rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains
Beckert P, Hillemann D, Kohl T, Kalinowski J, Richter E, Niemann S, Feuerriegel S (2012)
Antimicrobial Agents and Chemotherapy 56(5): 2743-2745.
Zeitschriftenaufsatz
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Autor*in
Beckert, Patrick;
Hillemann, Doris;
Kohl, ThomasUniBi;
Kalinowski, JörnUniBi;
Richter, Elvira;
Niemann, Stefan;
Feuerriegel, Silke
Einrichtung
Abstract / Bemerkung
The ribosomal L3 protein was identified as a novel target in linezolid (LZD)-resistant Mycobacterium tuberculosis strains. Next-generation sequencing confirmed rplC T460C as the sole mutation in an LZD-resistant M. tuberculosis H37Rv strain selected in vitro. Sequencing analysis revealed the rplC T460C mutation in eight further LZD-resistant isolates (three in vitro-selected mutants and five patient isolates, including isolates from three different patients that developed LZD resistance during treatment) but in none of the susceptible control strains (n = 84).
Erscheinungsjahr
2012
Zeitschriftentitel
Antimicrobial Agents and Chemotherapy
Band
56
Ausgabe
5
Seite(n)
2743-2745
ISSN
0066-4804
eISSN
1098-6596
Page URI
https://pub.uni-bielefeld.de/record/2501701
Zitieren
Beckert P, Hillemann D, Kohl T, et al. rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains. Antimicrobial Agents and Chemotherapy. 2012;56(5):2743-2745.
Beckert, P., Hillemann, D., Kohl, T., Kalinowski, J., Richter, E., Niemann, S., & Feuerriegel, S. (2012). rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains. Antimicrobial Agents and Chemotherapy, 56(5), 2743-2745. doi:10.1128/AAC.06227-11
Beckert, Patrick, Hillemann, Doris, Kohl, Thomas, Kalinowski, Jörn, Richter, Elvira, Niemann, Stefan, and Feuerriegel, Silke. 2012. “rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains”. Antimicrobial Agents and Chemotherapy 56 (5): 2743-2745.
Beckert, P., Hillemann, D., Kohl, T., Kalinowski, J., Richter, E., Niemann, S., and Feuerriegel, S. (2012). rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains. Antimicrobial Agents and Chemotherapy 56, 2743-2745.
Beckert, P., et al., 2012. rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains. Antimicrobial Agents and Chemotherapy, 56(5), p 2743-2745.
P. Beckert, et al., “rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains”, Antimicrobial Agents and Chemotherapy, vol. 56, 2012, pp. 2743-2745.
Beckert, P., Hillemann, D., Kohl, T., Kalinowski, J., Richter, E., Niemann, S., Feuerriegel, S.: rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains. Antimicrobial Agents and Chemotherapy. 56, 2743-2745 (2012).
Beckert, Patrick, Hillemann, Doris, Kohl, Thomas, Kalinowski, Jörn, Richter, Elvira, Niemann, Stefan, and Feuerriegel, Silke. “rplC T460C Identified as a Dominant Mutation in Linezolid-Resistant Mycobacterium tuberculosis Strains”. Antimicrobial Agents and Chemotherapy 56.5 (2012): 2743-2745.
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