lewandowska D, Liney M, Davidson D, Chapman S, Fuller J, McNicol J, Shaw P, Brown JW., New Phytol 203(2), 2014
PMID: 24749484
Structural basis of nucleic acid binding by Nicotiana tabacum glycine-rich RNA-binding protein: implications for its RNA chaperone function.
Khan F, Daniëls MA, Folkers GE, Boelens R, Saqlan Naqvi SM, van Ingen H., Nucleic Acids Res 42(13), 2014
PMID: 24957607
HnRNP-like proteins as post-transcriptional regulators.
Yeap WC, Namasivayam P, Ho CL., Plant Sci 227(), 2014
PMID: 25219311
O-GlcNAc-mediated interaction between VER2 and TaGRP2 elicits TaVRN1 mRNA accumulation during vernalization in winter wheat.
Xiao J, Xu S, Li C, Xu Y, Xing L, Niu Y, Huan Q, Tang Y, Zhao C, Wagner D, Gao C, Chong K., Nat Commun 5(), 2014
PMID: 25091017
Regulation of pri-miRNA processing by the hnRNP-like protein AtGRP7 in Arabidopsis.
Köster T, Meyer K, Weinholdt C, Smith LM, Lummer M, Speth C, Grosse I, Weigel D, Staiger D., Nucleic Acids Res 42(15), 2014
PMID: 25104024
Mutational definition of binding requirements of an hnRNP-like protein in Arabidopsis using fluorescence correlation spectroscopy.
Leder V, Lummer M, Tegeler K, Humpert F, Lewinski M, Schüttpelz M, Staiger D., Biochem Biophys Res Commun 453(1), 2014
PMID: 25251471
Genome-wide landscape of alternative splicing events in Brachypodium distachyon.
Walters B, Lum G, Sablok G, Min XJ., DNA Res 20(2), 2013
PMID: 23297300
A new set of reversibly photoswitchable fluorescent proteins for use in transgenic plants.
Lummer M, Humpert F, Wiedenlübbert M, Sauer M, Schüttpelz M, Staiger D., Mol Plant 6(5), 2013
PMID: 23434876
Small changes in ambient temperature affect alternative splicing in Arabidopsis thaliana.
Streitner C, Simpson CG, Shaw P, Danisman S, Brown JW, Staiger D., Plant Signal Behav 8(7), 2013
PMID: 23656882
The circadian clock goes genomic.
Staiger D, Shin J, Johansson M, Davis SJ., Genome Biol 14(6), 2013
PMID: 23796230
RNA-binding proteins associated with desiccation during seed development in rice.
Sano N, Masaki S, Tanabata T, Yamada T, Hirasawa T, Kashiwagi M, Kanekatsu M., Biotechnol Lett 35(11), 2013
PMID: 23873215
Complexity of the alternative splicing landscape in plants.
Reddy AS, Marquez Y, Kalyna M, Barta A., Plant Cell 25(10), 2013
PMID: 24179125

73 References

Daten bereitgestellt von Europe PubMed Central.

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense? Trends Biochem
McGlincy NJ, Smith CW., 2008
Degrade, move, regroup: signaling control of splicing proteins.
Heyd F, Lynch KW., Trends Biochem. Sci. 36(8), 2011
PMID: 21596569
SR proteins and splicing control.
Manley JL, Tacke R., Genes Dev. 10(13), 1996
PMID: 8682289
Alternative pre-mRNA splicing: the logic of combinatorial control.
Smith CW, Valcarcel J., Trends Biochem. Sci. 25(8), 2000
PMID: 10916158
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.
Xue Y, Zhou Y, Wu T, Zhu T, Ji X, Kwon YS, Zhang C, Yeo G, Black DL, Sun H, Fu XD, Zhang Y., Mol. Cell 36(6), 2009
PMID: 20064465
Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis.
Marquez Y, Brown JW, Simpson C, Barta A, Kalyna M., Genome Res. 22(6), 2012
PMID: 22391557
Genomewide comparative analysis of alternative splicing in plants.
Wang BB, Brendel V., Proc. Natl. Acad. Sci. U.S.A. 103(18), 2006
PMID: 16632598
Comprehensive analysis of alternative splicing in rice and comparative analyses with Arabidopsis.
Campbell MA, Haas BJ, Hamilton JP, Mount SM, Buell CR., BMC Genomics 7(), 2006
PMID: 17194304
Intron retention is a major phenomenon in alternative splicing in Arabidopsis.
Ner-Gaon H, Halachmi R, Savaldi-Goldstein S, Rubin E, Ophir R, Fluhr R., Plant J. 39(6), 2004
PMID: 15341630
Genome-wide analyses of alternative splicing in plants: opportunities and challenges.
Barbazuk WB, Fu Y, McGinnis KM., Genome Res. 18(9), 2008
PMID: 18669480
Localization and dynamics of nuclear speckles in plants.
Reddy AS, Day IS, Gohring J, Barta A., Plant Physiol. 158(1), 2011
PMID: 22045923
atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes.
Lopato S, Kalyna M, Dorner S, Kobayashi R, Krainer AR, Barta A., Genes Dev. 13(8), 1999
PMID: 10215626
UBP1, a novel hnRNP-like protein that functions at multiple steps of higher plant nuclear pre-mRNA maturation.
Lambermon MH, Simpson GG, Wieczorek Kirk DA, Hemmings-Mieszczak M, Klahre U, Filipowicz W., EMBO J. 19(7), 2000
PMID: 10747031
Dual functionality of a plant U-rich intronic sequence element.
Simpson CG, Jennings SN, Clark GP, Thow G, Brown JW., Plant J. 37(1), 2004
PMID: 14675434
RNA-binding proteins and circadian rhythms in Arabidopsis thaliana.
Staiger D., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 356(1415), 2001
PMID: 11710982
The circadian system of Arabidopsis thaliana: forward and reverse genetic approaches.
Staiger D, Heintzen C., Chronobiol. Int. 16(1), 1999
PMID: 10023572
A methyl transferase links the circadian clock to the regulation of alternative splicing.
Sanchez SE, Petrillo E, Beckwith EJ, Zhang X, Rugnone ML, Hernando CE, Cuevas JC, Godoy Herz MA, Depetris-Chauvin A, Simpson CG, Brown JW, Cerdan PD, Borevitz JO, Mas P, Ceriani MF, Kornblihtt AR, Yanovsky MJ., Nature 468(7320), 2010
PMID: 20962777
Monitoring changes in alternative precursor messenger RNA splicing in multiple gene transcripts.
Simpson CG, Fuller J, Maronova M, Kalyna M, Davidson D, McNicol J, Barta A, Brown JW., Plant J. 53(6), 2007
PMID: 18088312
Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana.
Raczynska KD, Simpson CG, Ciesiolka A, Szewc L, Lewandowska D, McNicol J, Szweykowska-Kulinska Z, Brown JW, Jarmolowski A., Nucleic Acids Res. 38(1), 2009
PMID: 19864257
Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis.
Kalyna M, Simpson CG, Syed NH, Lewandowska D, Marquez Y, Kusenda B, Marshall J, Fuller J, Cardle L, McNicol J, Dinh HQ, Barta A, Brown JW., Nucleic Acids Res. 40(6), 2011
PMID: 22127866
Auto-regulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation.
Schoning JC, Streitner C, Page DR, Hennig S, Uchida K, Wolf E, Furuya M, Staiger D., Plant J. 52(6), 2007
PMID: 17924945
Nonsense-mediated mRNA decay factors, UPF1 and UPF3, contribute to plant defense.
Jeong HJ, Kim YJ, Kim SH, Kim YH, Lee IJ, Kim YK, Shin JS., Plant Cell Physiol. 52(12), 2011
PMID: 22025558
The small glycine-rich RNA binding protein AtGRP7 promotes floral transition in Arabidopsis thaliana.
Streitner C, Danisman S, Wehrle F, Schoning JC, Alfano JR, Staiger D., Plant J. 56(2), 2008
PMID: 18573194
AtGRP7, a nuclear RNA-binding protein as a component of a circadian-regulated negative feedback loop in Arabidopsis thaliana.
Heintzen C, Nater M, Apel K, Staiger D., Proc. Natl. Acad. Sci. U.S.A. 94(16), 1997
PMID: 9238008
A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity.
Fu ZQ, Guo M, Jeong BR, Tian F, Elthon TE, Cerny RL, Staiger D, Alfano JR., Nature 447(7142), 2007
PMID: 17450127
Global transcript profiling of transgenic plants constitutively overexpressing the RNA-binding protein AtGRP7.
Streitner C, Hennig L, Korneli C, Staiger D., BMC Plant Biol. 10(), 2010
PMID: 20946635
Reversible photoswitchable DRONPA-s monitors nucleocytoplasmic transport of an RNA-binding protein in transgenic plants.
Lummer M, Humpert F, Steuwe C, Caesar K, Schuttpelz M, Sauer M, Staiger D., Traffic 12(6), 2011
PMID: 21453442
The 1001 genomes project for Arabidopsis thaliana.
Weigel D, Mott R., Genome Biol. 10(5), 2009
PMID: 19519932
Arabidopsis RNA immunoprecipitation.
Terzi LC, Simpson GG., Plant J. 59(1), 2009
PMID: 19419533
Genome-wide identification of polycomb-associated RNAs by RIP-seq.
Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT., Mol. Cell 40(6), 2010
PMID: 21172659
Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity.
Jeong BR, Lin Y, Joe A, Guo M, Korneli C, Yang H, Wang P, Yu M, Cerny RL, Staiger D, Alfano JR, Xu Y., J. Biol. Chem. 286(50), 2011
PMID: 22013065
The RNA structure alignment ontology.
Brown JW, Birmingham A, Griffiths PE, Jossinet F, Kachouri-Lafond R, Knight R, Lang BF, Leontis N, Steger G, Stombaugh J, Westhof E., RNA 15(9), 2009
PMID: 19622678
Changes in conformational dynamics of mRNA upon AtGRP7 binding studied by fluorescence correlation spectroscopy.
Schuttpelz M, Schoning JC, Doose S, Neuweiler H, Peters E, Staiger D, Sauer M., J. Am. Chem. Soc. 130(29), 2008
PMID: 18576621
Quantitative analysis of single-molecule RNA-protein interaction.
Fuhrmann A, Schoening JC, Anselmetti D, Staiger D, Ros R., Biophys. J. 96(12), 2009
PMID: 19527663
Multiple reference genomes and transcriptomes for Arabidopsis thaliana.
Gan X, Stegle O, Behr J, Steffen JG, Drewe P, Hildebrand KL, Lyngsoe R, Schultheiss SJ, Osborne EJ, Sreedharan VT, Kahles A, Bohnert R, Jean G, Derwent P, Kersey P, Belfield EJ, Harberd NP, Kemen E, Toomajian C, Kover PX, Clark RM, Ratsch G, Mott R., Nature 477(7365), 2011
PMID: 21874022
Deciphering the splicing code.
Barash Y, Calarco JA, Gao W, Pan Q, Wang X, Shai O, Blencowe BJ, Frey BJ., Nature 465(7294), 2010
PMID: 20445623
Understanding alternative splicing: towards a cellular code.
Matlin AJ, Clark F, Smith CW., Nat. Rev. Mol. Cell Biol. 6(5), 2005
PMID: 15956978
Plant SR proteins and their functions.
Barta A, Kalyna M, Lorkovic ZJ., Curr. Top. Microbiol. Immunol. 326(), 2008
PMID: 18630748
Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements.
Lareau LF, Inada M, Green RE, Wengrod JC, Brenner SE., Nature 446(7138), 2007
PMID: 17361132
Evolutionary conservation and regulation of particular alternative splicing events in plant SR proteins.
Kalyna M, Lopato S, Voronin V, Barta A., Nucleic Acids Res. 34(16), 2006
PMID: 16936312
Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay.
Ni JZ, Grate L, Donohue JP, Preston C, Nobida N, O'Brien G, Shiue L, Clark TA, Blume JE, Ares M Jr., Genes Dev. 21(6), 2007
PMID: 17369403
In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.
Duncan PI, Stojdl DF, Marius RM, Bell JC., Mol. Cell. Biol. 17(10), 1997
PMID: 9315658
LAMMER kinase Kic1 is involved in pre-mRNA processing.
Tang Z, Luca M, Portillio J, Ngo B, Chang C, Wen T, Murray J, Carr A., Exp. Cell Res. 317(16), 2011
PMID: 21745468
The ethylene-inducible PK12 kinase mediates the phosphorylation of SR splicing factors.
Savaldi-Goldstein S, Sessa G, Fluhr R., Plant J. 21(1), 2000
PMID: 10652154
Alternative splicing modulation by a LAMMER kinase impinges on developmental and transcriptome expression.
Savaldi-Goldstein S, Aviv D, Davydov O, Fluhr R., Plant Cell 15(4), 2003
PMID: 12671088
Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.
Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW., Nat. Struct. Mol. Biol. 17(9), 2010
PMID: 20711188
Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.
Deng X, Gu L, Liu C, Lu T, Lu F, Lu Z, Cui P, Pei Y, Wang B, Hu S, Cao X., Proc. Natl. Acad. Sci. U.S.A. 107(44), 2010
PMID: 20956294
Alternative splicing in plants--coming of age.
Syed NH, Kalyna M, Marquez Y, Barta A, Brown JW., Trends Plant Sci. 17(10), 2012
PMID: 22743067
RNA-based regulation in the plant circadian clock.
Staiger D, Green R., Trends Plant Sci. 16(10), 2011
PMID: 21782493
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