Structural insights into Met receptor activation

Niemann H (2011)
European Journal of Cell Biology 90(11): 972-981.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The receptor tyrosine kinase Met plays a pivotal role in vertebrate development and tissue regeneration, its deregulation contributes to cancer. Met is also targeted during the infection by the facultative intracellular bacterium Listeria monocytogenes. The mechanistic basis for Met activation by its natural ligand hepatocyte growth factor/scatter factor (HGF/SF) is only beginning to be understood at a structural level. Crystal structures of Met in complex with L. monocytogenes InlB suggest that Met dimerization by this bacterial invasion protein is mediated by a dimer contact of the ligand. Here, I review the structural basis of Met activation by InlB and highlight parallels and differences to the physiological Met ligand HGF/SF and its splice variant NK1.
Bacterial pathogenesis; InlB; Hepatocyte growth factor; Internalin; Met; Protein structure; Receptor tyrosine kinase; Transmembrane signaling; Signal transduction
European Journal of Cell Biology
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Niemann H. Structural insights into Met receptor activation. European Journal of Cell Biology. 2011;90(11):972-981.
Niemann, H. (2011). Structural insights into Met receptor activation. European Journal of Cell Biology, 90(11), 972-981.
Niemann, H. (2011). Structural insights into Met receptor activation. European Journal of Cell Biology 90, 972-981.
Niemann, H., 2011. Structural insights into Met receptor activation. European Journal of Cell Biology, 90(11), p 972-981.
H. Niemann, “Structural insights into Met receptor activation”, European Journal of Cell Biology, vol. 90, 2011, pp. 972-981.
Niemann, H.: Structural insights into Met receptor activation. European Journal of Cell Biology. 90, 972-981 (2011).
Niemann, Hartmut. “Structural insights into Met receptor activation”. European Journal of Cell Biology 90.11 (2011): 972-981.

19 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

C-MET inhibitors for advanced non-small cell lung cancer.
Pasquini G, Giaccone G., Expert Opin Investig Drugs 27(4), 2018
PMID: 29621416
Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor.
Ueki R, Ueki A, Kanda N, Sando S., Angew Chem Int Ed Engl 55(2), 2016
PMID: 26592704
Targeted therapies in gastric cancer treatment: where we are and where we are going.
Tomasello G, Ghidini M, Liguigli W, Ratti M, Toppo L, Passalacqua R., Invest New Drugs 34(3), 2016
PMID: 26873643
Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.
Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mély Y, Heilemann M, Niemann HH, Orian-Rousseau V., Biosci Rep 35(4), 2015
PMID: 26181364
Clinical impact of the HGF/MET pathway activation in patients with advanced gastric cancer treated with palliative chemotherapy.
Graziano F, Catalano V, Lorenzini P, Giacomini E, Sarti D, Fiorentini G, De Nictolis M, Magnani M, Ruzzo A., Pharmacogenomics J 14(5), 2014
PMID: 24663077
Crystal structure of an engineered YopM-InlB hybrid protein.
Breitsprecher D, Gherardi E, Bleymüller WM, Niemann HH., BMC Struct Biol 14(), 2014
PMID: 24669959
The challenge of targeted therapies for gastric cancer patients: the beginning of a long journey.
Aprile G, Giampieri R, Bonotto M, Bittoni A, Ongaro E, Cardellino GG, Graziano F, Giuliani F, Fasola G, Cascinu S, Scartozzi M., Expert Opin Investig Drugs 23(7), 2014
PMID: 24806575
Lipopolysaccharide-induced phosphorylation of c-Met tyrosine residue 1003 regulates c-Met intracellular trafficking and lung epithelial barrier function.
Zhao Y, Zhao J, Mialki RK, Wei J, Spannhake EW, Salgia R, Natarajan V., Am J Physiol Lung Cell Mol Physiol 305(1), 2013
PMID: 23624790
Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells.
Dietz MS, Haße D, Ferraris DM, Göhler A, Niemann HH, Heilemann M., BMC Biophys 6(1), 2013
PMID: 23731667
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Merchant M, Ma X, Maun HR, Zheng Z, Peng J, Romero M, Huang A, Yang NY, Nishimura M, Greve J, Santell L, Zhang YW, Su Y, Kaufman DW, Billeci KL, Mai E, Moffat B, Lim A, Duenas ET, Phillips HS, Xiang H, Young JC, Vande Woude GF, Dennis MS, Reilly DE, Schwall RH, Starovasnik MA, Lazarus RA, Yansura DG., Proc Natl Acad Sci U S A 110(32), 2013
PMID: 23882082
The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid.
Smith EJ, Corrigan RM, van der Sluis T, Gründling A, Speziale P, Geoghegan JA, Foster TJ., Mol Microbiol 83(4), 2012
PMID: 22256861
Decorin: a guardian from the matrix.
Neill T, Schaefer L, Iozzo RV., Am J Pathol 181(2), 2012
PMID: 22735579


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